An early Christmas present! The ICR’s new Hydra Bio FIB-SEM has been delivered, which will sit at the heart of a consortium between the @icr.ac.uk, Imperial, QMUL and KCL. Currently being stored at Imperial, it’ll be installed in a brand new lab at the ICR next year. Exciting things coming in 2026!🔬

Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study! www.nature.com/articles/s41...

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...

New paper out now in Science! Check it out! www.science.org/doi/10.1126/...

Great effort from everyone!

Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone! www.nature.com/articles/s41...

Now out in Structure: Paper on high-resolution #cryoEM using the 100 kV Tundra cryo-TEM by Dimple Karia, Adrian Koh, @abhaykot.bsky.social, @lingboyu.bsky.social, @landerlab.bsky.social and many others. Happy to have contributed to this effort. Check it out: www.sciencedirect.com/science/arti...

🎉👏 ICR's Dr. Natàlia de Martín Garrido @natalia-mg.bsky.social, a postdoc fellow in Dr. Basil Greber's lab @bjgreber.bsky.social was awarded the 'Short Talk Award' for her research on DNA repair at the “Machines acting on DNA and RNA, a molecular mechanistic perspective” conference held in Madrid.

Very grateful for receiving a Short Talk Award at #CFM_MolMech Thanks to the organisers for putting together such an amazing conference! @oscarllorca.bsky.social @rfleiro.bsky.social @nogaleslab.bsky.social @cniostopcancer.bsky.social

Delighted to hear that post-doc @natalia-mg.bsky.social has received the Short Talk Award for her #cryoEM studies of DNA repair at the conference on "Machines Acting on DNA and RNA, a molecular mechanistic perspective" at CNIO Madrid. Congratulations, Natàlia! Photo courtesy of @amunts.bsky.social.

For our latest paper, we worked with SYROS Pharmaceuticals, the groups of Dylan Taatjes and Robin Dowell at CU Boulder, and @abhaykot.bsky.social. Junjie Feng in my lab determined the #cryoEM structure of the CDK7 inhibitor SY5609 bound to its target... www.science.org/doi/10.1126/...

#InnovacióUB | 🔬 El president @salvadorilla.bsky.social i la consellera de Recerca i Universitats, Núria Montserrat, inauguren el nou microscopi electrònic d’última generació ubicat als espais que els @ccit.ub.edu tenen al @www.pcb.ub.edu. L’aparell obre la porta a estudis innovadors.

New pre-print! To support a CDK-cyclin docking motif discovery and characterisation project led by Norman Davey and colleagues, @natalia-mg.bsky.social in my lab determined the #cryoEM structures of three peptide-bound CDK2-cyclin A complexes. Check it out! www.biorxiv.org/content/10.1...

Thrilled to share that I have been selected as one of this year's new EMBO Young Investigators. I look forward to meeting many of the other Young Investigators in the coming years, and I am most grateful to the members of my laboratory at the ICR who made this possible. www.embo.org/press-releas...