I’m very happy (and grateful!) to share that I’m featured in a Nature Cancer Viewpoint about starting my lab at CNIO. In the Lab (www.rcglab.com) we’re combining AI, protein design and structural biology to study protein structures and design novel protein therapeutics for cancer. 🔬

Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control. www.science.org/doi/10.1126/...

It always surprises me when I encounter scientists with a religious faith. Very rare amongst biologists in my experience, but more common amongst astronomers. I guess it’s possible to fantasise about a creator if you don’t understand evolution.

Kickstarting our Bluesky🦋 account with great news! Our REPAIRome study finally out today in @science.org www.science.org/doi/10.1126/...

We’re looking for an enthusiastic postdoc to join our team. 😊 The project focuses on protein design and cryo-EM applied to cancer research. 🔬🧪 The position is fully funded for 3 years. Please share 🙏 Job description and application details (deadline: October 11th): www.cnio.es/en/empleo/po...

Exciting new study from new-PI Mohinder Pal on the role of CCDC103 and it's links to PCD as the most recent dynein assembly factor (DNAAF19). Congratulations to the entire team. @Mohinder Pal (currently not on Bluesky) @mike-wieczorek.bsky.social @laurencepearl.bsky.social

A team at #CNIOStopCancer finds a new cause for idiopatic pulmonary fibrosis: a mutation in gene POT1, which hinders tissue from regenerating. This makes breathing increasingly difficult in this potentially fatal disease currently without treatment  http://bit.ly/41MPOAB

Thrilled that our work is now finally out in Nature Comms! rdcu.be/eG3vP We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres. Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!

Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳 How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look. www.cell.com/structure/fu...

Highly collaborative efforts that involved 6 lab members and the labs of @yiliangding.bsky.social and @rdaslab.bsky.social. We uncovered a telomerase dimer and its potential role in telomere maintenance.

🧬 #CIDHD25 will bring together experts exploring how cells maintain genome stability & how these insights are driving new therapies. 4 days of exciting talks, plus lots of opportunity for networking! 🗓️ Poster & Reg Deadline: 14 Aug 🔗 bit.ly/44mBPU2 #FusionCellBio #FusionDNA

Very grateful for receiving a Short Talk Award at #CFM_MolMech Thanks to the organisers for putting together such an amazing conference! @oscarllorca.bsky.social @rfleiro.bsky.social @nogaleslab.bsky.social @cniostopcancer.bsky.social

Great work highlighting how important it is to carry out experimental structure determination instead relying on AlphaFold predictions. #crystallography #structure #biology #chemistry www.nature.com/articles/s41...

Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...

Speakers at #CNIOSeminars share innovative advances from the fields they lead. We have recently wellcomed:👇 1️⃣ Raman van Wee, from @oxfordchemistry.bsky.social. As @oscarllorca.bsky.social#CNIOSeminars's guest, he talked about the rol of protein Ku7080 in repairing double strand breaks in DNA

Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ @natcomms.nature.com BRCT domain in recruitment and activity of two Pol X members in NHEJ: a unified model for the interaction of Pol X with Ku70/80. www.nature.com/articles/s41...

Europe will always stand for science and the freedom to learn and invent. As of 11 am, tune in, and discover how the @ec.europa.eu wants to help the best and brightest ‘Choose Europe’. → europa.eu/!Tx43kH

The fourth session of #CFM_MolMech at #CNIOStopCancer will bring latest research on the specifity of RNA decay, the RNA exosome and macromolecular complexes in DNA processing. With @lapassmore.bsky.social , @cellbiol-mrclmb.bsky.social  Gina Buchel, @yale.edu  Elena Conti, @mpibiochem.bsky.social

The registration deadline for #CFM_MolMech is around the corner! 🔴May 5th, 20205🔴 📅Join us on May 28th - 30th at #CNIOStopCancer 🏃‍♀️Don't miss the opportunity! Read about the 4th session on the 🧵👇 With the support of CaixaResearch. 🔗More info: bit.ly/42hyRh0

📅 #CFM_MolMech will take place on May 28-30th at #CNIOStopCancer. 🔴Abstract Submission Deadline: April 24th 🏅Awards for: ▪The three best posters ▪The three best short talks 🤝With the support of CaixaResearch 🔗More info: https://bit.ly/42hyRh0

Nice! Our CAK-inhibitor #cryoEM paper with @NogalesLab and @simakali1 not only graced the cover of @BiophysJ but was also named the editor's pick and featured on the journal's blog: https://www.biophysics.org/blog/future-cancer-therapeutics-under-the-looking-glass

Happy to share our latest pre-print! We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨 www.biorxiv.org/content/10.1...

Conference alert: Machines acting on DNA and RNA Madrid, May 28-30 Abstract deadline: April 24 Organised by @cniostopcancer.bsky.social. Come to share your research with experts in the molecular mechanisms of DNA & RNA machines. See the list of speakers below. Please repost.

See you in Madrid! Speakers include: @costalaboratory.bsky.social @piratefernandez.bsky.social @nhoitsma.bsky.social @kellythd-nguyen.bsky.social @lapassmore.bsky.social @alessandrovannini.bsky.social @oscarllorca.bsky.social @rfleiro.bsky.social @nogaleslab.bsky.social www.cnio.es/en/eventos/m...

👉Today we present Session 1 of #CFM_MolMech: Chromatin structure and remodelling. 🗣With: @kellythd-nguyen.bsky.social from @mrclmb.bsky.social, from @colorado.edu, and Siddhant Jain from @harvardmed.bsky.social#CFM_MolMech: 🔗Info and registrations: https://bit.ly/MolMech

The structure of the R2T complex reveals a different architecture from the related HSP90 cochaperone R2TP: www.cell.com/structure/ab...

🔎#CFM_MolMech: a meeting exploring the integration of structural, biochemical, and biophysical insights into cryo-EM advances that reveal molecular machines behind DNA/RNA processes. 👥 Meet the organisers: @oscarllorca.bsky.social, @rfleiro.bsky.social and @nogaleslab.bsky.social#CFM_MolMech: 📆May 28-30th

🔴⚠CNIO-CaixaResearch Frontiers Meetings: Machines acting on DNA and RNA, a molecular mechanistic perspective. 📆May 28-30th 👥 @oscarllorca.bsky.social, @rfleiro.bsky.social and @nogaleslab.bsky.social. 🔗https://www.cnio.es/eventos/machines-acting-on-dna-and-rna-a-molecular-mechanistic-perspective/

Prof. Martin Beck’s group @mpibp.bsky.social publishing some beautiful #cryoET work investigating TRiC, a chaperonin essential for maintenance of cellular homeostasis. This work provides TRiC architecture, conformational dynamics and spatial organization. #teamtomo www.nature.com/articles/s41...

The @mrclmb.bsky.social believes in the benefits of a diverse workforce, and is proud of its history in training next-gen scientists. Three-year postdoc fellowships are now available for those who self-identify as being from a (mixed) Black heritage background. www2.mrc-lmb.cam.ac.uk/recruitment/...

Thrilled to share that our latest research on breaking the symmetry of designed protein cages has been featured on the cover of Protein Science's special issue on Protein Design! #proteincages #proteindesign #symmetrybreaking

Link to publication: “Design of a symmetry-broken tetrahedral protein cage by a method of internal steric occlusion” onlinelibrary.wiley.com/doi/10.1002/... Link to Protein Science's special issue on Protein Design: onlinelibrary.wiley.com/doi/toc/10.1...

Fresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — and how it cracks the gate! 🤯 💥 Incredible work from @becklab.bsky.social and @hummerlab.bsky.social 🤩 More here: www.biophys.mpg.de/2842024/hivcapsid-cracks-the-npc?c=2011019 🔗 #teamTOMO

Pretty cool work on designing antivenoms de novo! 😱😻👏 www.nature.com/articles/s41...

REGISTRATION OPEN!! - CNIO meeting, Machines acting on DNA and RNA, 2025 May 28-30th in Madrid, organized by @nogaleslab.bsky.social , @rfleiro.bsky.social , and @oscarllorca.bsky.social

Watched this really insightful talk by @sjorsscheres.bsky.social and thinking why on earth they'd decide to have a random keyboard as decoration -- 13 mins in Sjors tells why and its kinda heartwarming for computational folks! youtu.be/SoXAac2HIrY?...

Goodbye twitter. We had some good times. Just unfollowed everyone and deleted all my tweets...

The future in ribosome structural biology is here!

Super cool! Congratulations Rachael!

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m