Rafa F Leiro
@rfleiro.bsky.social
📤 849
📥 212
📝 2
Structural & Molecular biologist Group leader @ CNIO Genome Integrity & Structural Biology Lab
reposted by
Rafa F Leiro
AI x Bio Discovery
14 days ago
Automated and modular protein binder design with BinderFlow
[new] Streamlines protein binder design by providing a modular, automated, and easily monitored pipeline, increasing accessibility and scalability.
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Rafa F Leiro
bioRxiv Bioinfo
14 days ago
Automated and modular protein binder design with BinderFlow
https://www.biorxiv.org/content/10.1101/2025.09.10.675490v1
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Rafa F Leiro
Julio Abril Garrido
6 months ago
Happy to have hosted
@rfleiro.bsky.social
in
@mpi-nat.bsky.social
and hear the cool science he is doing in
@cniostopcancer.bsky.social
. Watch out for him!
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reposted by
Rafa F Leiro
Alexey Amunts
7 months ago
See you in Madrid! Speakers include:
@costalaboratory.bsky.social
@piratefernandez.bsky.social
@nhoitsma.bsky.social
@kellythd-nguyen.bsky.social
@lapassmore.bsky.social
@alessandrovannini.bsky.social
@oscarllorca.bsky.social
@rfleiro.bsky.social
@nogaleslab.bsky.social
www.cnio.es/en/eventos/m...
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Machines acting on DNA and RNA, a molecular mechanistic perspective (#CFM_MolMech)
https://www.cnio.es/en/eventos/machines-acting-on-dna-and-rna-a-molecular-mechanistic-perspective-2/
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reposted by
Rafa F Leiro
7 months ago
🔎#CFM_MolMech: a meeting exploring the integration of structural, biochemical, and biophysical insights into cryo-EM advances that reveal molecular machines behind DNA/RNA processes. 👥 Meet the organisers:
@oscarllorca.bsky.social
,
@rfleiro.bsky.social
and
@nogaleslab.bsky.social
#CFM_MolMech:
📆May 28-30th
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reposted by
Rafa F Leiro
8 months ago
🔴⚠CNIO-CaixaResearch Frontiers Meetings: Machines acting on DNA and RNA, a molecular mechanistic perspective. 📆May 28-30th 👥
@oscarllorca.bsky.social
,
@rfleiro.bsky.social
and
@nogaleslab.bsky.social
. 🔗
https://www.cnio.es/eventos/machines-acting-on-dna-and-rna-a-molecular-mechanistic-perspective/
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reposted by
Rafa F Leiro
9 months ago
“El CNIO ha estado construyendo una base importante en crio-microscopía electrónica”, dice Tafur; “la experiencia de grupos como el de
@rfleiro.bsky.social
y el
@oscarllorca.bsky.social
pueden complementarse con la nuestra de manera muy enriquecedora”, explica Tafur.
www.cnio.es/noticias/el-...
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El CNIO incorpora un nuevo grupo para ‘fotografiar’ a nivel atómico y en 3D las estructuras que hacen invasivas a las células cancerosas
Las células se adaptan a las condiciones del ambiente y a los nutrientes que tienen a su disposición. Lo hacen por medio de grupos de proteínas -técnicamente se llaman complejos de proteínas-, que det...
https://www.cnio.es/noticias/el-cnio-incorpora-un-nuevo-grupo-para-fotografiar-a-nivel-atomico-y-en-3d-las-estructuras-que-hacen-invasivas-a-las-celulas-cancerosas/
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reposted by
Rafa F Leiro
Timothy P. Jenkins
9 months ago
🚨 Revolutionising Snakebite Treatments with AI-Designed Proteins 🐍 I'm proud to share our latest study published in hashtag#Nature, driven by Susana Vazquez Torres, and co-led by David Baker (Institute for Protein Design, University of Washington) and myself.
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reposted by
Rafa F Leiro
Danve Castroverde
9 months ago
Pretty cool work on designing antivenoms de novo! 😱😻👏
www.nature.com/articles/s41...
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De novo designed proteins neutralize lethal snake venom toxins - Nature
Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...
https://www.nature.com/articles/s41586-024-08393-x
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reposted by
Rafa F Leiro
DNA replication and Genome Integrity Lab @ CIB-CSIC
9 months ago
We are still looking for candidates to apply for PhD and postdoctoral fellowships. Get in touch with us if you are interested in learning about the functional architecture of replisome protection using strand-specific genomics and AI modeling of molecular interactions!!!
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Rafa F Leiro
Corresponsables
9 months ago
🔬El
#CNIO
incorpora un nuevo grupo para ‘fotografiar’ a nivel atómico y en 3D las estructuras que hacen invasivas a las células cancerosas.
www.corresponsables.com/actualidad/c...
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El CNIO incorpora un nuevo grupo para ‘fotografiar’ a nivel atómico y en 3D las estructuras que hacen invasivas a las células cancerosas
Las células se adaptan a las condiciones del ambiente y a los nutrientes que tienen a su disposición. Lo hacen por medio de grupos de proteínas -técnicamente se llaman complejos […]
https://www.corresponsables.com/actualidad/cnio-incorpora-grupo-fotografiar-estructuras-nvasivas-celulas-cancerosas/
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reposted by
Rafa F Leiro
Infosalus
9 months ago
El CNIO incorpora un grupo para fotografiar a nivel atómico las estructuras que hacen invasivas a las células cancerosas
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El CNIO incorpora un grupo para fotografiar a nivel atómico las estructuras que hacen invasivas a las células cancerosas
https://www.infosalus.com/salud-investigacion/noticia-cnio-incorpora-grupo-fotografiar-nivel-atomico-estructuras-hacen-invasivas-celulas-cancerosas-20250109150630.html
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reposted by
Rafa F Leiro
9 months ago
REGISTRATION OPEN!! - CNIO meeting, Machines acting on DNA and RNA, 2025 May 28-30th in Madrid, organized by
@nogaleslab.bsky.social
,
@rfleiro.bsky.social
, and
@oscarllorca.bsky.social
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reposted by
Rafa F Leiro
Sjors Scheres
9 months ago
I don't know what happened here, but I do know that
@cniostopcancer.bsky.social
is one of very few places in Spain for excellent science. Care should be taken to protect the institute and its scientists from inaccurate reporting.
www.eldiario.es/sociedad/mar...
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Maria Blasco, directora del CNIO: “Soy víctima de una campaña, ni un euro contra el cáncer se ha destinado al arte”
La responsable del mayor centro de investigación contra el cáncer de España, en el ojo del huracán por su gestión, responde a las informaciones que apuntan a desviaciones de fondos y acoso laboral en ...
https://www.eldiario.es/sociedad/maria-blasco-directora-cnio-victima-campana-euro-cancer-destinado-arte_128_11916294.html
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reposted by
Rafa F Leiro
Chaitanya K. Joshi
10 months ago
Watched this really insightful talk by
@sjorsscheres.bsky.social
and thinking why on earth they'd decide to have a random keyboard as decoration -- 13 mins in Sjors tells why and its kinda heartwarming for computational folks!
youtu.be/SoXAac2HIrY?...
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Sjors Scheres - LMB Through the Years
YouTube video by MRC Laboratory of Molecular Biology
https://youtu.be/SoXAac2HIrY?feature=shared
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hello world! looking forward to a more sane and focused scrolling and interactions 😊
11 months ago
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