Francesca Ceroni
@ceronifranci.bsky.social
📤 633
📥 117
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Senior Lecturer @ Chemical Engineering Department, Imperial College London (views are my own)
pinned post!
So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli? Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing
@proftomellis.bsky.social
and AZ, now on BioRxiv:
doi.org/10.64898/202...
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Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation
Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...
https://doi.org/10.64898/2025.12.15.694402
18 days ago
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So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli? Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing
@proftomellis.bsky.social
and AZ, now on BioRxiv:
doi.org/10.64898/202...
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Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation
Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...
https://doi.org/10.64898/2025.12.15.694402
18 days ago
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Do you want to engineer mammalian protein secretion? We present STAMPS: signal-peptide transformer for tuning mammalian protein secretion! Led by Jacopo in the lab, in collaboration with Cleo Kontoravdi and colleagues at Astra Zeneca, STAMPS is now on Bioarxiv!
www.biorxiv.org/content/10.1...
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STAMPS: Signal-peptide Transformer for Augmenting Mammalian Protein Secretion
While secretion plays a key role in the diverse applications of cell engineering, to date only a handful of mammalian signal peptides have been characterised in depth and systematic efforts to build n...
https://www.biorxiv.org/content/10.1101/2025.11.20.689577v1
about 1 month ago
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'Transgene integration in mammalian cells' led by John Fong from the group, is out now! Check it at
www.sciencedirect.com/science/arti...
Thanks
@cp-cellsystems.bsky.social
for the opportunity!
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Transgene integration in mammalian cells: The tools, the challenges, and the future
Robust and stable expression of genes of interest is crucial for studying and engineering biology. While expressing desired gene products in some micr…
https://www.sciencedirect.com/science/article/pii/S2405471225002595
2 months ago
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PhD positions available in our group! Please share!
www.findaphd.com/phds/project...
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PhD Scholarship project: Engineering biology approaches to mammalian cells at Imperial College London on FindAPhD.com
PhD Project - PhD Scholarship project: Engineering biology approaches to mammalian cells at Imperial College London, listed on FindAPhD.com
https://www.findaphd.com/phds/project/phd-scholarship-project-engineering-biology-approaches-to-mammalian-cells/?p187157
3 months ago
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Just out: 'Aptamer-based burden biosensors' led by Alice in the lab. Funded by NSF-BBSRC in collaboration with
@francolab.bsky.social
, we show aptamers cause burden in E.coli. We then develop a burden biosensor for identification of low-burden genetic variants:
www.sciencedirect.com/science/arti...
add a skeleton here at some point
6 months ago
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reposted by
Francesca Ceroni
Tom Ellis
6 months ago
We're hiring for 2 postdocs to work in our lab in London on the newly announced Wellcome Trust SynHG project. If you know people looking to work on big-scale ambitious science like this, please RT and share this with them. Apply by 7/20, interviews in Aug.
imperial.ac.uk/jobs/search-...
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Thanks
@manishmicrobe.bsky.social
and
@oborkowski.bsky.social
for two wonderful days!
add a skeleton here at some point
7 months ago
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reposted by
Francesca Ceroni
Tom Ellis
7 months ago
Annalise Zouein's main PhD research paper is published today in Trends in Biotech. Building and using repetitive transcription factor-binding arrays to modulate gene regulation in mammalian cells. No RNA, no protein - just DNA doing the work!
www.sciencedirect.com/science/arti...
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Thrilled I am going to be speaking at the Royal Society Theo Murphy Workshop on Generative Biology next October!
royalsociety.org/science-even...
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Generative biology: new approaches to study developmental design principles | Royal Society
Theo Murphy meeting organised by Mr Jake Cornwall-Scoones, Dr Dirk Benzinger, and Professor Sally Lowell.
https://royalsociety.org/science-events-and-lectures/2025/10/generative-biology/
8 months ago
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reposted by
Francesca Ceroni
Taylor priest
9 months ago
A huge, new resource for plasmid research - PlasmidScope is a database of 852,000
#plasmid
sequences with a rich set of annotations, automated online analysis and interactive visualisation
academic.oup.com/nar/article/...
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PlasmidScope: a comprehensive plasmid database with rich annotations and online analytical tools
Abstract. Plasmids are extrachromosomal genetic molecules that replicate independent of chromosomes in bacteria, archaea, and eukaryotic organisms. They co
https://academic.oup.com/nar/article/53/D1/D179/7832352?login=false
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reposted by
Francesca Ceroni
Thomas Gorochowski
11 months ago
www.nature.com/articles/s41...
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Degradation bottlenecks and resource competition in transiently and stably engineered mammalian cells - Nature Communications
Resource competition leads to coupling of co-expressed heterologous genes in mammalian cell lines. Here, the authors highlight the effect of competition for protein degradation on gene expression of t...
https://www.nature.com/articles/s41467-024-55311-w
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reposted by
Francesca Ceroni
Nature Biotechnology
11 months ago
Rearranging mammalian genomes with recombinases to study structural variants at scale provides insights into genome organization and dispensability
#NBTHighlight
www.science.org/doi/10.1126/...
and
www.science.org/doi/10.1126/...
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Randomizing the human genome by engineering recombination between repeat elements
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...
https://www.science.org/doi/10.1126/science.ado3979
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Our work on 'Degradation bottlenecks in mammalian cells' is now out @NatureComms:
www.nature.com/articles/s41...
Well done to the whole team! You can read this at
rdcu.be/d5o2h
Happy 2025 everyone!
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https://nature.com/articles/s4146…
about 1 year ago
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reposted by
Francesca Ceroni
Geert De Jaeger’s lab
about 1 year ago
Check out our latest pre-print where we used our ASP-#SPARK
#sensor
to unveil
#SnRK1's
multifaceted role during
#plant
growth and
#development
!
bit.ly/49JVZrY
Including real-time
#spatiotemporal
visualization of SnRK1 activity in a growing
#Arabidopsis
root! 😀
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reposted by
Francesca Ceroni
Tom Ellis
about 1 year ago
Latest preprint from Jane (Xinyu Lu) in our group explores what happens when we build a synthetic genome cluster in yeast for Histidine biosynthesis and SCRaMbLE it to see whether selected-for gene rearrangements can guide better design.
add a skeleton here at some point
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Still time to apply, please share and spread the opportunity!
add a skeleton here at some point
about 1 year ago
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Great to have
@ciaranlkelly.bsky.social
presenting the exciting work his group is doing here at Imperial!
about 1 year ago
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NAPIC website is now live!:
www.napic.ac.uk
about 1 year ago
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Exciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg. Come and join us at @ImperialChemEng! Apply at the link below:
www.imperial.ac.uk/jobs/search-...
about 1 year ago
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