Good news from the ALab. We have just resubmitted our revised manuscript on the role of Homer proteins in YAP-Wnt signaling crosstalk. Here's the updated preprint: doi.org/10.1101/2025.... We’re truly grateful to the reviewers for their thoughtful comments and questions and hope they'll be happy...

James, J., Winn, L. B., Mottram-Epson, P., & Köster, D. (2025). Paths to stability–actin regulation of adherens junction mechanics. Journal of Cell Science, #EpitheilalMechanicsReview doi.org/10.1242/jcs....

An Archaea bacterium with an internal membrane system! Amazing and beautiful work!

1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...

Supracellular actomyosin assemblies: master coordinators of development In this Review, Katja Röper @katjaroeper.bsky.social discusses supracellular actomyosin structures, tissues where they function, their known roles as well as potential properties journals.biologists.com/dev/article/...

Our latest efforts to understand Enterococcal wound infection. In long-term collaboration with @gthibault.bsky.social, we discovered how E. faecalis makes extracellular ROS - via EET!⚡️Which in turn dysregulates host UPR to delay wound healing. Led by @aarontan.bsky.social - his videos below are 🤩!

We have some news! We find that the post-synaptic Homer proteins coordinate YAP and Wnt signaling in epithelial cells, downstream of the Crumbs polarity complex. They do so by sequestering YAP and beta-catenin in biomolecular condensates, and by suppressing a FRYL/NDR complex. Check it out!

Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio meetings.embo.org/event/26-org...

EMBO Cell Polarity and Membrane Dynamics workshop is off to a good start - as always :) #EMBO

How are specific cargos targeted to apical & basolateral domains within #EpithelialCells? This study uses a novel #vesicle tracking software "MSP-tracker" to show that the secretory pathway in #Drosophila follicle cells is unexpectedly spatially organized @plosbiology.org 🧪 plos.io/3EfJsBp

Our paper on the regulation of the tight junction leak pathway by Arhgap12/N-Wasp is out ! www.cell.com/cell-reports...

We have some exciting news about how epithelial cells initiate an apical lumen de novo, and how this is coordinated with cell-cell junction formation. Check it out: www.biorxiv.org/content/10.1...

Another beautiful tight junction. This time with scale bar :)

Not bad for a conventionally fixed and dehydrated TEM sample. No HPF/FS. OTO method. Stains the kissing points quite nicely.

First official post! A new paper out about #cytokinesis in #epithelia www.embopress.org/doi/full/10.... Explore our journey as we uncover how regulators of cell-cell and cell-matrix interactions modulate cytokinesis efficiency, while revealing new roles for the Dystrophin-Dystroglycan complex.

This is sabotage! And this may well be just the beginning.

You don’t have to be German to know what this stands for - it’s clear as mud - and it’s disgusting!

iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade https://www.biorxiv.org/content/10.1101/2025.01.10.632381v1

Our #CryoET paper on ciliary rootlet ultrastructure from mouse retina is now out in @elife.bsky.social! Have a peek with this video or dive deeper at bit.ly/3ZJzhgc. Big thanks to @carter-lab.bsky.social and #teamtomo. #CryoET #CryoEM #Cilia #Rootlet #Centriole #Research #Science

Mind blowing! Look at those nuclear pores.

Still one of my favourite tomograms, recorded ages ago at NCMIR (UCSD). It shows interconnected networks of caveolae (labeled with a miniSOG probe) at the rear of RPE1 cells. Bummer we so far haven't been able to image such networks in larger cell volumes; it's a lot of membrane that's stored here.

Woah. Bluesky seems to be much more than a much needed alternative to X. I didn't expect this big a science community here tbh. I love the start up packages; really cool to connect with so many people I never met or even heard of. Since I'm new to this, I'll briefly introduce my lab and what we do.

This will be a fantastic meeting! Looking forward to it