#Glycans probably have more "copies/cell" than #proteins and changes in #glycosylation could potentially be remarkable biomarkers for diseases as well as targets for therapeutics. This post explores the abundance of glycans on the cell surface and it is worth a read to recognize these #biomolecules.

The rate of global mean sea level rise has increased from ~2.1 mm/year in 1993 to ~4.5 mm/year in 2023. www.nature.com/articles/s43...

Happy new year 2026 #glycotime! 🥳 We just introduced some useful options to Re-Glyco Ensemble. In the Advanced Settings you can now select a seed (positive integer) to reproduce structural ensemble of your favourite glycoforms such as the one below that you will see soon in an upcoming paper,

OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy www.federalregister.gov/documents/20...

Happy birthday to us! 🥂🎂🥳 We are only 2 yo, but so much #glycotime happened since Dec 2023! ⬇️🧵 We truly appreciate your support, you fabulous glycoengineers around the world and we have so many exciting new tools for you coming up in 2026 to make your 3D glycoforms even better and faster! 🤩

Have you heard of sugar alcohols / artificial sweeteners, such as erythritol, sorbitol, mannitol and xylitol? Learn more about these interesting small sugars and where they are found in our latest blog post, research.bidmc.org/ncfg/blog/23... #glycotime #glycosylation #science #artificialsweeteners

Gut mucin fucosylation dictates the entry of botulinum toxin complexes www.nature.com/articles/s41...

For some unique #glycotime: C-man is a rare (but evolutionarily very old[1]) post translational modification of proteins, where the C2 of Trp in W-x-x-W/C sequons are linked to a single man through a C-C bond 🤯 This and its position within the structure stabilises the (unusual for man) 1C4 chair[2]

Cannot hide my joy, relief, excitement being able to share the outcome of persevering (to say the least) collaborative work. So... the MS glyco(proteomics) guidelines are published!! www.mcponline.org/article/S153... Many thanks to @beilstein-institut.bsky.social @glycosmos.bsky.social @sib.swiss

We are excited to share our #glycotime meeting report on the 1st GlyCosmos Symposium & Jamboree in *Glycobiology*! DOI: doi.org/10.1093/glyc... Participants advanced glycan-binding molecule resources through hands-on work on lectin curation and FAIR glycoinformatics within #GlyCosmos.

It's finally here! serversideup/php v4 is now stable 🎉 😅 Over a year of work 🐘 FrankenPHP & Laravel Octane support 🤖 LLM integration on our docs 🤝 13 new contributors ❤️ All open source Run PHP and Laravel anywhere you want. Now go build awesome stuff, Internet. 🚀

Big day for foundational glycoRNA research, with two preprints published in Nature EMM. Both urge greater analytical rigour in the field. 1. RNA-associated glycoconjugates highlight potential ambiguities in glycoRNA analysis 2. Proteins are a source of glycans found in preparations of glycoRNA

Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!

The @nuxt.com team is highly underrated 💯 I'm working with Nuxt Content, and this product blows my mind 🤯 It's easy, flexible, and fast. Open sourcing Nuxt UI was a solid move too. You know you're crushing it when a SERVER GUY compliments JavaScript 🤓

Sharing our recent pre-print where we drill down further into the transcriptional regulation of Siglec ligands. Here we show that tissue specific regulatory networks dictate changes in sialoglycan patterns. Work led by Rebecca Garnham and postdoc Adam Duxfield. www.biorxiv.org/content/10.1...

Breaking down fucoidan takes some innovative thinking, but evolution already got it! #glycotime 🧪🔺 "Remarkably, two-thirds of the interacting residues are dedicated to the recognition of sulfate groups along the glycoside chains." 🤯😍 www.nature.com/articles/s41...

You're kidding me!? 👀 TIL about "post_start" in Docker Compose 🐳 You can run commands as a privileged user on startup, but still run your services as an unprivileged user. This dramatically simplifies bootstrapping an app! 🤩

serversideup/php v4.0-beta1 is now available!!! It's a next level Docker image: 🐘 FrankenPHP now available ❤️ Improved native health checks 🤖 Advanced Laravel automations 🤩 12 new contributors Our biggest open source release yet. LET'S GO PHP!! 🚀

🧑‍💻 New GitHub integration is here! Connect your GitHub account, choose an existing markdown repo (or create a new one), and hosted.md will build your site automatically. Push to GitHub, rebuild instantly ⚡ Full update 👉 https://link.hosted.md/kDSFq

If there was a certain vendor developing a brand new ion mobility instrument and is in the process of choosing a file format, this is timed incredibly well for them to catch the wave.

We're hiring! 🚀 **PhD positions:** Computational focus: web103.reachmee.com/ext/I005/103... Experimental focus: web103.reachmee.com/ext/I005/103... **Postdoc positions:** Computational focus: web103.reachmee.com/ext/I005/103... Experimental focus: web103.reachmee.com/ext/I005/103...

employment.ku.dk/faculty/?sho... Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!

Most people think that #glycosylation is only extracellular. But there is increasing evidence for the existence of intracellular proteins also being glycosylated. Check out this blog post to learn more about this topic!

Here's something non-science-y for a change: Check out the free demo of my upcoming game on Steam! 🥳 store.steampowered.com/app/3858960/... (Arcaneering is a cozy factory automation game, with a bit of RPG elements, made in Godot) #gamedev #indie #pcgaming #automation #basebuilding

Our work @benschulz.bsky.social on the specificity and the mechanism of activation of the eukaryotic oligosaccharyltransferase is now on Glycopedia ⬇️🎉🥳, the largest repository of #glycotime news and educational material online! Thank you Serge Perez 🤓❤️ glycopedia.eu/2025/09/09/r...

A colleague received an 18 page review for a manuscript they recently submitted. They took several days to respond to all the comments meticulously (even though some of them didn't make any sense to them). When I saw the review, I was able to immediately recognize that this was AI generated. 🧵

Thrilled to share some news!! We'll be recruiting soon to start with some exciting new work in glycobiology, so watch this space... #ERCStG

New paper! The characterisation of PNGaseL published in The Royal Society Open Science New Talent Collection. This paper describes a successful bioprospecting-to-commercialisation project royalsocietypublishing.org/doi/10.1098/... #glycotime @cassiebakshani.bsky.social

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!

It’s certainly Not Good.

Preset searching in GlycoPOST will allow you to perform AND searches by keyword or by update date and time, making it much easier to find the desired preset among the large number of glycomics data registered. This feature will be available in the next release! #glycotime #glycosmos

Exciting virtual seminar by Dr. Maxence Noel (From Dr. Richard Cummings' Lab) - "Brain N and O glycosylation: Discoveries, Tools and Dysregulation in Disease", held by the BGDG. Thursday July 17, 2025 at 12pm EDT. Register: docs.google.com/forms/d/e/1F... #glycotime #neuroglycobiology #neuroscience

📢New article alert! 'Blood group O expression in normal tissues and tumors', just published in FEBS Journal, highlights findings using our lamprey-derived monoclonal antibodies towards specific H antigen epitopes. Read at: febs.onlinelibrary.wiley.com/doi/10.1111/... #glycotime #glycans #bloodgroups

Antifreeze glycoproteins: not just for fish! 🤔 They could revolutionize food preservation and organ cryopreservation. Read more about this exciting potential in our latest interesting fact: research.bidmc.org/ncfg/blog/19... #glycotime #glycofacts #cryopreservation

New fabulous #glycotime fresh off the bioRxiv press!⬇️ 🎉 In this brilliant team effort led by Klaudia Sobczak, Jesús Jimenez-Barbero, and June Ereño Orbea 🤩 with many contributions 🌍, we characterised the 3D structure + binding mechanism of sialosides by Siglec-10 🧵 1/3 doi.org/10.1101/2025...

By deep characterisation of 186 N-glycan standards, we @thencfg.bsky.social have made the most comprehensive targeted LC-MS glycomic assay to date. Non-reduced native glycan analysis is key. We hope this enables anyone with QqQ and interest in #glycotime to measure specific N-glycan structures.

Well, it turns out that you can actually make PyMOL do quite a lot of stuff. Here's the full workflow, integrating the amazing ReGlyco into PyMOL to re-glycosylate the LDLA linker. There's some serious magic needed to get it running as fast as it is within PyMOL. @elisafadda.bsky.social

Check out our latest interesting fact post where you can discover some weird dangerous carbohydrates.

Looking forward to presenting our work on difference in mice vs men platelet extracellular vesicles @plateletcarsten.bsky.social #ISTH2025 who's joining me? Thanks THANZ for funding!

📢 Our latest work describing a new versatile click chemistry glycan linker which enabled us to create glycan derivatives for use in microarrays, Luminex (bead based arrays) and ELISA assays. Check it out in @acs.org ACS Central Science doi.org/10.1021/acsc... #glycotime #clickchemistry #luminex

An update of GlyCosmos has been released today! You can see the release notes here doc.glycosmos.org/en/release-n... and minor releases are already planned for next week. #glycotime #glycans

Check out the latest interesting fact in our blog where we discuss 2 essential tiny #glycolipids #glycotime

Excited to share our latest on #miRNA regulation. miRs bidirectionally regulate CMAS, predicting high sialylation in pancreatic cancer. This makes our 6th gene with up- and down-regulation with 12 total upmiR sites identified. #RNAsky @faezehjame.bsky.social www.sciencedirect.com/science/arti...

From The Daily's science desk: Scientists move to Bluesky, transitioning away from X and Meta platforms @whysharksmatter.bsky.social @trevorabranch.bsky.social and @carlbergstrom.com share their motivations behind switching platforms. www.dailyuw.com/science/scie...

Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes. www.biorxiv.org/content/10.1...

GaLSIC video played during the Biophysical Society meeting this past weekend #glycotime #glycans m.youtube.com/watch?v=2iIl...

Come work with us! Check out this opportunity...

Well said @dereklowe.bsky.social. Academia produces two vital products: (1) knowledge, and (2) human capital that knows how to use it. If we can’t train enough young creative US scientists to fulfill biopharma industry needs… “I think they're being short-sighted, because fear does that to you.”