Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

Why do Americans refer to NAD+ as a “peptide” therapy?

New preprint from the lab! How do tissue shapes influence cell fate decisions? By manipulating brain organoid geometry, we show that lumen rounding directs apical progenitor division mode and promotes the emergence of basal progenitors. www.biorxiv.org/content/10.6... 1/

Parse or 10x? any advice? we're thinking about trying Parse but would love some feedback from the #immunology community. this sequencing project is for lung #macrophages if that matters? please circulate and send me any info about your experiences!! @jeffmold.bsky.social have you used Parse?

This is a great paper - even down to the honest way the authors critique their own findings in the final sentence of the results www.nature.com/articles/s41...

Cool demonstration of possible role of clonal heritability in cancer in mice - but not novel to show clonal heritability is a persistent driver of heterogeneity within cell types… www.nature.com/articles/s41...

A new mechanism for “RNA memory”! This time in Planaria! (Here's a video of a Planarian with mulitple heads, one of the heritable phenotypes we studied). This work summarizes >10 years of research and is an amazing collaboration with the labs of Jochen Rink and Omri Wurtzel labs. Read thrad below👇

Aging may feel gradual… but what if it’s not? In our recent paper, we tracked fish continuously from puberty until death. This gave us a unique view of how aging unfolds across the adult lifespan. 🧵

I wish some stats or comp bio labs would get together and draft a best practices paper on how to normalize and represent big omics datasets in published papers. The units people use in figures are out of control

Everyone I encounter a thread about how to fix publishing it reminds me of when Newman and Kramer try arbitrage recycling

I have a question for people who have a lot of experience on CNV calling on WGS data - does seeing this pattern in 1MB binned 10x coverage WGS (just looking at read depth) present an obvious signal for anything? These are two clones of a cell line (top and bottom) and focus on Chr5 (middle)

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

Finally someone did a nice characterization of TSC22D3 (GILZ) in T cell activation I know you T cell omics people have been wondering

Immunologists - can we PLEASE stop calling T cells senescent until there is some universally agreed upon definition for what that means... especially for T cells that are still capable of division. I am barely over the exhaustion ambiguity (sounds like a Big Bang Theory Episode...)

Australians - everything this man touches turns to shit - every building he has ever built is faux luxurious and the ones that are still standing are tainted with his con artist brand... don't let this guy plant his gold-leafed phallus in your country... edition.cnn.com/2026/02/24/a...

🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP

Ahhhh I get it! “Donald Trump’s bored of peace”.

ISR having a moment - might be important in drug persistor cancer clones www.science.org/doi/10.1126/...

Poor kitty cats are like us www.science.org/doi/10.1126/...

Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14

Very cool www.nature.com/articles/s41...

Jeans? In the tub? Jeans?

Have you ever wondered what you would find if you could keep your eyes on a bee for more than a few meters? Us, too! preprint (with videos!) + thread 🧵 Precise, individualized foraging flights in honey #bees 🐝 revealed by multicopter drone-based tracking www.biorxiv.org/content/10.6... 1/9

I’m thinking of starting as podcast to compete with Huberman where I’m gonna pitch a nucleic acid based diet

I find this to be a very interesting paper but have a few questions and I wonder what T cell experts think: www.cell.com/cell/fulltex...

I had no idea this was a thing… my god open.spotify.com/episode/0T6E...

This actually looks pretty neat - but if you wanted to do a comprehensive assessment of visual diversity among a cell type T cells must be the hardest to do, tiny round mostly nucleus... like if you wanted to assess visual diversity in a species and chose chipmunks www.biorxiv.org/content/10.6...

This guy is killing it now. youtu.be/vfpQbv7CmeE?...

Not something you see in textbooks very often: tripolar mitosis.

A near-complete map of human cytosolic degrons and their relevance for disease We measured degron potency of >200,000 30-residue tiles from >5,000 human proteins, and trained a model to predict degrons from sequence Led by @vvouts.bsky.social in @rhp-lab.bsky.social doi.org/10.1126/scia...

Skiing in Kosovo not bad!

This literally can be said of anything this man has touched since 1980…

Wise words Melania

This fits my biases in how I imagine tissues age www.science.org/doi/10.1126/...

I doubt I’ll understand this but I’ll try - www.science.org/doi/10.1126/...

Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de

Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection. Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social www.nature.com/articles/s41...

This article is now freely available to everyone in PubMed! www.ncbi.nlm.nih.gov/pmc/articles...

For everyone not fortunate enough to be at the Midwinter #Immunology conference in Seefeld, you can have a little taste of it through my talk on #tissueTregs and using lung Tregs to fight #respiratory #pathology (unpublished work from @drntombizodwa.bsky.social!) www.youtube.com/watch?v=o_X4...

Last term I tried an experiment: I walked into my Tech and Design Ethics class, admitted that I had *no idea* what to do about ChatGPT - so I would let them figure it out. As in: their first project was to decide and write the ChatGPT policy for the class. Here's what happened:

Towards the end of typological thinking in cell biology? "To answer these questions, we must link variability in cell phenotypes to underlying genetic variation and determine the evolutionary forces that gave rise to that genetic variation. This is not an easy task."

I have a serious question for the bioinformatics community - it is now very trendy to assign genes to modules or groups and then annotate those groups using various strategies. When I read the methods for papers it is unclear to me how one comes up with the strategy they use - see below:

Few will get this but watching Trump at Davos gave me flashbacks to Mario Incandenza’s puppet show explanatory chapter of the origins of ONAN in Infinite Jest…

Wow what a paper - www.nature.com/articles/s41...

As more and more high dimensional datasets are generated it seems like everyone is starting to discover that things form a 'continuum'. I bet once people adopt more barcoding tools we will move back towards a world where things fall in buckets but just a lot more than we thought.

Holy crap - is China going to take the USA position as the global peacemaker?! Remember they own an enormous amount of USA debt… edition.cnn.com/2026/01/21/c...