Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction! Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1 doi.org/10.1101/2025...

Please visit our newly refreshed and updated website mcclellandlab.com We seem to be hard to find on Google for some reason, any tips from website savvy people?? 🙏

Cute!

Ahh so beautiful

YES

We are pleased to share the Schizosaccharomyces orthogroup web resource (fsnibs10.github.io/SOG/) with the pombe community.

Yay YAY congrats to everyone - and am super happy for my neighbour (and friend!) Jody Rosenblatt! Jody doesn’t have Bluesky, let me bug her about that

How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint! www.biorxiv.org/content/10.1...

OMG IN ALL CAPS

Just out - a collaborative effort examining gene family evolution across yeast species. We found that fast-evolving yeasts lose more genes - especially ones for splicing, metabolism, and cell division. This is consistent with their narrow metabolic niche breadth. www.embopress.org/doi/full/10....

Omg AMAZEBALLS

Now published! Big congrats to first author @gginell.bsky.social We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions. www.science.org/doi/10.1126/...

Non-profit journals are on the critical list. The cause: academics obsession with the Nature brand, coupled with the APC $ model. Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..

😱💥❤️

Good efforts. Here, I broke my tibia jumping in triumph after crossing the finishing line at a dog agility competition.

Ahh what fun

Auspicious morning I just knew it

For those interested in yeast amino acid control, we've developed fluorescent reporters to simultaneously monitor amino acid synthesis and uptake activities (GAAC, TORC1, and SPS) in single cells: www.molbiolcell.org/doi/10.1091/...

An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...

The lab is on a roll. 2nd preprint in as many weeks! High levels of Cdc42 GTPase underlie an all-or-none decision to fuse. Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social www.biorxiv.org/content/10.1... @biology-unige.bsky.social

Fun!

Aww look at the little ❤️ it says, yay hello this is how you start your day

A blutorial on my latest manuscript, which will appear as a Hypothesis article in Journal of Cell Science (no embargo requested as far as I am aware). If you are interested in mitosis/meiosis/kinetochores/evolution/deep phylogeny, please read it (1/n)

Almost 17 years after opening our yeast cell division lab, our first transcription paper in mouse embryonic stem cells! www.science.org/doi/10.1126/...

OMG IT IS OUT EUKARYOTIC HOPANOIDS DESERVE ALL CAPS www.nature.com/articles/s41...

Why do -80Cs invariably conk out in the evenings asking for a friend 😭😭😭

Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony! www.science.org/doi/10.1126/...

😭😭😭

Important to support the societies that manage publications at the face of the onslaught from the commercial rivals.

Look! Mechanistic studies of autophagic cargo recruitment and membrane expansion through in vitro reconstitution biorxiv.org/cgi/content/...

Me, at 1am on the third day of #ASCB

We hope this method helps compare lipid affinities of proteins unsuitable for co-sedimentation assays :) - Protocol to compare relative protein-liposome binding affinity using a fluorescence microscopy-based approach star-protocols.cell.com/protocols/3910

We plant a tree for every peer-reviewed article published in JCS. These trees are planted in collaboration with the Woodland Trust. If you’re at #CellBio2024 and would like to find out more about publishing in JCS and contributing to The Forest of Biologists, visit booth 517 or see our website:

Jet lagged but hey look at this #ASCB

OMG TODAY IS THE DAY LOOK WHO IS NOW ON BLUESKY @sporemohan.bsky.social @drmichaelway.bsky.social

(\ (\ („• ֊ •„) ♡ ━O━O━━━━━ “Important” “convincing”

GAWD

૮˶• ﻌ •˶ა ./づ~ 🦴 @pombase.bsky.social have you guys seen this?

ᐢ. ֑ .ᐢ

Strong Introduction

The same is true of @jcellsci.bsky.social - we will consider articles with reviewer reports from other journals. We’re here to help you publish your work (and try our best to give back to the community). #notforprofit

Omg Atlantic salmon rules - turns out I should have read one of the references in this paper, ideally a couple years ago! www.pnas.org/doi/10.1073/... by @jpverta.bsky.social

Lost in my suddenly hopping Bluesky feed - all those links to click on. Like, today - by the time I’ve read through a paper on Atlantic salmon evolution (completely unrelated to what I do but hey it was fun), my commute was over. I mean, am totally into salmon right now and this is a good thing but

/) /) ପ(˶•-•˶)ଓ ♡ /づ づ

If you know someone who might be interested in a PhD project involving collaboration between academia and industry, here is an exciting opportunity in London: www.lido-dtp.ac.uk/apply/apply-.... We have a cool project on antisense oligonucleotide toxicity with AZ this year 😉. Please repost!

Each can make their own decisions, but rather than submit to eLife I'll choose non-profit journals or those run by scientific societies like the @jcellbiol.bsky.social , the Journal of Cell Science @biologists.bsky.social , Molecular Biology of the Cell, Genetics, or Development

NoCut people

Omg I’ve got new bluesky friends I should go on vacation more often

A metaphase arrest! w(°o°)w or w(°o°)w Congrats B!

Hi