Shalek Lab
@shaleklab.bsky.social
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Alex K. Shalek Lab | shaleklab.com | Genomics, immunology, systems biology.
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Shalek Lab
9 days ago
Excited to share our paper out today in
@science.org
! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4)
www.science.org/doi/10.1126/...
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Disordered protein LAT encodes relative levels of signaling pathways in T cell activation
The disordered adapter protein linker for activation of T cells (LAT) propagates T cell receptor signaling. To interrogate how LAT coordinates multiple downstream pathways, we developed a single-cell ...
https://www.science.org/doi/10.1126/science.ads6847
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We had a blast at the first All IMES retreat at the @icaboston.bsky.social !
7 months ago
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Thanks for the write up on The Tech!
thetech.com/2025/08/07/a...
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Meet Alex Shalek, Director of the Institute for Medical Engineering and Science | The Tech
For Shalek, institutes like IMES are all about creating cohesive units “greater than the sum of their parts.”
https://thetech.com/2025/08/07/alex-shalek-imes
9 months ago
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Thanks for the write up, MIT Chemistry!
chemistry.mit.edu/chemistry-ne...
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New AI system uncovers hidden cell subtypes, boosts precision medicine – MIT Department of Chemistry
https://chemistry.mit.edu/chemistry-news/new-ai-system-uncovers-hidden-cell-subtypes-boosts-precision-medicine/
10 months ago
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Last week, Alex attended the CTVD Annual Conference in Cape Town, South Africa. The conversations, company, and views were enlightening! Here’s what going for a run with Al Leslie, Tom Scriba and Tom Hawn looked like.
11 months ago
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A big week of celebrations! Congratulations to the lab members that defended this year: Constantine, Ivy, Sarah, and Josh (not pictured)! And also a farewell to Son ! Can't wait to see what's ahead for all of you!
11 months ago
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Last week, Alex presented at the Single Cell Biology: Unique Cells to Tissue Ecosystems Keystone Symposia in Whistler, BC, Canada. Thanks for the invite!
@keystonesymposia.bsky.social
#KSSingleCell25
12 months ago
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