🎉 Hot off the press! Our new review on liver resident CD8+ T cells is here - exploring the dual nature of these cells either as protective "Jekyll" 😇 or pathogenic "Hyde” 😈 Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!

Review @natrevgastrohep.nature.com @ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment www.nature.com/articles/s41...

SOOOOO excited to see this online IN REAL-LIFE!! Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪

🚨We're going on tour!🚨 Join us for 1 of our "Report Launch" networking events: Edinburgh, Manchester, London, or the comfort of your own home! We will present the 'Carers in STEMM' survey findings, host panel discussions w/ policy markers, EDI advocates & fellow parents/carers. Spread the word!📣

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...

MASH: the nexus of metabolism, inflammation and fibrosis This review by Gregory R Steinberg & colleagues is part of JCI’s ongoing series, Evolving Insights into MASLD and MASH Pathogenesis and Treatment with series editor @hepascott.bsky.social: buff.ly/BgLh6mn

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis www.nature.com/articles/s41...

Now online! Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures

TREM2 macrophages are associated with enhanced response to PD-1 blockade in human hepatocellular carcinoma @miriammerad.bsky.social www.biorxiv.org/content/10.1...

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...

🚨Job Offer🚨PhD Student Position The @lshtm.bsky.social, in partnership with the @mpidr.bsky.social is opening an 18-month Research Assistant position, with the successful candidate embarking on a PhD program at LSHTM. www.demogr.mpg.de/en/career_61... @ezagheni.bsky.social #phd #jobs #demography

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social academic.oup.com/jimmunol/adv...

AND.... some more good news from us, our recent BSc graduate from the lab - Keshav - will be returning in a few weeks as our newly appointed research tech. WELCOME TO THE TEAM, WELCOME TO THE MADNESS! #TeamScience

Fantastic to see this out 👏 ScRNAseq data from 77 patients as an atlas for all to use. Used to identify a new subpopulation of pro-inflammatory scar-associated macrophages which promote fibrosis from our friends in the Ramachandran lab. 🧪 #liversky #immunosky www.biorxiv.org/content/10.1...

Huge congrats to our superstar MRes student who absolutely smashed her project this year, won the best presentation prize and will be off to adventures new very soon for her PhD. Well done Jacky 👏

Are you a postdoc interested in the mechanisms of disease? Do you have a great record and an exciting vision? Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships. Deadline 30th September...pass it on! www.path.ox.ac.uk/work-with-us...

MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines www.science.org/doi/10.1126/... @sciimmunology.bsky.social @aliamini419.bsky.social @thelucygarner.bsky.social @nprovine.bsky.social

MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines #gdTcells

Cells need to sense nutrients so that they can adjust their metabolism and growth accordingly. A key node in cellular nutrient sensing is the protein complex GATOR2, for which binging of two nutrient-sensing proteins has been solved www.nature.com/articles/d41... www.nature.com/articles/s41...

Fantastic opportunity to go work for a dear friend of the lab @beckilee.bsky.social in Manchester!!! Spread the word 🧪

👶✈️ Balancing caregiving and academic travel? Join Dr. Laura Pallett for "The Dual Demands of Academic Travel and Caregiving" 🗓️ Sept 25 | 🕒15:00 CEST 🔗https://tinyurl.com/yefis2025-ia2 Hosted by the Improving Academia group of yEFIS

Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...

@biorxivpreprint.bsky.social CD8 T can switch from resource-intensive purine synthesis to purine salvage, allowing diversion of biosynthetic and bioenergetic resources towards enhancing effector molecule production @dergenger.bsky.social @bergthalerlab.bsky.social www.biorxiv.org/content/10.1...

The numbers of women in science falls substantially at the transition from postdoc to independent investigator/ PI So what can we do to prevent this? One initiative we now organise annually at #EACR is the highly successful 'Women in Leadership' workshop ⏬ #WomenInScience 🧪 @helloeacr.bsky.social

🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals. ✅ Wet & dry lab ✅ September 2025 enrolment ✅ UK tuition fees only www.ucl.ac.uk/medical-scie...

Fantastic immunology 101. Share widely 😊👏

Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis 😎 biology but double whammy for cancer patients www.nature.com/articles/s41... 🧪

TGFβ-mediated signals involving IL-4 and PD-1 enable CD8+ T cells to establish tissue-residence in skin www.nature.com/articles/s41... www.nature.com/articles/s41... @natimmunol.nature.com www.nature.com/articles/s41...

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥 www.nature.com/articles/s42...

And that's why they got a London Overground line named after them.

Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value

I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!

First copies of my book are here!! As a new faculty member, I realized that in addition to my research job, I also had a leadership job…and I wasn’t prepared for that. This book is the guide I wish I’d had then, with the goal of helping others now.   jenheemstra.com/book

Out now in #NatureMetabolism 🧪 This study shows that, compared to plant-based fats, animal-based fats accelerate tumour growth and impair anti-tumour response to melanoma in obese mice. Same calories, different outcomes! From the lab of @lydialynch.bsky.social doi.org/10.1038/s422...

The human proteome and organ age clocks across the lifespan, a tour de force report @cellpress.bsky.social www.cell.com/cell/abstrac...

#EMBObarrierTissues - ready to swim!! looking forward to hosting you all in Basel with @maurogaya.bsky.social in August

Dental floss as a #vaccination strategy? This study shows that floss-based vaccination can deliver protein, inactivated virus, peptide-presenting immunogenic nanoparticles, mRNA & induces #immuneresponses protecting against infectious disease in mice ➡️ www.nature.com/articles/s41... #immunity

Moving to a four-day work week without losing pay leaves employees happier, healthier and higher-performing go.nature.com/4mc53ep

TGF-β and IL-12 conversely orchestrate formation of CD103+ CD8 tumor-resident memory T cells to regulate response to therapeutic cancer vaccine www.cell.com/iscience/ful...

Preprint: Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans @profshanecrotty.bsky.social @hannahdstacey.bsky.social www.biorxiv.org/content/10.1...

Multi-parameter spectral flow cytometry panel for immune phenotyping of murine B and T cell responses www.biorxiv.org/content/10.1...

Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity www.science.org/doi/10.1126/...

Mitochondrial respiration is necessary for CD8+ T cell proliferation and cell fate @natimmunol.nature.com www.nature.com/articles/s41...

How does a Th2 response affect the formation of CD8 tissue-resident T cells at barrier surfaces? Glad to see the Bromley lab cracked it! IL-4 limits the formation of skin CD103+ TRM... intriguing implications for long-term mucosal immunity when Th1/2 are mixed

Cd69 mRNA levels distinguish potent and dysfunctional activation among CD69+ CD8 T cells in tumors @sciimmunology.bsky.social @maxkrummel.bsky.social www.science.org/doi/10.1126/...

Vote for your facourite topic for our 2026 LIG meeting 1️⃣ Immunology across the lifecourse 2️⃣ Immunology in a changing world 3️⃣ Signals & senses: external influences on imm.cells 4️⃣ Bench to bedside Immunology 📊 Show results

Let us know what YOU would like the theme of our next annual meeting to be! 🗳️ Vote now using this link: www.menti.com/alu97vcw5ezm... #LIG25

Weight loss improves health but What happens to cells in the fat during weight loss? Intriguingly, immune cell numbers decrease but their activated states persist w chronic inflammatory potential. Beautiful work from neighbors @mrc-lms.bsky.social Will Scott et al www.nature.com/articles/s41...

And we're off! Welcome all to our annual meeting 'Diversity in Immunology' 🥳 We have an exciting day ahead 🤩 Let us know your favourite moments of the day by using our hashtag! 😊 #LIG25