Did you know that all nuclear pore complexes (NPCs) are not the same? @luskinglab.bsky.social propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction. www.nature.com/articles/s41...

PomBase introduces two new interactive views for GO-CAM pathway models: Summary Maps (high-level, visual overview) and Mega-Models (connected models). Check them out here: lnkd.in/gfxNRdua

@pombase.bsky.social Dear all, Kaz and I submitted this manuscript to make it accessible. We don't have active labs now, so we will not submit it to any journals. We hope that some of you will find these data interesting and can complete the work, or use them as a starting point for future projects.

Latest paper from the de Crecy lab is out! A finding that answers a ~40 year old question: a eukaryotic high-specificity transporter for Q/q

European-based researchers can help support future #flybase curation by donating at this site: www.philanthropy.cam.ac.uk/give-to-camb...

We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.

The existence of FlyBase, the first model organism database, is under serious threat of extinction. Under the current funding, there will be no future updates after July 2025 and its curators are currently working flatout on the final release! PLEASE SUPPORT!

Today is the registration deadline for our bioML symposium on Aug 21-22. Last chance to secure your spot! More info at tinyurl.com/bioMLPrague25

This is terrible news, HMMER & Infernal are at the heart of DBs like Pfam, Rfam & Dfam. And vital pipelines such as AlphaFold.

Congrats Gautam, so well deserved!

🧬 If you are in London and you want to learn about a free & Open Source SnapGene/Benchling alternative that also supports automation 🤖, come to our next London Synbio Network meeting this Thursday 24th in Imperial!🎓 🎤 I’ll be giving a talk about #OpenCloning! events.humanitix.com/copy-of-lond...

Twitter is dead...

A periodic reminder to cite your resources. Although no @pombase.bsky.social update in this issue, we did sneak onto the cover illustration.

Nice work @leeba.bsky.social and congrats on your thesis submission.

OMG IT IS OUT EUKARYOTIC HOPANOIDS DESERVE ALL CAPS www.nature.com/articles/s41...

Pombe2025 registration will go live this week. We hope you can join us August 3-8 in Boston. We will provide computers to allow international attendees to leave their phones and laptops at home. You can find the program here: www.bc.edu/bc-web/sites...

🌍🔬 📣 Please spread the word! Join us! How can cell biology shape a more resilient planet? Virtual registration is still open for the EMBO Workshop on Cells 4 Climate Resilience → meetings.embo.org/event/25-cli... 🗓️ Deadline: April 11 🎥 Watch the teaser → youtu.be/8eMJ91udHDs @embo.org

So on March 9, a French scientist, on a visa to attend a conference in Houston, was denied entry to the US and subsequently expelled because his phone had messages decrying scientific policies put forward by the Trump administration: www.lemonde.fr/internationa...

Huge congrats to the 2025 Batten Disease Global Research Initiative grant recipients. This is the first year for the group’s research grant program and I’m thankful to see such investment in much-needed Batten Disease research! Photos via BDSRA More info here: battenresearch.org/batten-disea...

New SGD paper! Saccharomyces Genome Database: advances in genome annotation, expanded biochemical pathways, and other key enhancements academic.oup.com/genetics/art...

Friendly reminder that community resources like SGD rely on your usage and citation for continued funding. Make sure to follow the citation guidelines and include in-text citations, not just links. #modelOrganism

As have many others...

A small appeal to young scientists looking for internship and PhD positions - websites are hard to maintain, papers can take years to publish & often end up behind a paywall. Read the preprints if you really want to know what a lab is up to. If they don’t preprint… this tells you something too ;)

It is very cool but incredible that there is no reference to all of the existing work about RNA surveillance of meiotic initiation in fission yeast including mechanistic details.

You know about the PAN-GO #Functionome, but have you explored the power of the Functional Category search? Learn how to find #humangenes of interest in just a few clicks, using the Functional Categories community.alliancegenome.org/t/8362 🧬🧪 #GOSlims ICYMI: community.alliancegenome.org/t/8343

Bluetorial: My NIH grant got funded; The money is in the bank What happens behind the scenes with NIH fund transfers

Hello everybody! The first issue of #Yeast of 2025 is now out. You can browse it at this link: onlinelibrary.wiley.com/toc/10970061... We are still looking for a beautiful front cover for the new 2025 issues. If you haven't done it yet, send us your most beautiful yeast images at [email protected] 😀

Please share. 🙏🏻

Richest guy in the world telling us we can’t afford to have our government fund cancer research.

I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful). Let’s call it a Orwellial.

Interested in RNA biology, especially mRNA processing and export from nucleus to cytoplasm? We are looking for an enthusiastic PhD student to investigate the RNA-binding proteins Sub2 and Tho1 🧪🧫🔬 More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...

Fungi made Earth’s land liveable by building networks that released nutrients locked in primordial rock and supplied those nutrients to plant roots https://go.nature.com/41lvtBg

The Atlantic story on the situation at NIH is sobering. We are so screwed. www.theatlantic.com/health/archi...

The realignment of research in our group @fmiscience.bsky.social is beginning to bear fruit. Proud of our captain @merleskribbe.bsky.social and the whole team! www.sciencedirect.com/science/arti...

The PAN-GO paper is a remarkable milestone. It not only provides the most comprehensive picture of human gene function to date, but also carefully maps this knowledge across the tree of life! Congratulations @marcfeuermann.bsky.social, Pascale Gaudet & collaborators! www.sib.swiss/news/sib-hel...

Immediately address any missing or incorrect functions! Contact us to have information added, altered, or removed

To perform a GO enrichment, paste a list of genes here. You can even load our sample list to try it out immediately!

82% of human protein-coding genes now have robust, consistent functional annotations, thanks to the combined efforts of biocurators across the GO consortium, Model Organism Databases, SwissProt/UniProtKB, all based on explicit evolutionary modeling via PANTHER families!

Gut-wrenching insanity. www.nature.com/articles/d41...

So - I've actually led Ebola outbreak response at USAID. This is bunk from Elon. They have laid off most of the experts, they're bankrupting most of the partner orgs, have withdrawn from WHO, and muzzled CDC. What's left is a fig-leaf effort to cover their asses politically.

Today is a devastating reminder that infectious diseases don’t care what your ‘beliefs’ are. Everyone is likely to be affected directly or indirectly. Serious challenges require serious people at the helm. Protect your loved ones. Educate. Advocate. The cost of not doing so will be too much to bear.

@pombase.bsky.social is proud to have contributed annotation to this extensive effort. Along with @flybase.bsky.social we also played a crucial role in improving annotation across species. Over 7 years, PomBase submitted ~600 PAINT update requests. @cambiochem.bsky.social

In a preprint published today, we are excited to report the secondary structure of the 1212 nt fission-yeast S. pombe telomerase RNA, TER1, and its roles in the physicofunctional organization of this massive, flexible enzymatic RNP complex. www.biorxiv.org/content/10.1...

This work is not only an amazing resource for the community, it is also a total masterclass in code reusability, data FAIRness and reproducibility. Hopefully, this is the future!

Despite court order, NIH grants remain frozen. Newly awarded grants, grants with fundable scores, & funds for a new budget cycle of a current project are all *FROZEN*🥶 and not being released. US research is being choked to death & is on life support right now www.motherjones.com/politics/202...

Epigenetics Gordon Research Conference. Consider joining us for what will be an excellent, exciting meeting and will be held in Europe for the first time: 10-15 Aug25 Barcelona, Spain. Please repost and apply early - this meeting is popular! www.grc.org/epigenetics-...

Our director @dessimoz.bsky.social signed the GBC Open Letter calling for support to sustain global biodata resources. 👉 Read the letter: globalbiodata.org/open-letter-... #BioDataCounts

New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵 www.biorxiv.org/content/10.1...