Tim Yu
@timyu.bsky.social
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PhD student in Jesse Bloom’s lab at Fred Hutch. Viruses, evolution, and immunity.
reposted by
Tim Yu
Bloom lab
8 months ago
In new study led by
@timyu.bsky.social
, we measure how mutations to H3 flu HA affect cell entry, stability & antibody escape We find pleiotropic effects of mutations on these phenotypes shape evolution: epistasis alleviates cell-entry but not stability constraints
www.biorxiv.org/content/10.1...
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Pleiotropic mutational effects on function and stability constrain the antigenic evolution of influenza hemagglutinin
The evolution of human influenza virus hemagglutinin (HA) involves simultaneous selection to acquire antigenic mutations that escape population immunity while preserving protein function and stability...
https://www.biorxiv.org/content/10.1101/2025.05.24.655919v1
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reposted by
Tim Yu
Bloom lab
10 months ago
In study led by
@ckikawa.bsky.social
& Andrea Loes, we use new assay to measure ~10,000 neutralization titers to recent influenza strains & show titers correlate w evolutionary success of viral strains Similar data could help forecast evolution for vaccine selection
www.biorxiv.org/content/10.1...
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High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains
Human influenza viruses rapidly acquire mutations in their hemagglutinin (HA) protein that erode neutralization by antibodies from prior exposures. Here, we use a sequencing-based assay to measure neu...
https://www.biorxiv.org/content/10.1101/2025.03.04.641544v1
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