A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu

🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...

I take this example from @ceronifranci.bsky.social to highlight that we, at CSH Protocols, are also always interested in review articles like this, centered around techniques. So, if you have an idea, let's talk! www.sciencedirect.com/science/arti...

Transcriptional interferences ensure one olfactory receptor per ant neuron www.nature.com/articles/s41... Caviar for RNA-Seq nerds! Check this out

I am proud to be a member of the #ISSCR2026 Program Committee and to have helped develop the outstanding program, taking place in Montréal, Canada on 8-11 July 2026. Register to hear the excellent science presented! invt.io/1bxbi6gtbsl @isscr.org

I can't take any credit but I am still really excited about this LNP Review in @natbiomedeng.nature.com! Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level | Nature Biomedical Engineering share.google/vIhr3EOMUfke...

I’m very surprised that the frequently discussed topic of repeated adaptation through the same molecular pathways hadn’t been summarised in a review before. But that has now changed, and that’s a good thing. Thank you @siribirkeland.bsky.social www.cell.com/trends/genet...

We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3

Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...

The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...

**POSTDOC POSITION** My lab (www.goyallab.org) at Northwestern and CZ Biohub Chicago looking for a postdoctoc in quantitative biology. We work on a range of topics, including single-cell cancer plasticity, modeling single-cell perturbations, theory, and stem-embryo models. contact via email. Pls RT

Love RNA biology? Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇). PhD student/postdoc position co-supervised by Clemens Plaschka & myself. DM or email us if you’d like to know more! @vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social

Doomscrolling pause to chat CRISPR libraries! Preprint describes our new, data-driven approach to combine on-target and off-target predictions much more intelligently for *selecting* guides, which we use to develop our newest Cas9 knockout library, Jacquere. Thread: www.biorxiv.org/content/10.1...

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!

Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

🧪 Registrations open for the #BarcelonaBiomed conference "When Development Meets #Cancer: Origins, Models & Therapies in #ChildhoodCancer." Organised by Dr. Alexandra Avgustinova, Dr. Cayetano González (@irbbarcelona.org) & Dr. Jaume Mora (@sjdhospitalbarcelona.org#BarcelonaBiomed#Cancer:#ChildhoodCancer."➡️ https://f.mtr.cool/hpdbcpiant

📣Faculty Position Opening! 👩🏾‍🔬An exciting opportunity for an Assistant Professor position in aging research at @UMontreal 🗓️Application deadline 15 September #FacultyJobs #CdnSci #Research #Aging medicinoxy.com/assistant-pr...

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

last call! submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!

New preprint that we're super excited to share! With @ceo.onjcri.org.au and colleagues @wehi-research.bsky.social and @ONJCRI, along with teams @Genentech, we developed + demonstrate the use of Partita, a new suite of CRISPRa libraries for murine model systems. www.biorxiv.org/content/10.1...

Going deep on 2A peptides: www.cell.com/cell-reports... (Trying to pick between GSG:T2A, GSG:P2A, and furin site:GSG:T2A)

We’re thrilled to announce IGI–Bakar Labs. This new building will allow the IGI to continue expanding our impact in health and agricultural applications of #CRISPR, and will be shared with the Bakar Labs incubator for growing biotech companies. Learn more: news.berkeley.edu/2025/07/17/c...

Isoform-specific single-cell perturb-seq reveals distinct functions of alternative promoters in drug response https://www.biorxiv.org/content/10.1101/2025.07.14.664827v1

Excited to share our latest by my postdoc Ben KS: we use statistical physics & Bayesian inference to model genome-wide perturbation outcomes. Remarkably, perturbation responses are encoded in gene "chatter" even before the perturbation–a fundamental insight with broad implications shorturl.at/2LHbw

Please RT! The oncology department & McGill is hiring an Assistant professor for a lab to be located at Lady Davis Institute (where I am!). McGill and the Lady Davis are fantastic places to do research and Montreal is great city to live in. mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Here we go, my first skeet-torial(?) on Bluesky for my first paper from @talusbio.bsky.social ! www.biorxiv.org/content/10.1... This preprint describes our scalable, mass spec-based method for measuring which (and how many of them) proteins are interacting with DNA. 1/?

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. www.nature.com/articles/s41...

Now in @natcomms.nature.com‬! Our work on the molecular mechanisms of gymnosis & its relevance to ASO/oligo therapeutics. An amazing collaboration with F. Roudnicky, L. Malong, A. Spang & more. Thanks to the editor/reviewers for their thoughtful feedback. www.nature.com/articles/s41...

Broad's Machine Learning in Drug Discovery Symposium coming soon! Nov 7, 2025. Another great lineup. In person (Cambridge MA) and online options Register by July 4 for a discount www.broadinstitute.org/machine-lear...

Here is the official posting for a faculty job in Pharmacology and Therapeutics at Roswell Park Comprehensive Cancer Center! Feel free to DM or email with questions. roswellpark.wd5.myworkdayjobs.com/en-US/Ext-RP...

Acquired resistance limits the efficacy of cancer treatments & accounts for therapy failure in most patients. Our Roadmap explores how innovative technologies bridge the gap between fundamental research on resistance and clinical translation into actionable strategies www.nature.com/articles/s41...

Cool stuff re: plasmid chromatinization from the Stergachis Lab (not on Bluesky?). As they note in the discussion, it would be interesting to apply this to other extra-chromosomal contexts like AAV and the ecDNA found in some tumor cells. www.biorxiv.org/content/10.1...

@isabellease.bsky.social is drawing amazing artwork for each speaker at #VariantEffect25 - crazy beautiful and super good summaries in all cases, have a look🤯

One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...

Cool! And, potentially super useful for synbio applications!

Online now in Cancer Discovery for the #AACR25 session on Advances in #KRAS Biology in PDAC by session speaker Andrew Aguirre: Response and Resistance to RAS inhibition in Cancer doi.org/10.1158/2159...#AACR25

Another McGill Assistant Professor job at the Lady Davis Institute (where I am)! This is for an immunology (host-virus interactions) position! Come by my colleague! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

In @nature.com we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR enzymes, offering safer & more efficient genome editing tools 🧬🖥️ @rachelsilverstein9.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social www.nature.com/articles/s41...

Transplanting dopamine-releasing neurons into the brain is a promising regenerative therapy for Parkinson’s disease shown safe in two clinical trials @nature.com www.nature.com/articles/d41... www.nature.com/articles/s41... www.nature.com/articles/s41...

Engineering innate immune cells for cancer immunotherapy go.nature.com/3E9NbjZ

'We used a high-throughput platform to systematically evaluate the impact of co-expressing a TCR and CAR on the same CAR T cell. While strong TCR-antigen interactions enhanced CAR activation, weak TCR-antigen interactions actively antagonized their activation' #Immunology #Immunotherapy

OK. I don't need to explain the importance of 'blue-sky' research to people on here, but this story in @nature.com is so cool! The area of research that delivered CRISPR gene editing has exploded and is turning up all kinds of cool tools for molecular biology. www.nature.com/articles/d41...

If you’re interested in moving your lab to beautiful Montreal Canada, this program offers chairholders funding of up to 1M$ a year for 8 years. See link for details. www.nature.com/naturecareer...

We are seeking a new colleague to join us at the Vienna BioCenter, specifically at my beloved home institution, IMBA @imbavienna.bsky.social we value collegiality and a passion for curiosity driven science. Being a great and fun human being also helps!

Come by my colleague!! Assistant professor position in molecular neurobiology at @mcgill.ca and the Lady Davis Institute! mcgill.wd3.myworkdayjobs.com/McGill_Caree... Montreal is an amazing city and the Lady Davis is a great institute to work at!

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity many are "negative regulators" & misexpressed in cancer www.sciencedirect.com/science/arti...

Hey fellow Drosophila researchers - if you haven't heard, the UMGC is offering ultra low-cost genome sequencing! See here to learn more: z.umn.edu/UMGC-MOSS #Dros25

Exciting week for the lab. We fired up our @elembio.bsky.social Aviti for its inaugural run (a success!), fully enabling several ongoing CRISPR screens. Thx @gabsflors.bsky.social, Xiaozhen Wen, David Sharon, Pierre Chagnon, and members across our teams for helping to onboard the new sequencer!

In the ‘90s, Pelisson et al. found that gypsy retrotransposons in flies can go viral—literally—thanks to an envelope gene. Now, @mayavoichek.bsky.social uncovers a wild new path to retrotransposon infectivity. A fascinating story—see Maya's thread www.biorxiv.org/content/10.1101/2025.03.14.642691v2