Elif Karagöz
@gekaragoz.bsky.social
📤 503
📥 727
📝 32
Group leader at Max Perutz Labs interested in protein quality control
reposted by
Elif Karagöz
Max Perutz Labs Vienna
3 days ago
New opportunity with the Vienna BioCenter Scientific Training Team! 🙌 As PhD Program Manager, you’ll play a key role in empowering and shaping the careers of the next generation of world-class researchers ➡️
tinyurl.com/yrk23na2
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Congrats to Ni, Dagdas lab and everyone involved! Happy to contribute to this exciting work!
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3 days ago
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reposted by
Elif Karagöz
Kurianlab
4 days ago
Excited host
@hohmannulrich.bsky.social
from
@imbmainz.bsky.social
, along with
@manuelkaulich.bsky.social
Date: 07.04.2026 Time: 15:00 Venue: Haus 22 Seminar Room 1. (S22-1) Title: ‘Mechanistic insights into nuclear mRNA export and degradation’
@goetheuni.bsky.social
@cpi-exstra.bsky.social
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reposted by
Elif Karagöz
Max Perutz Labs Vienna
8 days ago
Looking for an exciting and ambitious Master’s project? 👀 Join the
@huis.bsky.social
lab, where two Master’s positions are currently available to explore how genome stability and chromosome segregation are controlled in human cells ➡️
tinyurl.com/ybddpx7c
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reposted by
Elif Karagöz
The EMBO Journal
8 days ago
What are the roles of UFMylation during ribosome-associated quality control?
@gekaragoz.bsky.social
@plantophagy.bsky.social
and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER
link.springer.com/article/10.1...
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The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
https://link.springer.com/article/10.1038/s44318-026-00753-9
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reposted by
Elif Karagöz
Yasin Dagdas
10 days ago
Congrats Milica
@alessandrick.bsky.social
& everyone
@gekaragoz.bsky.social
lab. Glad we could contribute to this awesome story on
#UFMylation
&
#RQC
crosstalk
@embojournal.org
link.springer.com/article/10.1...
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The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
https://link.springer.com/article/10.1038/s44318-026-00753-9
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Our work on the role of Ufmylation on ribosome quality control on the ER is out! Great work of two terrific first authors Milica and
@alessandrick.bsky.social
together with our wonderful collaborators, the one and only Dagdas lab
@plantophagy.bsky.social
!
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9 days ago
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reposted by
Elif Karagöz
Carter Lab
10 days ago
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with
@niakanlab.bsky.social
and work led by
@kashishsingh.bsky.social
and
@inaharasimov.bsky.social
. It is now out on BioRxiv:
www.biorxiv.org/content/10.6...
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reposted by
Elif Karagöz
André Nadler
12 days ago
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in
@natcellbio.nature.com
brought to you by
@mathilda95.bsky.social
changes that:
www.nature.com/articles/s41...
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reposted by
Elif Karagöz
Max Perutz Labs Vienna
12 days ago
The BioOptics facility will expand their team with a Junior Imaging Scientist with a background in Biological Sciences, who is enthusiastic about applying cutting-edge light microscopy for imaging-based research 🔬 Join a collaborative service team at the Perutz today! ➡️
tinyurl.com/5n7m2dyw
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reposted by
Elif Karagöz
Jakob Farnung
16 days ago
The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! 🎉🍾 We,
@bartellab.bsky.social
and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase.
@mpibiochem.bsky.social
www.nature.com/articles/s41...
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reposted by
Elif Karagöz
Max Perutz Labs Vienna
22 days ago
🚨 Out now! 🧫 In a new study in
@embojournal.org
, PhD student
@moberhuemer.bsky.social
(Leeb lab) presents a simpler, feeder-free way to grow human naïve pluripotent stem cells - making the system more scalable and accessible ➡️
tinyurl.com/29wrcdru
@univie.ac.at
@meduniwien.ac.at
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We are grateful to FWF for their support! It is a privilege to be part of this amazing team and work on this exciting truly collaborative project! Stay tuned!
add a skeleton here at some point
23 days ago
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reposted by
Elif Karagöz
Clausen Lab
29 days ago
Ubiquitin & Friends Fiesta in Vienna, 29-30 April 2026. Great speakers, small size, a friendly community, perfect for early-career researchers to connect with fellow ubiquitin enthusiasts. Sign up at
www.protein-degradation.org/symposium/
and submit abstracts for talks and awards.
#ubfriends26
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reposted by
Elif Karagöz
EMBO
29 days ago
Registration is now open for the EMBO Workshop "#Ubiquitin and ubiquitin-like proteins in health and disease" in #Monopoli, Italy, 28 Sep–2 Oct 2026. Registration deadline: 31 May Abstract submission deadline: 15 Jun
https://meetings.embo.org/event/26-ubiquitin
#Ubiquitin
#Monopoli
#EMBOubiquitin
#EMBOevents
🧪
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reposted by
Elif Karagöz
Max Perutz Labs Vienna
about 1 month ago
Fantastic news! 🙌 The Perutz is excited to welcome Danny Nedialkova as a new group leader starting this April! 🎉 She will strengthen the institute's research on the fundamental mechanisms that shape cellular physiology and disease ➡️
www.maxperutzlabs.ac.at/research/res...
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reposted by
Elif Karagöz
Tugce Aktas
about 1 month ago
Our most recent work on the “function and evolution” of
#nuclear-speckles
is now online at Cell
@cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.
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Redirecting
https://doi.org/10.1016/j.cell.2026.01.011
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reposted by
Elif Karagöz
James Olzmann
about 1 month ago
Sooo happy to share our new paper in
@nature.com
“CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with
@arrudalab.bsky.social
, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...
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CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature
CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...
https://www.nature.com/articles/s41586-025-10064-4
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reposted by
Elif Karagöz
about 1 month ago
Our paper on The Lipid Interactome is now published, and the database is open:
lipidinteractome.org
@ohsummi.bsky.social
@ohsunews.bsky.social
@nadlerlab.bsky.social
@jeremybaskin.bsky.social
Please RT to spread the word.
doi.org/10.1093/bioi...
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The Lipid Interactome: an interactive and open access platform for exploring cellular lipid–protein interactions
AbstractSummary. Lipid–protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has lon
https://doi.org/10.1093/bioinformatics/btaf651
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Very much looking forward to it!
add a skeleton here at some point
about 1 month ago
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Huge congrats to Alibek and everyone involved! It is a great work!
add a skeleton here at some point
about 1 month ago
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reposted by
Elif Karagöz
Vienna BioCenter
about 1 month ago
SAVE THE DATE: Ubiquitin & Friends Symposium 2026 on April 29-30 or even better, sign up now:
lnkd.in/eEQmaCYT
It takes place at Van Swieten Hall, 1090 Vienna & is organized by the SFB Targeted Protein Degradation (incl. numerous research groups at Vienna BioCenter)
@sfb-tpd-vienna.bsky.social
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reposted by
Elif Karagöz
Nature Cell Biology
about 1 month ago
🍰Read also the News & Views article written by Yu-Xi Xiao & Alan M. Moses: 👉https://rdcu.be/e4W1D
bit.ly/4kO0Lua
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Motifs and chemistry dictate the role of intrinsically disordered regions - Nature Cell Biology
Research shows that the function of intrinsically disordered regions within proteins relies on both linear sequence motifs and broader chemical context, allowing evolution to preserve function without...
https://bit.ly/4kO0Lua
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reposted by
Elif Karagöz
Molecular Cell
about 1 month ago
The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis
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The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis
Large oligomeric proteins constitute a major fraction of proteomes, but are difficult to refold in vitro, raising the question of how cells direct their biogenesis. Roeselová and Shivakumaraswamy et al. show how the ribosome orchestrates efficient cotranslational folding and assembly.
http://dlvr.it/TR3QXX
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reposted by
Elif Karagöz
Mara Mueller
about 1 month ago
Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with:
@andschwarz.bsky.social
with:
@lea-dietrich.bsky.social
,
@sgiando.bsky.social
,
@erin-schuman.bsky.social
and many more 🧵 0/6
#MolBio
🧪
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reposted by
Elif Karagöz
Max Perutz Labs Vienna
about 1 month ago
👀 Curious about how RNA is shaped inside cells? Apply for a Master’s thesis in the Martinez Lab and investigate the mechanisms and functions of tRNA processing in health and disease ➡️
tinyurl.com/4hxm6x8p
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reposted by
Elif Karagöz
about 2 months ago
Our paper is out in
@natcomms.nature.com
! APOBEC3s drive mutagenesis in cancer. We uncover a novel pathway keeping them in check. The key is APOBEC3 binding of cellular RNAs, which simultaneously controls their nuclear localization and shields them from degradation. Read it here:
rdcu.be/e4qaa
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reposted by
Elif Karagöz
Nature
about 2 months ago
Nature research paper: Sleep-dependent clearance of brain lipids by peripheral blood cells
go.nature.com/4rRrkAV
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Sleep-dependent clearance of brain lipids by peripheral blood cells - Nature
Peripheral macrophage-like haemocytes in Drosophila promote sleep by clearing lipid buildup in the brain, helping to maintain metabolic homeostasis and brain function and fitness.
https://go.nature.com/4rRrkAV
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reposted by
Elif Karagöz
Yasin Dagdas
about 2 months ago
@hanhtkvu.bsky.social
@embl.org
& we are looking for a
#postdoc
to study
#regeneration
x
#autophagy
across kingdoms of life. Pls spread the word & get in touch if you are interested
www.health-life-sciences.de/opportunitie...
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HEALTH + LIFE SCIENCE ALLIANCE | Interinstitutional Postdocs
https://www.health-life-sciences.de/opportunities/postdoc-call/
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reposted by
Elif Karagöz
Florian Fröhlich
about 2 months ago
New preprint from the lab together with
@labvanni.bsky.social
. We looked what happens to ER generated free very long chain fatty acids.. VLCFAs are partionig into lipid droplets and are extracted from the hydrophobic core by Fat1.
www.biorxiv.org/content/bior...
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https://bsky.app/profile/labvanni.bsky.social
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reposted by
Elif Karagöz
Bernd Bauer
about 2 months ago
Why do pathological protein aggregates persist in cells and how can we overcome this? In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy
#Tau
#Proteostasis
Out now 👇
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.02.12.705532v1
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reposted by
Elif Karagöz
Dominik Handler
about 2 months ago
How does the piRNA pathway solve the self vs. non-self problem? 🧬 Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
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reposted by
Elif Karagöz
Phil Holliger
about 2 months ago
New paper from my group in
@science.org
: "A small polymerase ribozyme that can synthesise itself and its complementary strand"
www.science.org/doi/10.1126/...
Outstanding work by
@edogia.bsky.social
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reposted by
Elif Karagöz
Haselbach Lab
about 2 months ago
This is a video summarizing our recent paper (
www.nature.com/articles/s41...
)
youtu.be/eNY2CRlYTRo
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A multivalent adaptor mechanism drives the nuclear import of proteasomes - Nature Communications
Nuclear protein homeostasis relies on proteasome import into the nucleus. Here the authors identify how assembled human proteasomes are transported across the nuclear pore complex and reveal a mechani...
https://www.nature.com/articles/s41467-026-69162-0
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reposted by
Elif Karagöz
Molecular Cell
about 2 months ago
Ribosome-NAC collaboration: A regulatory platform for cotranslational chaperones, enzymes, and targeting factors. @DeuerlingLab discusses how the NAC coordinates the fate of nascent proteins on the ribosome.
http://dlvr.it/TQnW4n
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reposted by
Elif Karagöz
Nature
about 2 months ago
Nature research paper: PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling
go.nature.com/4klvMp1
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PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling - Nature
Phosphatidylinositol 3,5-bisphosphate is a ligand of STING and, together with cGAMP, induces STING activation and innate immune responses.
https://go.nature.com/4klvMp1
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reposted by
Elif Karagöz
Eric Chevet
about 2 months ago
Activated ATF6α is a hepatic tumour driver restricting immunosurveillanc
www.nature.com/articles/s41...
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Activated ATF6α is a hepatic tumour driver restricting immunosurveillance - Nature
ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming...
https://www.nature.com/articles/s41586-025-10036-8
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reposted by
Elif Karagöz
Max Perutz Labs Vienna
2 months ago
Paper alert! 📢 How do cells fight viruses without harming themselves? 🧬 In
@natcomms.nature.com
, the
@versteegga.bsky.social
lab uncover a previously unknown safeguard that keeps DNA-mutating antiviral enzymes in check, protecting the genome while preserving antiviral defense ➡️
tinyurl.com/4xbxz9e8
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reposted by
Elif Karagöz
Juan Carlos De la Concepcion
2 months ago
Please share! My group at
@zmbp-tuebingen.bsky.social
is offering a post-doctoral position (4 years). We look for a structural biologist with experience in Cryo-EM/Cryo-ET to investigate the mechanisms of host invasion by pathogenic fungi. Deadline February 28th!
uni-tuebingen.de/universitaet...
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reposted by
Elif Karagöz
Marvin Tanenbaum
2 months ago
Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake!
rdcu.be/e1bBW
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Pre-assembly of biomolecular condensate seeds drives RSV replication
Nature - Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.
https://rdcu.be/e1bBW
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reposted by
Elif Karagöz
Martin Kampmann
2 months ago
Our paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
www.cell.com/cell/fulltex...
Great collaborative effort - read more from first author
@asamelson.bsky.social
below:
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reposted by
Elif Karagöz
Julia Rose Kraut
2 months ago
“Don’t be discouraged when you find that the process of self-discovery takes a long, long time,” she said. “Don’t even be surprised if at 50 you are still wondering what you are going to be when you grow up.” 🗃️ RIP Barbara Aronstein Black
www.nytimes.com/2026/01/21/u...
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Barbara Aronstein Black, a First as a Law School Dean, Dies at 92
https://www.nytimes.com/2026/01/21/us/barbara-aronstein-black-dead.html?smid=nytcore-android-share
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reposted by
Elif Karagöz
Max Perutz Labs Vienna
2 months ago
2026 is off to a strong start! 🎉 Erinc Hallacli has secured funding from the Herzfelder’sche Familienstiftung to explore how pathogenic protein aggregates disrupt RNA metabolism in human neurons ➡️
tinyurl.com/yrx9mhm5
@fwf-at.bsky.social
@univie.ac.at
@meduniwien.ac.at
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reposted by
Elif Karagöz
David Balchin
2 months ago
Our latest cotranslational folding story is now published
@cp-molcell.bsky.social
. Really cool (I think) new ideas about how exactly the ribosome directs folding and assembly to make sure complicated proteins mature efficiently in cells.
www.cell.com/molecular-ce...
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The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis
Large oligomeric proteins constitute a major fraction of proteomes, but are difficult to refold in vitro, raising the question of how cells direct their biogenesis. Roeselová and Shivakumaraswamy et a...
https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)01021-4
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reposted by
Elif Karagöz
IMP
2 months ago
🧪Scientists from our Haselbach lab captured how proteins begin to fold as they’re being made. Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome:
https://www.nature.com/articles/s41467-025-67685-6
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reposted by
Elif Karagöz
Osman Lab
3 months ago
How do cells assess mtDNA quality? Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection. We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae. Great collaboration with the Schmoller Lab.
journals.plos.org/plosgenetics...
🧬⚡
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Local mitochondrial physiology defined by mtDNA quality guides purifying selection
Author summary Mitochondria are essential organelles in our cells that convert nutrients into usable cellular energy. They contain their own DNA, and mutations in this DNA can compromise mitochondrial...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011836
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reposted by
Elif Karagöz
Evelina Tutucci
3 months ago
Happy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form
@natcomms.nature.com
www.nature.com/articles/s41...
Below a short🧵 with the key findings!
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reposted by
Elif Karagöz
David Bartel's Lab
3 months ago
We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by
@jakobfarnung.bsky.social
and
@elenaslo.bsky.social
in a fantastic collaboration with Brenda Schulman's lab.
tinyurl.com/E3TDMD
(1/5)
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Elif Karagöz
Nikolai Slavov
3 months ago
Signalling by ubiquitination regulates most cellular process in eukaryotes. The essential roles of ubiquitination in the immune system make it a common target for diverse infectious agents. The strategy used by L. pneumophila breaks the rules ! 3/3
www.nature.com/articles/nat...
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Ubiquitination independent of E1 and E2 enzymes by bacterial effectors - Nature
An unprecedented mechanism of ubiquitination that is independent of E1 and E2 enzymes, instead relying on activation of ubiquitin by ADP-ribosylation, and which is mediated by members of the SidE effe...
https://www.nature.com/articles/nature17657
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Elif Karagöz
Signal Transduction and Targeted Therapy
3 months ago
Scientists identify
#IGF2BP1
as a driver of
#ImmuneEvasion
in C5
#OvarianCancer
, suppressing IFN‑γ–IRF1–MHC‑I signaling and T‑cell infiltration; its inhibition restores
#antitumor
immunity and boosts
#PD1blockade
.
@unihalle.bsky.social
#OpenAccess
in
#STTT
:
doi.org/10.1038/s413...
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Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer
https://doi.org/10.1038/s41392-025-02515-1
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