Recap 2023 via @petterbrodin.bsky.social @theguardian.com www.theguardian.com/science/2023... The term “immunity debt” was first introduced by French researchers in 2021. It refers to a population-wide effect rather than an individual-level one.

Why are more and more people suffering from #allergies and autoimmune diseases? The answer may lie in the development of the immune system in newborns @petterbrodin.bsky.social @ki.se has developed a technique to map #immunesystem development from a single drop of blood. tinyurl.com/3j22dyw8

In new review @jhumimmunity.org, Andreakos et al. report the progress of the COVID Human Genetic Effort since its launch 5 years ago, with the aim to understand clinical variability, from resistance to severe outcomes, among individuals exposed to #SARSCoV2. rupress.org/jhi/article/...

Hehe, Thanks Grant!

The seven enigmas of #SARSCoV2: From the past to the future. New review from Evangelos Andreakos, Helen Su, Jean-Laurent Casanova (@casanovalab.bsky.social) and colleagues: rupress.org/jhi/article/... #InbornErrorsOfImmunity #InfectiousDiseases #PopulationGenetics

The American Association of Immunologists AAI meeting will be in Boston, April 15-19, 2026. Come join me and @chrysothemisbrown.bsky.social at this exciting Symposium on Early life immune development. Submit your abstracts by October 15th! immunology2026.aai.org/session/earl...

#Medsky🧪 #IDsky #immunosky #publichealth @petterbrodin.bsky.social , @casanovalab.bsky.social et al To determine the underlying genetic causes & other modifying factors like sex hormones , interferon responses impacting restrained #Tcell responses to #SARSCoV2 & #viralpersistence in #LongCOVID.

Thx for highlighting @sun-in-winter12.bsky.social

Variation in the human immune system is largely driven by non-heritable influences @petterbrodin.bsky.social P. Brodin et al. Cell. 2015.

Weight loss improves health but What happens to cells in the fat during weight loss? Intriguingly, immune cell numbers decrease but their activated states persist w chronic inflammatory potential. Beautiful work from neighbors @mrc-lms.bsky.social Will Scott et al www.nature.com/articles/s41...

New paper 📣! Pixelgen reports its incredible new Proximity Network Assay (PNA)->3D maps of 155 proteins in single cells by sequencing by barcoded antibodies and in situ rolling circle amplification yields >40,000 spatial nodes/cell: www.biorxiv.org/content/10.1...

No evidence for neutralizing IL1RN autoantibodies in our cohorts of MIS-C, SARS-CoV2 pneumonia or vaccine-induced myocarditis. onlinelibrary.wiley.com/doi/10.1111/... Great work by Anish Behere in Nils Landegren lab, Uppsala university

Exciting new cell state model from @arcinstitute.org

Absolute pleasure to be teaching human systems immunology @efis-immunology.bsky.social summer school in beautiful Alghero, Sardinia.

"Children should be included in ongoing and future clinical trials for Long Covid Age-related protections & regulations must be incorporated, including obtaining institutional review board/research ethics approval along with paediatric assent & parental publications.ersnet.org/content/erj/...

Reminder to join us June 5/6 in Paris if you're interested in pediatric immunity and cancer development ! @institutcurie.bsky.social @gustaveroussy.fr @hopitalnecker.bsky.social @institutimagine.bsky.social

New in @jumimmunity.org: Human #InbornErrorsOfImmunity: 2024 update on the classification from the @iuis-online.bsky.social Expert Committee: rupress.org/jhi/article/... See also the accompanying diagnostic guide by Bousfiha et al.: rupress.org/jhi/article/...

Human inborn errors of immunity: 2024 update on the classification from the International Union of Immunological Societies Expert Committee url:https://rupress.org/jhi/article/1/1/e20250003/277390/Human-inborn-errors-of-immunity-2024-update-on-the

Amazing study showing protective effect of herpes zoster vaccination against dementia with interesting sex differences @sexdiffimmunity.bsky.social #vaccines work! #immunosky #medsky

Co-senior author from this study Prof Coziana Ciurtin will be talking alongside @petterbrodin.bsky.social in a RITA webinar on Sex Biases on Autoimmunity next Tuesday - should be a great discussion. Register 👇 #ImmunoSky #sexdifferences register.gotowebinar.com/register/822...

🔥1/3. Next in the Fireside Chat series from The #LongCovid Clinic - What You CAN Do! ‘Covid & the Immune System’ 🗓️ Wednesday 12th March 2025 at 6pm GMT @binitakane.bsky.social & @helenoakleigh.bsky.social are joined by Consultant Immunologist @petterbrodin.bsky.social! Link ⬇️

Thx so much for highlighting!

#Medsky🧪#oncosky #pedsky @petterbrodin.bsky.social et al . A systems-level analysis of immune responses in 191 children within a population-based cohort with diverse tumors & reveal that age & tumor type shape immune responses differently.#immunotherapies for childhood cancer.

How do immune responses vary across different childhood ages and tumor types? A crucial study from @petterbrodin.bsky.social’s lab freshly baked on #SystemsImmunology, advancing precision medicine in pediatric diseases! www.cell.com/cell/fulltex...

#Paediatrics | #Cancer | #ImmuneSystem | #Immunotherapy | Yet Another Phenomenal Resource from @petterbrodin.bsky.social & Friends | Breaking OPEN ACCESS Study Online at @cellpress.bsky.social | #immunogenicity | #Tcells | #inflammation |

Interested in the relationship between the developing immune system and pediatric cancer ? Come join us for the first Paris Kids Cancer symposium June 5/6 institut-curie.org/symposium-pa... @institutcurie.bsky.social @aphp.bsky.social @gustaveroussy.fr @institutimagine.bsky.social

Great #immuno speakers including @belkaidlab.bsky.social @petterbrodin.bsky.social @florentginhoux.bsky.social Arndt Borkhardt, Melanie Conrad, Sonia Garel, Sylvain Latour, Johnny Ludvigsson, Bernard Malissen, Mihai Netea, Anindita Roy and Chenqu Suo

To commemorate #RareDiseaseDay, here are some recent #Science #Immunology research papers that elucidate the immune mechanisms underlying certain rare human diseases and/or report new strategies to treat them! @science.org

It’s approaching. Join us in person. Henry Kunkel Society Meeting on "Genes & Immunity" and join us in Belgrade from April 10-12, 2025. henrykunkelsociety.org/meetings/ #HKS2025 #Immunology 🧬🔬

Early in life, secondary bile acids are generated by colonizing microbes, associated with risks of immune-mediated diseases and act as immunomodulatory substances. Great collaborative study now online!

Out today in Nature Genetics: Using MS-based proteomics, we mapped 1,200+ plasma proteins in 2,100+ children, showing how genetics & development shape blood protein levels during childhood. nature.com/articles/s41588-025-02089-2 #PediatricProteomics #pQTL First author @liliniu.bsky.social explains ⬇️

Thanks for inviting me to this lovely meeting in beautiful Lorne, Australia

Nice op-ed from @polybiorf.bsky.social on the need for more Long COVID trials.

Honored to be a part of the work led by @polybioRF and @microbeminded2 published in @TheLancetInfDis discussing actionable strategies to adequately address SARS-CoV-2 persistence in #LongCovid. This paper covers discourse on how to look for and measure severity of persistence 1/

Looking for your next move as a clinician-scientist? 3 positions of Transition to Independence Fellow for 3 years in @mrc-lms.bsky.social @imperialcollegeldn.bsky.social 80% protected research time + 20% clinics in an amazing scientific environment in London 👩🏻‍⚕️👨🏻‍⚕️👩🏻‍🔬👨🏻‍🔬 🧫🔬deadline 4th March! DM me for info

This is a fantastic personal view paper just published in @thelancetinfdis.bsky.social on targeting the SARSCoV2 Reservoirs in long COVID. Great illustrations to go with the discussion on strategies to target these "reservoirs" #IDSky #MedSky 🧪 www.thelancet.com/journals/lan...

How can we clear persistent viruses and cure patients with #LongCOVID - led by @michaelpelusomd.bsky.social, Amy Proal @polybiorf.bsky.social www.sciencedirect.com/science/arti...

YES. Need to say this loudly and often! This 2.46x is also the short-term ROI. Long-term ROI (more difficult to estimate) may ~10x. Highest for any gov't spending. And the source of discoveries necessary for all new drugs (industry important too but without NIH funded science there's no foundation)

Even though some non-US scientist might see these massive cuts imposed on our US colleagues as an opportunity to get ahead, I do not. This decision will be negative for all of us as scientists…we all depend on each other and advance together…

HLH, a cytokine-mediated hyperinflammation syndrome, causes fever, pancytopenia, and hemophagocytosis and is often fatal. Antiinflammatory agents, etoposide, and interferon-γ antibody are the main treatments. Learn more in a new review: nej.md/40Jps19 #MedSky #Oncology

🧪Read today's #ResearchWatch: A Pediatric Pan-Cancer Cohort Enables the Study of Systemic Antitumor Immunity, a summary of a 📃by Qi Chen, Binbin Zhao, Ziyang Tan, Linda Ljungblad, @petterbrodin.bsky.social, et al @imperialcollegeldn.bsky.social @ki.se aacrjournals.org/cdnews/news/...

Gender-affirming testosterone treatment in trans men leads to an immune system bias towards TNF and away from a type I interferon response, evidenced by decreased pDCs, more TNF/less IFN I after stimulation of monocytes – Dysentangling genetic vs endocrine effects of immune system differences. 1/2

Thanks for highlighting! Great session

"If you are not an immunologist this is a hopeless name" (of an immune cell) 😅😂 Feeling so validated by Petter Brodin at #WomensHealth2025

To celebrate its 30th anniversary, Nature Medicine launches a new series to spotlight key challenges & opportunities over the next 30 years of biomedical innovation 🎉 🧪 @natureportfolio.bsky.social www.nature.com/collections/...

The #immune system of #children reacts differently to #cancer than that of adults. @petterbrodin.bsky.social#immune#children#cancerd colleagues at 🇸🇪 @karolinskainst.bsky.social and 🇸🇪 Karolinska University Hospital gained new insights into these differences which could lead to new tailored treatments.

Dear mucosal immunologists! Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open. Register and see you this July in Aachen! 👇🏼 emig2025.de @petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social

JHI Editor-in-Chief Jean-Laurent Casanova @casanovalab.bsky.social is a professor at The Rockefeller University and a Howard Hughes Medical Institute Investigator https://www.hgid.org Learn more about Journal of Human Immunity 📗 https://buff.ly/4ajqm8W

📢 Register for the 2025 Henry Kunkel Society Meeting on "Genes & Immunity" and join us in Belgrade from April 10-12, 2025. henrykunkelsociety.org/meetings/ #HKS2025 #Immunology 🧬🔬