Francesca Ceroni
@ceronifranci.bsky.social
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Senior Lecturer @ Chemical Engineering Department, Imperial College London (views are my own)
pinned post!
Just out: 'Aptamer-based burden biosensors' led by Alice in the lab. Funded by NSF-BBSRC in collaboration with
@francolab.bsky.social
, we show aptamers cause burden in E.coli. We then develop a burden biosensor for identification of low-burden genetic variants:
www.sciencedirect.com/science/arti...
add a skeleton here at some point
3 months ago
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Just out: 'Aptamer-based burden biosensors' led by Alice in the lab. Funded by NSF-BBSRC in collaboration with
@francolab.bsky.social
, we show aptamers cause burden in E.coli. We then develop a burden biosensor for identification of low-burden genetic variants:
www.sciencedirect.com/science/arti...
add a skeleton here at some point
3 months ago
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reposted by
Francesca Ceroni
Tom Ellis
3 months ago
We're hiring for 2 postdocs to work in our lab in London on the newly announced Wellcome Trust SynHG project. If you know people looking to work on big-scale ambitious science like this, please RT and share this with them. Apply by 7/20, interviews in Aug.
imperial.ac.uk/jobs/search-...
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Thanks
@manishmicrobe.bsky.social
and
@oborkowski.bsky.social
for two wonderful days!
add a skeleton here at some point
3 months ago
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reposted by
Francesca Ceroni
Tom Ellis
4 months ago
Annalise Zouein's main PhD research paper is published today in Trends in Biotech. Building and using repetitive transcription factor-binding arrays to modulate gene regulation in mammalian cells. No RNA, no protein - just DNA doing the work!
www.sciencedirect.com/science/arti...
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Thrilled I am going to be speaking at the Royal Society Theo Murphy Workshop on Generative Biology next October!
royalsociety.org/science-even...
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Generative biology: new approaches to study developmental design principles | Royal Society
Theo Murphy meeting organised by Mr Jake Cornwall-Scoones, Dr Dirk Benzinger, and Professor Sally Lowell.
https://royalsociety.org/science-events-and-lectures/2025/10/generative-biology/
5 months ago
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reposted by
Francesca Ceroni
Taylor priest
5 months ago
A huge, new resource for plasmid research - PlasmidScope is a database of 852,000
#plasmid
sequences with a rich set of annotations, automated online analysis and interactive visualisation
academic.oup.com/nar/article/...
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PlasmidScope: a comprehensive plasmid database with rich annotations and online analytical tools
Abstract. Plasmids are extrachromosomal genetic molecules that replicate independent of chromosomes in bacteria, archaea, and eukaryotic organisms. They co
https://academic.oup.com/nar/article/53/D1/D179/7832352?login=false
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reposted by
Francesca Ceroni
Thomas Gorochowski
8 months ago
www.nature.com/articles/s41...
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Degradation bottlenecks and resource competition in transiently and stably engineered mammalian cells - Nature Communications
Resource competition leads to coupling of co-expressed heterologous genes in mammalian cell lines. Here, the authors highlight the effect of competition for protein degradation on gene expression of t...
https://www.nature.com/articles/s41467-024-55311-w
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reposted by
Francesca Ceroni
Nature Biotechnology
8 months ago
Rearranging mammalian genomes with recombinases to study structural variants at scale provides insights into genome organization and dispensability
#NBTHighlight
www.science.org/doi/10.1126/...
and
www.science.org/doi/10.1126/...
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Randomizing the human genome by engineering recombination between repeat elements
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...
https://www.science.org/doi/10.1126/science.ado3979
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Our work on 'Degradation bottlenecks in mammalian cells' is now out @NatureComms:
www.nature.com/articles/s41...
Well done to the whole team! You can read this at
rdcu.be/d5o2h
Happy 2025 everyone!
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https://nature.com/articles/s4146…
9 months ago
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reposted by
Francesca Ceroni
Geert De Jaeger’s lab
9 months ago
Check out our latest pre-print where we used our ASP-#SPARK
#sensor
to unveil
#SnRK1's
multifaceted role during
#plant
growth and
#development
!
bit.ly/49JVZrY
Including real-time
#spatiotemporal
visualization of SnRK1 activity in a growing
#Arabidopsis
root! 😀
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reposted by
Francesca Ceroni
Tom Ellis
10 months ago
Latest preprint from Jane (Xinyu Lu) in our group explores what happens when we build a synthetic genome cluster in yeast for Histidine biosynthesis and SCRaMbLE it to see whether selected-for gene rearrangements can guide better design.
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Still time to apply, please share and spread the opportunity!
add a skeleton here at some point
10 months ago
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Great to have
@ciaranlkelly.bsky.social
presenting the exciting work his group is doing here at Imperial!
10 months ago
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NAPIC website is now live!:
www.napic.ac.uk
10 months ago
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Exciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg. Come and join us at @ImperialChemEng! Apply at the link below:
www.imperial.ac.uk/jobs/search-...
11 months ago
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