Check this out TuroID attached to inactive Cas to identify transcription regulators 👇 www.nature.com/articles/s41...

Learn about #axon regulation in the EMBO | The Company of Biologists Workshop "Axonal degeneration and regeneration" in Onna-son, JP, 18–22 Oct. Abstract submission/Registration by 31 May/15 Jun https://meetings.embo.org/event/26-axonal-degeneration#axon#EMBOAxonalRegeneration #EMBOevents #meeting 🧪

Introducing Cyclically Multiplexed Expansion Microscopy (Cy-ExM): a workflow for 3D nanoscale, high-plex imaging in whole cells. Cryo-preserved ultrastructure + iterative labeling + expansion microscopy → 20 targets in one dataset with ~70 nm lateral resolution. www.biorxiv.org/content/10.6...

mSumireF a Monomeric Violet Fluorescent Protein: pubs.acs.org/doi/full/10....

A hefty harvest of PhDs this year from our lab. Congratulations to Drs Karnika G, Lise S, Cecile C, Valentina D and Yilin X MPhil! 🎓

A hefty harvest of PhDs this year from our lab. Congratulations to Drs Karnika G, Lise S, Cecile C, Valentina D and Yilin X MPhil! 🎓

A glittery, festive #FluorescenceFriday today, spent playing with some fun samples 🪩🕺

Last week to submit an abstract to the "Intracellular mechanics and organelle mechanobiology" EMBO workshop #EMBOmechanobio 👇

FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation: pubs.acs.org/doi/10.1021/...

Induced proximity-based therapeutic modalities nature.com/articles/s41... rdcu.be/eOfBH This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more

New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️ www.biorxiv.org/content/10.1... #Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv

New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️ www.biorxiv.org/content/10.1... #Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv

Join us for the first @embo.org meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks! #EMBOMechanobio

Researchers led by Prof Jernej Ule (@ulelab.bsky.social) have discovered a new biological process that they’ve called ‘interstasis’ - a way for cells to keep groups of proteins in check💡 The team are now exploring the role of interstasis in neurodegeneration ⬇️ www.crick.ac.uk/news/2025-09...

Rethink? 🤔Factros presumed to be exported as signal molecules turn out to function inside the cell, working with ER HSP70/Bip - solid structural data for CDNF www.biorxiv.org/content/10.1... and MANF before www.nature.com/articles/s41...

and the reverse is also true ... factors believed to exert their functions inside playing roles outside ....

Rethink? 🤔Factros presumed to be exported as signal molecules turn out to function inside the cell, working with ER HSP70/Bip - solid structural data for CDNF www.biorxiv.org/content/10.1... and MANF before www.nature.com/articles/s41...

This week's selection of #preprints and articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... 🗣️: 4 #preprints from @qilabuva.bsky.social lab on SEL1L-HRD1 in ERAD doi.org/10.1101/2025... doi.org/10.1101/2025... doi.org/10.1101/2025... doi.org/10.1101/2025...

#ER - #membrane contact sites are often distorted by existing labeling methods. @steveroyle.bsky.social &co present an inducible labeling system (LaBeRling) using #LaminB receptor to fluorescently tag ER-membrane contact sites in live cells, preserving morphology @plosbiology.org 🧪 plos.io/4lv6gxu

Check this out 👇fly sleep and organelle morphology changes www.nature.com/articles/s41...

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox www.science.org/doi/10.1126/...

. @whiteheadinstitute.bsky.social researchers developed Perturb-Multimodal, a powerful new approach that simultaneously measures how genetic changes affect both #GeneExpression and cell structure in intact liver tissue. 📰: bit.ly/440TrVi 📝 @cellpress.bsky.social: bit.ly/3TEs2ST

Researchers at the Crick and UCL have developed laboratory models of dementia, including Alzheimer's, to show that certain genetic messages are misplaced in diseased nerve cells. The finding could offer a potential target for new treatments for neurodegeneration. www.crick.ac.uk/news/2025-06...

🧵 🧪 1/ Hi! I’m excited to share our latest work, now on arXiv: Repulsive particle interactions at cellular interfaces enable selective information processing (arxiv.org/abs/2506.14739) Where we explore how the physical properties of living systems can help cells process spatial information.

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

Researchers led by @clairedurrant1.bsky.social have used living human brain tissue to show for the first time how a toxic protein in Alzheimer’s can damage synapses👏 The team hope the cutting-edge tool could help accelerate the development of new treatments👉 buff.ly/cXK2LIa

Check out the latest version of MemBrain, spearheaded by computation superstar @lorenzlamm.bsky.social ! It can segment, pick particles and give you metrics on everything!

In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...

This is one to watch 🔬Congratulations!

A room full of microscopy enthusiasts, Cambridge Microscopy Meeting 2025. #CMM2025

Honored to help enable two back-to-back papers in @natureneuro.bsky.social; first DELTA www.nature.com/articles/s41... with collaborators at @hhmijanelia.bsky.social and then EPSILON www.nature.com/articles/s41... with @adamezracohen.bsky.social; @dyerfulchymist.bsky.social is always in the mix!

I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com. Check it out here! rdcu.be/eeY1J #COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES

😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with @knowleslab.bsky.social, Vendruscolo lab, @michael-e-ward.bsky.social lab, @deriverylab.bsky.social lab, @profmarciniak.bsky.social lab 🎉🎉🎉

This video, created by Andy Moore, a Research Scientist at @hhmijanelia.bsky.social, shows a cell w a dynamic network of endoplasmic reticulum (ER) tubules—present in every eukaryotic cell—as well as mitochondria migrating through the cell’s interior. The ER is orange, and the mitochondria are blue.

🤯 cryo-ET of copia viral-like particles lurking at the nuclear pore of intact Drosophila eggs! Amazing work by @svenklumpe.bsky.social & more cool findings in this collaborative paper illuminating the replication cycle of an iconic retrotransposon! www.cell.com/cell/fulltex...

Calling all... 🔬 Microscopists 💻 BioImage Analysts 👩‍🔬 Life Scientists 📅 Save the Date The 5th edition of the Crick BioImage Analysis Symposium will take place on November 24/25th 2025. More details to follow... #CBIAS2025

Reviewers should be paid. 🙃

Looks like very beautiful work. mRNA localisation in mature functional axons in vivo, and its role in long-term memory.

I was procrastinating making a smooth endoplasmic reticulum as the structure looks so complex when I remembered I can use metaballs! It is actually so much fun. What are you procrastinating today that could actually be very fun?

I’m excited to participate in the Women in Biophysics event organized by Divya Yadav, Lauren Conger and Jie Xiao. I look forward to sharing my perspectives and hearing those of inspiring colleagues.

Voting is open in our image competition with @the-node.bsky.social. Thanks to everyone that entered, and congratulations to our final 15. Now it's your turn to pick your favourite! Look out for our gallery of images at the Biologists @ 100 conference #biologists100.

Could inhaling Xenon be used someday to prevent or treat Alzheimer's disease? An intriguing experimental model study shows its effect on modulating brain microglia and reducing inflammation www.science.org/doi/10.1126/...

Check this out, Longevity defined by glia academic.oup.com/brain/articl...

Excited to see this year's #NeuroBioUK25 planned again in York for Sept 12th!

🧐

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....