McGill is recruiting top-tier researchers working abroad through the federally funded Canada Impact+ Research Chairs program, addressing global and national challenges. The first round is due in early 2026. Learn more and submit your candidacy: https://mcgill.ca/x/5Zh

📢 NEW exciting opportunity! Join Queen’s University as a tenure-track Assistant Professor in Cell Engineering and Biomanufacturing, with opportunities for interdisciplinary research across #ChemicalEngineering and #Biomedical and #MolecularSciences. 🔬 🔗 stemcellnetwork.ca/career-oppor...

Delivery of DLL1+FLT3L+IL-7 mRNA to hepatocytes boosted thymopoiesis to rejuvenate aged T cells & enhance DC abundance/function to restore immune function @nature.com @hhmi-science.bsky.social @broadinstitute.org @zhangf.bsky.social www.nature.com/articles/s41... www.nature.com/articles/d41...

Now in @natcomms.nature.com! Expanded well beyond the preprint, w/new experiments in iPSCs, kinetic analysis at the DNA & protein levels, & more. Kudos to the team (esp. Rajini Srinivasan, Tao Sun, and Andrew Ng) & the editor + reviewers for strengthening this work! www.nature.com/articles/s41...

In relapsed or refractory T-cell acute lymphoblastic leukemia, off-the-shelf allogeneic base-edited CAR7 T cells mediated responses in 11 patients, enabling stem-cell transplantation in 9 patients in deep remission. Full study results: nej.md/48wiyQL #ASH25 | @ash.hematology.org

Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!

🧪 @gingraslab.bsky.social compared 10 enzymes used for proximity biotinylation proteomics experiments. UltraID is the winner. www.biorxiv.org/content/10.1...

Grateful to the @src-crs.bsky.social for supporting our project using next-gen cell-based models + functional genomics to map how prostate cancer develops + how drug resistance arises! Many thanks to our collaborators + congrats to fellow awardees! cancerresearchsociety.ca/news/100-new...

🔊 Career opportunity: Professor / Associate Professor (Tenure) – Dr. Connie Eaves Chair in Cancer Stem Cell Research! This position offers a unique opportunity to drive transformative research integrating cutting-edge technologies to improve patient outcomes. 🔬 🔗 stemcellnetwork.ca/wp-content/u...

Influenza remains an important cause of illness and death. In a phase 3 trial, a nucleoside-modified mRNA (modRNA) quadrivalent vaccine was found to be superior to a standard quadrivalent vaccine in preventing influenza illness. Full trial results: nej.md/43udoTG #MedSky #IDSky

Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8

A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu

🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...

I take this example from @ceronifranci.bsky.social to highlight that we, at CSH Protocols, are also always interested in review articles like this, centered around techniques. So, if you have an idea, let's talk! www.sciencedirect.com/science/arti...

Transcriptional interferences ensure one olfactory receptor per ant neuron www.nature.com/articles/s41... Caviar for RNA-Seq nerds! Check this out

I am proud to be a member of the #ISSCR2026 Program Committee and to have helped develop the outstanding program, taking place in Montréal, Canada on 8-11 July 2026. Register to hear the excellent science presented! invt.io/1bxbi6gtbsl @isscr.org

I can't take any credit but I am still really excited about this LNP Review in @natbiomedeng.nature.com! Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level | Nature Biomedical Engineering share.google/vIhr3EOMUfke...

I’m very surprised that the frequently discussed topic of repeated adaptation through the same molecular pathways hadn’t been summarised in a review before. But that has now changed, and that’s a good thing. Thank you @siribirkeland.bsky.social www.cell.com/trends/genet...

We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3

Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...

The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...

**POSTDOC POSITION** My lab (www.goyallab.org) at Northwestern and CZ Biohub Chicago looking for a postdoctoc in quantitative biology. We work on a range of topics, including single-cell cancer plasticity, modeling single-cell perturbations, theory, and stem-embryo models. contact via email. Pls RT

Love RNA biology? Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇). PhD student/postdoc position co-supervised by Clemens Plaschka & myself. DM or email us if you’d like to know more! @vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social

Doomscrolling pause to chat CRISPR libraries! Preprint describes our new, data-driven approach to combine on-target and off-target predictions much more intelligently for *selecting* guides, which we use to develop our newest Cas9 knockout library, Jacquere. Thread: www.biorxiv.org/content/10.1...

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!

Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

🧪 Registrations open for the #BarcelonaBiomed conference "When Development Meets #Cancer: Origins, Models & Therapies in #ChildhoodCancer." Organised by Dr. Alexandra Avgustinova, Dr. Cayetano González (@irbbarcelona.org) & Dr. Jaume Mora (@sjdhospitalbarcelona.org#BarcelonaBiomed#Cancer:#ChildhoodCancer."➡️ https://f.mtr.cool/hpdbcpiant

📣Faculty Position Opening! 👩🏾‍🔬An exciting opportunity for an Assistant Professor position in aging research at @UMontreal 🗓️Application deadline 15 September #FacultyJobs #CdnSci #Research #Aging medicinoxy.com/assistant-pr...

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

last call! submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!

New preprint that we're super excited to share! With @ceo.onjcri.org.au and colleagues @wehi-research.bsky.social and @ONJCRI, along with teams @Genentech, we developed + demonstrate the use of Partita, a new suite of CRISPRa libraries for murine model systems. www.biorxiv.org/content/10.1...

Going deep on 2A peptides: www.cell.com/cell-reports... (Trying to pick between GSG:T2A, GSG:P2A, and furin site:GSG:T2A)

We’re thrilled to announce IGI–Bakar Labs. This new building will allow the IGI to continue expanding our impact in health and agricultural applications of #CRISPR, and will be shared with the Bakar Labs incubator for growing biotech companies. Learn more: news.berkeley.edu/2025/07/17/c...

Isoform-specific single-cell perturb-seq reveals distinct functions of alternative promoters in drug response https://www.biorxiv.org/content/10.1101/2025.07.14.664827v1

Excited to share our latest by my postdoc Ben KS: we use statistical physics & Bayesian inference to model genome-wide perturbation outcomes. Remarkably, perturbation responses are encoded in gene "chatter" even before the perturbation–a fundamental insight with broad implications shorturl.at/2LHbw

Please RT! The oncology department & McGill is hiring an Assistant professor for a lab to be located at Lady Davis Institute (where I am!). McGill and the Lady Davis are fantastic places to do research and Montreal is great city to live in. mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Here we go, my first skeet-torial(?) on Bluesky for my first paper from @talusbio.bsky.social ! www.biorxiv.org/content/10.1... This preprint describes our scalable, mass spec-based method for measuring which (and how many of them) proteins are interacting with DNA. 1/?

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. www.nature.com/articles/s41...

Now in @natcomms.nature.com‬! Our work on the molecular mechanisms of gymnosis & its relevance to ASO/oligo therapeutics. An amazing collaboration with F. Roudnicky, L. Malong, A. Spang & more. Thanks to the editor/reviewers for their thoughtful feedback. www.nature.com/articles/s41...

Broad's Machine Learning in Drug Discovery Symposium coming soon! Nov 7, 2025. Another great lineup. In person (Cambridge MA) and online options Register by July 4 for a discount www.broadinstitute.org/machine-lear...

Here is the official posting for a faculty job in Pharmacology and Therapeutics at Roswell Park Comprehensive Cancer Center! Feel free to DM or email with questions. roswellpark.wd5.myworkdayjobs.com/en-US/Ext-RP...

Acquired resistance limits the efficacy of cancer treatments & accounts for therapy failure in most patients. Our Roadmap explores how innovative technologies bridge the gap between fundamental research on resistance and clinical translation into actionable strategies www.nature.com/articles/s41...

Cool stuff re: plasmid chromatinization from the Stergachis Lab (not on Bluesky?). As they note in the discussion, it would be interesting to apply this to other extra-chromosomal contexts like AAV and the ecDNA found in some tumor cells. www.biorxiv.org/content/10.1...

@isabellease.bsky.social is drawing amazing artwork for each speaker at #VariantEffect25 - crazy beautiful and super good summaries in all cases, have a look🤯

One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...

Cool! And, potentially super useful for synbio applications!

Online now in Cancer Discovery for the #AACR25 session on Advances in #KRAS Biology in PDAC by session speaker Andrew Aguirre: Response and Resistance to RAS inhibition in Cancer doi.org/10.1158/2159...#AACR25

Another McGill Assistant Professor job at the Lady Davis Institute (where I am)! This is for an immunology (host-virus interactions) position! Come by my colleague! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

In @nature.com we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR enzymes, offering safer & more efficient genome editing tools 🧬🖥️ @rachelsilverstein9.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social www.nature.com/articles/s41...