Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers. www.dundee.ac.uk/work-for-us/...

I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩 www.biorxiv.org/content/10.1...

Such elegant work, as ever!

Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!! Make my day and check it out! www.biorxiv.org/content/10.1... #Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬

New preprint alert! Endogenous gene editing of alveolar organoids to investigate mechanisms of epithelial dysfunction in familial ILD. Kudos first author @eimearrutherford.bsky.social and thanks @thecimr.bsky.social @labrawlins.bsky.social @profmarciniak.bsky.social www.biorxiv.org/content/10.1...

Thrilled to collaborate with @zhixingchen2.bsky.social Lab @pku1898.bsky.social ! We tested new PK Mem dyes—gentle, photostable tools to label the plasma membrane in live neurons, making it easier to track growth cone motility & axonal transport. #liveimaging #neuroscience tiny.cc/3qhp001

Great opportunity!

Fantastic stuff by Sam and team! 3D tracking of individual proteins inside intracellular compartments. An amazing innovation towards understanding cellular environments.

Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution. Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time. www.nature.com/articles/s41...

#newPI and time is running. It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab: warwick.ac.uk/fac/sci/med/...

Well done Jessy @jessyzhu-jiayi.bsky.social who gave her #biologists100 flash talk today about her new GCN2 activators @biologists.bsky.social @thecimr.bsky.social

Fantastic Skytorial!

Congratulations @lily-wu.bsky.social for winning a poster prize at the @biologists.bsky.social #biologists100 conference! What a superstar! @thecimr.bsky.social @profmarciniak.bsky.social @matthoare20.bsky.social

Great to see this published! Congrats on a really beautiful paper!

I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday

The 16th ER & Redox club meeting ends. THANK YOU to co-organiser @fenech-lab.bsky.social & to everyone for outstanding presentations, discussions, posters and fun over the last 4 days in Namur. Huge thanks to @unamur.bsky.social @biologists.bsky.social @febspress.bsky.social for support and funding!

Delighted to share our latest paper on alpha-1-antitrypsin deficiency, in @naturegenet.bsky.social. A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell. @thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute

We present: Direct-view oblique plane microscopy www.biorxiv.org/content/10.1...

Amazing Conference Alert!! Registration is now open for EUROSERPIN2025. Come and join us in beautiful Brescia, Italy, this May to get excited about the wonderful world of serpin proteins! Visit euroserpin.eu to sign up. Early-bird rates offered until February 28th.

Great to see this collaborative effort out! Check out our new alveolar organoid model, ripe for studying disease mechanisms including those involving surfactant proteins: www.embopress.org/doi/full/10.... Front cover image to follow soon! @eimearrutherford.bsky.social @profmarciniak.bsky.social

We have a postdoc opportunity at the interface of metabolism and epigenetics! 🔥🧬 The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️ For more detail and to apply: babrahaminstitute.livevacancies.co.uk#/job/details...

‼️Deadline 16th January 2025‼️Applications are open for the 2025 Experience Postgrad Life Sciences programme. Paid 8-week summer internships aimed to enhance diversity among life scientists of the future!! @cambridgebiosci.bsky.social @corpuscambridge.bsky.social www.exppg.lifesci.cam.ac.uk

Taking back the ER - rupress.org/jcb/article/...

Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳

Golgins support extracellular matrix secretion by collectively maintaining the Golgi structure-function relationship https://www.biorxiv.org/content/10.1101/2024.11.19.624265v1

A bit of microscopy to get me off the mark! Single particle tracking of fluorescent, 20nm spherical protein assemblies (GEMs) as they dance through the ER-lumen of a COS7 cell. One of the tools we used to assess ER-biophysics in α1-antitrypsin deficiency science.org/doi/10.1126/sciadv.abm2094