This is the key point - it's not about Moderna's flu vaccine, it's about sending a signal to the rest of the industry that vaccine development isn't viable in the US. It's all part of the larger anti-vaccine agenda.

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

Welcome, piles of slop filling up the journals with clouds of useless wordy garbage. Case in point:

😳

1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...

NSF GRFP applicants (and mentors): Was your application Returned Without Review and deemed ineligible despite fitting in the allowed topics? 1) Write NSF 2) Write your Congressperson 3) CC us at [email protected] so we can compile + follow up Details and template at grant-witness.us/grfp-letter

I'm at the Willard Hotel where I've been denied entry and kicked out of the Reclaiming Science event with NIH director Bhattacharya & other top agency leaders. @jocelynkaiser.bsky.social and I registered for the event months ago yet were told capacity was full, even as they let in dozens of others.

Firmly believe this would serve multiple needs.

Watch this video if you want to cry over overwhelming decency rather than over rage about what some are trying to turn our country into.

Uh-oh

So we are the point of questioning polio vaccines. The chair of ACIP: “I think also, as you look at polio, we need to not be afraid to consider that we are in a different time now than we were then..." www.statnews.com/2026/01/22/v...

🔔 New paper alert 🔔 www.nature.com/articles/s41... Some regions in the genome replicate early and some late, but the why and how remain poorly understood. DNA replication and 3D genome organization appear linked, raising the question if one may regulate the other? (1/n)

The latest #GENETICS study shows that the sisters separate (Ssep) gene in #Drosophila is essential for centromere cohesion during meiosis and is probably a new member of the cohesin complex. buff.ly/Qo75cpB

Jose y Maria by Everett Patterson #ArtSky www.everettpatterson.com?p=1835 Alt text: illustration of a Joseph and Mary, at a payphone trying to find shelter for the night in the rain. References to the birth of Jesus are dropped all over the illustration including a hotel sign that reads: "man ger"

A Trump administration change to how the National Institutes of Health awards grants has sharply reduced early-stage investigators’ odds of securing funding, new data from the agency show. Teamed up with @aniloza.bsky.social for this @statnews.com story www.statnews.com/2025/12/18/n...

They want us to not want to be professors: So our students don't question their propaganda. So our research doesn't challenge their lies. So our institutions can be replaced with so-called AI.

The end goal is eugenicist. RFK and his ilk know that this will make vaccines more expensive and time-consuming — and therefore marginalized children are most likely to fall through the cracks. This is about killing kids who aren't born to privilege. www.washingtonpost.com/health/2025/...

Rare winter bloom in the Anza Borrego desert @anzaborrego.bsky.social

AMTRAK Pacific Surfliner (765) SAN->GTA [2025-12-11] Alert: Route Obstruction: As of 7:45 AM PT Train 765 is stopped at San Juan Capistrano (SNC) due to municipal services investigating an incident involving a commuter train.

AMTRAK Pacific Surfliner (562) LAX->SAN [2025-12-11] Alert: Route Obstruction: As of 7:23 AM PT Train 562 is stopped at Irvine (IRV) due to municipal services investigating an incident involving a commuter train.

A bunch of us did a piece on RFK Jr.'s attacks on vaccines. Please circulate. Scientists and clinicians are sounding the alarm. It's time to act. youtube.com/shorts/4wnNy...

Gift link to article www.nytimes.com/interactive/...

aw. Somewhere, I have pictures of Claude that I took maybe 15 years ago.

So apparently the administrators at Northwestern have caved to the extortionist demands of the Feds. Faculty voted 595-4 AGAINST this measure.

I don’t think people outside of healthcare realize how much AAP is standing out as a moral backbone of medicine right now, especially in pediatrics. There is so much fear at institutions. Seeing an org directly and repeatedly targeted refuse to budge an inch is extraordinary.

Gentle reminder that everyone should read Jacob and Monod, 1961. And then read it again every once in awhile. A master-class on clear writing (and, ya know, Nobel Prize winning stuff, too). www.sciencedirect.com/science/arti...

𝘐𝘯𝘤𝘦𝘯𝘥𝘪𝘢𝘮𝘰𝘦𝘣𝘢 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴 at 63°C 🔥 sure enough, wheels on fire... and faaast like the ayrton senna of amoebae

The HPV vaccine is erasing cancer – here's the proof www.gavi.org/vaccineswork... via @gavi.org

If you use GMail, AI (Gemini) was turned on yesterday by default and now scans all of your content for machine learning. To turn off, go to Settings>General and scroll down. Uncheck the box for "Smart features." There's other "Smart" add-ons as well, but that's the one that reads your content.

“We don’t deserve the trust of the nation if we’re unclear about the divisiveness of swastikas,” the official said, speaking on the condition of anonymity due to a fear of reprisal. www.washingtonpost.com/national-sec...

This is, of course excellent.

1. Will Bunch’s recent column in the Philadelphia Inquirer has stayed with me, because it weaves various threads of history and politics into a clear and compelling tapestry with which ordinary people can act. www.inquirer.com/opinion/trum...

Some nice thoughts here. Of course Meselson and Stahl (my personal favorite) make an appearance, as well as Nirenberg and Matthaei and many others. If you need inspiration today to keep plugging along (which I do!), this is for you. www.asimov.press/p/beautiful-...

CAN LLMs write about science? @science.org decided to find out, and they did it the curious, scientific way. They did an experiment. Love this thoughtful convo. www.lastwordonnothing.com/2025/11/12/w...

Just a fundamental misunderstanding of how the scientific method works: It's not that someone *disagrees* was theory or finding and then argues with it, it's that you've got data that doesn't align and you go from there. Science isn't really about agreement or disagreement in an emotional sense.

I never imagined I’d need to turn to our judicial system to explain the importance of America’s scientific research, but here we are. Thanks to @BrennanCenter.org for highlighting my amicus brief 1/2

If any Senator caves, never ever vote for any of them again. Any of them.

The premise of generative AI is that so much has been written, painted, drawn, and composed that we no longer need to make anything new and can be happy with regurgitations of everything from here on out.

New York Times editorial board has compiled "a list of 12 markers of democratic erosion." www.nytimes.com/interactive/... This is what "not the odds, but the stakes" was all about. During the 2024 campaign, those 12 markers could have been in place and operating to guide news coverage everywhere.

I just discovered i have a Wikipedia page. I didnt create it and it’s not entirely accurate. Now what.

I want @dieworkwear.bsky.social to comment on #dapperguy

@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"

Breaking: The Supreme Court is now officially considering taking up a case overturning same-sex marriage. This is the first time in history the court has considered rolling back this right.

“Meritocracy” www.science.org/content/arti...

My contribution today

you fucked around and now the Episcopalians are doing memes. are you happy now. are you

as well as I5 freeway, the railway will also be shut through Camp Pendleton tomorrow to avoid the live ammo being hurled onshore. Just severing the ENTIRE transport connection between the 2nd and 8th largest US metros

FIGHT ON!!!!