David Finlay
@davidfinlaytcd.bsky.social
š¤ 1807
š„ 886
š 36
Interested in all things Immunometabolism ORCID:0000-0003-2716-6679
pinned post!
New review article written by Cristhiane Favero de Aguiar and Carrie Corkish from my lab. They did a great job.
www.nature.com/articles/s41...
#SingleCell
#Immunometabolism
#ImmunoSky
Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level
10 months ago
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David Finlay
Philip O'Connor
9 days ago
At an absolute minimum, Ireland must immediately pass the full Occupied Territories Bill (NOT the watered-down version) & end the transport of Israeli war matƩriel through Irish airspace. And every Irish voter should be calling their TD tomorrow to ensure it happens.
www.ohchr.org/en/press-rel...
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Israel has committed genocide in the Gaza Strip, UN Commission finds
GENEVA āĀ Israel has committed genocide against Palestinians in the Gaza Strip,Ā the UN Independent International Commission of Inquiry on the Occupied Palestinian Territory, including East Jerusalem, a...
https://www.ohchr.org/en/press-releases/2025/09/israel-has-committed-genocide-gaza-strip-un-commission-finds
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David Finlay
Ireland-Palestine Solidarity Campaign
8 days ago
Please take this easy action, we must see sanctions on apartheid Israel for its genocide of Palestinians, we need, as a first step, the full Occupied Territories Bill enacted.
#SanctionsNow
Act now for Palestine ā rescue the Occupied Territories Bill
www.trocaire.org/petitions/ac...
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Act now for Palestine - rescue the Occupied Territories Bill - TrĆ³caire
https://www.trocaire.org/petitions/act-now-for-palestine-rescue-the-occupied-territories-bill/
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10,000 people marched in Dublin this weekend. Ireland stands against genocide. Free Palestine.
2 months ago
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reposted by
David Finlay
Eric Topol
8 months ago
A systematic review involving >130 million people and 1 million dementia cases found that anti-inflammatory medications, vaccinations, and antibiotics were associated with reduced dementia, whereas vitamins and supplements linked to higher risk
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
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Dataādriven discovery of associations between prescribed drugs and dementia risk: A systematic review
Abstract Recent clinical trials on slowing dementia progression have led to renewed focus on finding safer, more effective treatments. One approach to identify plausible candidates is to assess whet...
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70037
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David Finlay
Adrian Liston
8 months ago
Our paper on nurturing a
#PositiveResearchCulture
within your
#research
#team
published by
@wellcometrust.bsky.social
gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11
wellcomeopenresearch.org/articles/9-3...
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https://wellcomeopenresearch.org/articles/9-341/v1/f3
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Lots of interest in how to maintain healthy mitochondria for effective cell therapy, like
#NKcells
for cancer immunotherapy. Some interesting clues in this article.
#immunosky
#immunometabolism
Triacylglycerol mobilization underpins mitochondrial stress recovery
www.nature.com/articles/s41...
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Triacylglycerol mobilization underpins mitochondrial stress recovery - Nature Cell Biology
Baker et al. show that mitochondrial stress recovery requires mobilization of lipid droplet triacylglycerol stores to facilitate cardiolipin biosynthesis and mitochondrial biogenesis.
https://www.nature.com/articles/s41556-024-01586-6
8 months ago
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Exciting work from Sue Kaechās lab
@tcellogic.bsky.social
Tissue specific metabolites like
#BileAcids
in
#Liver
affect
#CD8Tcell
tumour responses
#immunometabolism
#immunosky
Bile acid synthesis impedes tumor-specific T cell responses during liver cancer
www.science.org/doi/10.1126/...
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Bile acid synthesis impedes tumor-specific T cell responses during liver cancer
The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that...
https://www.science.org/doi/10.1126/science.adl4100
8 months ago
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More nice research from Annie Curtisā lab on the circadian rhythm and the
#immunometabolism
of macrophages.
#immunosky
#mitochondria
#inflammasome
Timeāofāday control of mitochondria regulates NLRP3 inflammasome activation in macrophages
faseb.onlinelibrary.wiley.com/doi/10.1096/...
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Timeāofāday control of mitochondria regulates NLRP3 inflammasome activation in macrophages
The circadian clock, orchestrated by BMAL1, regulates the expression of Nlrp3 and Il1b in response to lipopolysaccharide (LPS), causing time-of-day production of pro-IL-1Ī². Mitochondria exhibit time-....
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202400508RR
8 months ago
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PKM2 has always been intriguing; complex roles in some cells, here involving adenosine in
#macrophages
, simple glycolytic enzyme in
#NKcells
(
doi.org/10.7554/eLif...
)
#immunometabolism
#immunosky
Metabolic reprogramming of macrophages by PKM2 promotes IL-10 via adenosine
www.cell.com/cell-reports...
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Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine
TEPP-46 activates PKM2 by inducing a tetramer formation, which leads to a metabolic reprogramming in macrophages, resulting in an increase in ATP and IL-10 production. Toller-Kawahisa etĀ al. showed th...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2824%2901523-7
8 months ago
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reposted by
David Finlay
Karen Slattery
8 months ago
Check out our new commentary on this interesting study by
@justinaguerrero.bsky.social
and team on Glut1 overexpressing CAR T cells. Excited to see what comes next for these metabolically enhanced T cells!
@davidfinlaytcd.bsky.social
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La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism
y of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immu...
https://journals.lww.com/immunometabolism/fulltext/2025/01000/la_dolce_vita__fueling_chimeric_antigen_receptor.3.aspx#
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La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism
#immunometabolism
#immunosky
#glucose
#CAR-T
journals.lww.com/immunometabo...
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La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism
y of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immu...
https://journals.lww.com/immunometabolism/fulltext/2025/01000/la_dolce_vita__fueling_chimeric_antigen_receptor.3.aspx
9 months ago
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Interesting new oxysterol research from Jason Cysterās lab. EBI2 (GPR183) and oxysterol ligand 7Ī±,25-HC are required for lymphocyte homing to inflamed LNs.
#immunology
#oxysterols
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into LN
www.cell.com/cell/fulltex...
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Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes
Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.
https://www.cell.com/cell/fulltext/S0092-8674%2824%2901347-3
9 months ago
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David Finlay
RyanLab_TCD
9 months ago
š¢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc EloĆÆse Marques. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n
www.biorxiv.org/content/10.1...
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An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses, but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this q...
https://www.biorxiv.org/content/10.1101/2025.01.05.631298v1
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Metabolic
#plasticity
to Slc1a5 loss involving upregulation of macropinocytosis. Important also for
#immune
cells to support glutamine requirements?
#immunometabolism
āMacropinocytosis mediates resistance to loss of glutamine transport in TNBCā
www.embopress.org/doi/full/10....
9 months ago
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āGlutamine sensing licenses cholesterol synthesisā
#glutamine
interacts with SCAP to alter the ER to Golgi trafficking needed to activate
#SREBP
transcriptional response.
www.embopress.org/doi/full/10....
Is this relevant to
#immunometabolism
, such as SREBP-dependent
#NKcell
responses?
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Glutamine sensing licenses cholesterol synthesis | The EMBO Journal
imageimageWhether cholesterol biosynthesis can be adjusted to the availability of input carbon sources remains unclear. This study demonstrates that glutamine is directly sensed by and required for ac...
https://www.embopress.org/doi/full/10.1038/s44318-024-00269-0
9 months ago
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Another important example of lactylation controlling metabolic pathways; stabilisation of TFEB to increase lysosomal activity. Will be interesting to see if this mechanism plays a role in
#immunometabolism
#immunology
responses.
rupress.org/jcb/article/...
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Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity | Journal of Cell Biology | Rockefeller University Press
Posttranslational modifications play a crucial role in regulating autophagy and lysosomeārelated transcription factor TFEB. Huang et al. find the increase
https://rupress.org/jcb/article/223/11/e202308099/276944
9 months ago
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Authors use an elegant transgenic model to demonstrate that acute oral administration of metformin targets mitochondrial complex I to lower blood glucose. A crucial contribution to the debate about the mechanisms of action of
#metformin
.
#metabolism
#glucose
doi.org/10.1126/scia...
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Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
https://doi.org/10.1126/sciadv.ads5466
9 months ago
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#Immunometabolism
role for Pyrimidine synthesis enzyme CTP synthetase-1. CTPS1 deaminates IRF3 and suppresses IFN response; important implications for antiviral
#immunology
? Yes indeedā¦. authors show that loss of CTPS1 elevates antiviral immune response in
www.cell.com/immunity/ful...
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Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3
The intersection between cellular metabolism and innate immunity lacks understanding. Here, Rao and Qin etĀ al. report that the metabolic enzyme, CTP synthetase 1, deamidates IRF3 to limit interferon induction, independent of its role in pyrimidine synthesis. This reveals how a key metabolic enzyme directly regulates innate immune activation.
https://www.cell.com/immunity/fulltext/S1074-7613%2824%2900535-1
9 months ago
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reposted by
David Finlay
Anupam Patgiri
9 months ago
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress
www.nature.com/articles/s41...
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AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress - Nature Cell Biology
Zhai, Yang et al. report a central role for AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy s...
https://www.nature.com/articles/s41556-024-01549-x
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Interesting new research from Antoine MarƧaisā lab showing a central role for pyruvate and the Citrate-Malate Shuttle (non-canonical TCA cycle) in human NK cells.
#immunology
#NKcells
#Immunometabolism
doi.org/10.1038/s422...
See our commentary article here:
www.nature.com/articles/s42...
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Natural killer loops: pyruvate in, lactate out - Nature Metabolism
Resting human CD56Dim natural killer cells utilize exogenous pyruvate to support energy metabolism. A new study shows that these cells take up exogenous pyruvate, which regenerates cytosolic NAD+ via ...
https://www.nature.com/articles/s42255-024-01195-5
9 months ago
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reposted by
David Finlay
Marc Veldhoen
9 months ago
Autism is still totally incorrectly associated with vaccinations (it is genetic). Autism was first described by a Russian doctor in 1926 (Dr. G. E. Ssucharewa). This was before any vaccines were distributed to children
link.springer.com/article/10.1...
Vaccines donāt cause autism.
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reposted by
David Finlay
Luke OāNeill
9 months ago
Had great fun talking all things immunological to Lara and Vyanka on their ImmunoTea Podcast.
open.spotify.com/episode/2YqS...
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ImmunoTea Episode 24 - Innate Immunity and Immunometabolism
ImmunoTea: Your Immunology Podcast Ā· Episode
https://open.spotify.com/episode/2YqSNlNw7j4Fw0ApYn8TPv?si=dEOy7IAQQiSMWigUEP266
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reposted by
David Finlay
Hannah Isles
9 months ago
This week in
#ScienceImmunology
: Germinal Center B cells require asparagine (Asn)
#metabolism
for their function. GC B cells can acquire exogenous Asn from their local environment, but when Asn is limited, they utilise the enzyme asparginine synthetase.
@ajclarke.bsky.social
@yfy1.bsky.social
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Asparagine availability controls germinal center B cell homeostasis
Asparagine metabolism is a critical regulator of germinal center B cell function.
https://www.science.org/doi/10.1126/sciimmunol.adl4613
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reposted by
David Finlay
Andy Hogan
10 months ago
This week
@eimearrryan.bsky.social
from our lab will present the second story from her PhD (only started year 3!) on human MAIT cells metabolism
add a skeleton here at some point
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The December
@immunometforum.bsky.social
will take place this Friday with three great early career researcher presenting: š§µ1/4
#immmunosky
#immunoology
#immunometabolism
10 months ago
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New review article written by Cristhiane Favero de Aguiar and Carrie Corkish from my lab. They did a great job.
www.nature.com/articles/s41...
#SingleCell
#Immunometabolism
#ImmunoSky
Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level
10 months ago
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New insight into the challenges for immunotherapy to treat Glioblastoma.
#GBM
#catecholamines
www.biorxiv.org/content/10.1...
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Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses
Intracranial tumors present unique challenges for immunotherapy. These can include both local and systemic modes of immune suppression whose mechanistic underpinnings are incompletely understood. Here...
https://www.biorxiv.org/content/10.1101/2023.11.02.565368v2
10 months ago
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Long chain acyl-carnitine Palmitoylcarnitine is elevated in diseases including T2D and obesity, and this study suggests it can cause mitochondrial dysfunction in immune cells. Palmitoylcarnitine impairs immunity in decompensated cirrhosis - JHEP Reports
www.jhep-reports.eu/article/S258...
10 months ago
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Interesting, a fluorescent biosensors to illuminate arginine metabolism in cells, mice, and clinical samples.
#Arginine
#biosensor
Lighting up arginine metabolism reveals its functional diversity in physiology and pathology: Cell Metabolism
www.cell.com/cell-metabol...
10 months ago
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Another lactate dependent immunosuppressant mechanism, here in Glioblastoma
#GBM
#Lactate
#CD47
#HistoneLactylation
JCI - Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation
www.jci.org/articles/vie...
10 months ago
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āA Ī²-hydroxybutyrate (BHB) shunt pathway generates anti-obesity ketone metabolitesā Interesting parallels between Lac-Phe and BHB-Phe as CNDP2 generated metabolites with appetite regulating functions.
www.cell.com/cell/fulltex...
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A Ī²-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites
Conserved ketone body-amino acid metabolites suppress food intake in mice, demonstrating that secondary ketone body metabolism contributes to energy balance.
https://www.cell.com/cell/fulltext/S0092-8674%2824%2901214-5
10 months ago
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reposted by
David Finlay
Andy Hogan
10 months ago
Obesity imprints adipose tissue even after weight loss - promoting regain and progression. Same is observed with GLP-1 therapies were we see regain in the majority of individuals who stop TX
www.nature.com/articles/s41...
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Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...
https://www.nature.com/articles/s41586-024-08165-7
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reposted by
David Finlay
Pallett Lab UCL
10 months ago
A while back we wrote an article calling for accelerated change in policy for those w/ caring responsibilities in
#STEMM
Sharing insights into the challenges, highlighting personal experiences & proposing a strategy to improve culture
#AcademicSky
Read it here:
www.nature.com/articles/d41...
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Researcher parents are paying a high price for conference travel ā hereās how to fix it
Three scientist mothers call for a change in how conference childcare costs are reimbursed, drawing on their personal experiences.
https://www.nature.com/articles/d41586-024-01571-x
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reposted by
David Finlay
Sarah Dimeloe
10 months ago
It was great to work with Kendle Maslowskiās group
@mmimic.bsky.social
and others on this project, interrogating the curious question of why T cells arenāt engaged by bacterial cancer therapy, and how to make them so! Itās all down to metabolism of course šā¦
add a skeleton here at some point
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reposted by
David Finlay
Sarah Crome
10 months ago
Will have a more detailed post soon, but sharing advanced online pre-proof version of our new study - Single cell profiling of Hematopoietic Stem Cell Transplant recipients reveals TGF-Ī²1 and IL-2 confer immunoregulatory functions to NK cells:
www.cell.com/iscience/ful...
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Single cell profiling of Hematopoietic Stem Cell Transplant recipients reveals TGF-Ī²1 and IL-2 confer immunoregulatory functions to NK cells
Natural Killer (NK) cell activity is influenced by cytokines and microenvironment factors, resulting in remarkably diverse functions, by contributing to inflammatory responses or serving as rheostats ...
https://www.cell.com/iscience/fulltext/S2589-0042%2824%2902641-5
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ZDHHC3 as a target to reduce cholesterol in the TME and rejuvenate T cell function ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma: Cell Reports
www.cell.com/cell-reports...
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ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma
Wu etĀ al. demonstrate that ZDHHC3-mediated S-acylation of SCAP at C264 antagonizes HACE1-mediated SCAP ubiquitination, enhancing SCAP/SREBP2 signaling and increasing cholesterol levels in the tumor mi...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2824%2901313-5
10 months ago
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David Finlay
RyanLab_TCD
10 months ago
š¢Last weeks
#immunometabolism
discoveries @Bims_BiomedNewsā¬ļøā¬ļøā¬ļø
biomed.news/bims-imicid/...
A lot of interesting articles within but highlighting a study I hadn't come across yet: I) Functional identification of soluble uric acid as an endogenous inhibitor of CD38
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David Finlay
Bob Salmond
10 months ago
Asparaginase expression impedes T cell responses but is required for anti-tumour efficacy during salmonella CRC therapy. More evidence for importance of Asn for T cells! Great work Kendle and colleagues!
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Slc13a3, the Itaconate transporter, improves hepatic antibacterial innate immunity
www.cell.com/developmenta...
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Itaconate uptake via SLC13A3 improves hepatic antibacterial innate immunity
It has been reported that itaconate is an immunoregulatory metabolite secreted by activated myeloid cells, including neutrophils and macrophages. Here, Chen etĀ al. demonstrate that SLC13A3 is an itaco...
https://www.cell.com/developmental-cell/fulltext/S1534-5807%2824%2900448-9
10 months ago
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reposted by
David Finlay
Thiago Carvalho
10 months ago
Putting LIPSTIC on CARTs "We reasoned that target-induced labelling of CAR molecules within the immunologic synapse, instead of surface CD8 expression levels, could be used to distinguish and characterize first-division proximal- and distal-daughter CARTs"
#Immunology
www.nature.com/articles/s41...
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Fate induction in CD8 CAR T cells through asymmetric cell division - Nature
We show that target-induced proximity labelling enables isolation of first-division CD8 chimeric antigen receptor T cells that asymmetrically distribute their surface proteome and transcriptome, resul...
https://www.nature.com/articles/s41586-024-07862-7
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Summary of @lydialynch and Aaron Douglasā recent exciting paper
#IL17
#gdTcells
#lipogenesis
#AdiposeTissue
Fat keeps metabolism in tune and on time using an inflammatory immune protein
www.nature.com/articles/d41...
Actual paper here
www.nature.com/articles/s41...
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Fat keeps metabolism in tune and on time using an inflammatory immune protein
Immune cells that release the molecule IL-17A help to drive the metabolic rhythms of fat.
https://www.nature.com/articles/d41586-024-03602-z
10 months ago
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reposted by
David Finlay
Jon Lim, MRCP PhD
10 months ago
š” Inspired by others, as we grow our
#AcademicSky
#MedSky#ImmunoSky
community here
@bsky.app
š¦, thought it might be cool to have a
#StarterPack
for
#CancerImmunology
. Please join in or recommend a colleague! Hope this is useful š
go.bsky.app/PRdmHCP
add a skeleton here at some point
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reposted by
David Finlay
Timo RĆ¼ckert
10 months ago
To introduce myself and what I do: in my PhD
@romagnanilab.bsky.social
, I found that human NK cells maintain clonal immune memory to CMV infection
www.nature.com/articles/s41...
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Clonal expansion and epigenetic inheritance of long-lasting NK cell memory - Nature Immunology
Here, the authors use single-cell multiomics and profiling of mitochondrial mutations as endogenous barcodes to show that human adaptive NK cells induced by CMV persist as clonal expansions that inher...
https://www.nature.com/articles/s41590-022-01327-7
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Study argues glutamine diminishes activation and recruitment of neutrophils
#Neutrophils
#glutamine
#mitochondria
#glutathione
#transglutaminase2
āGlutamine modulates neutrophil recruitment and effector functions during sterile inflammationā
doi.org/10.1093/jleu...
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Glutamine modulates neutrophil recruitment and effector functions during sterile inflammation
Glutamine modulates neutrophil responses during sterile inflammation.
https://doi.org/10.1093/jleuko/qiae243
10 months ago
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Interesting link between high glucose in T2D patients and impaired T cells responses towards virus.
#LipidPeroxidation
#TcellSignalling
#T2D
Hyperglycemia-triggered lipid peroxidation destabilizes STAT4 and impairs anti-viral Th1 responses in type 2 diabetes
www.sciencedirect.com/science/arti...
10 months ago
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reposted by
David Finlay
Lauren Palmer
10 months ago
SO EXCITED to share our recent work on dietary zinc deficiency worsening Acinetobacter baumannii pneumonia, out today with
@natureportfolio.bsky.social
!! Surprisingly, this is due at least in part to the allergic-type cytokine IL-13. SharedIt link:
rdcu.be/d0h4h
Eat your zinc rich foods! š¦Ŗš«š§š„©š„
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Dietary zinc deficiency promotes Acinetobacter baumannii lung infection via IL-13 in mice
Nature Microbiology - Increased IL-13 drives increased bacterial dissemination and mortality following Acinetobacter baumannii lung infection of zinc-deficient mice and can be countered by...
https://rdcu.be/d0h4h
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Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells
#immunometabolism
#TME
#immunosuppression
www.nature.com/articles/s41...
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Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells - Nature Communications
Mechanisms of prostaglandin E2 (PGE2)-mediated immunosuppression in the tumor microenvironment (TME) have been previously reported. Here, the authors profile PGE2 functions in human cancer, suggesting...
https://www.nature.com/articles/s41467-024-53706-3
10 months ago
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Always thought there were additional complexities to how cells sense glutamine. Interesting link here to SREBP2 activation. Glutamine sensing licenses cholesterol synthesis | The EMBO Journal
www.embopress.org/doi/full/10....
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Glutamine sensing licenses cholesterol synthesis | The EMBO Journal
imageimageWhether cholesterol biosynthesis can be adjusted to the availability of input carbon sources remains unclear. This study demonstrates that glutamine is directly sensed by and required for ac...
https://www.embopress.org/doi/full/10.1038/s44318-024-00269-0
10 months ago
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Would this antidepressant also have anti inflammatory effects through hitting Glut1 on activated immune cells?
#immunometabolism
SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1
www.cell.com/cell-reports...
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SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1
Dong etĀ al. find that commonly prescribed antidepressants, SSRIs, have significant anti-tumor effects in HCC. SSRIs, including citalopram, target GLUT1 instead of their classical target, SERT, leading...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2824%2901169-0
10 months ago
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