Thrilled to share our lab’s latest work in JBC! 🎉 We uncovered a critical role for APE1 Asn174 in stabilizing AP-sites using mutagenesis, enzymology, crystallography, and MD-simulations. Congrats to Kaitlin Dehart and all the co-authors! Check it out: www.jbc.org/article/S002...

My lab is looking to hire a Postdoc to study mechanisms of DNA repair in chromatin using biochemical, biophysical, and structural biology approaches! Feel free to share with anyone you think may be interested. jobs.virginia.edu/us/en/job/R0...

Our paper on the strange ATP-dependent chromatin remodeler Smarcad1 paper is out and freely accessible. Differential regulation of its many activities by phosphorylation. Congrats to Briana and @nhoitsma.bsky.social 🧪https://www.sciencedirect.com/science/article/pii/S0021925824023950?via%3Dihub

Not to take anything away from the fantastic scientists who were recognized this year, and unreservedly applauding the choices.... but i guess we are back to all guys now for the STEM Nobels. Just an observation..... 🧪👩‍🔬