'B' frequently happens and would grind my gears if it weren't so funny.

Great to hear good news on reproducibility!

Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells. www.embopress.org/doi/full/10....

Assaying lung samples using spectral flow cytometry? Check out AutoSpectral:

Some good weekend reading. If you thought we’d put the final nails in the coffin of ivermectin as a Covid treatment, you’d be right. But this Perspective goes the extra mile to put the coffin in a lead-lined box and sink it to the bottom of the ocean. 🧵

It’s official! 🎉 Our latest paper on the role of the extracellular matrix (ECM) in megakaryopoiesis is out in @elife.bsky.social ! 🔗 elifesciences.org/articles/104... I’m thrilled to share this story with you in a short thread 👇

BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

PhD scholarships available incl. a project with me & Alex Ivetic at King's College London - great programme, facilities, city, colleagues! Please forward to any suitable undergraduates/MSc students/research assistants. Info: kcl-mrcdtp.com/project/enha...

Pleased to see this out now in @jem.org 🔬 We characterise the early immune response during M. tuberculosis infection in mouse models and demonstrate a detrimental role for type I interferon activated neutrophils in TB lesions. Thanks to all involved @crick.ac.uk and i3S, Porto.

🚨 New paper in @jclinical-invest.bsky.social! Kidney lymphatics are a promising target in transplant rejection 🗺️ In rejection, lymphatics expand and adversely remodel ⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system www.jci.org/articles/vie... 1/4

New postdoc position available in my lab team! For microscopy of immune cells: please apply or repost or pass on: www.imperial.ac.uk/jobs/search-...

PhD opportunity: please contact me if you know someone with a strong interest in respiratory science who would like to apply for a Sir David Jack PhD scholarship. Details here: www.bps.ac.uk/membership-a... Course fee waivers possible for outstanding international students.

Thrilled that our paper is in print @science.org!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight

Vav-Cre has been transformative for the field, but it is a pain in the a** of a line to work with. Has anyone made a better pan-hematopoietic line? Which one? How specific is it?

Needing some help from all the mouse doctors around! Does anyone know who might keep a B10.D2 mouse colony in the UK (or even mainland Europe)?

New postdoc position in my lab investigating interstitial lung abnormalities (ILA) and mechanisms driving early lung fibrosis @kingscollegelondon.bsky.social @rbandh.bsky.social @gstt-nhs.bsky.social @crick.ac.uk Closing date 7th August. Please do consider applying! my.corehr.com/pls/coreport...

Enjoyed writing about this important discovery of a 'sluice gate' system enabling lymphatic vessels in the lungs to sense injury and respond by increasing uptake of fluid from the spaces around blood vessels and airways: rdcu.be/ewCMo Congrats Chou Chou, Hasina Outtz Reed and colleagues!

Very excited to share our new study comparing the metabolic profile of patient-derived CAR-T cells ex vivo. CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients: Cell Reports www.cell.com/cell-reports...

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...

Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...

Our Review just published in Thorax takes a fresh look at how ageing-associated cellular changes lead to epithelial dysfunction and vulnerability, priming the development of pulmonary fibrosis. @jennydickens41.bsky.social @lpearmain.bsky.social thorax.bmj.com/content/earl...

Public access link: rdcu.be/er3Iq

Interested in new ways to study interactions between cancers and the immune system? If yes, have a read of this article on mine and Longhui Qiu's recent work, featured in Nature Reviews Cancer's Tools of the Trade series: rdcu.be/er3Iq

For #FluorescenceFriday I'm sharing the fantastic work of postdoc Sarah McLarnon! A follow up to our '23 Development paper where we asked: Does precise vascular patterning matter for function and what happens after ischemic injury? The results were surprising! journals.physiology.org/doi/full/10....

My PhD student isolated some liver endothelial cells and got this brilliant image showing the gradual transition of health EC to full EndMT in a very satisfying circle. #fluorescencefriday #fibrosis

Need help with bioimage analysis? Contact the UK Euro-BioImaging Node to see how we can help! www.eurobioimaging-access.eu/nodes/uk-node

Very excited about this paper that came online today! InterpolAI can predict missing image data from light microscopy to H&E to MRI for improved volumetric imaging and image analysis.

You did scRNA-seq of the lung, but can't decide on stromal annotation? Or trying to pick up Xenium probes? We got you! We wrote a review of stromal heterogeneity in the adult lung delineated by recent single-cell genomics studies. journals.physiology.org/doi/full/10....

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations. Read our work in ‪@natcardiovascres.nature.com by Marle Kraft et al. rdcu.be/enhST

🚨 We did it! Our latest work—led by my lab and the @lloydlab.bsky.social is now published in Nature Immunology! 🎉 Using single-cell spatial transcriptomics, we provide the first map of the airway wall. 🔗 www.nature.com/articles/s41... #spatialbiology #asthma #mastcells #lungimmunology

*Paid internship opportunity* @biologists.bsky.social is looking for a 3-month intern this summer to work across the Node, @prelights.bsky.social and @focalplane.bsky.social If you're interested in #SciCommm & #publishing, and have the right to work in the UK, apply by 5 June 👇

Amazing imaging and useful research from @daniyaljafree.bsky.social !

Our work featured on the cover of this month's J Exp Med!

One week left to apply! Join my lab in beautiful Vienna for your #PhD studying #metastasis.

🚨 Exciting news for #UKCellMicro2025! The meeting is now supported by the EMBO Young Investigator Programme We’re thrilled to have their backing for this year’s meeting. 🌟 🔗 Full details & programme: www.ukcellmicro.org #CellMicro #ECR #EMBO

Fancy an academic job in London? Apply below and come join us at our amazing institute! 👏🧪🧠 #PainResearch #PainScience

Thrilled to share a new paper from my PhD in David Long’s lab at UCL, published in the Disease Models & Mechanisms journal! doi.org/10.1242/dmm.... We studied kidney microvasculature in polycystic kidney disease (PKD), the most common genetic cause of kidney failure (1/5)

Excellent study putting together important pieces of the puzzle of why lymphatic endothelial cells resemble puzzle pieces! 🧩

We are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcome in patients with ARDS @wwiem-qub.bsky.social #ARDS #criticialcare - any questions please get in touch! (open to UK and RoI) www.findaphd.com/phds/project...

Nice news feature on Cathi Conrad's identification of a reservoir of functional haematopoietic stem cells in human lungs! www.ucsf.edu/news/2025/02/429531/how-our-lungs-back-bone-marrow-make-our-blood

Awestruck by these cage-like structures that regulate escape of megakaryocytes from bone marrow into blood vessels. Congratulations to authors of this study, which I see is now also available as a reviewed preprint at eLife: elifesciences.org/reviewed-preprints/104963v1

Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer @jem.org @simoncleary.bsky.social doi.org/10.1084/jem....

Check out our movie featured as Biomedical Picture of the Day! 'Bluetorial' in preparation!

🚨 We have TWO exciting open positions in our lab! 🚨 We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as: 🔬 Research Assistant www.kennedy.ox.ac.uk/jobs/researc... 💻 Bioinformatics Postdoc www.kennedy.ox.ac.uk/jobs/bioinfo... 📢 Please share!

UK academics: If you know a talented undergraduate from a disadvantaged background who is interested in imaging research, encourage them to apply for these funded summer placements:

A role for the druggable kinase TNIK in promoting vascular leak in inflammation! Grateful to have had the opportunity to contribute to this study: science.org/doi/10.1126/sciadv.adk6583

1/x Online now: Our work on platelet aging and inflammation in @bloodjournal.bsky.social led by superstar PhD student Afra Anjum: ashpublications.org/blood/articl...

Neutrophils (red) and Platelets (cyan) chasing each other in the murine ischemic stroke brain... (1/2 reduced speed)

Congrats to Farsh Moussavi-Harami for discovering that deficiencies in SHP-1 (Ptpn6) lead to vasculitis and inflammatory bleeding in lung infections, and that increasing SHP-1 activity might be a useful way to suppress harmful neutrophil responses!