Tal Laviv
@lavivtal.bsky.social
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Neuroscientists, microscopy, biosensors www.lavivlab.com
I am excited to share our new paper, where we developed and used a new approach that allows us to dynamically monitor autophagy in the intact mouse brain!
biorxiv.org/cgi/content/...
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Fluorescence lifetime-based biosensor for monitoring compartmentalized autophagy dynamics in the intact mammalian brain
Synaptic architecture underlies neuronal computation, with autophagy serving as a key regulator of synaptic plasticity, function and local metabolism. Yet, autophagy dynamics and regulation within int...
https://biorxiv.org/cgi/content/short/2025.12.25.693346v1
17 days ago
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I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in
@naturemethods.bsky.social
www.nature.com/articles/s41...
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Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods
A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...
https://www.nature.com/articles/s41592-025-02610-9
11 months ago
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reposted by
Tal Laviv
Inna Slutsky
12 months ago
Yesterday, we held the 2024 Sieratzki Prizes Ceremony at the ISFN meeting in Eilat. We are so proud of our 2024 winners:
@yoavlivneh.bsky.social
, Arseny Finkelstein, David Omer,
@lavivtal.bsky.social
, and Inbal Ben-Ami Bartal!
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Tal Laviv
Eric Topol
about 1 year ago
How to improve memory and cognitive function in aged mice Fix the mitochondrial EC (excitation-coupling)
@science.org
representing a new potential path for replenishing neuronal energy reserves to counter brain aging
www.science.org/doi/10.1126/...
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Beautiful work by my the lab of Huan Ma, which I had the pleasure to contribute to. A fascinating link between neuronal activity, and transcription-excitation coupling in mitochodria to brain function and ageing
www.science.org/doi/10.1126/...
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Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice
Deciphering the complex interplay between neuronal activity and mitochondrial function is pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic function and mitoc...
https://www.science.org/doi/10.1126/science.adp6547
about 1 year ago
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Hello there! My first try here: Sharing an in vivo image of a beautiful dendrite with a GFP knock-in to endogenous CaMKIIa
about 1 year ago
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Tal Laviv
Michael Ward
about 1 year ago
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
www.science.org/doi/10.1126/...
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Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
https://www.science.org/doi/10.1126/science.adi5295
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Tal Laviv
Danielle Beckman
about 1 year ago
I'm very happy with how this image turned out and can't even wait for
#FluorescenceFriday
! I'm trying to detect Tau protein phosphorylation before forming full fibrillary tangles in
#Alzheimer
disease. Healthy neurons: (🟠NeuN), Dying neurons: pTau ( 🟣422), (🔵AT8). More info in the Alt tex! 🧠🔬
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