🚨 New paper in @jclinical-invest.bsky.social! Kidney lymphatics are a promising target in transplant rejection 🗺️ In rejection, lymphatics expand and adversely remodel ⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system www.jci.org/articles/vie... 1/4

New postdoc position available in my lab team! For microscopy of immune cells: please apply or repost or pass on: www.imperial.ac.uk/jobs/search-...

PhD opportunity: please contact me if you know someone with a strong interest in respiratory science who would like to apply for a Sir David Jack PhD scholarship. Details here: www.bps.ac.uk/membership-a... Course fee waivers possible for outstanding international students.

Thrilled that our paper is in print @science.org!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight

Vav-Cre has been transformative for the field, but it is a pain in the a** of a line to work with. Has anyone made a better pan-hematopoietic line? Which one? How specific is it?

Needing some help from all the mouse doctors around! Does anyone know who might keep a B10.D2 mouse colony in the UK (or even mainland Europe)?

New postdoc position in my lab investigating interstitial lung abnormalities (ILA) and mechanisms driving early lung fibrosis @kingscollegelondon.bsky.social @rbandh.bsky.social @gstt-nhs.bsky.social @crick.ac.uk Closing date 7th August. Please do consider applying! my.corehr.com/pls/coreport...

Enjoyed writing about this important discovery of a 'sluice gate' system enabling lymphatic vessels in the lungs to sense injury and respond by increasing uptake of fluid from the spaces around blood vessels and airways: rdcu.be/ewCMo Congrats Chou Chou, Hasina Outtz Reed and colleagues!

Very excited to share our new study comparing the metabolic profile of patient-derived CAR-T cells ex vivo. CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients: Cell Reports www.cell.com/cell-reports...

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...

Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...

Our Review just published in Thorax takes a fresh look at how ageing-associated cellular changes lead to epithelial dysfunction and vulnerability, priming the development of pulmonary fibrosis. @jennydickens41.bsky.social @lpearmain.bsky.social thorax.bmj.com/content/earl...

Public access link: rdcu.be/er3Iq

Interested in new ways to study interactions between cancers and the immune system? If yes, have a read of this article on mine and Longhui Qiu's recent work, featured in Nature Reviews Cancer's Tools of the Trade series: rdcu.be/er3Iq

For #FluorescenceFriday I'm sharing the fantastic work of postdoc Sarah McLarnon! A follow up to our '23 Development paper where we asked: Does precise vascular patterning matter for function and what happens after ischemic injury? The results were surprising! journals.physiology.org/doi/full/10....

My PhD student isolated some liver endothelial cells and got this brilliant image showing the gradual transition of health EC to full EndMT in a very satisfying circle. #fluorescencefriday #fibrosis

Need help with bioimage analysis? Contact the UK Euro-BioImaging Node to see how we can help! www.eurobioimaging-access.eu/nodes/uk-node

Very excited about this paper that came online today! InterpolAI can predict missing image data from light microscopy to H&E to MRI for improved volumetric imaging and image analysis.

You did scRNA-seq of the lung, but can't decide on stromal annotation? Or trying to pick up Xenium probes? We got you! We wrote a review of stromal heterogeneity in the adult lung delineated by recent single-cell genomics studies. journals.physiology.org/doi/full/10....

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations. Read our work in ‪@natcardiovascres.nature.com by Marle Kraft et al. rdcu.be/enhST

🚨 We did it! Our latest work—led by my lab and the @lloydlab.bsky.social is now published in Nature Immunology! 🎉 Using single-cell spatial transcriptomics, we provide the first map of the airway wall. 🔗 www.nature.com/articles/s41... #spatialbiology #asthma #mastcells #lungimmunology

*Paid internship opportunity* @biologists.bsky.social is looking for a 3-month intern this summer to work across the Node, @prelights.bsky.social and @focalplane.bsky.social If you're interested in #SciCommm & #publishing, and have the right to work in the UK, apply by 5 June 👇

Amazing imaging and useful research from @daniyaljafree.bsky.social !

Our work featured on the cover of this month's J Exp Med!

One week left to apply! Join my lab in beautiful Vienna for your #PhD studying #metastasis.

🚨 Exciting news for #UKCellMicro2025! The meeting is now supported by the EMBO Young Investigator Programme We’re thrilled to have their backing for this year’s meeting. 🌟 🔗 Full details & programme: www.ukcellmicro.org #CellMicro #ECR #EMBO

Fancy an academic job in London? Apply below and come join us at our amazing institute! 👏🧪🧠 #PainResearch #PainScience

Thrilled to share a new paper from my PhD in David Long’s lab at UCL, published in the Disease Models & Mechanisms journal! doi.org/10.1242/dmm.... We studied kidney microvasculature in polycystic kidney disease (PKD), the most common genetic cause of kidney failure (1/5)

Excellent study putting together important pieces of the puzzle of why lymphatic endothelial cells resemble puzzle pieces! 🧩

We are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcome in patients with ARDS @wwiem-qub.bsky.social #ARDS #criticialcare - any questions please get in touch! (open to UK and RoI) www.findaphd.com/phds/project...

Nice news feature on Cathi Conrad's identification of a reservoir of functional haematopoietic stem cells in human lungs! www.ucsf.edu/news/2025/02/429531/how-our-lungs-back-bone-marrow-make-our-blood

Awestruck by these cage-like structures that regulate escape of megakaryocytes from bone marrow into blood vessels. Congratulations to authors of this study, which I see is now also available as a reviewed preprint at eLife: elifesciences.org/reviewed-preprints/104963v1

Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer @jem.org @simoncleary.bsky.social doi.org/10.1084/jem....

Check out our movie featured as Biomedical Picture of the Day! 'Bluetorial' in preparation!

🚨 We have TWO exciting open positions in our lab! 🚨 We are looking for talented, highly motivated, and collaborative individuals to join our dynamic team as: 🔬 Research Assistant www.kennedy.ox.ac.uk/jobs/researc... 💻 Bioinformatics Postdoc www.kennedy.ox.ac.uk/jobs/bioinfo... 📢 Please share!

UK academics: If you know a talented undergraduate from a disadvantaged background who is interested in imaging research, encourage them to apply for these funded summer placements:

A role for the druggable kinase TNIK in promoting vascular leak in inflammation! Grateful to have had the opportunity to contribute to this study: science.org/doi/10.1126/sciadv.adk6583

1/x Online now: Our work on platelet aging and inflammation in @bloodjournal.bsky.social led by superstar PhD student Afra Anjum: ashpublications.org/blood/articl...

Neutrophils (red) and Platelets (cyan) chasing each other in the murine ischemic stroke brain... (1/2 reduced speed)

Congrats to Farsh Moussavi-Harami for discovering that deficiencies in SHP-1 (Ptpn6) lead to vasculitis and inflammatory bleeding in lung infections, and that increasing SHP-1 activity might be a useful way to suppress harmful neutrophil responses!