A nice discussion here of our work on the early immune response in M. tuberculosis infection and the great recent paper from @bengern.bsky.social et al

Stetsenko et al. show that TCR clonotypes from individuals latently infected w/ M. #tuberculosis demonstrate dominant but not exclusive recognition of infected #macrophages, specificity for type VII secretion system substrates, & expression of canonical effector programs rupress.org/jem/article/...

Pleased to see this out now in @jem.org 🔬 We characterise the early immune response during M. tuberculosis infection in mouse models and demonstrate a detrimental role for type I interferon activated neutrophils in TB lesions. Thanks to all involved @crick.ac.uk and i3S, Porto.

Great day out talking all things infection at #LINEsymposium2025 today. Thanks for having me!

Looking forward to presenting our work on early mechanisms of TB susceptibility at the @londoninfectionecr.bsky.social Symposium in June 🦠🔬