🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October. More info: www.imb.de/students-pos...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Opportunity for skilled hands and sharp minds - at any career stage! 💪 The Köhler Lab is seeking a full-time lab technician to support their research on nuclear envelope biology, chromatin regulation, and cellular stress resilience - apply here ➡️ tinyurl.com/bdfy3w2h

Thank you for including our Paper as a highlight! for anyone interested in the accompanying blog post: go.nature.com/4mFNYdb

Fantastic opportunity. Vienna rocks!

Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...

We are looking for a Master’s student to join a project on in vitro reconstitution of signaling networks in pathogen–host interactions: combine protein biochemistry, fluorescence microscopy & image analysis. Deadline: September 15. Find out more and apply here: ist.ac.at/en/job/maste...

💫NEW: Mauthe et al. find that protein aggregate clearance requires fragmentation of the aggregate by a chaperone module and a proteasomal regulatory particle for recruitment and clustering of selective #autophagy receptors to initiate phagophore formation. bit.ly/3JJeJPp

Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social www.cell.com/cell/fulltex...

📢 New preprint: Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes. We addressed a long-standing question that people debated already in the 1970s - but it still remained open: Do proteins in crystals move as they do in solution? We used ring flips to find out. 1/n

Exciting new work from Dagdas lab! Congrats to Alibek and all the team!

Excited to share our latest study in @natcomms.nature.com , where we characterize the chaperone function of the ER membrane protein complex (EMC)—supporting membrane protein biogenesis beyond insertion! 1/9 www.nature.com/articles/s41...

My colleagues are awesome!

Join us at the Perutz, part of the Vienna Biocenter! Opening for a full professorship in Molecular Mechanisms of Disease 👇🏻 @maxperutzlabs.bsky.social @viennabiocenter.bsky.social @univie.ac.at

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Molecular Mechanisms of Disease. More information ➡️ tinyurl.com/3yn883b8

👏 Big CONGRATS to @sramundo.bsky.social for receiving an FWF @fwf-at.bsky.social ASTRA Award 🌠✨ See all about it 👇

It is finally out! My first Science paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Dikic for all the support and trust ! 🫶. #RNA #Proteostasis #ubiquitin #autophagy #RP doi.org/10.1126/scie...

#TCTeAC ... what's more than organizing one conference? Two conferences! This one is more Day Science on biology of Argonaute proteins from prokaryotes to Metazoa. Great line up of invited speakers. Some special fun included!

Last call to apply for the Susan Lindquist School on Proteostasis EMBO-FEBS Lecture Course, 16-19 Sept 2025 in Espoo, Finland! Open for postdocs and PhD students. DL June 15! meetings.embo.org/event/25-pro...

Are you interested in doing a masters in RNA biology? We are accepting students for 2-years masters by research degree (1 year research, 1 year write up). Only 1 year tuition fees (£25k international, £5k home) fees include bench fees normally worth £4k. @biouea.bsky.social www.theakaylab.com

REFEREE 1: “I conclude with a simple, direct statement - this is the best paper I have read all year!” #TransparentPeerReview Co-evolving infectivity and expression patterns drive the diversification of endogenous retroviruses @juliusbrennecke.bsky.social et al www.embopress.org/doi/full/10....

📣 Our new VIP3 Postdoc program is accepting applications! Wondering what's it's like to do a postdoc at the Vienna Biocenter? Find out here👇 🎉

Innovative Forschung zur Entstehung & Kontrolle von #Metastasen ⤵️ Wir gratulieren @jwinkler.bsky.social von der #MedUniWien zur Auszeichnung der @oeaw.bsky.social#Metastasen#MedUniWienit dem Johann Wilhelm Ritter von Mannagetta-Preis!

ER needs ATP for processes like protein quality control, but can't make its own. Here, how ATP is imported into the ER lumen and exchanged for ADP.

Finding faulty ribosomes: A new collaboration from the @kkostova.bsky.social Lab uncovers how cells cope with defective #ribosomes published in @cp-molcell.bsky.social. This could shed light on how failure to clear such ribosomes can lead to disease. Read more: bit.ly/3SlXxQZ

We are looking for PhD students using time resolved cryoEM or cryoET on topics of the ubiquitin proteasome system, fertility and immunity. However, there is freedom to shape projects in own ways.

Check out our new preprint, in which brilliant @alessandrick.bsky.social‬ revealed a novel function of the RNA-binding protein IGF2BP3 in regulating the unfolded protein response. Please see the wonderful thread by @alessandrick.bsky.social‬ for more detail! www.biorxiv.org/content/10.1...

Ubiquitin & Friends Fiesta in Vienna 2025 -- Final Call despite these challenging times for science, we look forward to gather for a lively meeting and share the joy of discovery. to join an exciting program and connect with fellow ubiquitinists sign up at www.protein-degradation.org/symposium/

IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.

Amazing story from #MolecularTherapeutics faculty @robzonculab.bsky.social with lead author @aakritijain.bsky.social describing membrane protein degradation in the lysosome. Congratulations!! www.science.org/doi/10.1126/...

~1 week left to register for the EMBO workshop on RNA meets protein decay! #EMBOrnaDecay Come join us for a fun time and invigorating scientific discussions in Vienna! meetings.embo.org/event/25-rna...

Super excited to share our latest work on deciphering the #Ubiquitin Code “𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀” @cp-molcell.bsky.social 1/8 www.cell.com/molecular-ce...

One week left to register and submit abstracts for being considered for talks at our upcoming #EMBO Meeting "RNA Meets Protein Degradation" in Vienna! Check out the program with a fantastic line-up of speakers, including keynotes by Rachel Green and Manu Hedge. meetings.embo.org/event/25-rna...

🎉 Today, we look back on a milestone moment in Perutz history! On this day in 2005, the rectors of the University of Vienna and the Medical University of Vienna, Georg Winckler and Wolfgang Schütz, signed the notarial deed, officially establishing the Max Perutz Labs. 🧬🎊 #MaxPerutzLabs20Years

And now for something slightly different…. I am thrilled that @isabellavoelkl.bsky.social PhD project is out on BiorXiv. I usually focus on chromatin, but Isa was brave enough to take on a very different project: centrioles and cilia in mouse embryonic development! www.biorxiv.org/content/10.1...

Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab! Thankful for any retweet! 🫶 imba.onlyfy.jobs/job/l6u2m980

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

Sign up now for EMBO | FEBS Lecture Course "Susan Lindquist School on Proteostasis" in Espoo, Finland, 16 – 19 September 2025 Abstract submission & registration deadline: 15 June meetings.embo.org/event/25-pro... #EMBOFEBSproteostasis #EMBOevents🧪

Sascha Gratzl from @univie.ac.at joined the lab of Elif Karagöz @gekaragoz.bsky.social at @maxperutzlabs.bsky.social to characterize the activation of the PERK branch of the unfolded protein response in vitro.

🚨New preprint alert!!! We show using #Celegans that mothers control the #ribosome levels of their offspring depending on their diet. Pioneered by fantastic Sigma Pradhan (not yet on 🟦). #worms biorxiv.org/content/10.1.... 🧵

🇯🇵 Congratulations to @shotarootsuka.bsky.social on receiving the Kazato Prize! 🏆 This award honors outstanding young Japanese researchers making significant contributions to electron microscopy research and development 👏🔬 Omedetō, Shotaro! @univie.ac.at

The registration for the 2025 Ubiquitin & Friends Symposium is open! We can't wait to welcome all our TPD friends in Vienna @martenslab.bsky.social @plantophagy.bsky.social @haselbachlab.bsky.social @clausenlab.bsky.social @gekaragoz.bsky.social @thewittysquare.bsky.social @georgwinter.bsky.social

Candidate PhD students. This is for you! We are recruiting a PhD student for our MSCA Doctoral Network on the topic of metabolic regulation of genome function and cell identity. !!! importantly: we will recruit a PhD student for our brand new lab at SciLifeLab in Stockholm

Happy to share our review on the cellular responses to RNA damage 🥂 Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social www.cell.com/cell/fulltex...

The breakneck pace and devastating impact of the Trump administration’s policy changes has researchers shocked. https://go.nature.com/3CMl75y

💫NEW: Kraft, Wilfling & co show that low-affinity cargo–receptor interactions promote #autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub and phagophore formation. www.nature.com/articles/s41...

We discovered 3 RNA families that form homo-oligomeric RNA-only complexes! Studying nature continues to expand my wildest imagination. Read about it: doi.org/10.1101/2024... Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu

Exciting #Master's thesis oppportunity in Parkinson's disease research @martenslab.bsky.social @maxperutzlabs.bsky.social 👇