New preprint 🚨 We systematically measured 17 million phospho-specific dose-response curves (133 kinase inhibitors × 5 cell lines) to decrypt the kinases that shape the human phosphoproteome. We show that drug perturbation potency (not effect size) links kinases to substrates while controlling FDR.

Exited to share our latest work! Out now in @natcomms.nature.com Koina aims to transform how #proteomics uses machine learning. You no longer need to be a tech wizard to use ML and now can easily run #ML models. Integrated with FragPipe, Skyline and EncyclopeDIA! www.nature.com/articles/s41...

Hello Toronto!🍁The Terrific TUM Team is happy to be attending #HUPO2025. Kusterlab, Wilhelmlab and Leelab have a diverse set of presentations for you that we can't wait to share 🤓. We're excited to spend the next days reuniting with old friends and making new connections. See you there!

Our new review paper about Pathway-Centric PTM Data Analysis is out this week in #Proteomics! We cover databases, enrichment tools, software for pathway reconstruction, and full-fledged platforms that help to interpret high-throughput PTM datasets. Check it out here: doi.org/10.1002/pmic...

New preprint: We isolate peptide–RNA photo-crosslinks with tunable RNA chains from living cells for mass spec. This maps over 4,700 crosslinking sites across 744 proteins and offers the first glimpse into the RNA sequences in crosslinks by MS. Read here: doi.org/10.1101/2025...

New Preprint: High-intensity 365 nm irradiation accelerates photoreactions in living cells by up to 1000×. We show protein–drug 💊, –protein 💪, –DNA 🧬, –RNA 🧬 crosslinking within seconds, and analysis by #massspec for #proteomics, #chembio, #chromatin and #RNAbiology. www.biorxiv.org/content/10.1...

Thanks @tum.de for highlighting Jakob's recent paper in @cellpress.bsky.social in the university news: www.ls.tum.de/en/ls/public... If you haven't had the chance to read the publication, you can check it out here: doi.org/10.1016/j.ce...

Excited to share our latest work published in #ScienceSignaling! 🚀 www.science.org/doi/10.1126/... (1/4)

Kusterlab is looking for a new member to join our Bioinformatics team. Apply now if you're interested in working with us!

Another day of #ASMS2025 in Baltimore, and we're back with another poster! Make sure to visit Flo today - he'll present the latest insights from his large-scale decryptM project. Go #TeamMassSpec!

Hello Baltimore! We're looking forward to #ASMS2025 and all the new developments in mass-spec and proteomics. If you're attending today, make sure to check out @msleelab.bsky.social's poster on citrullination in multiple sclerosis. Sophia 'Lapo' Laposchan is excited to see you there!

🚨Our new paper is online🚨 We use zero-distance⚡photo-crosslinking⚡to reveal direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes. #DNA #Chromatin #Proteomics www.cell.com/cell/fulltex...

New paper! Our chemoproteomic survey of phenylhydroxamic acids identifies the first drug-like inhibitors for nucleotide-binding protein HINT1 and nucleoside kinases NME1-4. On top, we found probes for the HDAC inhibitor off-target MBLAC2. Check out the open-access article! tinyurl.com/yh92vh6b

New paper! Our chemoproteomic survey of phenylhydroxamic acids identifies the first drug-like inhibitors for nucleotide-binding protein HINT1 and nucleoside kinases NME1-4. On top, we found probes for the HDAC inhibitor off-target MBLAC2. Check out the open-access article! tinyurl.com/yh92vh6b

One algorithm to rule them all? CHIMERYS bridges the gap — DDA,DIA and PRM — together at last! With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible. doi.org/10.1038/s41592-025-02663-w #KusterLab #WilhelmLab #MSAID #Proteomics

3/2025 Issue ➡️ www.embopress.org/toc/17444292... metabolic mutations drive bacterial antibiotic resistance evolution, prior knowledge for GRN inference, HPA drugs fail mood disorder clinical trials Cover: ATR kinase inhibitors work together to overcome chemoresistance @kusterlab.bsky.social

🚀 Exciting news from our lab! Our latest paper has been featured on the cover of @molsystbiol.org - "Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response" by Höfer et al.! 🧬🎉 doi.org/10.1038/s44320-025-00085-6 (1/4)

🎉 We're happy to announce that our latest project was published in @naturecomms.bsky.social this week: PTMNavigator, a #bioinformatics web platform for in-depth analysis of post-translational modification (PTM) perturbation datasets. 📄 doi.org/10.1038/s414... (1/6)

(1/5) 🚨 New Research Alert! 🚨 Excited to share our latest work in @embojournal.bsky.social "Towards routine proteome profiling of FFPE tissue: insights from a 1,220-case pan-cancer study" ✨ doi.org/10.1038/s443... 📌 Key Highlights:

That's a wrap on #HUPO2024! Kusterlab, Leelab, Wilhelmlab, and BayBioMS had an awesome time in Dresden. It was good to meet so many familiar and new faces in the community. See you next time! https://t.co/n306Mxe1fw

#HUPO2024 starts tomorrow and the Terrific TUM Team is ready! Kusterlab, Wilhelmlab (@wilhelm_compms), Leelab (@msleemslab) and BayBioMS (@BayBioMS) have printed their posters and prepared their talks, and we're very excited for the next days. See you in Dresden! https://t.co/RtEIuAOLok

Shoutout to our colleagues at @proteomicsdb who are working overtime to solve this!

ProteomicsDB has had some downtime lately because of hardware issues. We're sorry for that and promise that it will be up and running again soon! https://t.co/kN4uJ2gMxA

... and it's back: https://t.co/1tFPnJWsyv

Our friends at https://t.co/1tFPnJWsyv are rolling out an update. Stay tuned for new content and features 👀 https://t.co/fpp2LUm3NI

Final Day of #ASMS2024 in Anaheim, but the Terrific TUM Team is far from done! Ludwig from Wilhelmlab will tell you all about Koina today. And at their posters, meet Flo (Kusterlab), Joel (Wilhelmlab), and Miri (@BayBioMS). See you there! One final time: Go #TeamMassSpec! https://t.co/yeX48Go2nZ

Here's to another day of exciting posters and talks at #ASMS2024! Kusterlab and @msleemslab are looking forward to meeting you! https://t.co/ls0R8hhQfu

You're interested in Computational Mass Spec? We got you covered! Check out our three posters today, presenting the latest updates from SIMSI, Prosit, and Oktoberfest! See you at #ASMS2024! 🧪+💻=😍 https://t.co/XJfps6pwWT

What's up Anaheim! The Terrific TUM Team, aka Kusterlab, Wilhelmlab, and Leelab, is excited for #ASMS2024. Here is our program for the next few days. We hope to meet many of you there and are excited to check out all of your presentations! Let's go #TeamMassSpec https://t.co/KoI40riq9A

Another #decryptM story out! 💪 Congrats to Yun and co-authors! 🥳 Our latest study in @CellReports deciphers KDAC inhibitor action through... (1/2)

You can interactively explore the data in the accompanying ShinyApp (https://t.co/QyYpBtBIDW) as well as on ProteomicsDB (https://t.co/jUdFpnnbTH) (4/4)

We are happy to announce that decryptE is out, another step towards better understanding of drug MoAs. 🎉After elucidating the target space of drugs and how they dose-dependently alter PTMs in cells (decryptM),... (1/4)

...and another new Preprint coming right on its heels! This time by Jakob Trendel and colleagues. https://t.co/EIyIomahOS

Check out our new Preprint, authored by @Stefanie_Hoefer et al.! https://t.co/kWszLj53k1

Some impressions from #DGMS2024 Congratulations to the winners of the Wolfgang Paul Study Awards (Sarah Brandtner and @kimgreis), and a big thank you to the @TU_Muenchen helper team! https://t.co/ODlog91bK2

Hello again #DGMS2024! We're ready for the next day of #TeamMassSpec! Today, Cory will show you her work on peptide ID and Quant based only on MS1 spectra 🤯 Later, you can meet and greet no less than 7 of us at their posters. See you there! 👋 https://t.co/53fp3PYVjg

Johanna is about to kick off with her talk about coupling the timsTOF HT with a micro-flow LC. In the afternoon, make sure to check out the posters of Shuyao, Armin, and Andi. See you at #DGMS2024 #TeamMassSpec https://t.co/uy00m9Qqbr

We are happy to see CurveCurator and its "relevance score" highlighted in the bigger picture of omics data analysis. https://t.co/LxN7ZvvQ4q. Original Article: https://t.co/PURcSXB1e0 https://t.co/dXE4BtyrTh

And another paper out today - congrats to Chien-Yun (@msleemslab) and Co-Authors 🎉! In their story they shed light on phenotypic drug responses of Sarcoma cells using (phospho)proteomics, leading to some interesting insights into drug MoA. Read all about it in @MolSystBiol! https://t.co/vBCmC18yfw

Thanks @NatureComms for featuring CurveCurator on the Editors' Highlights for "Biotechnology and Methods": https://t.co/k520oNBUNm 🎉. We are honored! Nice to see that people like the package. 😊 Stay tuned for more dose-response content...

CurveCurator fits log-logistic models to data from any kind of dose-dependent assay and provides characteristics such as effect potency, effect size, and statistical significance. (2/3) https://t.co/88toeadUwn

Out today in @NatureComms: CurveCurator, a software to support the analysis of dose-dependent data sets. Congrats to Flo and Co.! 🍾🥳 (1/3) https://t.co/Q4Fk0ol95q

Once again, Bernhard made the list of "Highly Cited Researchers", along with 10 other @TU_Muenchen scientists. We are proud!🥳 Thanks for all the citations and congratulations to all the awesome researchers around the globe that have made the list! 🎉 https://t.co/GpHqfS1IyK

And another paper out today: We congratulate Johanna on her publication in @embojournal! She and her colleagues optimized a workflow for the analysis of brain🧠 tissue from FFPE material. Read all about it here: https://t.co/uzHHIewsEB

Our alumna Maria published her latest research in @nchembio! 🎉 In best #kusterscale fashion she acquired target profiles for over 1000 kinase inhibitors and gained interesting insights, which you can read about here: https://t.co/qM4dTJOFh6 Congrats to you, Queen of Kinobeads!👑

Congratulations🎉 to Severin Lechner (@SevLechner), who has been awarded a prize for his doctoral thesis by the TUM Association of Alumni and Friends!🎓🥳 @medardlab and @kusterlab are proud of you, Sev! 🍾

Kusterlab, Leelab (@msleemslab) and BayBioMS (@BayBioMS) had a terrific time at #HUPO2023 in Busan! 😊 See you again next year! https://t.co/05xIXRQ63k

Good morning Busan! Today it is time for @HalitiGenc to present 'The Proteomes that Feed the World'. Also don't miss Chien-Yun (@msleemslab), Giorgi, and Marius at their posters! https://t.co/m0VLG9KHBt

Congrats to Johannes! Our former colleague, who graduated last year, just published his latest research in @molcellprot 🥳 https://t.co/jiVgTVCjcH

Check out Polina's talk today at #HUPO2023! 4.30 pm - Plenary Hall. See you there! https://t.co/JcsuoNw8K6