Aberrant neuron-OPC synaptic transmission and deficient myelination define sex bias in major depressive disorder https://www.biorxiv.org/content/10.64898/2026.06.14.732204v1

Fatty acid binding protein-8 (FABP8/PMP2) reveals molecular heterogeneity of myelin sheaths in the human CNS https://www.biorxiv.org/content/10.64898/2026.06.09.730898v1

Antibody-mediated rescue of endogenous retrovirus-induced damage in the demyelinated central nervous system https://www.biorxiv.org/content/10.64898/2026.06.10.731326v1

Intact learning and memory in mice incapable of de novo myelination https://www.biorxiv.org/content/10.64898/2026.06.12.730403v1

Disruption of Myelin-Associated Glycoprotein Activity Drives Aberrant Cerebellar Neurodevelopment and Autism-Like Behaviors. https://www.biorxiv.org/content/10.64898/2026.06.11.731430v1

Quantitative determination of longitudinal CNS cholesterol loss during myelin damage and repair https://www.biorxiv.org/content/10.64898/2026.06.04.729895v1

Chronic Mild Stress Impairs Hippocampal Myelination through SOX6-Dependent Dysfunction of Oligodendrocyte Lineage Cells https://www.biorxiv.org/content/10.64898/2026.05.29.728722v1

Targeting UBE3A and downstream estrogen receptor-β signaling to restore oligodendroglial homeostasis in Angelman syndrome https://www.biorxiv.org/content/10.64898/2026.05.21.726878v1

Stage-specific exposure to an activity-permissive media enhances neuronal maturation in oligodendrocyte-enriched cortical organoids https://www.biorxiv.org/content/10.64898/2026.05.17.725797v1

Myelin basic protein is an RNA chaperone in microglial nuclear retro-transport https://www.biorxiv.org/content/10.64898/2026.05.14.725089v1

Caregiver-infant interactions selectively shape emerging functional connectivity in the neonatal brain https://www.biorxiv.org/content/10.64898/2026.05.13.724776v1

An organotypic neocortical slice culture for studying neuroglial interactions https://www.biorxiv.org/content/10.64898/2026.05.15.725074v1

Actin disassembly triggers CNS myelin compaction and wrapping https://www.biorxiv.org/content/10.64898/2026.05.14.722739v1

Multiphasic myelination and dendritic growth modulate qMRI signals in human visual cortex. https://www.biorxiv.org/content/10.64898/2026.05.03.722280v1

An exciting initiative! Go out and #Move for #your #GLIA! ... and share with us! All information here: redeglial.weebly.com/move-for-you...

PIEZOs regulate oligodendrocyte sheath formation, expansion, and myelination potential https://www.biorxiv.org/content/10.64898/2026.04.23.720488v1

A novel reporter mouse for astrocyte-derived extracellular vesicles reveals trafficking of cargo to neuronal mitochondria https://www.biorxiv.org/content/10.64898/2026.04.16.718987v1

Red fluorescent labeling of myelin by membrane-targeted tdTomato in transgenic mouse lines https://www.biorxiv.org/content/10.64898/2026.04.17.718425v1

High neuron-microglia interaction at the node of Ranvier predicts recovery in an inflammatory model of Multiple Sclerosis https://www.biorxiv.org/content/10.64898/2026.04.14.718431v1

Teriflunomide has been proven to be effective in the therapy of relapsing–remitting multiple sclerosis (RMS). In an ex-vivo demyelination model, it attenuated myelin degradation induced by lysolecithin and preserved oligodendrocytes. #MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

Loss of myelinating oligodendrocytes and myelin impairs motor and cognitive functions. Transplantation of OPCs from human BMSCs holds promise for treatment of such diseases. Single-cell RNA sequencing data revealed a CD90hiEGFR+PDGFRA+ p... #MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

Short-term monocular deprivation engages rapid, inhibition-gated ocular dominance plasticity in mouse visual cortex https://www.biorxiv.org/content/10.64898/2026.04.13.718078v1

Point of View: An easy way to improve lab meetings doi.org/10.7554/eLif... I'm really happy to see this one out @elife.bsky.social. Awesome Cara Glynn and I describe and reflect on a year-long, low-cost practice that transformed our group meetings. #researchculture #ECR #labmeetings

Short-term synaptic plasticity at neuron-OPC synapses in the corpus callosum during postnatal development of mice: experimental and computational study https://www.biorxiv.org/content/10.64898/2026.03.31.715637v1

Early demyelination by off-target complement injury in a mouse model of neuromyelitis optica https://www.biorxiv.org/content/10.64898/2026.03.13.711636v1

Registrations and abstract submissions for #AstrocyteCafe2026 are now OPEN! Abstract submission will close on April 1st!!! We hope to see many of you on June 3-5 in Pamplona 🤩 Thanks KernelScience for our new website & for helping organize this conference! 👇👇👇👇 astrocytecafe.com#/conference-...

Megan Doty et al discovered that myelin remains for weeks after cortical axons degenerate. We call the sheaths without an axon de-axoned myelin. During the slow, asynchronous, degeneration, microglia don't play a major role in clearing the axon or de-axoned myelin. www.science.org/doi/10.1126/...

Global O-GlcNAcome Identifies O-GlcNAcylated Proteins Regulating Oligodendrocyte Precursor Cells Differentiation https://www.biorxiv.org/content/10.64898/2026.03.02.709210v1

Premyelinating Oligodendrocyte Survival Governs CNS Remyelination https://www.biorxiv.org/content/10.64898/2026.02.23.707571v1

Selective Cortical Myelination Reflects Axon-Driven Progression of the BCAS1-positive Oligodendrocyte Lineage https://www.biorxiv.org/content/10.64898/2026.02.15.705957v1

Longitudinal magnetic resonance imaging and spectroscopy in a mouse model of cuprizone-induced demyelination https://www.biorxiv.org/content/10.64898/2026.02.18.706313v1

Local demyelination rekindles oligodendrocyte precursor dynamics and remyelination in old age https://www.biorxiv.org/content/10.64898/2026.02.15.705983v1

I am delighted to see this work published. A big thanks to everyone, particularly the excellent supervision of @lyons-lab.bsky.social, the work of co-first author @juliavdkorput.bsky.social and wonderful collaborators in Amsterdam and Oregon. www.science.org/doi/10.1126/...

Really happy to share that we’ve been awarded a #Telethon grant www.fondazionetelethon.it/storie-e-new... (continues...)

Diverging routes of oligodendrocyte recruitment in adaptive and regenerative myelination https://www.biorxiv.org/content/10.64898/2026.02.04.703508v1

COUNTERING AGE-ASSOCIATED ALTERATIONS IN OLIGODENDROCYTE-DERIVED EXTRACELLULAR MATRIX REJUVENATES COGNITION https://www.biorxiv.org/content/10.64898/2026.02.03.702938v1

ASCL1 and OLIG2 Expression Dynamics Control Glial Cell Fate and Regional Diversity in the Dorsal Forebrain https://www.biorxiv.org/content/10.64898/2026.02.02.703158v1

Wow! So cool!

🧠 Beautiful seminars by Marie-Eve Paquet and Yves De Koninck (Université Laval & CERVO Brain Research Centre, Quebec) today. Great opportunity to hear about novel tools to target, stimulate and record neurons. Thanks to our friend and collaborator Francesco Ferrini, who organized the meeting.

If you're interested in the factors that enable the regular structure of CNS #myelin sheaths by #oligodendrocytes, check this out. Featuring a #CDC42 - effector proteins - #septin axis. Congrats to 1st author Sophie, and a big thank you to all who contributed onlinelibrary.wiley.com/doi/10.1002/...

💡New preprint out! 💥 "Transcranial direct current stimulation (tDCS) promotes myelin repair and plasticity in the mouse motor cortex" in now in Biorxiv, thanks to the collaboration between our lab at Neuroscience Institute Cavalieri Ottolenghi and Marco Cambiaghi's group at University of Verona

👏👏 Big congrats to Martino Bonato who just defended his PhD thesis on Particulate Matter effects in #MultipleSclerosis preclinical models! Ad maiora, Martino!👏👏 And thanks🙏🙏 to Georgia Mandolesi, Davide Lecca, and Alessandra Fiorio Pla for serving as PhD committee!!

💡New preprint out! 💥 "Transcranial direct current stimulation (tDCS) promotes myelin repair and plasticity in the mouse motor cortex" in now in Biorxiv, thanks to the collaboration between our lab at Neuroscience Institute Cavalieri Ottolenghi and Marco Cambiaghi's group at University of Verona

The ApoC2 mimetic peptide D6PV enhances remyelination by stimulating oxidative phosphorylation in oligodendrocytes https://www.biorxiv.org/content/10.64898/2026.01.22.701034v1

Pre-myelinating oligodendrocyte ADGRG1 is required for axon ensheathment and CNS myelin formation https://www.biorxiv.org/content/10.64898/2026.01.26.701898v1

We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth. Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...

Our Paper is out! We studied cortical microglia and regenerating oligodendrocyte (OL) interactions. In short: demyelination induces transiently reactive microglia and depletion of these reactive microglia increase recovering OL number onlinelibrary.wiley.com/doi/10.1002/...

Transcriptional Heterogeneity Reveals a Synaptic Gene Program in Developing and Adult Human Oligodendrocyte Precursor Cells https://www.biorxiv.org/content/10.64898/2026.01.01.697017v1

Dlx2 reprograms the transcriptome and laminar position of glia-derivedAscl1-induced interneurons https://www.biorxiv.org/content/10.64898/2026.01.02.697435v1

Tbx1 heterozygosity in the oligodendrocyte lineage has distinct effects on myelinated axons in the fimbria and on behaviors related to neurodevelopmental disorders in mice. https://www.biorxiv.org/content/10.64898/2025.12.30.697076v1