Nicole Hoitsma
@nhoitsma.bsky.social
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Nicole Hoitsma
Bret Freudenthal
21 days ago
Thrilled to share our lab’s latest work in JBC! 🎉 We uncovered a critical role for APE1 Asn174 in stabilizing AP-sites using mutagenesis, enzymology, crystallography, and MD-simulations. Congrats to Kaitlin Dehart and all the co-authors! Check it out:
www.jbc.org/article/S002...
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APE1 active site residue Asn174 stabilizes the AP-site and is essential for catalysis
Apurinic/Apyrimidinic (AP)-sites are common and highly mutagenic DNA lesions that can arise spontaneously or as intermediates during Base Excision Repair (BER). The enzyme apurinic/apyrimidinic endonu...
https://www.jbc.org/article/S0021-9258%2825%2902507-4/fulltext
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Nicole Hoitsma
Tyler Weaver
8 months ago
My lab is looking to hire a Postdoc to study mechanisms of DNA repair in chromatin using biochemical, biophysical, and structural biology approaches! Feel free to share with anyone you think may be interested.
jobs.virginia.edu/us/en/job/R0...
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Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab in Charlottesville, Virginia, United States of America | Research at University of Virginia
Apply for Postdoctoral Research Associate in Biochemistry and Molecular Genetics – Weaver Lab job with University of Virginia in Charlottesville, Virginia, United States of America. Research at Univer...
https://jobs.virginia.edu/us/en/job/R0068848/Postdoctoral-Research-Associate-in-Biochemistry-and-Molecular-Genetics-Weaver-Lab
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Nicole Hoitsma
Karolin Luger
10 months ago
Our paper on the strange ATP-dependent chromatin remodeler Smarcad1 paper is out and freely accessible. Differential regulation of its many activities by phosphorylation. Congrats to Briana and
@nhoitsma.bsky.social
🧪https://www.sciencedirect.com/science/article/pii/S0021925824023950?via%3Dihub
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Phosphorylation regulates the chromatin remodeler SMARCAD1 in nucleosome binding, ATP hydrolysis, and histone exchange
Maintaining the dynamic structure of chromatin is critical for regulating the cellular processes that require access to the DNA template, such as DNA …
https://www.sciencedirect.com/science/article/pii/S0021925824023950?via%3Dihub
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Nicole Hoitsma
Karolin Luger
12 months ago
Not to take anything away from the fantastic scientists who were recognized this year, and unreservedly applauding the choices.... but i guess we are back to all guys now for the STEM Nobels. Just an observation..... 🧪👩🔬
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