Progenitor Timing Shapes NG2-Glia Fate and Oligodendrocyte Differentiation https://www.biorxiv.org/content/10.1101/2025.09.24.678191v1

Oligodendrocyte progenitor cell responses to inflammatory demyelination with aging https://www.biorxiv.org/content/10.1101/2025.09.22.677854v1

Over the last 8 years, Oliver Burton has tested >1000 different fix/perm combos, and here the final verdict is: "Burton's Best Buffer": 2% formalin, 0.05% Fairy dish soap, 0.5% Tween-20, 0.1% Triton X-100. Yep, replace all of those expensive detergents with @pg.com dishwashing liquid

🧵How to write and manage your first research budgets The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.

en.ilsole24ore.com/art/by-vallo... Marsilio Editori

Temporal Requirement for Stearoyl-CoA Desaturase 1 in Oligodendrocyte Development but Not Myelin Maintenance https://www.biorxiv.org/content/10.1101/2025.09.18.676928v1

Patient-derived lymphocytes drive smoldering lesion pathology in a chimeric multiple sclerosis mouse model https://www.biorxiv.org/content/10.1101/2025.09.16.676229v1

Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease url: academic.oup.com/brain/articl... #tao @nfranzme.bsky.social

Very pleased to publish this new review with Farah Wahbeh on the role of #EBV in #Multiplesclerosis. I learned a lot writing this, I hope others find it useful too www.neurology.org/doi/10.1212/...

Developmental Connectomics of the Mouse Cerebellum https://www.biorxiv.org/content/10.1101/2025.09.15.676403v1

Spatial transcriptomics of compartmentalised inflammation in a natural disease multiple sclerosis cohort. https://www.biorxiv.org/content/10.1101/2025.09.10.675210v1

Super!

We’ve known for some time that air #pollution is bad for human #health. But the focus was mostly on the lungs and heart. Yet somewhere along the way, it became more mainstream to consider how air pollution might affects brains too. What I found surprising was the recency of that. #neuroskyence

Dual role of GABAB receptor in oligodendrocyte function and immune modulation in experimental multiple sclerosis https://www.biorxiv.org/content/10.1101/2025.09.09.675094v1

Erythropoietin alleviates intellectual disability and autism-like behavior of mice caused by Zbtb20 haploinsufficiency, a construct-valid model of Primrose syndrome https://www.biorxiv.org/content/10.1101/2025.09.11.675680v1

Transcriptional dynamics of the oligodendrocyte lineageand its regulation by the brain erythropoietin system https://www.biorxiv.org/content/10.1101/2025.09.11.675672v1

Incredible resource and a big step forward in modelling neurodevelopmental disorders 👇🏻 #organoids #neurodevelopment

Temporal dynamics of CNS cholesterol esters correlate with demyelination and remyelination https://www.biorxiv.org/content/10.1101/2025.09.06.674663v1

Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function: Cell Reports www.cell.com/cell-reports...

Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies www.science.org/doi/10.1126/...

🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience ➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism? Check out what we found! 🧵1/n

🔬 Researchers at Stanford University have developed a new #method that turns the mouse scalp transparent, making it possible to image the living #brain during its development. Learn more: www.eara.eu/post/transpa... #AnimalResearch #3Rs #liveimaging #microscopy

Teach others how to use the EDA to design rigorous in vivo experiments that use the minimum number of animals: nc3rs.org.uk/events/ukrn-... ⏳ Registration closing soon: Wednesday 17 September 🤝Delivered by @drejpearl.bsky.social and @ukrepro.bsky.social 📅 Thursday 13 November, 10.00 – 16.00 (GMT)

Today Lucía takes you by the hand and walks you through the entire ERC #evaluation process — from panel selection to interview. Learn who reviews your #proposal, how decisions are made, & how to best increase your chance of success. 👇 #research #funding #grant #AcademicSky

Developmental excitation-inhibition imbalance permanently reprograms autism-relevant social brain circuits https://www.biorxiv.org/content/10.1101/2025.09.07.674483v1

“Just when you think you’ve seen it all, social insects reveal another surprise.” https://scim.ag/47sVFyS

Epigenomic regulation of human oligodendrocyte myelination properties, relation to age and lineage https://www.biorxiv.org/content/10.1101/2025.09.04.674347v1

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system https://www.biorxiv.org/content/10.1101/2025.09.02.673641v1

The lab is having a good few months for publications with this one as well in case you missed it: doi.org/10.1016/j.ym... www.sciencedirect.com/science/arti... (Thank you Themis and Francesca, and all!)

Took a little hiatus from social media so I'm a bit late posting this one. This one was a labour of love - very happy to see it out. Congrats to Dr Ben Summers and the rest of the team.

Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD Thanks to Nina and all of the team!

Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function www.nature.com/articles/s41...

Characterizing oligodendrocyte-lineage cells and myelination in the basolateral amygdala: Insights from a novel methodology in postmortem human brain www.sciencedirect.com/science/arti...

Oligodendrocyte precursor cell transplantation attenuates inflammation after ischemic stroke in mice www.frontiersin.org/journals/neu...

Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence academic.oup.com/cercor/artic...

Reduced Accumulation Rate and Morphological Changes of Newly Generated Myelinating Oligodendrocytes in the Corpus Callosum of Aged Mice onlinelibrary.wiley.com/doi/10.1002/...

Sex-dependent impairments in oligodendrocyte maturation and myelination in offspring mice exposed to preeclampsia www.sciencedirect.com/science/arti...

Scn2a-linked myelination deficits and synaptic plasticity alterations drive auditory processing disorders in an ASD mouse model www.nature.com/articles/s41...

AAV-Based Intracerebral Administration of BDNF Promotes Myelin Repair and Cognitive Improvement After Cuprizone-Induced Demyelination. onlinelibrary.wiley.com/doi/10.1002/...

NF-κB RelA regulates temporal oligodendrocyte differentiation in the postnatal brains www.frontiersin.org/journals/cel...

A focus on the normal-appearing white and gray matter within the multiple sclerosis brain: a link to smoldering progression link.springer.com/article/10.1...

Oligodendrogenesis inhibition in the juvenile and adolescent periods differentially alters myelin in mice karger.com/dne/article/...

Demystifying The Myelin g Ratio: Its Origin, Derivation and Interpretation www.tandfonline.com/doi/full/10....

Tissue stiffness controls neuroblast migratory behavior and reprogramming during myelin repair www.cell.com/iscience/ful...

FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system www.nature.com/articles/s41...

Imaging myelin degradation in ex vivo prefrontal cortex tissue blocks in Alzheimer's disease and chronic traumatic encephalopathy. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

The lncRNA MYRACL regulates human oligodendrocyte maturation and myelination www.sciencedirect.com/science/arti...

Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination journals.lww.com/nrronline/ci...

Small brains but big challenges: white matter tractography in early life samples link.springer.com/article/10.1...

Multiscale characterization of myelin distribution with polarized THG microscopy Morizet et al, Optica 2025 doi.org/10.1364/OPTI... @laboptbio.bsky.social @institutducerveau.bsky.social @cnrs.fr ‪‪ @ip-paris.bsky.social @inserm.fr (1/8)