Hexokinase 2, the latest glycolytic enzyme that also controls mRNA translation! Nonmetabolic function of HK2 acting as an RBP and translation regulator. dx.plos.org/10.1371/jour...

Preserving intracellular glutamate supports CD8 T cell anti tumour function. Research from the Rathmell lab point to Glutamine synthetase a potential target for cancer immunotherapy academic.oup.com/jimmunol/art...

Ireland must act now. Our government has failed to defend international law, failed to protect Irish citizens detained in international waters, and failed to enact the Occupied Territories Bill. We demand action: 1️⃣ Implement the ICJ’s findings. 2️⃣ Enact the Occupied Territories Bill.

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis www.nature.com/articles/s41...

Caution : Expression of p-glycoprotein (ABCB1b) affects mitochondrial staining with MTG and TMRM 1-3k copies in NK cells. Assess mitochondrial mass using multiple methods. -10-nonyl acridine orange (NA0) stains mito-specific lipid cardiolipin, -Antibody staining of proteins like ATP5b

In case you missed it….great study from @lindavsinclair.bsky.social and Doreen Cantrell. Autophagy and how it shapes CD8 T cell responses -Differentially pruning naive and effector T cell proteomes -Dynamically repressed by antigen receptors and inflammatory cytokines rdcu.be/eJBFA

Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization. www.cmghjournal.org/article/S235... Wonder how metformin induced LacPhe (pmc.ncbi.nlm.nih.gov/articles/PMC...) affects macrophages and gut inflammation. @immunometforum.bsky.social

Maternal obesity alters function of offspring’s liver Kupffer cells leading to fatty liver disease. Reprogramming during gestation requires #HIF1alpha. Nice 👌. @masslab.bsky.social I wonder how altered KC affects immunometabolism of other liver resident cells? www.nature.com/articles/s41...

ENPP1 senses cytosolic mtDNA and promotes increased Slc2a1 and glucose uptake. Ultimately contributes to mal-differentiation of T cells in SLE #mTorc1 #AMPK Cell Reports www.cell.com/cell-reports...

Interesting insights into why iron is important for T cell proliferation, from @drakesmith-lab.bsky.social and Megan Teh (linkedin.com/in/megan-teh...) @ox.ac.uk Iron scarcity creates a mitochondrial-located metabolic bottleneck in CD8 T cells. www.nature.com/articles/s41...

An interesting new angle on trained immunity and coagulation. Nice study by @aislingrehill.bsky.social and @rogerpreston.bsky.social from @rcsi.bsky.social @researchireland.ie pmc.ncbi.nlm.nih.gov/articles/PMC...

At an absolute minimum, Ireland must immediately pass the full Occupied Territories Bill (NOT the watered-down version) & end the transport of Israeli war matériel through Irish airspace. And every Irish voter should be calling their TD tomorrow to ensure it happens. www.ohchr.org/en/press-rel...

Please take this easy action, we must see sanctions on apartheid Israel for its genocide of Palestinians, we need, as a first step, the full Occupied Territories Bill enacted. #SanctionsNow Act now for Palestine – rescue the Occupied Territories Bill www.trocaire.org/petitions/ac...

10,000 people marched in Dublin this weekend. Ireland stands against genocide. Free Palestine.

A systematic review involving >130 million people and 1 million dementia cases found that anti-inflammatory medications, vaccinations, and antibiotics were associated with reduced dementia, whereas vitamins and supplements linked to higher risk alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11 wellcomeopenresearch.org/articles/9-3...

Lots of interest in how to maintain healthy mitochondria for effective cell therapy, like #NKcells for cancer immunotherapy. Some interesting clues in this article. #immunosky #immunometabolism Triacylglycerol mobilization underpins mitochondrial stress recovery www.nature.com/articles/s41...

Exciting work from Sue Kaech’s lab @tcellogic.bsky.social Tissue specific metabolites like #BileAcids in #Liver affect #CD8Tcell tumour responses #immunometabolism #immunosky Bile acid synthesis impedes tumor-specific T cell responses during liver cancer www.science.org/doi/10.1126/...

More nice research from Annie Curtis’ lab on the circadian rhythm and the #immunometabolism of macrophages. #immunosky #mitochondria #inflammasome Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in macrophages faseb.onlinelibrary.wiley.com/doi/10.1096/...

PKM2 has always been intriguing; complex roles in some cells, here involving adenosine in #macrophages, simple glycolytic enzyme in #NKcells (doi.org/10.7554/eLif...) #immunometabolism #immunosky Metabolic reprogramming of macrophages by PKM2 promotes IL-10 via adenosine www.cell.com/cell-reports...

Check out our new commentary on this interesting study by @justinaguerrero.bsky.social and team on Glut1 overexpressing CAR T cells. Excited to see what comes next for these metabolically enhanced T cells! @davidfinlaytcd.bsky.social

La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism #immunometabolism #immunosky #glucose #CAR-T journals.lww.com/immunometabo...

Interesting new oxysterol research from Jason Cyster’s lab. EBI2 (GPR183) and oxysterol ligand 7α,25-HC are required for lymphocyte homing to inflamed LNs. #immunology #oxysterols Inflammation switches the chemoattractant requirements for naive lymphocyte entry into LN www.cell.com/cell/fulltex...

📢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc Eloïse Marques. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n www.biorxiv.org/content/10.1...

Metabolic #plasticity to Slc1a5 loss involving upregulation of macropinocytosis. Important also for #immune cells to support glutamine requirements? #immunometabolism “Macropinocytosis mediates resistance to loss of glutamine transport in TNBC” www.embopress.org/doi/full/10....

“Glutamine sensing licenses cholesterol synthesis” #glutamine interacts with SCAP to alter the ER to Golgi trafficking needed to activate #SREBP transcriptional response. www.embopress.org/doi/full/10.... Is this relevant to #immunometabolism, such as SREBP-dependent #NKcell responses?

Another important example of lactylation controlling metabolic pathways; stabilisation of TFEB to increase lysosomal activity. Will be interesting to see if this mechanism plays a role in #immunometabolism #immunology responses. rupress.org/jcb/article/...

Authors use an elegant transgenic model to demonstrate that acute oral administration of metformin targets mitochondrial complex I to lower blood glucose. A crucial contribution to the debate about the mechanisms of action of #metformin. #metabolism #glucose doi.org/10.1126/scia...

#Immunometabolism role for Pyrimidine synthesis enzyme CTP synthetase-1. CTPS1 deaminates IRF3 and suppresses IFN response; important implications for antiviral #immunology? Yes indeed…. authors show that loss of CTPS1 elevates antiviral immune response in www.cell.com/immunity/ful...

AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress www.nature.com/articles/s41...

Interesting new research from Antoine Marçais’ lab showing a central role for pyruvate and the Citrate-Malate Shuttle (non-canonical TCA cycle) in human NK cells. #immunology #NKcells #Immunometabolism doi.org/10.1038/s422... See our commentary article here: www.nature.com/articles/s42...

Autism is still totally incorrectly associated with vaccinations (it is genetic). Autism was first described by a Russian doctor in 1926 (Dr. G. E. Ssucharewa). This was before any vaccines were distributed to children link.springer.com/article/10.1... Vaccines don’t cause autism.

Had great fun talking all things immunological to Lara and Vyanka on their ImmunoTea Podcast. open.spotify.com/episode/2YqS...

This week in #ScienceImmunology: Germinal Center B cells require asparagine (Asn) #metabolism for their function. GC B cells can acquire exogenous Asn from their local environment, but when Asn is limited, they utilise the enzyme asparginine synthetase. @ajclarke.bsky.social @yfy1.bsky.social

This week @eimearrryan.bsky.social from our lab will present the second story from her PhD (only started year 3!) on human MAIT cells metabolism

The December @immunometforum.bsky.social will take place this Friday with three great early career researcher presenting: 🧵1/4 #immmunosky #immunoology #immunometabolism

New review article written by Cristhiane Favero de Aguiar and Carrie Corkish from my lab. They did a great job. www.nature.com/articles/s41... #SingleCell #Immunometabolism #ImmunoSky Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level

New insight into the challenges for immunotherapy to treat Glioblastoma. #GBM #catecholamines www.biorxiv.org/content/10.1...

Long chain acyl-carnitine Palmitoylcarnitine is elevated in diseases including T2D and obesity, and this study suggests it can cause mitochondrial dysfunction in immune cells. Palmitoylcarnitine impairs immunity in decompensated cirrhosis - JHEP Reports www.jhep-reports.eu/article/S258...

Interesting, a fluorescent biosensors to illuminate arginine metabolism in cells, mice, and clinical samples. #Arginine #biosensor Lighting up arginine metabolism reveals its functional diversity in physiology and pathology: Cell Metabolism www.cell.com/cell-metabol...

Another lactate dependent immunosuppressant mechanism, here in Glioblastoma #GBM #Lactate #CD47 #HistoneLactylation JCI - Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation www.jci.org/articles/vie...

“A β-hydroxybutyrate (BHB) shunt pathway generates anti-obesity ketone metabolites” Interesting parallels between Lac-Phe and BHB-Phe as CNDP2 generated metabolites with appetite regulating functions. www.cell.com/cell/fulltex...

Obesity imprints adipose tissue even after weight loss - promoting regain and progression. Same is observed with GLP-1 therapies were we see regain in the majority of individuals who stop TX www.nature.com/articles/s41...

A while back we wrote an article calling for accelerated change in policy for those w/ caring responsibilities in #STEMM Sharing insights into the challenges, highlighting personal experiences & proposing a strategy to improve culture #AcademicSky Read it here: www.nature.com/articles/d41...

It was great to work with Kendle Maslowski’s group @mmimic.bsky.social and others on this project, interrogating the curious question of why T cells aren’t engaged by bacterial cancer therapy, and how to make them so! It’s all down to metabolism of course 😉…

Will have a more detailed post soon, but sharing advanced online pre-proof version of our new study - Single cell profiling of Hematopoietic Stem Cell Transplant recipients reveals TGF-β1 and IL-2 confer immunoregulatory functions to NK cells: www.cell.com/iscience/ful...

ZDHHC3 as a target to reduce cholesterol in the TME and rejuvenate T cell function ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma: Cell Reports www.cell.com/cell-reports...

📢Last weeks #immunometabolism discoveries @Bims_BiomedNews⬇️⬇️⬇️ biomed.news/bims-imicid/... A lot of interesting articles within but highlighting a study I hadn't come across yet: I) Functional identification of soluble uric acid as an endogenous inhibitor of CD38

Asparaginase expression impedes T cell responses but is required for anti-tumour efficacy during salmonella CRC therapy. More evidence for importance of Asn for T cells! Great work Kendle and colleagues!