Alessandro Vannini (@alessandrovannini.bsky.social)

Excited to share the (hard) work of @zawarshah.bsky.social in its final form: www.nature.com/articles/s41... A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work

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Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters - Nature Communications The snRNA Activating Protein Complex (SNAPc) mediates snRNA transcription by RNA Pol II and III. Here, the authors have used cryo-EM to resolve the structure of the SNAPc-bound RNA Pol III pre-initiat... https://www.nature.com/articles/s41467-024-55553-8?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20250103&utm_content=10.1038/s41467-024-55553-8