Sharing this here at the request of Dr. Florian Krammer: semmelweisinstitute.ac.at/training-car...

Spillover of #influenza A viruses from animals to humans represents a threat to our health. In this Perspective, Silke Stertz @virology.uzh.ch discusses emerging research that suggests some influenza A viruses can enter host cells via MHC-II receptors across species 🧪 #virology plos.io/4pP3Gnq

Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...

Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇

Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...

warwick.ac.uk/fac/cross_fa... I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays. If you're interested reach out and I'd be happy to have a chat.

Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET! 🔗 rdcu.be/eMmct We are very excited that our paper is finally out! 🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.

“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science www.science.org/doi/10.1126/...

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids. Link: www.biorxiv.org/content/10.1...

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit www.nexperion.net/semcm2026

Since it was published at peak holiday season, I'm taking the liberty to re-introduce our recent review article. We hope it will be a useful overview of RNA virus replication strategies, and how in situ cryo-EM have helped us understand them: www.sciencedirect.com/science/arti...

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social www.biorxiv.org/cgi/content/... @mrclmb.bsky.social @wellcometrust.bsky.social

One week left to apply for a fully funded PhD position in my group! Please repost. jobrxiv.org/job/max-plan...

Awesome malaria study out now in Nature Microbiology: An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues! @freddyfrischknecht.bsky.social www.nature.com/articles/s41...

Really enjoyed writing about one of my favorite topics (influenza filaments). There is so much exciting new filament research now, it is clearly no longer 'the graveyard of postdocs' Bob Lamb called the topic during my PhD. www.embopress.org/doi/full/10....

Very nice News&Views summary written by ‪@brucelab.bsky.social‬ about our work and work by Ed Partlow et al. (NIH) that influenza A virus filamentous morphology plays an important role in infection (www.nature.com/articles/s41...) can. ‪Thank you! (www.embopress.org/doi/full/10....)

We are happy this work by Sarah Peterl et al. is out in EMBO J! It was an exciting collaborative effort of several groups in the SFB1129 consortium on pathogen replication and spread. Check out the correlated light and scanning EM method to study virus morphology changes during spread!

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...

Please RT. Post-doc opportunity alert! 💥 closing 5th May.. Come join our team (thelowlab.org) at Imperial, London, working on bacterial secretion systems. The position is funded by the Wellcome Trust. For more details and to apply please see www.imperial.ac.uk/jobs/search-...

Check out the latest version of MemBrain, spearheaded by computation superstar @lorenzlamm.bsky.social ! It can segment, pick particles and give you metrics on everything!

A colder frontier in cryo-EM 🧪🔬 Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins). Read more: tinyurl.com/mwwcunkc #LMBResearch

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...

I’m delighted that we could contribute the #cryoEM data to this incredible antiviral discovery project from the group of @neytsjohan.bsky.social 💊 "A coronavirus assembly inhibitor that targets the viral membrane protein" www.nature.com/articles/s41... A huge congrats to everyone involved! 🎉

Automated Removal of Corrupted Tilts in Cryo-Electron Tomography https://www.biorxiv.org/content/10.1101/2025.03.13.642992v1

This is a great opportunity to establish a virology research group at CIID, Heidelberg University!

🚨 We are hiring 🚨 We seek to fill a full-time teaching position starting September 1, 2025! We look forward to your application (cover letter, CV, certificates, etc.) in a single PDF. Deadline: March 14, 2025 @uniheidelberg.bsky.social @bzh-hd.bsky.social 👇👇👇👇👇👇👇

Very nice work showing fusion intermediates of SARS-CoV-2!

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1... We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️

Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1 pubmed.ncbi.nlm.nih.gov/39894818/ #cryoem

I'd like to draw your attention to this truly excellent paper from the Taraska lab on cryoET of plasma membrane associated proteins. Everyone who is thinking about probes in the cryoET space should also see what they could do with ferritag (fig 6) www.nature.com/articles/s41...

We are pleased to invite you to attend the next CSSB Symposium entitled "Mechanisms of Infection - from structure to translation.” Find out more about the programme, invited speakers, and registration on the website: cssb-hamburg.de/symposium2025

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

We just can't stop recruiting! Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly Come and be our colleague Deadline 28 Feb, please spread the word www.path.ox.ac.uk/vacancy/asso...

This work has been a collaborative effort by Bianca S. Bodmer, Konstantin Fischer, @janamakroczyova.bsky.social, Sophie L. Winter, @lisawendt.bsky.social, Moritz Wachsmuth-Melm, @thomas-hoenen.bsky.social @chlandalab.bsky.social Read the full article here: ⬇️ authors.elsevier.com/sd/article/S...

It’s on 🥳: We are excited that our newly funded #HorizonEurope project DEFENDER is now starting and are looking forward to exciting science within a great consortium!

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜: www.biorxiv.org/content/10.1... A short thread🧵👇

Please find here our newest research paper on Ebola virus Nucleoprotein phosphorylation, published as christmas present in Emerging Microbes and Infections :-) what a good start into 2025, happy new year! www.tandfonline.com/doi/10.1080/...

We are happy this work by Melina Vallbracht et al, a great collaboration with Thomas Hoenen and his team is finally out.

Nucleocapsid assembly drives #Ebola viral factory maturation and dispersion. Cryo-ET reveals the molecular architecture of Ebola virus replication compartments. www.cell.com/cell/fulltex... #MicroSky #IDSky

Nice work from @mclellanlab.bsky.social 👇🏼 "Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes" www.cell.com/cell/fulltex...

Registration is open for the EMBO|FEBS Lecture Course Physical Virology: across length scales #EMBOPhysicalVirology organized by Marta Bally, Pedro de Pablo, Susan Daniel & Ekaterina Selivanovitch 🦠🔬💻🧪 Sign up and share! meetings.embo.org/event/25-phy...

Our Herpesfolds paper is out in Nature Communications! rdcu.be/d1uM7 Congrats to Timothy Soh, @sofiaaognibene , Saskia Sanders, Robin Schaeper and Benedikt Kaufer! Have a look at our database at herpesfolds.org by Malte Kansy

Great talks, discussions and "FIBing" at Summer cryo-FIB/ET school with wonderful participants! Thanks a lot to Anna Steyer, Zhengyi Yang, Georg Wolff, and Simone Mattei for the organisation at EMBL Imaging Center and to the guest speaker Florent Waltz. Many thanks to @researchlifesci.bsky.social!

We are excited to share our latest #preprint Wachsmuth-Melm et al on cryo-ET of influenza infection in collaboration with the Amorim team on @researchsquare : Influenza A virus hemagglutinin remodels membranes into a vRNP clustering platform www.researchsquare.com/article/rs-4...

Last call for applications for  Alliance ***Interinstitutional Postdoc Program***   Apply by April 5, 2024.  Find the documents and the registration link on our website  health-life-sciences.de/postdocs #postdoc @ResearchLifesci @UniHeidelberg

The book "Virus Infected Cells" edited by Swetha Vijayakrishan, Yaming Jiu and Robin Harris is out! Thank you for letting us contribute. The book contains many nice chapters including cryo-ET and soft-X-ray! Happy to share the online version privately upon request. link.springer.com/book/10.1007...

Our paper on SARS-CoV-2 minimal pore by Zimmermann L et al is finaly out at Nature Comms nsp3-4 are minimal components, MAC2 and MAC3 play a role in crown stability, which is important for DMV formation. We propose to term +ssRNA viral pores-"replicopores" rdcu.be/dsreD

Influenza virus RNA genome segments undergo a full cycle of replication in a test tube in the presence of viral RNA polymerase, viral nucleoprotein and human ANP32B, an essential host factor for influenza virus genome replication. journals.plos.org/plosbiology/...