Why do pathological protein aggregates persist in cells and how can we overcome this? In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored. #Autophagy #Tau #Proteostasis Out now 👇 www.biorxiv.org/content/10.6...

How does the piRNA pathway solve the self vs. non-self problem? 🧬 Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)

New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/... Outstanding work by @edogia.bsky.social

This is a video summarizing our recent paper (www.nature.com/articles/s41...) youtu.be/eNY2CRlYTRo

Ribosome-NAC collaboration: A regulatory platform for cotranslational chaperones, enzymes, and targeting factors. @DeuerlingLab discusses how the NAC coordinates the fate of nascent proteins on the ribosome. http://dlvr.it/TQnW4n

Nature research paper: PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling go.nature.com/4klvMp1

Activated ATF6α is a hepatic tumour driver restricting immunosurveillanc www.nature.com/articles/s41...

Paper alert! 📢 How do cells fight viruses without harming themselves? 🧬 In @natcomms.nature.com, the @versteegga.bsky.social lab uncover a previously unknown safeguard that keeps DNA-mutating antiviral enzymes in check, protecting the genome while preserving antiviral defense ➡️ tinyurl.com/4xbxz9e8

Please share! My group at @zmbp-tuebingen.bsky.social is offering a post-doctoral position (4 years). We look for a structural biologist with experience in Cryo-EM/Cryo-ET to investigate the mechanisms of host invasion by pathogenic fungi. Deadline February 28th! uni-tuebingen.de/universitaet...

Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake! rdcu.be/e1bBW

Our paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex... Great collaborative effort - read more from first author @asamelson.bsky.social below:

“Don’t be discouraged when you find that the process of self-discovery takes a long, long time,” she said. “Don’t even be surprised if at 50 you are still wondering what you are going to be when you grow up.” 🗃️ RIP Barbara Aronstein Black www.nytimes.com/2026/01/21/u...

2026 is off to a strong start! 🎉 Erinc Hallacli has secured funding from the Herzfelder’sche Familienstiftung to explore how pathogenic protein aggregates disrupt RNA metabolism in human neurons ➡️ tinyurl.com/yrx9mhm5 @fwf-at.bsky.social @univie.ac.at @meduniwien.ac.at

Our latest cotranslational folding story is now published @cp-molcell.bsky.social. Really cool (I think) new ideas about how exactly the ribosome directs folding and assembly to make sure complicated proteins mature efficiently in cells. www.cell.com/molecular-ce...

🧪Scientists from our Haselbach lab captured how proteins begin to fold as they’re being made. Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6

How do cells assess mtDNA quality? Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection. We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae. Great collaboration with the Schmoller Lab. journals.plos.org/plosgenetics... 🧬⚡

Happy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com www.nature.com/articles/s41... Below a short🧵 with the key findings!

We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)

Signalling by ubiquitination regulates most cellular process in eukaryotes. The essential roles of ubiquitination in the immune system make it a common target for diverse infectious agents. The strategy used by L. pneumophila breaks the rules ! 3/3 www.nature.com/articles/nat...

Scientists identify #IGF2BP1 as a driver of #ImmuneEvasion in C5 #OvarianCancer, suppressing IFN‑γ–IRF1–MHC‑I signaling and T‑cell infiltration; its inhibition restores #antitumor immunity and boosts #PD1blockade. @unihalle.bsky.social #OpenAccess in #STTT: doi.org/10.1038/s413...

🔬 Love science and keeping a lab running smoothly? Join the @leeboratory.bsky.social as a lab manager/research technician and help uncover how cells choose and maintain their identity 🧫 More information ➡️ tinyurl.com/y7a8he88

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

A proud moment for me and our lab. Sanya defended her thesis with flying colors. Thanks to the reviewers for the fruitful discussion and their feedback.

Take a look at this recently published paper in LSA: The unfolded protein response in progeria arteries originates from non-endothelial cell types @maxperutzlabs.ac.at @gekaragoz.bsky.social www.life-science-alliance.org/content/9/2/...

The Frankfurt Institute for Advanced Studies (FIAS) and the newly funded Cluster of Excellence SCALE are seeking several Independent Research Group Leaders to drive theoretical and computational research in molecular and cellular life science. fias.institute/de/das-fias/...

Progeroid endothelial cells do not show a robust activation of the unfolded protein response, contrary to what has been reported in other arterial cell types such as vascular smooth muscle cells @maxperutzlabs.ac.at, @gekaragoz.bsky.social www.life-science-alliance.org/content/9/2/...

Glad to have this finally published: www.sciencedirect.com/science/arti... lots of new data since the #preprint. If you are into selective #autophagy, #evolution, #proteostasis Please have a look!

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫 www.nature.com/articles/s41... A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

Join our vibrant scientific community @viennabiocenter.bsky.social! It’s an extremely supportive environment to start a lab 🚀 www.imp.ac.at/career/open-...

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

New paper alert! Scientists in Julius Brennecke’s lab at IMBA and Clemens Plaschka’s lab at @impvienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: https://imba.science/3Xl2hJ3

Big news! Group leader Sascha Martens has been awarded a prestigious @erc.europa.eu Synergy Grant for the collaborative project DegrAbility to explore how cells can better recycle harmful protein aggregates linked to diseases like Alzheimer’s ➡️ tinyurl.com/2zuz9jcf @univie.ac.at @meduniwien.ac.at

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct

This Halloween, we have a spooky evolutionary story for you. The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41... Here’s why I love this work — and why I think you’ll enjoy it too. 👇

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...

Our latest review is now online! 👇 @martenslab.bsky.social Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

🎉 Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the 🏅 Otto Warburg Medal 2026! Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨ #OWM #WeizmannInstitute @elsevierconnect.bsky.social

Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...

Quiescent cells stay alive by eating less. They downregulate amino acid transporters to match reduced demand. When this brake fails -> cell death & disease. More info in our new paper 👇

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9

RNA biology is a major research focus at the Perutz - and the new @fwf-at.bsky.social grants strengthen it even further 🙌 Elif Karagöz and Pavel Kovarik will investigate how RNA-binding proteins regulate cellular stress and immune responses ➡️ tinyurl.com/2s3f3mu8 @univie.ac.at @meduniwien.ac.at

A good day to remember John Gurdon’s school report from his biology master at Eton

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October. More info: www.imb.de/students-pos...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...