The Long COVID Treatment Trial – Tirzepatide (LoCITT-T) is officially open for enrollment for people with Long COVID in: Alabama, Alaska, California, Florida, Illinois, Indiana, Michigan, Ohio, Pennsylvania, Texas, Utah longcovid.scripps.edu/locitt-t/?ut... 1/16

Looks like OpenFold3 has been formally released in a public "preview". Not quite on parity with AlphaFold3 on a few benchmarks shown, in particular for antibody interactions. All info on the github link. I am sure we will hear more about this from the developers github.com/aqlaboratory...

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...

1/ This is my first time posting a comment on a bioRxiv manuscript, but since I've been asked my opinion on this one a bunch, and I was actually one of the reviewers and waived my anonymity in review, I decided to post my review as a comment: www.biorxiv.org/content/10.1...

1/ This is my first time posting a comment on a bioRxiv manuscript, but since I've been asked my opinion on this one a bunch, and I was actually one of the reviewers and waived my anonymity in review, I decided to post my review as a comment: www.biorxiv.org/content/10.1...

It should be noted that Google has noticed the backlash enough that they quietly published a code that would removed AI results for their searches. An enterprising person built a default site to search without AI, and the results are goddamn refreshing as hell. udm14.org

Sex differences matter! www.sciencealert.com/half-of-hear...

Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor | @natmicrobiol.nature.com sco.lt/6i4kd6

My cousin died from a vaccine preventable illness, and that's part of why it's so important to me to work on the immunology of infectious disease. I know what's on the line.

What if this was your kid, you ask? I'll tell you. As an infectious disease immunologist, I protect my kids through vaccination. A measles outbreak reached my county when I had an infant. Knowing the risk for severe outcomes, I read the literature, vaccinated him EARLY and then rejoined the schedule

Immune Booster 2: Sex differences in immune responses with Michal Tal

"If you're not vaccinated...there may not be any time."-Michal Tal From Immune Booster 2: Sex differences in immune responses with Michal Tal (@immunofever.bsky.social ) Hosts: @cindyleifer.bsky.social @bioprofbarker.bsky.social

Doubling down as a Toxicologist. The benefits far outweigh the harms.

What if this was your kid, you ask? I'll tell you. As an infectious disease immunologist, I protect my kids through vaccination. A measles outbreak reached my county when I had an infant. Knowing the risk for severe outcomes, I read the literature, vaccinated him EARLY and then rejoined the schedule

The only question now is what huge problem do YOU (reader) want to address with this incredible data set? The world's sequences are your oyster. Go make pearls!

🌎👩‍🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open. doi.org/10.1101/2024...

Earth’s genetic diversity is a heritage of humanity. It has been an honour to explore this data with a team of dedicated scientists who shared our vision of making this data free and accessible to all 🌍🧬❤️ Thank you! Updated preprint: doi.org/10.1101/2024...

All Logan data is freely-available (cc0) right now. We show how Logan-Search (www.logan-search.org) can be used to uncover viral reactivation (HHV-6) in cell therapy products (TIL and CAR-T).

Adrenal insufficiency is a syndrome of cortisol deficiency. This Review summarizes the pathophysiology of adrenal insufficiency and approaches to diagnosis, treatment, and prevention of adrenal crisis. ja.ma/3HKk9Jr

9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American." It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...

Sometimes we’re unsatisfied with a thing we made because when it only existed in our head, we saw all the things it could have been and when it’s done we know all the things that it isn’t, but we can’t see the way it expands into a million new things when someone else unpacks it in their head. 🖊️🦑

“Over the past 20 years, Paris has undergone a major physical transformation, trading automotive arteries for bike lanes, adding green spaces and eliminating 50,000 parking spaces. Part of the payoff has been invisible — in the air itself.” Leadership, strategy, real action, common sense. #Paris

A federal-state partnership that monitors for foodborne illnesses quietly scaled back its operations nearly two months ago. As of July 1, the critical surveillance program is monitoring for only two pathogens instead of the usual eight, a spokesperson for the CDC says.

The year I was born. we basically had no idea why cancers happened and now we understand the underlying force behind it with 100% clarity and the molecular forces behind it with many orders of magnitude more resolution. We were entirely in the dark, and now the room is lit.

Important paper by members of the European Academy of Neurology. "Healthcare systems should be aware of, and be prepared for a potential increase in the incidence of neurodegenerative diseases in the upcoming years." What has been the state of surveillance and awareness so far? #NeuroCovid

Shared Immune and Epigenetic Pathways in Systemic Lupus Erythematosus and Melanoma Immunotherapy: A Cross-Disease Analysis with Prognostic and Therapeutic Implications https://www.biorxiv.org/content/10.1101/2025.08.19.671053v1

@biorxivpreprint.bsky.social Pediatric long COVID Is characterized by myeloid CCR6 suppression and immune dysregulation @sarmoronlo.bsky.social www.biorxiv.org/content/10.1...

'LAIR1 inhibition enhanced peripheral and intratumoral CD8 memory T cell populations, induced a phenotypic shift of M2-like macrophages toward M1 macrophages, and normalized tumor collagen IV and structural components in the TME' www.jci.org/articles/vie...

NB: I had never hear of LAIR1 until a stunning paper 9 years ago from Tan, Lanzavecchia et al that showed LAIR1 insertions into Ig loci, with somatic mutations in the LAIR1 sequences that shifted affinity from collagen to plasmodium-infected erythrocytes www.nature.com/articles/nat...

Before you open the preprint, can you guess the 12?

Second we sought to highlight bias in the distribution of what clades and types of protists are researched and where our major gaps are within protists - TDLR - most organisms studied are parasites biasing our understanding of the capabilities of eukaryotic cells...

New lab pre-print up! "Twelve species of human parasites make up half the literature on microbial eukaryotes" doi.org/10.1101/2025... We (led by UG Joanna Lepper and with @hbrappap.bsky.social) quantified all mentions of protist species in the scientific literature 🧵 #protistsonsky #microsky

#NewResearch SARS-CoV-2 infection can lead to sustained increased macrophage numbers and formation of enlarged lipid-laden macrophages after viral clearance. This can be prevented with antiviral treatment in mice. #MicroSky www.nature.com/articles/s41...

Why voice of science must still be heard “Multiple large, robust & peer-reviewed clinical studies concluded millions of lives were saved during the COVID-19 pandemic from mRNA vaccines. Not by stopping transmission but by preventing severe disease, hospitalisation & death” @atscommunity.bsky.social

Individual-based modeling (IbM) unravels spatial and social interactions in bacterial communities #ISMEJournal from @janfmvi.bsky.social academic.oup.com/ismej/advanc...

'Electron microscopy and electrical conduction analyses reveal that cancer cells degrade the nerve fibre myelin sheets. The injured neurons respond by autonomously initiating IL-6- and type I interferon-mediated inflammation to promote nerve healing and regeneration' www.nature.com/articles/s41...

🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!

@biorxivpreprint.bsky.social Mapping leukocyte dynamics during neuroinflammation identifies meningeal monocyte-derived macrophages as drivers of progressive disease @villarvesga.bsky.social @florianingelfinger.bsky.social www.biorxiv.org/content/10.1...

Microbial dysbiosis sculpts a systemic ILC3/IL-17 axis governing lung inflammatory responses and central hematopoiesis from @kmcnagny.bsky.social and colleagues www.mucosalimmunology.org/article/S193...

Machine Learning of Serum Cytokine and Chemokine Profiles Can Classify Inflammatory Bowel Disease Beyond Clinical Diagnosis from SMI member Tadakazu Hisamatsu. www.sciencedirect.com/science/arti... #SMIMemberPaper

A must-read, must-share piece - clearly deconstructing the shoddy science of the Geiers (who are inexplicably in charge of studies at HHS). Consider this an early warning for what lies ahead. 🛟🩺🧪 www.nytimes.com/interactive/...

NEW: For years, Robert F. Kennedy Jr. has pushed discredited theories linking vaccines to autism. Now, scientists studying the condition fear he has preconceived notions that will harm the field and taint new funding for research. propub.li/41JYl7o

Health departments struggle to adequately survey for ticks to warn doctors about new species and the diseases they carry. n.pr/45trxlq

Fantastic review of #SexxAndImmunity! @soniasharma.bsky.social www.science.org/doi/10.1126/...

Toronto Star: 'Long COVID left her son with debilitating stomach pain. Why it’s an ‘uphill battle’ for so many kids to get treated' 'Children living with long COVID face an uphill battle to access care or even have their symptoms believed, parents and doctors say' www.thestar.com/news/canada/...

If pundits would like to talk about violence, a terrorist recently shot up the CDC and another assassinated Democratic officials in Minnesota but they sort of let both stories disappear Not as threatening as motorbikes in DC I know but maybe we could circle back?

Miraculously, he didn’t hit a single CDC employee! But he did kill David Rose, the police officer who responded, who leaves behind two children and a pregnant wife. I can't help but imagine the vast attention this case would have received if the race of the shooter and the victim were reversed.

I went, I survived (so far), and I came away feeling incredibly energized and inspired. The Long COVID/IACCI research field is just chock full of kind, creative, and innovative people. I am so grateful to them.

I got to try this too and more of my my capillaries were enlarged (85%!) than anyone else’s that evening

You can learn more about capillaroscopy and how it's being used in our clinical study MAESTRO, as well as other technologies in these short explainer videos by Caleb Rother, and undergraduate researcher in my lab: www.youtube.com/channel/UCgD...