🔬 Love science and keeping a lab running smoothly? Join the @leeboratory.bsky.social as a lab manager/research technician and help uncover how cells choose and maintain their identity 🧫 More information ➡️ tinyurl.com/y7a8he88

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

A proud moment for me and our lab. Sanya defended her thesis with flying colors. Thanks to the reviewers for the fruitful discussion and their feedback.

Take a look at this recently published paper in LSA: The unfolded protein response in progeria arteries originates from non-endothelial cell types @maxperutzlabs.ac.at @gekaragoz.bsky.social www.life-science-alliance.org/content/9/2/...

The Frankfurt Institute for Advanced Studies (FIAS) and the newly funded Cluster of Excellence SCALE are seeking several Independent Research Group Leaders to drive theoretical and computational research in molecular and cellular life science. fias.institute/de/das-fias/...

Progeroid endothelial cells do not show a robust activation of the unfolded protein response, contrary to what has been reported in other arterial cell types such as vascular smooth muscle cells @maxperutzlabs.ac.at, @gekaragoz.bsky.social www.life-science-alliance.org/content/9/2/...

Glad to have this finally published: www.sciencedirect.com/science/arti... lots of new data since the #preprint. If you are into selective #autophagy, #evolution, #proteostasis Please have a look!

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫 www.nature.com/articles/s41... A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

Join our vibrant scientific community @viennabiocenter.bsky.social! It’s an extremely supportive environment to start a lab 🚀 www.imp.ac.at/career/open-...

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

New paper alert! Scientists in Julius Brennecke’s lab at IMBA and Clemens Plaschka’s lab at @impvienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: https://imba.science/3Xl2hJ3

Big news! Group leader Sascha Martens has been awarded a prestigious @erc.europa.eu Synergy Grant for the collaborative project DegrAbility to explore how cells can better recycle harmful protein aggregates linked to diseases like Alzheimer’s ➡️ tinyurl.com/2zuz9jcf @univie.ac.at @meduniwien.ac.at

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct

This Halloween, we have a spooky evolutionary story for you. The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41... Here’s why I love this work — and why I think you’ll enjoy it too. 👇

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...

Our latest review is now online! 👇 @martenslab.bsky.social Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

🎉 Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the 🏅 Otto Warburg Medal 2026! Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨ #OWM #WeizmannInstitute @elsevierconnect.bsky.social

Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...

Quiescent cells stay alive by eating less. They downregulate amino acid transporters to match reduced demand. When this brake fails -> cell death & disease. More info in our new paper 👇

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9

RNA biology is a major research focus at the Perutz - and the new @fwf-at.bsky.social grants strengthen it even further 🙌 Elif Karagöz and Pavel Kovarik will investigate how RNA-binding proteins regulate cellular stress and immune responses ➡️ tinyurl.com/2s3f3mu8 @univie.ac.at @meduniwien.ac.at

A good day to remember John Gurdon’s school report from his biology master at Eton

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October. More info: www.imb.de/students-pos...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Opportunity for skilled hands and sharp minds - at any career stage! 💪 The Köhler Lab is seeking a full-time lab technician to support their research on nuclear envelope biology, chromatin regulation, and cellular stress resilience - apply here ➡️ tinyurl.com/bdfy3w2h

Thank you for including our Paper as a highlight! for anyone interested in the accompanying blog post: go.nature.com/4mFNYdb

Fantastic opportunity. Vienna rocks!

Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...

We are looking for a Master’s student to join a project on in vitro reconstitution of signaling networks in pathogen–host interactions: combine protein biochemistry, fluorescence microscopy & image analysis. Deadline: September 15. Find out more and apply here: ist.ac.at/en/job/maste...

💫NEW: Mauthe et al. find that protein aggregate clearance requires fragmentation of the aggregate by a chaperone module and a proteasomal regulatory particle for recruitment and clustering of selective #autophagy receptors to initiate phagophore formation. bit.ly/3JJeJPp

Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social www.cell.com/cell/fulltex...

📢 New preprint: Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes. We addressed a long-standing question that people debated already in the 1970s - but it still remained open: Do proteins in crystals move as they do in solution? We used ring flips to find out. 1/n

Exciting new work from Dagdas lab! Congrats to Alibek and all the team!

Excited to share our latest study in @natcomms.nature.com , where we characterize the chaperone function of the ER membrane protein complex (EMC)—supporting membrane protein biogenesis beyond insertion! 1/9 www.nature.com/articles/s41...

My colleagues are awesome!

Join us at the Perutz, part of the Vienna Biocenter! Opening for a full professorship in Molecular Mechanisms of Disease 👇🏻 @maxperutzlabs.bsky.social @viennabiocenter.bsky.social @univie.ac.at

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Molecular Mechanisms of Disease. More information ➡️ tinyurl.com/3yn883b8

👏 Big CONGRATS to @sramundo.bsky.social for receiving an FWF @fwf-at.bsky.social ASTRA Award 🌠✨ See all about it 👇

It is finally out! My first Science paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Dikic for all the support and trust ! 🫶. #RNA #Proteostasis #ubiquitin #autophagy #RP doi.org/10.1126/scie...

#TCTeAC ... what's more than organizing one conference? Two conferences! This one is more Day Science on biology of Argonaute proteins from prokaryotes to Metazoa. Great line up of invited speakers. Some special fun included!

Last call to apply for the Susan Lindquist School on Proteostasis EMBO-FEBS Lecture Course, 16-19 Sept 2025 in Espoo, Finland! Open for postdocs and PhD students. DL June 15! meetings.embo.org/event/25-pro...

Are you interested in doing a masters in RNA biology? We are accepting students for 2-years masters by research degree (1 year research, 1 year write up). Only 1 year tuition fees (£25k international, £5k home) fees include bench fees normally worth £4k. @biouea.bsky.social www.theakaylab.com

REFEREE 1: “I conclude with a simple, direct statement - this is the best paper I have read all year!” #TransparentPeerReview Co-evolving infectivity and expression patterns drive the diversification of endogenous retroviruses @juliusbrennecke.bsky.social et al www.embopress.org/doi/full/10....