Tal Laviv
@lavivtal.bsky.social
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Neuroscientists, microscopy, biosensors www.lavivlab.com
I am excited to share our new paper, where we developed and used a new approach that allows us to dynamically monitor autophagy in the intact mouse brain!
biorxiv.org/cgi/content/...
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Fluorescence lifetime-based biosensor for monitoring compartmentalized autophagy dynamics in the intact mammalian brain
Synaptic architecture underlies neuronal computation, with autophagy serving as a key regulator of synaptic plasticity, function and local metabolism. Yet, autophagy dynamics and regulation within int...
https://biorxiv.org/cgi/content/short/2025.12.25.693346v1
4 months ago
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I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in
@naturemethods.bsky.social
www.nature.com/articles/s41...
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Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods
A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...
https://www.nature.com/articles/s41592-025-02610-9
about 1 year ago
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reposted by
Tal Laviv
Inna Slutsky
over 1 year ago
Yesterday, we held the 2024 Sieratzki Prizes Ceremony at the ISFN meeting in Eilat. We are so proud of our 2024 winners:
@yoavlivneh.bsky.social
, Arseny Finkelstein, David Omer,
@lavivtal.bsky.social
, and Inbal Ben-Ami Bartal!
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Tal Laviv
Eric Topol
over 1 year ago
How to improve memory and cognitive function in aged mice Fix the mitochondrial EC (excitation-coupling)
@science.org
representing a new potential path for replenishing neuronal energy reserves to counter brain aging
www.science.org/doi/10.1126/...
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Beautiful work by my the lab of Huan Ma, which I had the pleasure to contribute to. A fascinating link between neuronal activity, and transcription-excitation coupling in mitochodria to brain function and ageing
www.science.org/doi/10.1126/...
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Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice
Deciphering the complex interplay between neuronal activity and mitochondrial function is pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic function and mitoc...
https://www.science.org/doi/10.1126/science.adp6547
over 1 year ago
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Hello there! My first try here: Sharing an in vivo image of a beautiful dendrite with a GFP knock-in to endogenous CaMKIIa
over 1 year ago
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reposted by
Tal Laviv
Michael Ward
over 1 year ago
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
www.science.org/doi/10.1126/...
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Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
https://www.science.org/doi/10.1126/science.adi5295
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reposted by
Tal Laviv
Danielle Beckman
over 1 year ago
I'm very happy with how this image turned out and can't even wait for
#FluorescenceFriday
! I'm trying to detect Tau protein phosphorylation before forming full fibrillary tangles in
#Alzheimer
disease. Healthy neurons: (🟠NeuN), Dying neurons: pTau ( 🟣422), (🔵AT8). More info in the Alt tex! 🧠🔬
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