Similar to shutterless mode in X-ray data collection 🤯

Delighted to share our lab's first foray into Paramyxoviruses with a #cryoEM structure of a potent human #antibody against #Hipah virus. This was a great collaboration at Mount Sinai led by Benhur Lee! www.science.org/doi/10.1126/...

Beyond excited about this manuscript in collaboration with Aaron Schmidt's lab! They isolated #antibodies from wild-caught Egyptian rousette #bats targeting bat-borne H9N2 #influenza and Bruno Bonnettaz in our lab determined their complex structures by #cryoEM! www.biorxiv.org/content/10.6...

For years, the #cryoEM community viewed ~50 kDa as the practical lower size limit for SPA. This was challenged by Kim et al., who introduced the HR-HAIR method and demonstrated structure determination of proteins below 30 kDa using #CryoSPARC. Read more 👉 bit.ly/3RHMxAt

Latest pre-print from our lab. We report 6 new #cryoEM structures here: www.biorxiv.org/content/10.6...

Jason is killing it! 😍

Latest from Steve Harrison

NY state friends, please do this today! The Governor’s State of the State is tomorrow, January 13 at 1:00 PM. We are hopeful she will announce the Empire Biomedical Research Institute (EBRI). Email the Governor and your Reps! actionnetwork.org/letters/supp...

We’re calling on @governor.ny.gov to invest in the Empire Biomedical Research Institute. A robust, stable research ecosystem protects jobs, fuels innovation, and builds community health statewide. NY must invest in our global leadership in science. @gothamist.com reports: tinyurl.com/5fab5k7u

The Bajic lab annual holiday outing! This year, we went to the Kiehl’s flagship store, learned about good skincare practices and walked out with some goodies. #HappyHolidays

"The Trump administration in May canceled a $700 million contract with Moderna to develop a human bird flu vaccine. Secretary Kennedy has cut other funding for vaccine research and scrapped long-held federal vaccine guidance." www.reuters.com/business/hea...

New York Times article on science funding with some depressing but familiar curves with interactive graphics. www.nytimes.com/interactive/...

SBGrid's eLife paper received a citation in October [email protected] from Icahn School of Medicine at Mount Sinai in @science.org Immunology. Read more here: buff.ly/s8uVL86 #SBGrid #ScienceMatters #StayConnected

How to develop good research questions "This Comment describes the iterative creative process for designing good research questions, and includes practical suggestions and ways to avoid common traps." www.nature.com/articles/s41...

**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: [email protected]

Read the latest from us here: www.science.org/doi/10.1126/... #antibody #cryoEM

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8) Preprint: www.biorxiv.org/content/10.1...

Feeling mitochondrially challenged lately? Here are two classic reviews on #mitochondria that should help. www.cell.com/current-biol... www.cell.com/current-biol...

Heads up: @science.org is looking for a new research #editor based in the US or UK to handle papers in #InfectiousDiseases (e.g., #virology, #microbiology, #parasitology) & #microbiome research! This is an amazing opportunity, so don't delay! Applications are due 22 SEP!

New paper from the Coelho lab with a modest contribution from us:

🚨 New Publication!!! I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”. www.cell.com/cell-reports... [1/4]

The latest from us: www.cell.com/cell-reports... With Camila Coelho’s lab, we describe how public clonotype #antibody affinity matures against an occluded epitope on #spike we call the central interface epitope! #cryoEM

Mix-it-up: Accessible time-resolved cryo-EM on the millisecond timescale www.biorxiv.org/content/10.1101/2025.07.22.666177v1 #cryoem

To celebrate @focisimmunology.bsky.social 's annual meeting this week, #Science #Immunology has just released a new free sample collection of recent papers with a focus on human immunology! The collection will be available online to read until the end of July 2025! #FOCIS2025 bit.ly/SciImm_free

Another fruitful collaboration with the Coelho lab! www.sciencedirect.com/science/arti...

Latest from us: another productive collaboration with the Schmidt lab on #flu #antibody www.science.org/doi/10.1126/...

Can’t wait to try this new feature out!

All props to our students, Vishal and Iden, who spearheaded this study!

Really disappointed with #HHMI www.science.org/content/arti...

Our long-awaited study in collaboration with the Schmidt lab on H5Nx influenza recognition by naive B cells is out! #antibody #bcell #flu #avianflu #cryoEM www.science.org/doi/10.1126/...

Tonight is a fun night of proofreading manuscript journal proofs with Dionne Warwick in the background. #staytuned

We are hosting a cryo-EM grid nanofabrication workshop on 28 April 2025, as part of the Canadian Cryo-EM Nexus (ccemn.ca). Learn how to make holey gold or holey carbon grids in your own laboratory! Space is limited, so please apply at web.cvent.com/event/ee88ac...

Latest from us: www.biorxiv.org/content/10.1... Antibody 52 hits every variant we tested. #cryoEM

Couldn’t find a virology starter pack so here’s one to get the ball rolling. Repost/reply if you are a virologist so I can find and add you to the list! go.bsky.app/SinqoJU