We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6...

UK-based cell biologist? Interested in membrane trafficking? Want to find a conference? Looking for a job (PI, postdoc...)? Do link to www.ukmembranetraffic.com, where @jezcarlton.bsky.social and Chris Stefan (not here?) do sterling work

Sad to hear of the loss of Richard Lehman. Grateful to him and @raj-mehta.bsky.social for recording this podcast - an excellent teaching resource: creators.spotify.com/pod/profile/...

Happy to share that our latest work on VEGFR2 in lymphatic endothelium is published @natcomms.nature.com “VEGFR2 is required for VEGF-C–VEGFR3–PI3Kα-mediated sprouting lymphangiogenesis” tinyurl.com/47bns9pp This project has been a long journey for the lab @taijamakinenlab.bsky.social , A thread.

🔬 PhD position at Imperial College London! Uncover how pericytes, mysterious vascular cells, drive asthma inflammation. Use spatial transcriptomics, 3D imaging & transgenic models to unlock new therapies. 3-year funded PhD | Oct 2026 start 👉 www.findaphd.com/phds/project... 📧[email protected]

Happy #FluorescenceFriday. I feel so lucky to get to work with these weird and curious primary macrophages from 🐸. They exhibit myriad different morphologies and behaviours, including spinning endlessly and stationary, kinda like progenitor cells under compression from 🐟. Also actomyosin is strong!

Great to see how this research into mechanisms of neutrophil-assisted breast cancer metastasis has developed! Updates summarised in a postlight: doi.org/10.1242/prel... @prelights.bsky.social

Thrilled to share the first paper from the lab, out now in Molecular Cell! A wonderful collaboration with @thurstonlab.bsky.social bridging Salmonella host-pathogen interactions and regulatory genomics - two of my favourite things in one story. www.cell.com/molecular-ce... 🦠 🧵1/10

Thank you to all the fantastic students, supervisors, co-organisers and advisors who took part in this (very) oversubscribed Summer Studentship scheme. Delighted that it has opened doors for the students involved!

After a negative decade - finally a good year for IPF patients - Inhaled Treprostinil associated with a smaller decline in FVC & fewer clinical-worsening events (but also ~30%). Still no improvement - but let’s all hope momentum continues #CurePF4ALL www.nejm.org/doi/full/10....

Do we study the right biology after myocardial infarction (MI)? • Surgery in standard mouse model disrupts bone marrow & masks MI-specific immune responses • Minimally invasive model better reflects patient immune responses & reveals immature neutrophils worsen heart function tinyurl.com/MImodels

This was so fun! Thank you so much to @cindyleifer.bsky.social and @microbetv.bsky.social for the opportunity to discuss pregnancy immunology ✨

Ok pals. Looking to move all my teaching materials open and online, and am developing new modules that I want to start off this way. Content = reading, quizzes, videos, and code tutorials. Opinions on the best platform? Good examples of best practice I can steal from? Many thanks.

Few but mighty - check out this cool study implicating gamma delta T cells in controlling macrophage responses in lung cancer!

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

@simoncleary.bsky.social, Longhui Qiu, Mark Looney et al. developed a new #intravital technique for imaging pulmonary lymphatics. rupress.org/jem/article/... 📘 In our #Lymphatics collection: rupress.org/jem/collecti...

Happy to share a write-up of our recent publication @natcomms.nature.com demonstrating how circumferential actomyosin-driven endothelial cell contractions constrict vessel diameter, providing insights into mechanisms of normal vessel remodelling and CCM. www.bdr.riken.jp/en/news/rese...

The rules of immunity are different in early life! Lead author Dr. Yue Xing finds that early life DCs sense allergens and trigger inflammation directly in skin. This in-situ activation state emerges from a developing HPA and low glucocorticoids. #Naiklab @nature.com www.nature.com/articles/s41...

www.biorxiv.org/content/10.6... Excited to share our new preprint: Not all microglia are the same. In this study, we identify a specialized ApoE-dependent program in the median eminence positioning microglial lipid metabolism as a driver of hypothalamic adaptation to nutritional stress.

I am looking for an Illustrator to help with making schematics and diagrams. Might anyone guide me on who to contact? Thanks #science #Illustration #Academia

Cool to see data backing up an anecdote I have been told - that short (1 hour) formaldehyde fixation can be better than longer (6 hours+) fixation for staining some antigens:

Anyone ever tried super glue (cyanoacrylate) for mounting coverslips with stained mammalian cells, to be used for fluorescence microscopy? I'm looking for ways to conserve microscopy samples for a looooooong time...

Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...

Useful article addressing an often-overlooked way in which research impacts the environment:

Good news!! Oral Nalbuphine reduces cough count baseline by ~50 % in Idiopathic Pulmonary Fibrosis–Associated Cough jamanetwork.com/journals/jam...

Nice evidence for a role for the ectonucleotidase CD39 in limiting pulmonary thromboembolism in sickle cell disease with striking footage of this process!

"Does this handle survival plots too?" asked @load-dependent.bsky.social Yes it does! See below for RECOVERY. Only catch is it doesn't like the dotted lines that appear in some survival plots (because the PDF geometry treats this as lots of little separate lines rather than one single entry).

Tumor-draining Lymph nodes - Online event next week! follow the link to register On January 13 from 11:30 – 1:00 pm ET, @thelundlab.bsky.social , Dr. Ivan Maillard, @actonlab.bsky.social , & Dr. Burkhard Ludewig will discuss lymph node remodeling in cancer: events.cancer.gov/dcb/tdln #TLDNForums

Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!

This is cool stuff - imaging covalent drug biodistribution using tissue clearing methods

Please check out our job post @biologists.bsky.social! We are recruiting a Postdoc Scientist to develop cutting-edge tools and techniques for bioengineering human lymphatic networks, as part of an interdisciplinary collaboration with the group of Prof Dame Molly Stevens! bit.ly/3La9idq

Enjoyed learning about the importance of Batf3 for IL-17-producing γδ T cell responses that protect neonates during influenza infection! Congrats Pedro and colleagues!

Are you an emerging clinical academic leader in respiratory medicine? Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career! Get in touch if you’d like to discuss. www.cam.ac.uk/jobs/assista...

Fun revisiting this study and looking at the eLife peer review system for this postLight:

Heading to BSI congress? Plan on attending this all-star session, Thursday at 11AM, chaired by @doreenlau.bsky.social and me!

Outstanding PhD fellowship call OPEN for excellent students. lacaixafoundation.org/en/doctoral-... This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels). If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!

Looking forward to chairing a session with @doreenlau.bsky.social at the British Society for Immunology Congress next week! Great line-up of speakers. Send an email if you would like to meet at or around the conference.

We are recruiting a Reader/Professor of Immunobiology at @kingslsm.bsky.social . This is a unique opportunity to shape basic immunology at @kingscollegelondon.bsky.social . Please RP. www.kcl.ac.uk/jobs/131447-...

'B' frequently happens and would grind my gears if it weren't so funny.

Great to hear good news on reproducibility!

Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells. www.embopress.org/doi/full/10....

Assaying lung samples using spectral flow cytometry? Check out AutoSpectral:

Some good weekend reading. If you thought we’d put the final nails in the coffin of ivermectin as a Covid treatment, you’d be right. But this Perspective goes the extra mile to put the coffin in a lead-lined box and sink it to the bottom of the ocean. 🧵

It’s official! 🎉 Our latest paper on the role of the extracellular matrix (ECM) in megakaryopoiesis is out in @elife.bsky.social ! 🔗 elifesciences.org/articles/104... I’m thrilled to share this story with you in a short thread 👇

BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

PhD scholarships available incl. a project with me & Alex Ivetic at King's College London - great programme, facilities, city, colleagues! Please forward to any suitable undergraduates/MSc students/research assistants. Info: kcl-mrcdtp.com/project/enha...

Pleased to see this out now in @jem.org 🔬 We characterise the early immune response during M. tuberculosis infection in mouse models and demonstrate a detrimental role for type I interferon activated neutrophils in TB lesions. Thanks to all involved @crick.ac.uk and i3S, Porto.

🚨 New paper in @jclinical-invest.bsky.social! Kidney lymphatics are a promising target in transplant rejection 🗺️ In rejection, lymphatics expand and adversely remodel ⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system www.jci.org/articles/vie... 1/4

New postdoc position available in my lab team! For microscopy of immune cells: please apply or repost or pass on: www.imperial.ac.uk/jobs/search-...