Calling all Scientists! Research Administrators! Deans! Fans of Science! No one is coming to save us. Here is your assignment. I have written a step by step, easy to understand "how-to" document to help you comment on the proposed OMB rule. elizabethginexi.substack.com/p/what-we-ne...

The public comment period closes approximately July 13, 2026 (45 days from May 29 publication). Comments must be submitted to regulations.gov, Docket OMB-2026-0034

Excellent summary of how Vought’s proposed rule will destroy science. Please be ready to comment tomorrow, call Congress, tell your friends. If you’ve been waiting for the right moment to speak up, that moment is now.

A pleasure to give @stanfordimmunology.bsky.social seminar last week for a few reasons: - to be invited by trainees - to visit the place that got me hooked on immunology - to share results from my lab @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social Thanks for having me!

Honored to receive a Pershing Square Sohn Cancer Prize and excited about the work this award will support! Learn more about our efforts to target glycans to enable precision immunotherapies for cancer: pershingsquarephilanthropies.org/prize-winner... @mitdeptofbe.bsky.social @mitcheme.bsky.social

Congrats to @jcstark.bsky.social on being named a 2026 Pershing Square Sohn Cancer Prize awardee, supporting bold, high-risk ideas w/ potential to transform cancer research. Her work explores how cancer-cell glycans can be harnessed for new approaches to precision immunotherapy. mit-ki.org/42kmCAX

Grateful to @natbiotech.nature.com for the opportunity to reflect on my scientific journey, including launching my lab @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social www.nature.com/articles/s41...

Five questions with Jessica Stark @jcstark.bsky.social go.nature.com/42sA99y

We are searching for a talented administrative assistant to provide critical support for our team @mitkochinstitute.bsky.social. Learn more and apply: tinyurl.com/3r9crrbm Please share widely! #hiring #sciencejobs

New research grants in essentially all fields (as judged by NIH Institutes and Center missions) fell by 20-25% from fiscal year 2024 to fiscal year 2025. 2/5

"There is perhaps no stronger evidence of the [Trump] administration’s objectives to reduce the quality of the US scientific workforce than its treatment of the [NSF]’s flagship Graduate Research Fellowship Program," writes H. Holden Thorp in a new #ScienceEditorial. https://scim.ag/4d0fi3N

@biorxivpreprint.bsky.social Single-Cell and Spatial Methods for Multimodal Functional Glycan Profiling in Tissues www.biorxiv.org/content/10.6... @harvard.edu @broadinstitute.org @shaleklab.bsky.social @ragoninstitute.bsky.social @laurakiessling.bsky.social

Great to see our work to engineer AbLecs as a new immunotherapy modality featured in @natrevdrugdiscov.nature.com! www.nature.com/articles/d41...

Cancer cells use sugar-based immune checkpoints to suppress immune attack. New work from Jessica Stark & Carolyn Bertozzi shows that blocking these glycan checkpoints with AbLecs can release that brake & boost anti-tumor immunity across cancer types. news.mit.edu/2025/new-imm...

Vaccines, the most impressive public health intervention in medical history, and where we could be headed if there was not efforts to negate truth, facts, and evidence A great, open-access, review and perspective by @scientificdiscovery.dev

Researchers led by Dr. Jessica Stark (@jcstark.bsky.social) have developed a new way to stimulate the immune system to attack tumor cells, using a strategy that could make #CancerImmunotherapy work for many more patients. 📰 MIT News: https://bit.ly/3YlpCeq

New online in @natbiotech.nature.com: Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.

Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions

Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8

A new jump forward in cancer immunotherapy blocking glycan sugar molecules (antibodies to lectin, AbLec) that releases the immune system brakes against many types of tumors @carolynbertozzi.bskyverified.social @jcstark.bsky.social www.nature.com/articles/s41...

Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy. www.nature.com/articles/s41... www.nature.com/articles/s41... @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social

Fewer funded grants and graduate fellowships mean fewer innovative technologies and disease cures in our future. www.nytimes.com/interactive/...

🚨 Attention undergraduate scientists and engineers! 🚨 Want to spend a summer doing research at MIT? Join us for the 2026 MIT Summer Research Program! Learn more and apply: oge.mit.edu/msrp/ @mitdeptofbe.bsky.social @mitcheme.bsky.social @mitkochinstitute.bsky.social

It's a great year to join the Leading Edge community 🕊️🤍

Great to see this story in print! Congrats @megtriesscience.bsky.social @douglaspdyer.bsky.social and team! Looking forward to sharing Megan's first contributions as a postdoc in our lab at @mitdeptofbe.bsky.social @mitcheme.bsky.social @mitkochinstitute.bsky.social soon... 👀

Why fundamental research is fundamental to progress, seeding major breakthroughs Editorial @nature.com this week And 7 basic science discoveries that changed the world nature.com/articles/d41... nature.com/articles/d41...

We are recruiting new faculty in IMES at MIT! IMES (Institute for Medical Engineering and Science) is the MIT home of the famous HST program. As faculty are also appointed in a department at MIT, we have diverse research programs, all focused on human health. faculty-searches.mit.edu/imes-search/

“It will take decades to recover from this, if we ever do.” America’s cancer research system, which has helped save millions of lives and is in one of its most productive moments, is under threat by the Trump administration.

Wow! Covid vaccine development and delivery cost $79.4 billion, but the health and economic benefits of vaccination were valued between $4.83 trillion–$37.8 trillion. A return on investment of $59.8–$475 per dollar invested!! This is why vaccine equity matters! www.medrxiv.org/content/10.1...

#ThrowbackThursday: In 1980 the 🌍🌎🌏 was declared #smallpox free, thanks to mass vaccination efforts. Smallpox was an acute contagious disease caused by the variola virus. It was one of the most devastating diseases known to humanity. #VaccinesWork

"The ideas and technologies that are being destroyed today, ... some of them irreversibly, those are the cures that would have been present 20 years from now." "It’s people who will get cancer in 10, 20, or 30 years who will really pay the price for these cuts." www.nytimes.com/2025/08/24/o...

Spending a few days with intramural researcher at NIH has me thinking about the old Bell Labs, the storied research institute where major breakthroughs in physics, chemistry and mat sci (and associated @nobelprize.bsky.social awards) were made in the 70s-80s 1/n

Federal science cuts aren’t just halting medical research or disrupting clinical trials. They are already costing us $8.1 billion and 35,000 jobs. The projected loss is $16 billion and 68,000 jobs every year. This reaches every corner of America. scienceimpacts.org

“As the Trump administration continues to drastically defund and dismantle basic science in America, the United States is presenting other countries with opportunities to take the lead …” writes H. Holden Thorp in a new #ScienceEditorial. scim.ag/43R82B5

Sign on in support of the #BethesdaDeclaration actionnetwork.org/forms/add-na... 2/2

The gutting of US biomedical research with loss of ~2,500 grants affecting research for cancer, Alzheimer’s, infectious disease, global health and much more www.nytimes.com/interactive/...

Where was this important 1st randomized trial performed? China Where are 8 of the 10 most productive research institutions in the world as of March 2025? China nature.com/nature-index... What country is radically defunding research and will lose its competitiveness? USA

MIT ACCESS is an opportunity for undergraduates to explore cutting-edge research and graduate education in science and engineering. See for yourself what grad life is like at MIT! Applications open June 1: access.mit.edu @mitdeptofbe.bsky.social @mitcheme.bsky.social @mitchemistry.bsky.social

On a day when all research grants at Harvard were terminated, and in a context where Congress seems to broadly accept the notion that destroying science and health research in the US is fine, it’s worth noting that this is not what the public wants.

Go beyond the ABCs of ADCs! Join us for the 23rd Annual @kochinstitute Symposium on Antibody Drug Conjugates, June 27th! Our keynote speaker is Nobel-prize winner @carolynbertozzi.bskyverified.social of @stanford.edu & an array of industry and academic leaders. Register: mit-ki.org/4lfoxiz

youtu.be/aXdoExz_cd4?... The anti-vaccine movement has been so successful that children are now dying from preventable infections.

Enjoyed discussing the interface of glycobiology and immunology with @mitcheme.bsky.social colleague Brandon Dekosky on The Chain podcast. Looking forward to sharing our work at #PEGSummit next month! @mitdeptofbe.bsky.social @mitkochinstitute.bsky.social www.healthtech.com/the-chain/pe...

Great summary of last month's senate forum on what cuts to NIH funding mean for Americans: fewer treatments and fewer cures for diseases that collectively affect us all. Worth the ~12 min watch!

Yesterday we celebrated @mitdeptofbe.bsky.social PhD student Brian Cho, who received an honorable mention in this year's #NSFGRFP competition. Brian's work promises to shed new light on the adaptive immune response to glycans and glycoproteins. Congratulations! 🍾

"The vaccine provides close to 100% protection against infections and pre-cancers caused by certain types of HPV. That is remarkable." Effective cancer prevention. www.voicesforvaccines.org/hpv-vaccine-...

Peter Marks’s resignation letter. Everyone should read this.

Looking forward to representing @mitdeptofbe.bsky.social and @mitkochinstitute.bsky.social at #AACRIO! Thanks @theaacr.bsky.social for highlighting our work on glycans as emerging targets for cancer immunotherapy, just one of many exciting stories on the agenda: www.aacr.org/about-the-aa...

More good news from our team: @mitdeptofbe.bsky.social PhD student Tran Luu is one of this year's MIT-Accenture Fellows, recognized for her efforts to understand how glycans mediate immune tolerance in cancer. Learn more about Tran's work here: convergence.mit.edu/fellowships/ Congratulations! 🍾

Megan, our lab's first postdoc, has set a record that will be hard to beat: securing a competitive fellowship in her first week on the job! I'm grateful to TBBCF for their support and privileged to work with outstanding scientists like Megan, more on her work here: tbbcf.org/research/ Congrats! 🍾

Congratulations, Megan!! 👏