The populist right wants to remake the UK in the image of Dubai. We should all be careful what they wish for | Jonathan Liew

Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...

We now have a very exciting technician post advertised as part of our long term Wellcome Trust funded team investigating the role of the glycocalyx during CNS inflammation. Supporint the lab, developing glycan analysis and research experience www.jobs.manchester.ac.uk/Job/JobDetai...

Excellent but slightly sad to see this one out, my last contribution as a Postdoc to the Handel lab is in here, congrats to the main people on it!! More of evidence and mechanism of chemokine specificity! www.jbc.org/article/S002...

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins | Science Immunology www.science.org/doi/10.1126/... 🎉🎉 @hetompkins.bsky.social @drtesutherland.bsky.social @mattoburgess.bsky.social @james-ep.bsky.social @profjudiallen.bsky.social

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...

Join the Dyer Lab (Dr @douglaspdyer.bsky.social) as a Research Associate in Neuro-Immunology & Extracellular Matrix Biology (ImmunoMatrix). 🔬 Focus: chemokines, glycocalyx & inflammatory disease 📍 Cutting-edge biochem, biophysics & in vivo biology Apply now 👉 shorturl.at/jEQ6G

Great opportunity available in my PhD lab! An exciting project with a really fun and supportive team 🦠

We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...

Following on from the PDRA adverts, we are also happy to announce the MRC Core in Exposome Immunology PhD scheme, details below. Reach out with any questions www.findaphd.com/phds/program... www.bmh.manchester.ac.uk/study/resear...

New Postdoc position as part of the recently awarded MRC Core in Exposome Immunology, led by Jo Konkel here @lydiabeckeriii.bsky.social. Job ad and more info below: www.jobs.manchester.ac.uk/Job/JobDetai... www.bmh.manchester.ac.uk/research/ins...

🧵How to write and manage your first research budgets The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.

It was a great day! @nabalabuic.bsky.social @douglaspdyer.bsky.social @wellcometrust.bsky.social A great chance for a discussion about how we bring together all our specialities to build a useful matrix atlas - and what that should look like. Matrix assemble!

My "Crash Course in …Immunology" is now posted on YouTube youtu.be/nBC9vvlTxF8. Taken from a public lecture @crick.ac.uk on history and basic concepts in immunity. Aimed at the lay public and those seeking an introductory overview.

I thought it might be helpful to do a more general immunology explainer which I can then build on for example when I discuss specific papers or political actions. Do let me know if its useful and other topics if so. This first one is a general one about how we tackle infections... 🧪 #ImmunoSky

🚨 A new £50M MRC Centre at @manchester.ac.uk and @ox.ac.uk will explore how pollution, microbes & other environmental exposures rewire our immune system and cause chronic inflammatory diseases. #Exposome #ImmunoSky sites.manchester.ac.uk/lydia-becker...

So excited to FINALLY be able to share exciting news from @lydiabeckeriii.bsky.social on our newly awarded MRC Centre of Research Excellence (MRC CoRE) in Exposome Immunology #ImmunoSky 🧪 🧵

Super excited to announce that MRC has funded a new Centre of Research Excellence in Exposome Immunology. Working together, Manchester and Oxford are going to tackle a major challenge of our times. For those who wonder what the Exposome is - see yesterday's posts! www.ukri.org/news/centre-...

Our director @rachellennon.bsky.social on how we will achieve the future aims of the centre

Celebrating the 30th anniversary of the matrix centre today!!

With the right link: www.science.org/doi/10.1126/...

In our science.org/doi/10.1126/... we describe the hitherto overlooked erythroblast expression of CXCR4, which do not migrate in response to CXCR4 ligation by CXCL12. Instead, in these cells CXCR4 localises to the nucleus and mediates alternative cell responses in maturation and triggers enucleation

Are you looking for a postdoc? I will be looking for 2-4 people after the summer to join the lab !! Do not hesitate to reach out and disseminate !!

Not all chemokine signaling is about cell migration! In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation. 🔗 science.org/doi/10.1126/sc…#chemokinen#CXCR4R4

Leukocyte #TransEndothelialMigration #TransPericyteMigration hotspots at a glance 😍 Jaap van Buul Lab @jcellsci.bsky.social 2025 journals.biologists.com/jcs/article-...

🚨 The Menon lab is hiring a postdoc! Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases @ukri.org @lydiabeckeriii.bsky.social Please help spread the word #ImmunoSky www.jobs.manchester.ac.uk/Job/JobDetai...

And congratulations to Richard @lydiabeckeriii.bsky.social for winning the @britsocimm.bsky.social research excellence award!

New discoveries are reshaping how scientists understand the molecular connections between the extracellular matrix and lysosomes—and the resulting implications for research and therapeutics for neurodegenerative disorders. Learn more in this #ScienceSignaling Review: scim.ag/4kG61io

Some nice work we contributed to from my time @ucsdhealthsci.bsky.social on the reasons for specificity of function between CCL27 and 28 including GAG binding, www.biorxiv.org/content/10.1...

Beautiful paper in @cp-neuron.bsky.social from the Lodato lab demonstrating how inborn errors of immunity can directly lead to neuropathology. Mutations causing Cxcr4 hyperactivation perturb cerebellar progenitor dynamics and lead to sensorimotor defects. www.sciencedirect.com/science/arti...

Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉 authors.elsevier.com/a/1l7l75FFzL...

Our latest podcast takes a fascinating look at the life and legacy of Sir Geoffrey Jefferson, the pioneering neurosurgeon whose name inspires our centre. Listen now! the-brain-fix.transistor.fm/episodes/who... #TheBrainFix Podcast

Hi everyone, just a reminder that I’ve been nominated for the role of ECR representative position on the Member Representative Forum at @britsocimm.bsky.social. If you’d like to see me in this position and want to vote for me, you can follow this link: www.immunology.org/news/bsi-com... #immunosky 🧪

Today we've announced the new Faraday Fellowship accelerated international route, which will grant up to £30 million in funding over the next two years to attract global talent and support the development of world-leading research groups in the UK: #RSGrants royalsociety.org/news/2025/05...

New Faraday Fellowships for international applicants moving to the UK Up to £4 million per researcher over 5-10 years Fast-track option for mid-career researchers looking to relocate to the UK

We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!! #ChemSky #ChemBio www.findaphd.com/phds/project...

Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation. #ImmunoSky www.biorxiv.org/content/10.1...

It doesn't happen very often that you receive an award on the same day as your mentor. Congratulations to Peter Seeberger on winning the @rsc.org Khorana Award #glycotime! And I am very thankful to the amazing lab members, colleagues and mentors that led to winning the Norman Heatley Award!

Cool - ever multitalented endothelial cells!

Well done!

Hi everyone 👋 I’ve been nominated for the role of ECR representative position on the Member Representative Forum at @britsocimm.bsky.social. If you’d like to see me in this position and want to vote for me, you can follow this link: www.immunology.org/news/bsi-com... #immunosky

As well as my own nomination, check out all of the other great candidates like Diana 👇

Very honoured to be shortlisted for an award for the work we have done in Ardwick, Manchester on clean air and active travel. Also Looking forward to being inspired by the incredible projects celebrated tonight in research teaching and social responsibility

Specificity in glycosylation! Have you ever wondered why some glycosyltransferases recognize glycoproteins, some glycolipids, and some both? Together with @kmikolajczyk.bsky.social and @rkaczmarekdr.bsky.social, we try to answer that complicated question. #glycotime tinyurl.com/5b6kxhp3

Celebrating an acceptance!

GLYCAN ATLASSING: NANOSCALE ANALYSIS OF GLYCOCALYX ARCHITECTURE ENABLES FUNCTIONAL TRACING OF CELL STATE 🍭🔬🧬 Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy www.biorxiv.org/content/10.1...

Our literature review ⏰ that accompanies the BSMB #ECR Award is now out in The International Journal of Experimental Pathology. Well done to Ask Møbjerg and Sara Dietz Pedersen for putting it together! 💪 #tendon #translationalmedicine #circadianclock onlinelibrary.wiley.com/doi/10.1111/...

*Today* Dr Melissa Conroy from @tcddublin.bsky.social will deliver a @britsocimm.bsky.social MIG seminar entitled: "Uncovering the multifaceted role of fractalkine (CX3CL1) in obesity-associated cancer” 📅 Thursday 1st May 🕐 12 pm 📍 Michael Smith Lecture Theatre #ImmunoSky