1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ link.springer.com/article/10.1...

This graph basically shows that the MSCA are, as of now, useless unless the EU governance does something about it 🧪

📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere. 🔗 Apply here 👉 recruitment.crg.eu/content/jobs...

Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other. emploi.cnrs.fr/Offres/CDD/U...

🧬 #Yeast condensin does more than organize chromosomes. New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins. #YeastResearch #SGD www.yeastgenome.org/reference/S1...

The Muppet Show on Disney+ is glorious. They haven't tried to update it, or twist it in any way. It's just The Muppet Show you watched when you were a kid.

Hi all- we are searching for a new manager/operator to run and develop KCL's Cryo-EM Structural Discovery Facility: a JEOL cryoARM200 + k3 and sample preparation equipment. This 200kV set up recently achieved a 1.2 Å apoferritin! www.biorxiv.org/content/10.6... www.kcl.ac.uk/jobs/137165-...

So much here that I just cannot wrap my head around... "Asked about the shooting of Ms. Good, more than half of Republicans said it was a necessary use of force. Asked about Mr. Pretti, just 33 percent said it was a necessary use of force. A large share, 43 percent, said they were not sure."

Please repost and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science

Melike Lakadamyali @melikel.bsky.social, Jérôme Solon and Manuel Mendoza @longchrom.bsky.social share the behind the paper story of their research interrogating how chromosome compaction scales with cell size using a combination of live confocal microscopy and 3D STORM.

Mitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing. We explore this link in our new preprint. 🔗 www.biorxiv.org/content/10.6...

I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good. Stay free

Thanks to @focalplane.bsky.social for the invitation to highlight our recent @biophysj.bsky.social paper! With @melikel.bsky.social and Jérôme Solon, we combined super-resolution and live imaging to connect interphase chromatin organisation to mitotic chromosome compaction across cell sizes.

I’ll soon share a call for a postdoc at Institut Jacques Monod (Paris) on fundamental mechanisms of membrane traffic and protein/collagen secretion in health and disease. Please get in touch if interested.

“A student joining a lab is often presented with a hypothesis to work on and may see science as a hypothesis-testing endeavor. Many young postdocs have been told that as a PhD student their job was to answer questions—now they have to discover their own unknown unknowns.”

Comme promis, un texte où je persiste et signe : le film "Le mage du Kremlin" est dangereux, car il se met au service du pouvoir russe en diffusant une vision du pays exactement conforme à ce que le Kremlin veut nous faire penser. colinlebedev.fr/2026/01/22/h...

We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT

This photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition, The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance Iconic imo

Who’s behind this? The answer will not surprise you www.cidrap.umn.edu/childhood-va...

This is nuts

1/10 In this thread we will explain you how we put together #SPT #SMLM #cryoET #cryoCLEM + #modeling to learn about the higher-order mechanism that controls exocytosis (constitutive exocytosis, the one😜) (Illustrative animation made by the amazing Dylan Godfrey)

0/10 🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology Continuum architecture dynamics of vesicle tethering in exocytosis www.cell.com/cell/fulltex...

@science.org Scientists turn cells’ most mysterious structures into spies on genetic activity | Science | AAAS www.science.org/content/arti...

Happy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com www.nature.com/articles/s41... Below a short🧵 with the key findings!

Trump trying to conquer a foreign country. ICE killing someone and lying about it. We're not even a year into this Trump term and we're already here.

This is basically the view of the world that Plato sets out to refute in the Republic. One of the core questions asked therein is: why do powerful people think the mere fact of them exercising dominion makes it good for them to do so? Sure, you *can* get away with stuff if you're powerful - so what?

📢 Open PhD position Phasing polyploid genomes to decipher their phenotypic & adaptive potential 📍 IGBMC - Strasbourg ⏰ Start: Spring 🔍 Profile: MSc in bioinformatics, Python/Bash, R, sequencing data experience a plus. 📩 Application: see below

A las barricadas compañeros, a trabajar conjuntamente en una agenda de cooperación

So much for revolutionary fervor

My sophisticated take on this is that when Trump said he was going to “run Venezuela” he was, in fact, full of shit

Party like it’s the 1970s

Some people were angry I was preaching caution in #Venezuela instead of celebrating. Yes, Maduro out is a relief; but Delcy & Gang with wartime powers to suspend rights is a terrifying perspective. I wasn't doing cartwheels because I fear we Venezuelans will be off worse.

“Maduro is gone. It’s tempting to think that, without him, the regime will implode. But Maduro’s system was always a team effort; the kind of regime that could very well survive decapitation. And if it does, Venezuelans will get the worst of it.”

Welcome to 2026, the year of the Putinisation of American foreign policy

There is of course zero internal logic. Former Honduran President Hernandez was extradited, convicted and sentenced to 45 years of prison for exactly the type of crimes Maduro is accused of - and Trump pardoned him. It's power, money and oil all the way down...

Bardella and Le Pen are being clever, but hypocritical. The French far right has always been anti American, even during the Cold War. But they have been less wholehearted in their condemnation of Russian expansionism/imperialism

Remember that there is a legitimately elected president of Venezuela: Edmundo Gonzalez. He won the election in 2024.

Bang on.

Read our new preprint where we uncover a hierarchy in human PIC assembly and establish a quantitative framework that connects factor exchange kinetics to the regulation of Pol II activity in living human cells. doi: doi.org/10.64898/202... By A. Oravecz and our collaborators @molinalab.bsky.social

An in vivo imaging technique can track the way molecules move through the nuclear pore complex go.nature.com/3KODM4A

Hierarchical buffering of cellular RNA polymerase II pools maintains transcriptional homeostasis https://www.biorxiv.org/content/10.64898/2025.12.22.695869v1

Happy holiday ❄️⛄🎅! Global protein synthesis rates can fluctuate dramatically as a function of food intake, infections, energy resources, etc. Wondering whether/how protein elimination routes adapt to these changes to maintain proteome homeostasis ? Find out here: www.cell.com/cell-systems....

In case any other Early-career scientist is interested in the call, I am based in Italy and we work on Transcription Factors cooperativity and their activation domains, co-translational assembly, promoter architecture (human cells). Very open to ideas! #HFSP #EarlyCareer

Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍 W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social journals.biologists.com/jcs/article/...

My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!

Fellow yeast enthusiasts, does anyone have the genomic or amino-acid substitution for the cdc20-1 ts mutant - thanks!

Postdoc position available in our lab @igbmc.bsky.social We have an exciting project aimed at re-visiting the (epi-)genomic functions of AT-binding proteins using state-of-the-art technologies: www.igbmc.fr/en/igbmc/lif... Expected start: from March 2026 Please share 📢

🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥 www.biorxiv.org/content/10.6...