Sarah Jäkel
@sjaekel.bsky.social
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Neuroscientist, oligodendrocyte lover, Emmy-Noether junior group leader, mother
I have a question for the research commumity. I am looking into buying a vibratome to prepare actute organotypic slices from mouse brains and I am unsure which brand to buy. Currently the choice is between Leica and Precisionary Instruments. Amy recommendations?
11 months ago
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It was a real pleasure to visit Hamburg and get to knowamy new people!
add a skeleton here at some point
about 1 year ago
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Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction.
journals.plos.org/plosbiology/...
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Are oligodendrocytes bystanders or drivers of Parkinson’s disease pathology?
The major pathological feature of Parkinson ‘s disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002977
about 1 year ago
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This work was a huge collaborative effort, it is a brilliant resource for many researchers, and I am really glad to see this out!
add a skeleton here at some point
about 1 year ago
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The first paper of the Jäkel lab is out! We have shown that the RNA detection in human FFPE brain tissue significantly changes with fixation time. Chose your tissue well before doing an experiment!
doi.org/10.1093/brai...
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Impact of fixation duration on messenger RNA detectability in human formalin-fixed paraffin embedded brain tissue
Hurler et al. performed RNAScope on post-mortem human brain tissue and found mRNA signal detection to be highly dependent on fixation time. Considering the
https://doi.org/10.1093/braincomms/fcae430
over 1 year ago
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