Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11 wellcomeopenresearch.org/articles/9-3...

Check out our new commentary on this interesting study by @justinaguerrero.bsky.social and team on Glut1 overexpressing CAR T cells. Excited to see what comes next for these metabolically enhanced T cells! @davidfinlaytcd.bsky.social

PKM2 has always been intriguing; complex roles in some cells, here involving adenosine in #macrophages, simple glycolytic enzyme in #NKcells (doi.org/10.7554/eLif...) #immunometabolism #immunosky Metabolic reprogramming of macrophages by PKM2 promotes IL-10 via adenosine www.cell.com/cell-reports...

More nice research from Annie Curtis’ lab on the circadian rhythm and the #immunometabolism of macrophages. #immunosky #mitochondria #inflammasome Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in macrophages faseb.onlinelibrary.wiley.com/doi/10.1096/...

Exciting work from Sue Kaech’s lab @tcellogic.bsky.social Tissue specific metabolites like #BileAcids in #Liver affect #CD8Tcell tumour responses #immunometabolism #immunosky Bile acid synthesis impedes tumor-specific T cell responses during liver cancer www.science.org/doi/10.1126/...

Lots of interest in how to maintain healthy mitochondria for effective cell therapy, like #NKcells for cancer immunotherapy. Some interesting clues in this article. #immunosky #immunometabolism Triacylglycerol mobilization underpins mitochondrial stress recovery www.nature.com/articles/s41...

AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress www.nature.com/articles/s41...

#Immunometabolism role for Pyrimidine synthesis enzyme CTP synthetase-1. CTPS1 deaminates IRF3 and suppresses IFN response; important implications for antiviral #immunology? Yes indeed…. authors show that loss of CTPS1 elevates antiviral immune response in www.cell.com/immunity/ful...

Authors use an elegant transgenic model to demonstrate that acute oral administration of metformin targets mitochondrial complex I to lower blood glucose. A crucial contribution to the debate about the mechanisms of action of #metformin. #metabolism #glucose doi.org/10.1126/scia...

Another important example of lactylation controlling metabolic pathways; stabilisation of TFEB to increase lysosomal activity. Will be interesting to see if this mechanism plays a role in #immunometabolism #immunology responses. rupress.org/jcb/article/...

“Glutamine sensing licenses cholesterol synthesis” #glutamine interacts with SCAP to alter the ER to Golgi trafficking needed to activate #SREBP transcriptional response. www.embopress.org/doi/full/10.... Is this relevant to #immunometabolism, such as SREBP-dependent #NKcell responses?

Metabolic #plasticity to Slc1a5 loss involving upregulation of macropinocytosis. Important also for #immune cells to support glutamine requirements? #immunometabolism “Macropinocytosis mediates resistance to loss of glutamine transport in TNBC” www.embopress.org/doi/full/10....

📢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc Eloïse Marques. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n www.biorxiv.org/content/10.1...

Interesting new oxysterol research from Jason Cyster’s lab. EBI2 (GPR183) and oxysterol ligand 7α,25-HC are required for lymphocyte homing to inflamed LNs. #immunology #oxysterols Inflammation switches the chemoattractant requirements for naive lymphocyte entry into LN www.cell.com/cell/fulltex...

New review article written by Cristhiane Favero de Aguiar and Carrie Corkish from my lab. They did a great job. www.nature.com/articles/s41... #SingleCell #Immunometabolism #ImmunoSky Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level

Interesting new research from Antoine Marçais’ lab showing a central role for pyruvate and the Citrate-Malate Shuttle (non-canonical TCA cycle) in human NK cells. #immunology #NKcells #Immunometabolism doi.org/10.1038/s422... See our commentary article here: www.nature.com/articles/s42...

And from National University of Ireland Maynooth (NUIM), Eimear Ryan from @andyhogan82.bsky.social lab will present her work at the December @immunometforum.bsky.social on #MAITcell #metabolism. #immmunosky #immunoology #immunometabolism

From Leiden in the Netherlands, @thiagoapatente.bsky.social from Bart Everts lab will present work at the December @immunometforum.bsky.social on #DCs and #Tregs. #immmunosky #immunoology #immunometabolism

From Madrid in Spain, Gillian Dunphy from the @sancholab.bsky.social lab will present her work c on #macrophages and #mitochondria. #immmunosky #immunoology #immunometabolism

The December @immunometforum.bsky.social will take place this Friday with three great early career researcher presenting: 🧵1/4 #immmunosky #immunoology #immunometabolism

Some useful starter packs 👍 Cancer Immunology: bsky.app/starter-pack... A repertoire of immunologists II: bsky.app/starter-pack... Immunometabolism: bsky.app/starter-pack... A repertoire of immunologists: bsky.app/starter-pack...

Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells #immunometabolism #TME #immunosuppression www.nature.com/articles/s41...

Interesting link between high glucose in T2D patients and impaired T cells responses towards virus. #LipidPeroxidation #TcellSignalling #T2D Hyperglycemia-triggered lipid peroxidation destabilizes STAT4 and impairs anti-viral Th1 responses in type 2 diabetes www.sciencedirect.com/science/arti...

Study argues glutamine diminishes activation and recruitment of neutrophils #Neutrophils #glutamine #mitochondria #glutathione #transglutaminase2 “Glutamine modulates neutrophil recruitment and effector functions during sterile inflammation” doi.org/10.1093/jleu...

Summary of @lydialynch and Aaron Douglas’ recent exciting paper #IL17 #gdTcells #lipogenesis #AdiposeTissue Fat keeps metabolism in tune and on time using an inflammatory immune protein www.nature.com/articles/d41... Actual paper here www.nature.com/articles/s41...

Putting LIPSTIC on CARTs "We reasoned that target-induced labelling of CAR molecules within the immunologic synapse, instead of surface CD8 expression levels, could be used to distinguish and characterize first-division proximal- and distal-daughter CARTs" #Immunology www.nature.com/articles/s41...

Slc13a3, the itaconate transporter, expressed on tumour cells impairs anti-tumour immunity www.cell.com/cancer-cell/...

Slc13a3, the Itaconate transporter, improves hepatic antibacterial innate immunity www.cell.com/developmenta...

Would this antidepressant also have anti inflammatory effects through hitting Glut1 on activated immune cells? #immunometabolism SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1 www.cell.com/cell-reports...

SO EXCITED to share our recent work on dietary zinc deficiency worsening Acinetobacter baumannii pneumonia, out today with @natureportfolio.bsky.social!! Surprisingly, this is due at least in part to the allergic-type cytokine IL-13. SharedIt link: rdcu.be/d0h4h Eat your zinc rich foods! 🦪🫘🧀🥩🥜

New pre-print out from Rusty Jones’ team: Dietary restriction enhances CD8+T cell metabolic fitness via increased ketolysis ->boosts mitochondrial membrane potential ->fuels TCA cycle-dependent pathways —>more effective CD8 effectors in TME #immunosky #immunometabolism #CD8Tcells #cancermetabolism

Always thought there were additional complexities to how cells sense glutamine. Interesting link here to SREBP2 activation. Glutamine sensing licenses cholesterol synthesis | The EMBO Journal www.embopress.org/doi/full/10....