One of the most-viewed PNAS articles in the last week is “Neurodevelopmental disorder–linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3′→5′ trimming.” Explore now: https://ow.ly/hwP450XxHM6 For more trending articles, visit https://ow.ly/q6Cl50XxHGN.

Just published! AGO syndrome mutants slow passenger ejection, leaving the guide’s 3′ end exposed to 3′→5′ exonucleases that generate tyRNAs. This atypical trimming may occur during periods of stress or viral infection, potentially leading to neurodevelopmental disorders. www.pnas.org/doi/10.1073/...

Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors! genesdev.cshlp.org/cgi/content/...

Excited to announce the submission of our CTA to the @mhragovuk.bsky.social to initiate a Phase 1 study of CITY-FXI, an investigational RNAi therapeutic targeting Factor XI w/ the potential to safely & effectively prevent blood clots without increasing bleeding risk. www.citytx.com/news/city-th...

Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)

Jacob Schwartz received an outstanding poster award at the Rustbelt RNA Meeting 2025🎉 Congrats👏👏👏

It’s nice to see Nature Biotech’s article featuring CityTX and my work! www.nature.com/articles/s41... * Phil is Yuki Tomari’s advisor, not mine. I had my postdoc training under Dinshaw Patel (MSKCC).

Today’s MLS Seminar Dr. Phil Zamore, Howard Hughes Medical Institute 4:10 — 5:05PM DHLRI 170

Argonaute conference #Argonaute2025 in Prague – researchers, clinicians & patient families coming together. Honored to co-organize this fantastic, inspiring meeting with amazing colleagues @svobodalab.bsky.social, @farmgirlphd.bsky.social & @curiousdina.bsky.social

in these mostly wretched times, you have to find joy wherever you can. last week my ad hoc band the Argonautes (me, Yuki Tomari, Germano Cecere) had a blast playing in Prague. we rocked some old and new songs, and can't wait to do it again in Toronto 2027!

Kicking off our third day of #argonautes2025 with a talk by Nobel Prize winner and all around amazing person, scientist, and mentor, Victor Ambros! 🐙

The Argonautes 2025 - we made a special gift for participants - a card set with 32 different Argonautes + an extension pack with four Nobel prize winners from the small RNA field. Mello, Fire, Ambros & Ruvkun as jokers :-) #argonautes2025

I will speak about “𝗚𝗲𝗻𝗲 𝗦𝗶𝗹𝗲𝗻𝗰𝗶𝗻𝗴 𝗯𝘆 𝗰𝗶𝘁𝘆𝗥𝗡𝗔𝘀" at RNA Collaborative on 𝗦𝗲𝗽𝘁. 𝟭𝟬𝘁𝗵! Zoom Registration:https://us02web.zoom.us/webinar/register/WN_G5a1Vp9oTvmF2NWKmdAGxw#/registration

Argonautes are coming :-) ... soon at @imgprague.bsky.social ... finishing preparations. Still missing a few things like drums, guitar, badges, beer ... but it's under control. I think. I hope. :-)) #argonautes2025

My team has updated our free database of POSTDOC fellowships. This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria. Download this updated and expanded database here: research.jhu.edu/rdt/funding-...

REMINDER: The registration deadline for ARGONAUTES 2025 is 31/7. It won't be extended. So, if you want to join us in Prague for the most important 🫣 Argonaute & RNA silencing meeting of the year, you have one week left! #microRNA #piRNA #RNAi

Biogen and City Therapeutics announce strategic research collaboration to develop select novel RNAi-based therapies. Congratulations to this #OhioStateStartup founded on technology developed by Kotaro Nakanishi

Exciting news from City! We’ve partnered with Biogen to develop select novel RNAi-based therapies leveraging our next-generation RNAi engineering technologies. Learn more: www.globenewswire.com/news-release...

My research group seeks a highly motivated Post-Bacc (or Tech). This position offers a unique opportunity to contribute to research on cleavage-inducing tiny RNAs (cityRNAs) to treat neurological and neuromuscular disorders, Cancer, Alzheimer's diseases, etc. u.osu.edu/cbcundergrad...

I'm honored that the Science Coalition highlights our research on cityRNAs as the science sparking American economic growth in 2025! www.sciencecoalition.org/2025/04/29/s...

Tulip festival in Ohio.

Argonautes 2025 will cover progress in: Structural insights Effector complexes: formation, composition & function Post-transcriptional silencing Transcriptional silencing & DNA cleavage Post-translational modifications and regulations Medical aspects 27-30/8/2025 argonautes.img.cas.cz Pls RT!

Why NIH/NIGMS funding of basic research matters with our latest work now out in @cp-cellreports.bsky.social sky.social. We solved a >30-year-old mystery of what transcription factor drives the Flamenco piRNA cluster required for female Drosophila fertility. /1 www.cell.com/cell-reports...

What was that you said? You are looking for new #RNA research to read in the weekend? You are in luck! 📣 📣 Check out the new preprint from our lab!!!! 📣 📣 www.biorxiv.org/content/10.1...

In the midst of everything it feels particularly appropriate to highlight all the amazing #RNA research taking place at #NIH! Follow this thread to join us for our biannual #RNASymposium, this year featuring intramural research superstars!

Check out the latest study from our lab, led by @mhall98.bsky.social : www.biorxiv.org/content/10.1... (1/2)

openRxiv has arrived! We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences. openrxiv.org/introducing-... #openRxiv #OpenScience #Preprints #bioRxiv #medRxiv

ARGONAUTES 2025 - argonautes.img.cas.cz The grassroot meeting of Argonaute afficionados lives on! The registration for Argonautes 2025 is open. Join us in Prague at the Institute of Molecular Genetics @imgprague.bsky.social during 27-30/8, 2025. Check #Argonautes2025 for updates.

#Argonautes2025 update ... it will happen this August (27-30) @imgprague.bsky.social. Our ITs are finishing and testing the website, the registration will open on March 1st. More info will be provided later (once all speakers reply to my e-mail, just saying, not pushing 😁). Poster announcement:

Looking for postdocs in regulatory RNAs in an international research environment. If you’re excited about using cutting-edge biophysical and structural biology (NMR, RNA probing), we’d love to hear from you. petzoldlab.com/join-our-rna...

Interested in computational NMR? Join us in beautiful Switzerland in June! Many slots for selected talks and great hiking opportunities. GRC conference 1-6th of June with GRS ( @chrisdkolloff.bsky.social and Stase) on 30.05. please share @nmr900.bsky.social www.grc.org/computationa...

Additionally, we designed binders against another large nuclease – the prokaryotic Argonaute protein. Together with @patrickbarendse.bsky.social and Daan Swarts we show that are our binders can inhibit Argonaute cleavage activity!

My NMR center is looking for a new staff scientist. It’s an amazing work environment at Uppsala University, Sweden. Come join us! www.uu.se/en/about-uu/...

Hofstenia miamia is an emerging model species for regeneration and embryology. We report this in-depth identification and developmental profiling of Hofstenia microRNAs.

Thanks, @katjapetzold.bsky.social, for having me as the opponent! It was a great experience. Congrats on your new Ph.D.!

Perfect timing to visit Stockholm!