How will our increasingly deep understanding of diverse immune archetypes in cancers guide our search for cures? This perspective describes a future in which we discover drugs based on transitions of tissue/immunobiology through intermediate states, to health. authors.elsevier.com/a/1llig5TA51...

Intravital imaging of pulmonary lymphatics in #inflammation and metastatic cancer. A new imaging approach developed by Simon Cleary (@simoncleary.bsky.social), Longhui Qiu, Mark Looney and colleagues: https://buff.ly/41msQjZ @maxkrummel.bsky.social

Tired of traditional peer review?  Join the Discovery Stack Pilot study to help reshape scientific publishing!  Contribute as a Reviewer or an Author. Learn more here: bit.ly/DiscoverySta... #ScienceRevolution #PeerImprovement #DiscoveryStackPilot #immunosky

Many tx studies (Mujal... Azizi…)failed to validate M1/M2 signatures in vivo. Many also suspected that calling cells bearing ‘prototypical M2’ genes ‘‘immunosuppressive’ was simplistic + incorrect. Nonetheless many (us too!) leaned on the simplification. Arja addresses the reality head on…thnx JEM

Are so-called 'M2-like' CD206+ macrophages immunosuppressive? On the contrary, we find that they are critical for T cell mediated anti-tumor immunity. Arja Ray drove this study with help from Ken Hu, Kelly Kersten, Alexis Combes and others www.biorxiv.org/content/10.1...