I love lamp

People had questions, like "Are there apples that taste & crunch like Honeycrisp? But without the existential rage about being alive?" Yep! Let's talk about them!

Job alert! Looking for a mass spectrometry expert to come join our team. Please share and let me know if you have any personal recommendations. #teammassspec www.linkedin.com/jobs/view/43...

Silly take for a vacation day. Those couples that are smiling while sharing a slice and a hot dog at Costco, you just know they're gonna be together forever.

Chembio in the Pub! The tastier, chattier version of the popular Boston conference. Jun 12th is pretty close to the GRC too so whether you're a local or visiting it would be great to hang out www.eventbrite.com/e/chembio-in... #chembio #chemicalbiology #bostonbiotech

#NeilPostman #Trump #MAGA #Musk #ElonMusk #Project2025 #TheFourthReich #BadFaith #Fascism archive.is/6TBfY Still Amusing Ourselves Why does this 40-year-old book by a career academic still hit so hard? ⏬ Bluesky 'bite-sized' article thread (12 min) with added links 📖🍿🔊

Truncated gRNA sequences to target Cas9 fusions to hundreds of sites with similar sequences: www.nature.com/articles/s41... This should address a question I commonly get for GLoPro (PMID: 29735997), about targeting TF binding sites throughout the genome, rather than a single locus. Cool work.

Whom would you like to hear at our next event? The planning for the 5th Virtual ChemBioTalks is starting. We are excited for talks by @oconnorlab.bsky.social, @craigmcrews.bsky.social and Kelly Chibale. Let us know in reply to this post, whom you would additionally like to hear!

There are no shortcuts in drug discovery. And it takes incredible efforts to make sense of what you can find in the scientific literature. This is an excellent piece of work to quality check what has been claimed as a new avenue in targeted protein degradation (TPD). www.nature.com/articles/s41...

We asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?” You can read that they said in our Feature “Thoughts for the future” – Free to read in January. rdcu.be/d5Ksw

1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens TRACeR for MHC-I: go.nature.com/4gcLzn5 TRACeR for MHC-II: go.nature.com/4gj5OQk

Come with me as I troubleshoot this very high GC PCR toward clonable homology arms in an actinobacteria. Testing DMSO, Betaine 1M, and Propylene Glycol to see if we get amplification. Arms are 1000bp. Full length with arms and gene is 2800bp. Let's go! 🧵 1/n

Very neat system from Alice's team. I love the name too!

Fellow Genetics professors - rejoice! This is pedagogy heaven: the paradigmatic epiallele in calico cats … is built on a cis-regulatory deletion, not a coding mutation! We can teach it all off 1 paper! 1. Woo 2. Hoooo!!! H/t @lianafaye.bsky.social www.biorxiv.org/content/10.1...

Delighted these fun explainers have made it to bluesky

Assume all small molecules are unselective for their protein target until proven otherwise. Even if the vendor tells you it’s a selective inhibitor for X, there’s a decent chance it isn’t selective! So how do we find quality molecules for scientific experiments? academic.oup.com/nar/advance-...

Nice new large proteomics dataset on drug MoA applying proteome integral solubility alteration (PISA) from @dschweppe.bsky.social and Gygi lab #TeamMassSpec Article: doi.org/10.7554/eLif... Blog post by @dereklowe.bsky.social: www.science.org/content/blog...

Is ProteomicsDb dead? Even a single protein search just infinitely loads for me

In a wonderful intersection of my science and local policy bluesky worlds, Somerville City Councilor @benforward3.bsky.social created a better split-Gal4 system

Interesting @biorxivpreprint.bsky.social preprint by a team around Jason Thomas and Andrea Byrnes of Novartis. They developed a photoaffinity probe based on the RNA-splicing modulator branaplam for the transcriptome-wide identification of RNA binding events in native cells. doi.org/10.1101/2024...

Been a while since I checked this app and glad to see it's on the up again. Welcome new and old friends!

Thinking about how a research lab could learn from the discipline, teamwork and efficiency from a commercial kitchen as I watch Syd from The Bear think about how you could learn similar from college basketball. Minus the shouting preferably

Then we talked about on-tip processing of sorted cells. Started with @proteomicsnews.bsky.social writing about EvoSep-based method. But fortunately @schejbaljlab.bsky.social was here to talk about his on-tip method too. 5/n

For some reason bluesky is suggesting a ton of ornithology to me and I'm not mad at all. Significant improvement over the suggested posts on the other bird site.

🧪 Scientist? 🟦 New to BlueSky? 👀 Wanna find posts by other people in your area and use the right hashtags in your own posts? 📃 Here’s a list of around 160 science-related feeds and their hashtags. #AcademicSky #PhDSky

Instead of just trying to find the people I followed on Twitter here anyone got suggestions for scientists I should be following on blue sky?

Hello world? Nice to see so many friends from "that other site" over here. Hopefully this will be a better alternative to that slow embering dumpster fire