Eugene Makeyev
@emakeyev.bsky.social
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📥 287
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We explore the world of RNA in the brain and beyond
reposted by
Eugene Makeyev
Snezhka Oliferenko
about 2 months ago
Homeostasis! Membranes! Evolution! Yay
add a skeleton here at some point
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Our paper describing enhanced hybridization-proximity labeling technology is finally out! Enhanced HyPro can identify proteins associated with small RNA compartments and even some individual transcripts, such as pathological C9orf72 transcripts:
www.nature.com/articles/s41...
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Enhanced hybridization-proximity labeling discovers protein interactomes of single RNA molecules - Nature Communications
Systematic discovery of proteins interacting with low-abundance RNAs is challenging. Here, the authors develop an enhanced HyPro technology to identify proteins associated with compact RNA compartment...
https://www.nature.com/articles/s41467-025-64282-5
2 months ago
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reposted by
Eugene Makeyev
Snezhka Oliferenko
9 months ago
OMG IT IS OUT EUKARYOTIC HOPANOIDS DESERVE ALL CAPS
www.nature.com/articles/s41...
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Horizontal acquisition of prokaryotic hopanoid biosynthesis reorganizes membrane physiology driving lifestyle innovation in a eukaryote - Nature Communications
Horizontally transferred genes must be integrated into host biology. Here, the authors show that the domestication of bacterial hopanoid synthesis has rewired lipid metabolism of a eukaryote leading t...
https://www.nature.com/articles/s41467-025-58515-w
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Happy to share the fully reviewed and revised version of our recent study, where we focus on recurrent mutations in cleavage and polyadenylation sites in tumor suppressor genes. Huge congrats to
@ykainov.bsky.social
and Fursham Hamid!
doi.org/10.7554/eLif...
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Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals
Somatic mutations frequently disrupt cleavage and polyadenylation signals in tumour suppressor genes in human cancers, likely contributing to tumour progression.
https://doi.org/10.7554/eLife.99040.3
about 1 year ago
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If you know someone who might be interested in a PhD project involving collaboration between academia and industry, here is an exciting opportunity in London:
www.lido-dtp.ac.uk/apply/apply-...
. We have a cool project on antisense oligonucleotide toxicity with AZ this year 😉. Please repost!
about 1 year ago
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