It’s been a long time coming! Grateful to all co-authors and colleagues who supported this study, especially @yilanfan.bsky.social 🙌 We have been working on this complex for nearly 3 years together and finally managed to tame it. MRN gave us Many Restless Nights, but we’re More Relaxed Now 😎

Check out our pre-print on how the human INO80 complex acts on nucleosomes and hexasomes: PostDocs Priyanka & Manmohan et al. solved structures of INO80 bound to several substrates and completed missing questions about similarities of modes of actions across species🧬 www.biorxiv.org/content/10.1...

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social. www.science.org/doi/10.1126/...

📢Stigler lab in collaboration with the Holt lab decipher that LINE-1 ORF1p forms super-saturated co-condensates with RNA that enable DNA binding and nuclear entry during mitosis. Congratulations!👏👏👏 Details: www.science.org/doi/10.1126/...

🚨New preprint🚨We developed a transverse flow imaging approach to directly visualize bacterial replisomes challenged by topological barriers and discovered a fast rotational mode of replisome operation. Fantastic work by thomasmretzer.bsky.social and Hamdan Lab! tinyurl.com/replisomerot...

Happy to share our latest pre-print! We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨 www.biorxiv.org/content/10.1...

Happy to share our review on the cellular responses to RNA damage 🥂 Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social www.cell.com/cell/fulltex...

Hello, Bluesky! To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities. Check out our new paper here www.nature.com/articles/s41... + movie