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An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

What a day for The RNA Pirate Republic! Along with: Chase Beisel (BBIE, Basel) Sam Sternberg (Columbia Uni, NYC) and Raul Perez-Jimenez (BioGune, Bilbao) We have been awarded an ERC Synergy grant to explore the ancestry and evolution of RNA-guided nucleases! Yey! 🎉 #ERCSyG

💥 Another Cryo-ET study from the Way lab by ‪@miguel-virus-cells.bsky.social‬ in collaboration with Rosenthal lab @crick.ac.uk‬ examining Vaccinia virus egress 😀👇 www.biorxiv.org/content/10.1...

A comprehensive statistical analysis of how Q-scores are related to reported resolution, based on ∼10 000 EMDB maps and associated PDB atomic coordinate models archived in the EMDB #CryoEM #QScores #Validation doi.org/10.1107/S205...

Researchers have developed a #DeepLearning system called BioEmu that rapidly generates diverse protein conformations, enabling fast, accurate insights into protein flexibility and function. Learn more this week in Science: https://scim.ag/3JdQVD4

The EMPIAR datasets related to my work on human cystathionine beta-synthase are now released. Hopefully they are useful unusual filament cases for #cryoEM data processing www.nature.com/articles/s41... 1. www.ebi.ac.uk/empiar/EMPIA... 2. www.ebi.ac.uk/empiar/EMPIA... 3. www.ebi.ac.uk/empiar/EMPIA...

In-situ SPA 🧨 www.biorxiv.org/content/10.1...

This is great stuff! Congrats!

EtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment. But how does EtfD work? And how can you assay its activity? In his final PhD manuscript @courbongautier.bsky.social provides answers! www.biorxiv.org/content/10.1...

A tribute to George Sheldrick and SHELX and the impact on macromolecular and small-molecule crystallography journals.iucr.org/a/issues/202...

1/5: Over the last few months, I have been working on an update for the #FollowRelionGracefully dashboard, which offers improved real-time job previews for #cryoEM #Relion jobs.

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See you in Madrid! Speakers include: @costalaboratory.bsky.social @piratefernandez.bsky.social @nhoitsma.bsky.social @kellythd-nguyen.bsky.social @lapassmore.bsky.social @alessandrovannini.bsky.social @oscarllorca.bsky.social @rfleiro.bsky.social @nogaleslab.bsky.social www.cnio.es/en/eventos/m...

trying to use WarpTools with particles picked in another program? a few tips here forum.image.sc/t/how-to-ext...

Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. @minhuanli.bsky.social and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.

Reminder - still one month to apply to be a tenure track group leader at MRC LMB. Please do reach out for any information.

Beautiful results and figures here!

Interested in learning to process cryo-ET data in the latest version of Warp? I'll be running a workshop on April 22nd in central London, UK details+registration: forms.gle/FLDr3ZWtVGXs... Hope to see you there!

If you're coming to #BPS2025, please come check out the #CryoEM symposium on Sat Feb 15th, 8:30AM-12:30PM, Room 515B. Also! Join us for the CryoEM happy hour in the evening, 6:30-8:30PM at 33 Taps DTLA. Get your tickets *now*, as ticket sales end Feb 10th! www.biophysics.org/store/produc...

Cool stuff!

www.nytimes.com/2025/02/07/u... This is catastrophic.

This is massive for the US-University based science… flat rate of 15% for indirect cost allocation in NIH funding!!!! Not sure how Universities will respond to this…

Opportunity to join Science-Paradise on Earth!

Very cool! As Harry already pointed out!

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Friends, do not miss this great meeting in wonderful Madrid in May! Good weather, amazing food and best of all great speakers ( and me…👀)

My new life in blue starts with sharing a preprint of amazing Max Gemmer’s ex vivo analysis that sheds light on the machinery responsible for inserting many multispanning transmembrane proteins into the ER membrane #teamtomo: www.biorxiv.org/content/10.1...

RNA virologists, check out "The protein structurome of Orthornavirae and its dark matter" by Pascal Mutz, Valerian Dolja, Eugene Koonin et al (including @simrouxvirus.bsky.social, @apcamargo.bsky.social, @urineri.bsky.social, @anamarijabutkovic.bsky.social) journals.asm.org/doi/10.1128/...

Merry Christmas and our best wishes for a peaceful 2025. Say goodbye to the noise with CryoSamba, our self-supervised deep denoising algorithm for CryoET now published in JSB.

Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos. Read more about the role here: www.nature.com/naturecareer... Apply by 30 DEC #ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering

Fantastic!

Happy to share our UBR4 structures. Check out the preprint to see how this giant E4 ligase complex selects substrates for ubiquitin chain extension. We also look at conservation and adaptations across humans, nematodes and plants. www.biorxiv.org/content/10.1... @clausenlab.bsky.social

A liitle over two weeks left to register for what looks to be a fantastic workshop for anyone interested in in situ structural biology! 🧪🧬🔬

Shit! You know you are something right when you get likes from Nobel Laureates! (And Oli! but Oli is a good friend so those count less!)

Cool stuff Tanmay et al!

SPACEtomo v1.2 is online! github.com/eisfabian/SP... - Improved GUIs for lamella detection, target selection and CLEM registration make it the best target selection workflow for PACEtomo on any kind of lamella sample. - Easier installation and configuration Any feedback is much appreciated! :)

Ever wondered how some of the automation in cryo-EM data collection works? Read Bram Koster's 1989 thesis! repository.tudelft.nl/record/uuid:...

Eva Nogales received today a big Spanish prize ! The CSIC medal of excellence! So well deserved!

Revolutionary!

The future in ribosome structural biology is here!

This is very cool read!

One of those #cryoEM papers were using "near-atomic resolution" in the title would be entirely ok. 😉 academic.oup.com/nar/advance-...

A long-waited refinement tool for cofactors with metal-coordination, MetalCoord. By Garib Murshudov group @mrclmb.bsky.social Compiles distances & angles from CCP4 monomer library and classifies the metal-coordination geometry. The updated dictionaries and restraints then used for refinement.

Perfect for a gin&tonic! Good weekend friends!

Great option here for getting your PhD degree !

All right I have tilt fata, I have a conda env working let’s do this!

Latest paper from our lab out now! #TeamTomo #CryoET www.nature.com/articles/s41...

Our latest discovery of “lowest recorded temperature for eukaryotic cell motility” going all the way down to -15deg C. Come for the crazy cold Arctic & stay for diatoms. Will write longer thread - but enjoy video below of diatoms gliding on frozen ice surfaces. Congrats @zqing.bsky.social & team.

Gold-grid making day. Always seduced by gold beauty!