In Wilmington, North Carolina, in 1898, a white mob murdered Black men in the street and overthrew the city’s democratically elected biracial government. North Carolina would not elect another Black person to Congress until 1992. newyorkermag.visitlink.me/cRGMCD

📯 Our paper “VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair” out now in Nature Communications rdcu.be/frKmN

I am excited to announce the latest paper from our lab, published in Science ! In this study, we show that thalamocortical-like circuits in the zebrafish brain process sensory information hierarchically across topographically organized forebrain circuits.

Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.

I wanted to like QED's new 1% preprint ranking. I really did. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review. open.substack.com/pub/blekhman...

Take a look at this new paper in @science.org Reversible suppression of autophagy in a mouse model reveals neuronal resilience | Science www.science.org/doi/10.1126/...

🆕 publication! How do cells build their molecular machines? Tsimafei Navalayeu (Ameres lab) in @embojournal.org maps the stepwise assembly of the RNA exosome in mammalian cells, revealing the quality control mechanisms that ensure this essential complex is built correctly ➡️ tinyurl.com/84c2298e

In our latest paper in @natchem.nature.com, we reported how the crystalline environment alters protein dynamics. If you want to get the big picture quickly, have a look at the News & Views article by Lars Schäfer. www.nature.com/articles/s41... @istaresearch.bsky.social

🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly www.nature.com/articles/s41... rdcu.be/fqa92

Come join the new Novo Nordisk Foundation Center for Protein Design as a group leader Cool science in a great scientific environment in wonderful and very family friendly Copenhagen There are two positions that can either be at TT assistant or associate prof level employment.ku.dk/tenure-track...

Ina @inahuppertz.bsky.social and Kathrin @katleppek.bsky.social cordially invite all RNA enthusiasts based in the Rhineland region to attend our series of inspiring in-person talks on RNA-related topics by local and invited speakers. This time on Monday July 13th in the DZNE auditorium in Bonn.

a small attempt to capture this enormous loss and what Greg meant and means to so many. www.cell.com/cell/fulltex...

BacPROTACs outperform inhibitors in Mycobacterium tuberculosis https://www.biorxiv.org/content/10.64898/2026.06.12.731830v1

Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...

Nature research paper: Substrate selectivity of the human RNA m5C methyltransferase NSUN2 go.nature.com/4v7ZeTt

Single molecule studies from Arda Mizrak in the Farese/Walther @msk & Harper Labs @harvardcellbio.bsky.social shows how lipid droplet proteins track through ER networks to ultimately partition into nanodomains on droplets, dependent upon Trp-containing hairpin motifs www.nature.com/articles/s41...

The first cut is the deepest: Cleavable signal peptides direct thousands of different nascent proteins to the endoplasmic reticulum. Oddly, SPs are all different and nevertheless cleaved with exquisite specificity. Our new cryo-EM structures + MD solve this paradox: www.nature.com/articles/s41...

New insights into #fertilization from the @pauligroup.bsky.social & Ikawa labs! In a tour-de-force study, we discovered ✨ SPARK ✨, a conserved sperm fertilization complex that couples sperm-egg binding to membrane fusion. Read on 🧵👇 and check out our preprint for more details! tinyurl.com/34cm4xat

Open Postdoc Position - Giant E3 ligases: mysterious mechanisms & non‑protein substrates. Interested? Join us to uncover how these molecular giants tag lipids, RNAs, sugars beyond proteins, on organelles and pathogens, to defend the cell. Details & Application here www.imp.ac.at/career/open-...

📣 Registration is open for the 20th Microsymposium on RNA Biology! Join in at the Vienna BioCenter for three days of cutting-edge science, discussion & networking. 📅 17-19 June 2026 🧬 Poster abstract deadline: 19 May Info & registration: www.oeaw.ac.at/imba/seminar...

Excited to share a new preprint from the lab led by @lukekoblan.bsky.social and William Colgan in which we describe our efforts to define a quantitative cell fate map of mouse embryogenesis! www.biorxiv.org/content/10.6...

Check out the phenomenal PhD work by Katie Copley, a current postdoc in our lab @yaleneuro.bsky.social @yalerna.bsky.social. www.science.org/doi/10.1126/...

How do mitochondrial ribosomes keep pace with membrane insertion? Now out in NSMB: We show that mitoribosomes slow down at defined positions linked to membrane insertion and protein topology: rdcu.be/fhqIT #Mitochondria #Ribosome #CryoEM

Now online at @natplants.nature.com ‼️ Led by Jierui Zhao, a former PhD student @gmivienna.bsky.social & together w/ @moritznowack.bsky.social lab, we uncover how #autophagy shapes salt stress tolerance and lifespan. www.nature.com/articles/s41... www.nature.com/articles/s41... A short 🧵👇

My favourite meeting of the year has arrived again! 👇🤩

🚨 Paper out now in #ScienceAdvances @science.org 🌱🦠 Pathogens don’t just target protein degradation—they also hijack host translation. "Bacteria use P-body condensates to attenuate host translation during infection" ⚖️♻️ led by @manuelgonzalezfuen.bsky.social www.science.org/doi/10.1126/...

Final call for postdoctoral positions in my lab in wonderful Århus. You may apply using this link: mbg.au.dk/en/news-and-...

A new paper in which we could contribute structural insights to the great biochemical work from our collaborators from UNC Chapel Hill. Sascha Amann from our lab was yet again able to solve several very challenging structures. This time of a SCF with Protac and target www.nature.com/articles/s41...

New from our lab @crick.ac.uk. Nascent proteins emerge from the human ribosome into a cytosol packed with hundreds of different molecular chaperones. Which chaperones recognise specific nascent chains, and what dictates their binding preferences? www.biorxiv.org/content/10.6...

This is .wild. !

Now out in its final form! www.science.org/doi/10.1126/...

Out now in @science.org Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape | Science www.science.org/doi/10.1126/...

Our lab is looking for a lab technician! If you share our passion for fundamental research and happy to contribute, join us!

🔬 Passionate about RNA biology? Join the lab of @sebastianfalk.bsky.social for your Master's project to explore the function of proteins and protein complexes using cutting-edge biochemical, structural, and cell biology approaches ➡️ tinyurl.com/3k7upan4

We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!

Out now in @science.org Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response | Science www.science.org/doi/10.1126/...

Exciting job offer: PhD Program Manager. Lead recruitment, support PhD candidates, and shape doctoral training at a top international life sciences campus. https://ow.ly/3YkN50YAuGM Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology

New opportunity with the Vienna BioCenter Scientific Training Team! 🙌 As PhD Program Manager, you’ll play a key role in empowering and shaping the careers of the next generation of world-class researchers ➡️ tinyurl.com/yrk23na2

Congrats to Ni, Dagdas lab and everyone involved! Happy to contribute to this exciting work!

Excited host @hohmannulrich.bsky.social from @imbmainz.bsky.social, along with @manuelkaulich.bsky.social Date: 07.04.2026 Time: 15:00 Venue: Haus 22 Seminar Room 1. (S22-1) Title: ‘Mechanistic insights into nuclear mRNA export and degradation’ @goetheuni.bsky.social @cpi-exstra.bsky.social

Looking for an exciting and ambitious Master’s project? 👀 Join the @huis.bsky.social lab, where two Master’s positions are currently available to explore how genome stability and chromosome segregation are controlled in human cells ➡️ tinyurl.com/ybddpx7c

What are the roles of UFMylation during ribosome-associated quality control? @gekaragoz.bsky.social @plantophagy.bsky.social and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER link.springer.com/article/10.1...

Congrats Milica @alessandrick.bsky.social & everyone @gekaragoz.bsky.social lab. Glad we could contribute to this awesome story on #UFMylation & #RQC crosstalk @embojournal.org link.springer.com/article/10.1...

Our work on the role of Ufmylation on ribosome quality control on the ER is out! Great work of two terrific first authors Milica and @alessandrick.bsky.social together with our wonderful collaborators, the one and only Dagdas lab @plantophagy.bsky.social!

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in @natcellbio.nature.com brought to you by @mathilda95.bsky.social changes that: www.nature.com/articles/s41...

The BioOptics facility will expand their team with a Junior Imaging Scientist with a background in Biological Sciences, who is enthusiastic about applying cutting-edge light microscopy for imaging-based research 🔬 Join a collaborative service team at the Perutz today! ➡️ tinyurl.com/5n7m2dyw