Felix Campelo
@felixmendu.bsky.social
📤 484
📥 581
📝 81
Lorem ipsum
pinned post!
Announcing a new
@embo.org
Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at
@icfo.eu
(Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏
#EMBOmechanobio
meetings.embo.org/event/26-org...
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Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
https://meetings.embo.org/event/26-organelle-mechanobiology
5 months ago
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reposted by
Felix Campelo
Fran Bottanelli
5 days ago
#membrane
seminars are back this THURSDAY for a super session with
@dr-downes.bsky.social
from the
@giuliazanetti.bsky.social
lab and Xin Zhou from the Ikonen lab!
@felixmendu.bsky.social
@ishier.bsky.social
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reposted by
Felix Campelo
Javier Espadas
7 days ago
New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...
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Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism
The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex con...
https://www.biorxiv.org/content/10.1101/2025.11.28.690958v1
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Last week to submit an abstract to the "Intracellular mechanics and organelle mechanobiology" EMBO workshop
#EMBOmechanobio
👇
add a skeleton here at some point
7 days ago
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reposted by
Felix Campelo
Ishier Raote
11 days ago
Nice paper from
@leventallab.bsky.social
suggess lipid-driven domains organise cargo and trafficking machinery at ERES to sort and export transmembrane proteins. ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export.
rdcu.be/eR8jj
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ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export
Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...
https://rdcu.be/eR8jj
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reposted by
Felix Campelo
Philip Ball
19 days ago
It was fun, and a great honour, to receive this award in Barcelona last night. I'm speaking tonight about quantum matters for the City Biennal.
www.biennalciutaticiencia.barcelona/en/activitie...
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https://www.biennalciutaticiencia.barcelona/en/activities/nat-prize-barcelona-museum-natural-sciences
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Felix Campelo
Nature Reviews Molecular Cell Biology
25 days ago
ICYMI: New Online! Mechanistic insights into cargo sorting and export from the Golgi apparatus
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Mechanistic insights into cargo sorting and export from the Golgi apparatus
Nature Reviews Molecular Cell Biology, Published online: 10 November 2025; doi:10.1038/s41580-025-00907-3Protein and lipid cargoes are modified and sorted in the Golgi apparatus and packaged for delivery to diverse cellular destinations at the trans-Golgi network (TGN). This Review discusses recent insights into Golgi transport mechanisms and carrier biogenesis at the TGN.
https://bit.ly/4nRQTiI
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reposted by
Felix Campelo
Prasanna Satpute-Krishnan
29 days ago
Check out our
@ascbiology.bsky.social
#CellBio2025
Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself! So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
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Join us at
@icfo.eu
in Barcelona next February for the 1st
@embo.org
Workshop on "Intracellular mechanics and organelle mechanobiology". I am convinced it will be very interesting! We have extended the abstract submission deadline to December 8, so no excuses :)
#EMBOmechanobio
add a skeleton here at some point
26 days ago
0
6
1
reposted by
Felix Campelo
Announcing a new
@embo.org
Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at
@icfo.eu
(Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏
#EMBOmechanobio
meetings.embo.org/event/26-org...
loading . . .
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
https://meetings.embo.org/event/26-organelle-mechanobiology
5 months ago
1
71
50
reposted by
Felix Campelo
The Company of Biologists
2 months ago
Registration is now open to attend Journal of Cell Science's meeting on Imaging Cell Dynamics, organised by Francesca Bottanelli, Guillaume Jacquemet, Michael Way and Giulia Zanetti. Find out more:
biologists.com/meetings/jcs...
#JCSimaging
#Microscopy
#Microscope
#Imaging
#Cells
#CellScience
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reposted by
Felix Campelo
Ishier Raote
about 1 month ago
#MembraneTraffickers
! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST! We’ll hear from
@agatawitkowska.bsky.social
on mechanical control of neurotransmission and
@abdourachidthiam.bsky.social
on lipid storage mechanisms in health and disease. Spread the word and join the discussion!
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reposted by
Felix Campelo
Nadia Halidi
about 1 month ago
I have two open positions @ALMU
@crg.eu
: 1. Imaging Scientist (permanent position. Deadline 11th Nov.)
recruitment.crg.eu/content/jobs...
2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.)
recruitment.crg.eu/content/jobs...
Reposts appreciated.
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reposted by
Felix Campelo
UPF Medicine and Life Sciences
about 1 month ago
Another great opportunity to join us! 👏
#PostDocPosition
#AcademicJobs
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Interested in intracellular organization and membrane trafficking? 🥞 Join us at
@melisupf.bsky.social
in Barcelona! We’re looking for postdocs to apply for a Juan de la Cierva fellowship (PhD between Jan’24–Dec ’25). If you’d like to work with us, get in touch!
www.aei.gob.es/en/announcem...
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Ayudas para contratos Juan de la Cierva 2025 | Agencia Estatal de Investigación
Las ayudas Juan de la Cierva tienen como finalidad fomentar la incorporación de jóvenes, en posesión del grado de doctor, con objeto de que completen su formación investigadora postdoctoral en centros...
https://www.aei.gob.es/en/announcements/announcements-finder/ayudas-contratos-juan-cierva-2025
about 1 month ago
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reposted by
Felix Campelo
Monica Bettencourt-Dias
about 1 month ago
📣 We are moving to Barcelona to join the amazing
@crg.eu
and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for PhD students
www.crg.eu/en/content/t...
Postdocs
gimm.pt/jobs/postdoc...
Other calls to open, also for an experienced lab manager. Get in touch!
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Felix Campelo
Hiren Joshi
about 1 month ago
Reminder: our postdoc and PhD positions are still open. We work across different areas (wet and dry lab), but I am especially after people with a computational biology, bioinformatics, pytorch whisperer kind of background. Protein design and OpenFold/AF also counts.
add a skeleton here at some point
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Calling all
#Membrane
enthusiasts! Our
#MembraneTrafficking
online seminar series is back for the 2025-26 season: 8 fantastic speakers from Nov'25 to Feb'26. The first talks are already next Thursday (Nov 6, 5pm CET) with
@agatawitkowska.bsky.social
and
@abdourachidthiam.bsky.social
!
about 1 month ago
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reposted by
Felix Campelo
Manuel Irimia
about 2 months ago
🚨🚨🚨 Two super well-funded PhD grants from our MSCA Doctoral Network
@evomg-dn.bsky.social
at our lab at
@melisupf.bsky.social
,
@crg.eu
and the
@evomg-bcn.bsky.social
Program. If you're excited about evolution, genomics and biomedical research, this is your DN! 😃 Further info:
www.evomg-dn.eu
and 👇
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EVOMG-DN
EvoMG-DN is a European Doctoral Network funded by the Horizon Europe Marie Skłodowska-Curie Actions (MSCA), composed of 14 beneficiaries and associated partners from both academic and non-academic sectors.
https://www.evomg-dn.eu/
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reposted by
Felix Campelo
about 2 months ago
I'm hiring a postdoc! If you're interested in researching mechanisms of 3D tissue morphogenesis and have experience studying cell dynamics and performing quantitative image analysis, consider joining us
@mbisg.bsky.social
!
www.mbi.nus.edu.sg/jobs/seeking...
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https://www.mbi.nus.edu.sg/jobs/seeking-postdoctoral-fellow-in-asst-prof-natalie-dyes-laboratory-at-the-mechanobiology-institute-nus-2/
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reposted by
Felix Campelo
Luis Bonet-Ponce
about 2 months ago
🚨 We’re hiring a postdoc! 🚨 Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab! Reach out directly:
[email protected]
Learn more:
bonetponcelab.com
Let’s chat!
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reposted by
Felix Campelo
Cristina Pujades
2 months ago
We are hiring ! Interested in understanding how neuronal cell diversity arises? Come and join us
@upf.edu
for a
#PhD
#FPI
fellowship
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reposted by
Felix Campelo
preLights
2 months ago
Happy October 1st! A good time to share another
#CellBio
#preprint
reading list put together by a team of preLighters:
@sristi.bsky.social
, Matthew Davies,
@vibhasingh.bsky.social
,
@fadelvalle.bsky.social
& Barbora Knotkova. Check out their picks ⬇️👀
prelights.biologists.com/prelists/sep...
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September in preprints – Cell biology edition - preLights
https://prelights.biologists.com/prelists/september-in-preprints-cell-biology-edition/
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reposted by
Felix Campelo
Markus Deserno
2 months ago
I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪 Interfolio link:
apply.interfolio.com/174360
PLEASE, share widely across the blue skies! Let me briefly explain what we're looking for: 1/10
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Felix Campelo
Manuel Thery
2 months ago
intracellular mechanics ! in Barcelona in February (when its freezing anywherelse) !
add a skeleton here at some point
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reposted by
Felix Campelo
Lisa Heinke
2 months ago
Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:
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reposted by
Felix Campelo
Hesso Farhan
2 months ago
It was a great pleasure to work on this paper. What started as a small meeting in January this year resulted in this beautiful piece of work.
add a skeleton here at some point
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reposted by
Felix Campelo
Ishier Raote
2 months ago
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
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Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
https://www.nature.com/articles/s41580-025-00899-0?utm_source=%5Bbluesky%5D&utm_medium=social&utm_campaign=%5Bnrm%5D
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Join us for the first
@embo.org
meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks!
#EMBOMechanobio
add a skeleton here at some point
2 months ago
0
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🧵 I've been meaning to write a
#Skytorial
on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉
www.biorxiv.org/content/10.1...
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Mechanical forces stimulate Golgi export
Human cells face a wide range of external mechanical stimuli that vary with cell type, state, and pathological conditions. The rapidly growing field of mechanobiology investigates how cells sense and ...
https://www.biorxiv.org/content/10.1101/2025.09.02.673725v1
3 months ago
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This is already This Thursday (25th September)! Join us at the
@focalplane.bsky.social
features
#MembraneTrafficking
for lots of amazing microscopy and interesting membrane biology!
@franbottanelli.bsky.social
@ishier.bsky.social
@biologists.bsky.social
add a skeleton here at some point
3 months ago
0
5
4
reposted by
Felix Campelo
Rachel Lennon
3 months ago
Check out our latest review on Basement Membranes! Including scaled representation of protein & glycan components 😊
@mcrcellmatrix.bsky.social
add a skeleton here at some point
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Next Thursday Sept 25 (4-6pm CET) we have our first
#FocalPlaneFeatures
together with our
#membranetrafficking
community! Thanks to all who submitted such exciting abstracts. The final program is out, featuring a keynote by Gillian Griffiths. Register here:
focalplane.biologists.com/2025/09/16/f...
3 months ago
1
15
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reposted by
Felix Campelo
Richard Sever
3 months ago
Lovely to see David Stephens highlighted in 100 years of cell biologists at J. Cell Sci., alongside Linda Amos, Peter Medawar, Juan Bonifacino, and others
journals.biologists.com/jcs/article/...
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‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science
Summary: JCS highlights the lives and careers of 10 notable scientists from around the world who published first author papers in our journal over the last 100 years.
https://journals.biologists.com/jcs/article/138/17/jcs264351/369118/First-Persons-through-the-decades-100-years-of
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Felix Campelo
eLife
3 months ago
Membrane Biology: Nothing can replace polyunsaturated lipids Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN
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reposted by
Felix Campelo
Ishier Raote
3 months ago
Exciting preprint on organelle mechanoadaptation from Stephanie Miserey and Felix Campelo
@felixmendu.bsky.social
! Extracellular forces modulate Golgi secretory output by tuning carrier biogenesis via microtubule acetylation, DAG, and PKD. Golgi is a mechanoregulator!
www.biorxiv.org/content/10.1...
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reposted by
Felix Campelo
Emmanuelle Bayer
4 months ago
We have two open Post-Doc positions in my group at the interface with: 1-
@ataly.bsky.social
for molecular dynamics 2- Bruno Guillotin from protein mobility Apply by sending CV, two ref letters and a short motivation letter to me :
[email protected]
. Deadline 15 sept.
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Felix Campelo
Parc de Recerca Biomèdica de Barcelona
4 months ago
𝐎𝐥𝐠𝐚 𝐕𝐚𝐥𝐯𝐞𝐫𝐝𝐞, head of the research group GReNeC-Neurobio, is the new director of the Department of Medicine and Life Sciences (MELIS) at
@upf.edu
👉Valverde will be the first female director of the department. With her there are currently 3 women leading PRBB institutions ℹ️
https://tuit.cat/N3ms3
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reposted by
Felix Campelo
PlantEvolution 🌱🌾
5 months ago
1/2 Interesting read: The authors by the original "arsenic instead of phosphorous can sustain life" paper in Science write why they disagree with the Retraction. It's indeed a tricky question. The original paper was clearly wrong, but there was no data fabrication.
www.science.org/doi/10.1126/...
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reposted by
Felix Campelo
Susanne Wegmann
5 months ago
very excited to be part of this!
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reposted by
Felix Campelo
MOREL Lab / MEMBRAMICS research
5 months ago
(again!) new publication for
@membramics-lab.bsky.social
, by
@carlaalemany.bsky.social
&
@julianedagraca.bsky.social
in collaboration with N Naffakh & JB Brault, we show that Influenza virus triggers an ATG16L1/Rab11 PI4P response at ER membrane for viral export
journals.plos.org/plosbiology/...
1
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reposted by
Felix Campelo
FocalPlane
5 months ago
🗓️Save the date for our mini-symposium Thursday 25 September, 15:00-17:00 BST (GMT+1) Our keynote speaker is Gillian Griffiths
@griffithslab.bsky.social
, who will share their research on ‘Unexpected membrane dynamics in T cells’.
#membranetrafficking
#FocalPlaneFeatures
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reposted by
Felix Campelo
FocalPlane
5 months ago
📢Call for speakers We are looking for ECRs to speak in our mini-symposium run together with the popular membrane trafficking webinar series organised by @franbottanelli.bsky.social
@felixmendu.bsky.social
&
@ishier.bsky.social
.
focalplane.biologists.com/2025/07/14/f...
Apply by 24 August
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FocalPlane features... membrane trafficking - apply to give a talk - FocalPlane
FocalPlane features... membrane trafficking - apply to give a talk - News
https://focalplane.biologists.com/2025/07/14/focalplane-features-membrane-trafficking-apply-to-give-a-talk/
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Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH–dependent exocytosis of GOLIM4 | PNAS
www.pnas.org/doi/abs/10.1...
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Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH–dependent exocytosis of GOLIM4 | PNAS
Despite extensive efforts to develop strategies to inhibit cancer metastasis—the leading cause of cancer-related deaths—progress has been limited i...
https://www.pnas.org/doi/abs/10.1073/pnas.2501347122
5 months ago
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With
@ishier.bsky.social
and
@franbottanelli.bsky.social
, we're helping
@focalplane.bsky.social
organize a
#FocalPlanFeatures
... on membrane trafficking happening Sept. 25th! Keynote by Gillian Griffiths
@yale.edu
. Calling all ECRs: apply to give a talk
focalplane.biologists.com/2025/07/14/f...
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FocalPlane features... membrane trafficking - apply to give a talk - FocalPlane
FocalPlane features... membrane trafficking - apply to give a talk - News
https://focalplane.biologists.com/2025/07/14/focalplane-features-membrane-trafficking-apply-to-give-a-talk/
5 months ago
0
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reposted by
Felix Campelo
Carmen?
5 months ago
Check out our new preprint on the role of T cell actin-rich protrusion in CAR signalling initiation. Spoiler alert: Protrusions do it better
www.biorxiv.org/content/10.1...
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T cell protrusions enable fast, localised initiation of CAR signalling
Actin-rich protrusions densely cover the surface of T cells and are well characterised for their role in cell migration. However, recent studies have uncovered their role in antigen surveillance and immune signalling initiation. To investigate how membrane protrusions initiate and contribute to signalling, from the first cell-cell contact to immunological synapse formation, we performed dynamic imaging experiments of endogenously tagged signalling proteins in T cells. To quantitatively capture the early dynamics of cell-cell interactions, we employed HER2‑CAR-expressing T cells targeting HER2⁺ breast cancer cells. By harnessing live-cell imaging and super-resolution stimulated emission depletion (STED) microscopy we were able to capture topological membrane changes and their correlation with mesoscale protein rearrangements over time. Our findings indicate that, prior to activation, key molecular players in T cell activation, including the kinase Lck, the phosphatase CD45 and the adaptor LAT, as well as the exogenously expressed CAR, lack any enrichment in actin-rich protrusions. However, upon initial contact of the T cell with the target cell, a dynamic and fast rearrangement of the surface receptors, phosphatases, and kinases occurs within the protrusions, ensuring a rapid and effective initiation of the immune signalling cascade. The rapid clustering of the HER2-CAR occurs preferentially within protrusions rather than flat membrane regions and is accompanied by enhanced recruitment of the kinase ZAP-70 and LAT. While the localisation of the kinase Lck remained unchanged, protrusion-cell contacts trigger a pronounced exclusion of the phosphatase CD45, an effect observed both with and without the cytosolic signalling domain of the CAR. Overall, the signalling machinery rearranged more rapidly and efficiently at contacts mediated by protrusive structures compared to non-protrusive regions. Together, our data provide a quantitative framework illustrating how signalling proteins are dynamically reorganised to facilitate CAR-mediated activation within these specialised structures. ### Competing Interest Statement The authors have declared no competing interest.
https://www.biorxiv.org/content/10.1101/2025.07.08.662959v1
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reposted by
Felix Campelo
Fran Bottanelli
5 months ago
For
#TcellThursday
I am going to repost our recent work where we use CRISPR and imaging to highlight the role of protrusions in early T cell signaling. I think Carmen’s work beautifully shows how one can extract quant info by imaging processes as they happen in cells!
www.biorxiv.org/content/10.1...
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T cell protrusions enable fast, localised initiation of CAR signalling
Actin-rich protrusions densely cover the surface of T cells and are well characterised for their role in cell migration. However, recent studies have uncovered their role in antigen surveillance and i...
https://www.biorxiv.org/content/10.1101/2025.07.08.662959v1
1
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reposted by
Felix Campelo
Hesso Farhan
5 months ago
Our review on the role of ER proteostasis in bone disease is out today in Trends in Molecular Medicine
www.cell.com/trends/molec...
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The endoplasmic reticulum proteostasis network and bone disease
Bone homeostasis relies on the coordinated activity of osteoblasts and osteoclasts that balances bone formation and resorption, and of osteocytes for biomechanical sensing and hormone secretion. A key...
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914%2825%2900145-5
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reposted by
Felix Campelo
The Company of Biologists
5 months ago
Looking for new
#microscopy
collaborations, organising speakers for a conference, assembling a committee? Visit and join the
@focalplane.bsky.social
network to broaden your contacts and find those who may not come to mind.
focalplane.biologists.com/network
#Microscope
#Imaging
#CellBiology
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Felix Campelo
Marko Kaksonen
5 months ago
Hello microscopy and imaging experts and enthusiasts! We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English). Please apply and/or repost!
jobs.unige.ch/www/wd_porta...
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Felix Campelo
EMBO
5 months ago
Sign up now for EMBO Workshop "Intracellular mechanics and organelle
#mechanobiology
" in Barcelona, Spain, 16–20 Feb 2026! Registration Deadline (in person/virtual): 15 Dec 2025/1 Feb 2026 Abstract Submission Deadline: 14 Nov 2025
meetings.embo.org/event/26-org...
#EMBOmechanobio
#EMBOevents
🧪
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Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
https://meetings.embo.org/event/26-organelle-mechanobiology
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