We've spent the last year building something at @humantechnopole.bsky.social that we think is genuinely needed: #AI that works across biological scales and data modalities, not just within them. A thread on what we're doing, why, and who we're looking for. A 🧵... 1/9

Just WOW! Tremendous work

We are #hiring! #GroupLeader positions open at #IRBBarcelona in #ChemicalBiology and #StructuralBiology. Application deadline: May 22, 2026 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗖𝗵𝗲𝗺𝗶𝗰𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ https://shorturl.at/1tE3n 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗦𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ https://shorturl.at/eKiJn #IRBJobs #Jobs #AcademicSky

“I think it’s a real mistake to forget where the pipeline for all this begins.” John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it. www.crick.ac.uk/news/2026-03...

🚨 Preprint alert! We solved the structure of human NSUN2 bound to Asp tRNA, revealing how it installs m⁵C and recognizes RNAs #CryoEM #RNABiology A collab between Casañal & Gullerova labs, with @miclass.bsky.social and me working side by side as co-first authors 🔗 doi.org/10.64898/202... (0/7🧵)

📢 First preprint from the Casañal Lab! Excited to share our work on human NSUN2, done together with the brilliant @ecleroy.bsky.social. Using #CryoEM, we capture the dramatic structural rearrangement of tRNA as it flips a cytidine into the NSUN2 catalytic pocket for m⁵C modification. Take a look👇

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

Astounding words and performance. Take 2 mins to listen to it.

🔬 How do proteins know when and how to move? Our @francescryoem.bsky.social Group reveals how sortilin recognises thyroglobulin on its path to #thyroid hormone release via a short, flexible molecular “tag”. Published in @natcomms.nature.com humantechnopole.it/en/news/how-... @iboniardi.bsky.social

@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.

🧪An international study led by Prof. Roderick Lim has discovered that nuclear pore complexes—gateways in the nuclear membrane—are not rigid or gel-like as once thought. Instead, their interiors are constantly moving and rearranging. @unibas.ch @snsf.ch 👉 www.biozentrum.unibas.ch/news/detail/...

This alternative view of “condensate” biogenesis is compatible with everything that LLPS claims for itself, including the apparent liquid-like behavior that people a bit ignorant of dynamics find so exciting. I explained this here www.embopress.org/doi/full/10....

The things you find in your photo roll #2. For some reason, in August 2013 I took a picture of this charming letter from Max Perutz to Jim Watson, written shortly before Max died.

Major modes of behavior within low-pLDDT regions were identified through a survey of human proteome predictions provided by the AlphaFold Protein Structure Database #AlphaFold2 #StructurePrediction #ConditionalFolding doi.org/10.1107/S205...

Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social. www.sciencedirect.com/science/arti... Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.

This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues go.nature.com/3VNrH1s

Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪 @mpi-nat.bsky.social #Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation

@gabrieleniola.bsky.social @ilpost.it vi segnalo questo errore in un vostro articolo. Nel film di Del Toro Waltz non è Pretorius, né uno scienziato che fa cose dopo la presunta morte del barone. Ciao e keep it up!

Final days to get signed up for the Symposium on Structural Proteomics in Milan, 6-8 October! Registrations and abstract submissions for posters and talks still open until ❗this sunday August 31st! @humantechnopole.bsky.social Find out more at ssp2025.squarespace.com

This ‘landmark’ study describes the structural mechanism of strand exchange by the RAD51 filament using cryogenic structural, biochemical, and single-molecule analyses. buff.ly/Ieh84gj

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...

🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 ssp2025.squarespace.com ▶️ @ssp2025.bsky.social

NEW from me at STAT: We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out. More @statnews.com: www.statnews.com/2025/07/21/c... 🖥️🩺🧪🧬 #bioML

Online Now: Condensin II activation by M18BP1 Online now:

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

🔴 Registrations are open! Join us at OPEN HT, a day dedicated to #lifesciences research, on the occasion of the 10th anniversary of the MIND district. Register by 15 April 👉 humantechnopole.it/en/trainings... The event will be held in Italian.

As always, excellent talk by Alessandro Borsellini from @alessandrovannini.bsky.social Lab, at @humantechnopole.bsky.social, showcasing his work at the 6th AIC-BMM meeting in Firenze! #associazioneitalianacristallografia sezione macromolecole biologiche

The new Call for Access to services provided by the National Facilities of Human Technopole is online! Check out our *new services*! Fully funded access to services, including consumables, as well as complete access to HT and training (for services for which it is applicable)

Great to have @martinpacesa.bsky.social as invited speaker to our weekly Structural Biology Colloquia. Such a solid, functional and impactful workflow 🤩. Thanks a lot for coming!

A real milestone for the local community, today we celebrate the beginning of service provision by @humantechnopole.bsky.social National Facility for Structural Biology. Lucky to have a smiling @luigiscietti.bsky.social (in pic with our Gaetano D'Urso) from IEO as first user to the Cryo-EM Unit.

Excited to see the first batch of biomass safely delivered from our National Facility for Structural Biology @humantechnopole.bsky.social to Filippo Acconcia of Università Roma Tre. A big thank you to our stellar Biomass Unit, onward to more milestones!

Abbiamo due notizie: riguardano Luca Sofri e Francesco Costa. Insomma, al Post cambieranno un po' di cose. Le raccontano qui i diretti interessati (anzi, ora possiamo dire: i direttori interessati) ilpost.link/e1oRRcnU1t

Excited to share the (hard) work of @zawarshah.bsky.social in its final form: www.nature.com/articles/s41... A lot of insights into RNA Polymerase selectivity at snRNAs promoters !! As these promoters are often used for heterologous expression of RNAs (ie guide RNAs), you better know how they work

Human Technopole - Technician/Senior Technician in Structural Proteomics careers.humantechnop... --- #proteomics #prot-jobs

Wishing everybody a great holiday season form the staff of the National Facility for Structural Biology of @humantechnopole.bsky.social! It’s been a wild year getting things started and opening to the Italian community, but it’s also been wild fun, with these amazing people! Have a great time!

Calling all #SciComm people who specialise in scientific animations. I would like to talk to someone about making some animations to communicate our research in single-molecule biophysics. Please message me if you are interested and share with your networks! 🧪

JOB ALERT!!! The National Facility for Structural Biology at @humantechnopole.bsky.social is HIRING!! BlueSky-less Andrea Graziadei is looking for a technician to join his Unit and push #structuralproteomics to new, uncharted territories!! 1/3

Thanks for the endorsement @pscryoem.bsky.social! Always a great pleasure having the chance to review the activity done so far and putting some of our technologies on the spotlight! Onto the next one! #biophysics #structuralbiology 🧪

Research integrity on the spotlight today at @humantechnopole.bsky.social with an internal course to bring awareness and share policies on the topic to the whole HT community

😱📣 BlueSky-ers: WE NEED YOUR HELP!!! 🙏 All of you who ever liked a lecture of mine... All of you who liked one of the courses I teach in... All of you I work(ed) with in one way or another... All of you who see my desperation! 😜 PLEASE re-post! 🙏 careers.humantechnopole.it/o/postdoc-in...

. @zawarshah.bsky.social and @nikklena.bsky.social killing it at the Milan Joint Structural Biology Lab Meeting! Great afternoon gathering the Attu bio community in #uniMI Amazing showcase of @humantechnopole.bsky.social science from @alessandrovannini.bsky.social and @gaiapigino.bsky.social lab

Per chi mette contenuti scientifici, se alla fine del post inserite questa icona 🧪 verrete rilevati dal feed che raggruppa questi contenuti.

Our review of Intraflagellar transport is out now! We cover lots of the recent advances in our understanding of IFT, and where we think there are still some gaps. www.nature.com/articles/s41...

Please consider joining us at the next EMBO Chromosome Segregation and Aneuploidy Meeting co-organised by @mcclellandlab.bsky.social @foijer-lab.bsky.social @bendavidlab.bsky.social Elsa Logarinho Dani Fachinetti and myself meetings.embo.org/event/25-ane... 🧬🔬😎

ok to all synchrotron and cryoEM people out there ...a hastily put together starter pack! go.bsky.app/UThze5z

*Chemists