Don't know about this particular drug, but if there would be drugs supporting patients with cahexia it would be so important. This is a terrible symptom which leads to very fast decline, preventing treatments because the patient is to frail for it.

Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope www.nature.com/articles/s41... #jcampubs

Oh, the “vomiting ferret” model is absolutely a real thing - I’ve encountered it in my own drug discovery career. They’re one of the smallest animals that show this response- weirdly, rodents can’t do it at all.

My book, One Hand Clapping, landed in the NYU bookstore! Preorder yours today! Out everywhere Oct 21 www.barnesandnoble.com/w/one-hand-c...

Thread of things I'm learning as I read The Discovery of Insulin by Michael Bliss

as this unexpectedly went semi-viral - NB: I only tried this protocol, all credit goes to www.med.upenn.edu/markslab/ and probably someone even before :)

What you think your brain is supposed to do

Tonight, the adventure begins! I could not be more thrilled to embark on this epic journey with these amazing performers. The world of Aramán awaits, tune in tonight at 7pm PT for the premiere of Campaign 4 of Critical Role!

Classic Soviet joke. American: " Our system is better! We have free speech! I can come to the White House and shout, "Reagan is a fool! Down with him!" Russian: " So what? I cal also come to the Red Square and shout, "Reagan is a fool"

Pete Davidson just became the only victim of 9/11 to get reparations from the Saudi regime.

These plasmids from @promegacorporation.bsky.social are exceptional new offerings from Addgene for a few reasons: - Since there is no MTA, they are available to industry customers (joining an ever-growing catalog subset: www.addgene.org/industry/) - They are available in a DNA format!

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass... I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands) #WesternBlot #cellsky

If you are in NYC, join us for my book launch party! Tuesday October 7th 5:30pm, NYU, Liberal Studies lobby, 726 Broadway, 6th floor (non-NYU: dm me to register). Conversation between myself and Prof. Jared Simard, our resident classicist! Books available! Slavic food! events.nyu.edu/event/onehan...

It's probably the deterioration of social media (I hope) but i'm exposed to a lot less cool science. It used to feel like a new cool study is being preprinted/published every week, and lately it's rare (at least so it seems). Share a recent study that's worth knowing!

It is Folsom weekend and I have divided my wardrobe up into three piles: Clothes that are old enough to vote. Clothes that are old enough to drink. Clothes that are too old to date Leonardo DiCaprio.

Very happy to report people are hiring! So far the Jelle Hendrix lab and Jessica Houston lab have advertised grad student and postdoc positions at the PicoQuant single molecule and SRM meeting!!

This is so cool. Sperm whales are probably the most amaizing animals on Earth.

Terrific @scientificdiscovery.dev post on randomized controlled trials in @ourworldindata.org. Including this important chart on the impact of pre-registration. Magically, when people had to pre-register outcomes, many of the benefits disappeared. ourworldindata.org/randomized-c...

Openness means more than access. We’re pleased to announce that we now publish Replication Studies, helping make science more reliable, transparent, and trustworthy. buff.ly/Gebypvq

Link to HHMI preprint mandate hhmicdn.blob.core.windows.net/policies/Imm...

Cell and developmental biologists; This is well worth a read: Maik and Roberto synthesize work over decades to propose a provocative model of who mesenchymal cells migrate and shape tissues 🧪 Go for the cool Figures, stay for the deep insights

How many PhDs does it take...

Very neat for mRNA imaging

Banger of a special (and free on Youtube!)

Tired of illustrating survivorship bias with the Wald's chart of a WW2 bomber? Use Marshall Oudinot instead! :))

Tired of illustrating survivorship bias with the Wald's chart of a WW2 bomber? Use Marshall Oudinot instead! :))

ggplot2 is my most used R package and by itself a reason why everyone in science should learn to use R. It turned 18 and got a major update, which changes the way some things are achieved and also adds some new options!

OK--fluorescent protein friends. We want an antibody to TagRFP that works in immunofluorescence. Any suggestions? Re-post please

Will spend a few days in Edinburgh. In general, I have Saturday free, so what should I do? I have been there before, but what must I see/do that I’m likely to have missed?

Very fascinating story (and this is why there is so much phones stolen in Britain)

Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant hematopoiesis. www.cell.com/trends/cance...

It’s great when you get the chance to model a complete, functioning eukaryotic replication fork while working on a commercial project.

Posts about scientific research on Bluesky receive substantially more attention than similar posts on Twitter. More importantly, you're far less likely to get sexist or racist replies.

📢📢Hiring 2 Research Assistants & 2 Postdocs at Emory University in Atlanta to study cytoskeletal biophysics/biochemistry. Please RT. RAs: great for recent bachelor's/master's in Physics/Bio/Chem/Biochem. Email CV and interests to [email protected]. More info: www.shekharlab.org

Imagine millions of security cameras walking around. Law enforcement, companies like Palantir, ad companies will have access. Maybe not to the feed, only to metadata, it will be enough. Let's add another layer of dystopia to our lives, sure.

O, wow, how cool I am. Single-handedly did the Peace of Westphalia, apparently!

This is a great article by @richardsever.bsky.social on history and new ideas in sci publishing, and the costs per article in box 1 are actually shocking. (Article is 2023, but I only read it) 📌 to read those articles on publishing costs referenced here

No new pictures, where you at mentally?

love Kazuaki Kitamura's cat tattoos IG horitomo_stateofgrace

Anyone out there have experience with chemaxon as a structure drawing software? Please RT #chemsky ⚗️🧪

This list has three Russians (and two Cellinis) and it's such a strange list. Why Lermontov?? The only conversation I would have with this guy is to try understand this list.

A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate. www.philanthropy.cam.ac.uk/give-to-camb...

This is one of the most beautiful things I have witnessed, the craft here is impeccable.

Here's another share of my long physics blog post, if you ever wanted to learn about entropy and Maxwell's demon! 🧪

“The AI in the study probably prompted doctors to become over-reliant on its recommendations, ‘leading to clinicians becoming less motivated, less focused, and less responsible when making cognitive decisions without AI assistance,’ the scientists said in the paper.”

In dystopian future of 2030 Ireland solves the priest shortage by randomly drafting citizens through a lottery. At any time anyone could be selected to become a priest. Refusals are harshly punished. The only way to escape priesthood is through anti-priest underground which may or may not exist.

Unreal!

In praise of the strangeness of scientific research, which these days I think could use a few good words said for it: