Epelmanlab
@epelmanlab.bsky.social
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Macrophages, cardio-immunology, regenerative medicine Epelmanlab.com
reposted by
Epelmanlab
Daniel Durocher
about 1 month ago
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at
@sinaihealth.bsky.social
. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
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Job alert 🚨! If you are looking for a post-doc in cell engineering, macrophage biology, 🫀 regenerative medicine - we are hiring! Toronto is a great city to launch your career!
jobs.smartrecruiters.com/UniversityHeal…
@uhnresearch.
c
a @stemcellnetwork.
ca
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https://jobs.smartrecruiters.com/UniversityHeal…
about 2 months ago
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Epelmanlab
Nature Reviews Immunology
6 months ago
More great content from
@preprintclub.bsky.social
@epelmanlab.bsky.social
. This
@biorxiv-immuno.bsky.social
preprint from Liu et al. reports that resident tissue macrophages in the conventional outflow tract regulate intraocular pressure.
add a skeleton here at some point
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Epelmanlab
Andres Hidalgo
7 months ago
Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo,
@alazozcan.bsky.social
and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork! Free link:
rdcu.be/eeeA2
www.nature.com/articles/s41...
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Matrix-producing neutrophils populate and shield the skin
Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...
https://rdcu.be/eeeA2
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Epelmanlab
IPEK
6 months ago
📢Next joint CRC/IRTG 1123 🧑🏫Seminar Series next week 🗓️
@dfg.de
@lmumuenchen.bsky.social
🗣️ Slava Epelman
@epelmanlab.bsky.social
@uhnresearch.bsky.social
@uoft.bsky.social
@trogersresearch.bsky.social
📌 Enhancing engineered 🧫heart 🫀 tissues with macrophages
tinyurl.com/rd9ayw56
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Epelmanlab
Edward Nirenberg
8 months ago
If you have ever wondered why we scratch itchy things... we have a new answer for that question: it promotes clearance of Staph bacteria on the skin via activation of mast cells.
www.science.org/doi/10.1126/...
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Epelmanlab
Agnete Kirkeby
9 months ago
We've summarised the landscape of human pluripotent stem cell trials worldwide in a review in Cell Stem Cell. Fun fact: Over 1200 patients have to date received treatment with hPSC products in 116 different trials, and more than 100 billion hPSC-derived cells have been dosed!
doi.org/10.1016/j.st...
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Epelmanlab
Eric Topol
8 months ago
A pro-inflammatory protein panel signature that accurately identified Long Covid in kids compared with controls
www.nature.com/articles/s41...
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Epelmanlab
Alexander Dent
9 months ago
I certainly didn't have IL-22 on my bingo card as an anxiolytic (anti-anxiety) factor
#Immunosky
www.cell.com/immunity/ful...
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Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior
Immune activation is often thought to exacerbate stress-related mental disorders. Here, Xia, Lu, Lan, et al. reveal elevated IL-22 derived from the gut during the early phase of repeated stress. IL-22...
https://www.cell.com/immunity/fulltext/S1074-7613(24)00523-5?dgcid=raven_jbs_etoc_email
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Epelmanlab
Claus Wilke
10 months ago
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov
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Epelmanlab
Eric Topol
10 months ago
What should we eat? Or avoid? The new Ground Truths podcast is with
@kevinh-phd.bsky.social
, a leader in nutrition science and metabolism
erictopol.substack.com/p/kevin-hall...
Full transcript with links to multiple publications
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Kevin Hall: What Should We Eat?
Insights from the research by a leading scientist in nutrition and metabolism
https://open.substack.com/pub/erictopol/p/kevin-hall-what-should-we-eat?r=158dl&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
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Epelmanlab
Jeff Mold
10 months ago
Neat!
www.nature.com/articles/s41...
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Haematological setpoints are a stable and patient-specific deep phenotype - Nature
Complete blood count indices are tightly regulated around setpoints for decades in healthy adults, and represent a deep phenotype providing opportunities for investigating differential disease risks, ...
https://www.nature.com/articles/s41586-024-08264-5
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Epelmanlab
Vienna Airway Lab
10 months ago
Fantastic paper by
@mhaniffa.bsky.social
@humancellatlas.org
www.nature.com/articles/s41...
We know
#macrophages
are versatile but inducing skin vascularisation! 🤩
#immunosky
#medsky
🧪
#morphogenesis
#organoid
#spatialtranscriptomics
#singlecellsequencing
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A prenatal skin atlas reveals immune regulation of human skin morphogenesis - Nature
A comprehensive multi-omics reference atlas of prenatal human skin shows that innate immune cells crosstalk with non-immune cells to perform pivotal roles in skin morphogenesis, including the formatio...
https://www.nature.com/articles/s41586-024-08002-x
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Epelmanlab
Jalees Rehman
10 months ago
Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes
www.nature.com/articles/s41...
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Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes - Nature Biomedical Engineering
Arrayed CRISPR libraries with each plasmid encoding an array of four non-overlapping single-guide RNAs allow for the efficient genome-wide ablation, activation and epigenetic silencing of human protei...
https://www.nature.com/articles/s41551-024-01278-4
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Epelmanlab
Ivan Zanoni
10 months ago
#WeekendRead
!
#ZombieNeutrophils
!
#InterferonsFriendsOrFoes
?! Stallings &co show @ Cell Host & Microbe that micobacterium drives the releases of NET from live neutrophils (that lose their 🧠!) thanks to PAD4 & type I
#interferons
, favoring
#Myb
growth!
www.cell.com/cell-host-mi...
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Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation
Sur Chowdhury et al. report that Mycobacterium tuberculosis (Mtb) infection results in the release of neutrophil extracellular traps (NETs) that promote Mtb replication and associate with tissue damage. Blocking NET release results in better control of Mtb replication, revealing a strategy for treating these deadly infections.
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00439-6
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Epelmanlab
Eric Topol
10 months ago
We have very limited means of tracking inflammation in the body, like a one-off hs-CRP blood test. Today
@science.org
Continuous real-time monitoring of inflammation and protein biomarkers in the body with a shaking sensor
science.org/doi/10.1126/...
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Epelmanlab
Mass Lab
10 months ago
#macrophage
#barcoding
🤯 Time to get rid of the "fetal liver monocyte" origin for resident macrophages?!? Congrats to the Rodewald lab for this work!
www.biorxiv.org/content/10.1...
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Holistic genetic barcoding reveals a lineage tree of tissue macrophage development
Tissue macrophages are crucial for organ development and homeostasis, yet the developmental routes leading to tissue macrophages remain controversial. By combining unbiased Polylox barcoding with comp...
https://www.biorxiv.org/content/10.1101/2024.11.29.625985v1
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Epelmanlab
Eric Topol
10 months ago
The SARS-CoV-2 spike protein can persist in the brain—in the skull bone marrow and meninges—to induce neurologic damage
www.cell.com/cell-host-mi...
open-access
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