Our 3D Denoising Deep Learning Algorithm, CryoSamba, is now available to all SBGrid users freely. Instructions on how to use are provided on the official SBGrid page - sbgrid.org/software/tit... Please source the programs tree every time you want to use CryoSamba!

Happy holidays with Holey Endosomes. We share our work using 3D EM demonstrating that tiny perforations in endosomes in neurons allow access of cyrtosolic alpha-synuclein to endocytosed alpha-synuclein pre-formed fibrils, thereby triggering toxic alpha-synuclein aggregation.

Merry Christmas and our best wishes for a peaceful 2025. Say goodbye to the noise with CryoSamba, our self-supervised deep denoising algorithm for CryoET now published in JSB.

Official account of the Kirchhausen Lab @harvardmed.bsky.social , @harvardcellbio.bsky.social and @bostonchildrens.bsky.social. We'll be tweeting about papers, projects, events and seminars. Follow us!