7/ 🔬 What researcher @sancholab.bsky.social (CNIC) sees as an advance to improve cardiovascular health, artist and #laCaixaFoundFellows @guillermomora.bsky.social#laCaixaFoundFellowssees as a moving map. 🎨 They explain it to us in this #SnapshotsOfTheMonth. 👇 https://bit.ly/3XMZfOc

I had the pleasure of acting as an external PhD examiner for @aitorjarit.bsky.social in the lab of @sancholab.bsky.social 🇪🇸 during the summer. Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile. Thank you very much!

🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism. www.embopress.org/doi/full/10.... (1/9)

🌞 Day 2 begins at La Cristalera! Today we welcome 2 Invited Plenary Speakers: 🔶 Prof. David Sancho, @sancholab.bsky.social (CNIC) 🔶 Prof. Susana Guerrero Salazar (University of Málaga) ✨Another full day of science, ideas, and inspiring talks ahead! #RetreatIIBM_2025 #IIBmCSICUAM @csic.es @uam.es

Gracias @caixaresearch.bsky.social por el sólido apoyo a nuestra investigación. Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo www.ahajournals.org/doi/10.1161/... También apoyo fundamental en: www.nature.com/articles/s41...

This work identifies 'imidazole propionate' as a causal microbial metabolite that promotes atherosclerosis and shows that modulating its levels can potentially prevent cardiovascular disease risk, a promising therapeutic strategy.👇

A gut microbiota metabolite linked to atherosclerosis could revolutionise diagnosis and treatment|ERC erc.europa.eu/news-events/...

Fantástico resumen por @manuelansede.bsky.social 🙏 @caixaresearch.bsky.social por financiar proyecto con 1 millón € 🙏 @ageinves.bsky.social por Severo Ochoa que inició el proyecto + 100K€ a nuestro lab 🙏 @erc.europa.eu ERC-CoG ERC-POC #CNIC_CARDIO Open acess: www.nature.com/articles/s41...

Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del @sancholab.bsky.social, se acaba de publicar en la revista @nature.com 👇 elpais.com/salud-y-bien...

Esta investigación del CNIC revela que un metabolito de la microbiota intestinal favorece la aterosclerosis. Descubre más de la mano de uno de los investigadores del equipo 👇🧬

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s41... #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky

Thank you to my co-author @iroblesv.bsky.social and @sancholab.bsky.social for believing in this project and to all the researchers who contributed to this work!!

Congrats @iannaconelab.bsky.social & team on a wonderful work @natimmunol.nature.com on the immune regulation in the liver: CD4+ T cells license Kupffer cells to rescue CD8+ T cells through IL12 & mainly IL27. Highly relevant for liver immunotherapy!!! 👏🏻👏🏻👏🏻👏🏻👏🏻 #immunosky 👇🏻👇🏻👇🏻

🧬 New immunotherapy for atherosclerosis @ahajournals.bsky.social #CircRes Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles. 🔗 doi.org/10.1161/CIRC... #Immunotherapy #Atherosclerosis #Nanomedicine #CNIC_CARDIO #immunosky #cardiosky

Congrats Irene Adán-Barrientos: great thesis presentation & defense at CNIC & @uam.es Thx thesis commitee: Julián Aragonés, Arantxa Cruz-Adalia & Bart Everts on wonderful discussion and visit! Thx Gillian Dunphy @gilliandunphy.bsky.social on fantastic co-supervision!!!

A type of immune system cell boosts #immunotherapy and prevents #cancer relapse in animal models. ✍️ @ignaciohm.bsky.social @swculek.bsky.social @sancholab.bsky.social et al. 📰 @naturecomms.bsky.social  ➡️ https://shorturl.at/DaPr3 📌DOI: 10.1038/s41467-025-58289-1. PMID: 40204706 🧪

This week the world gained another Doctor of Immunology, and we are all the richer for it! Congratulations Dr. Irene on a great thesis and defense. Thank you to the examiners for the interesting discusion and to @sancholab.bsky.social for cosupervising with me these years - it has been a pleasure!

Heras-Murillo et al. treated mice with tumor cell lysate-loaded syngeneic splenic selected cDC populations. bit.ly/4cKkXJp  @sancholab.bsky.social

Great talk by @sancholab.bsky.social shedding light on the role of #dendriticcells in #atherosclerosis: players in shaping immune responses within plaques. #ImmunoAthero

Put a dendritic cell (DC) in your tumor #immunotherapy! cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse! #CNIC @ageinves.bsky.social @contracancerinv.bsky.social www.nature.com/articles/s41... #immunosky #cancersky (1/7)

Immunotherapy with cDC1 induces immune memory and limits tumor relapse @naturecomms.bsky.social @sancholab.bsky.social @swculek.bsky.social www.nature.com/articles/s41...

Kudos to @sancholab.bsky.social and @swculek.bsky.social for this work in @naturecomms.bsky.social showing that "that cDC1-based vaccination excels at immune memory induction and prevention of cancer recurrence" www.nature.com/articles/s41...

And it gives me the chance the highlight the best CD4+ T cell/ice cream crossover review: doi.org/10.1038/s415...

Stanley Huang told us about metabolic regulation of macrophages and Roser Vento gave us a great talk on spatial analysis of macrophages in reproductive tissues! What an amazing end of session. #EPW2025 #immunosky

I had a wonderful time! Great conference and speakers! Thanks @casanova-acebes.bsky.social @sancholab.bsky.social and Carlos Silvestre for the great work organizing such an amazing meeting!

#ElodieSegura investigating cellular and molecular changes of in monocytes upon AhR signaling at #EPW2025

Kati Mauel from our lab talking about splenic #macrophages and their response to #malaria infection at #EPW2025 🤩

#teamOrganizers at #EPW2025

🧪🔬And Joaquin Canton Sandoval brings home a Best Poster Award from the #EPW2025 YAY🤗🥳 #proudmentor 🤧 #zebrafish

We start the 3rd session of the #EPW2025 on Phagocytes in Motion! With the one and only Sussan Nourshargh! #immunosky

Time matters in Lung Cancer! And neutrophils (of course) are the main suspects! Great talk by Alba de Juan @casanova-acebes.bsky.social lab. #EPW2025 #immunosky

Last flash talk by Lucia de Prado Rivas on mTorc1 in macrophages and atherosclerosis. #EPW2025 #immunosky

We start the 3rd and final day! #EPW2025 with Venizelos Papayannopoulos and neutrophil heterogeneous anti-microbial activities! #immunosky

Mind blowing talk by Alejo Fraticelli! New techniques to understand HSC phylogeny! @alejofraticelli.bsky.social #EPW2025 #immunesky

María Luisa Gil on Trained neutrophils in infection! #EPW2025 #immunosky

@adrover.bsky.social rocking on a fantastic new and vascular-damaging Ly6Clo neutrophils, he will now investigate deeper in his #brandnewlab #EPW2025

Thanks to the organisers @silvestreroiglab.bsky.social @casanova-acebes.bsky.social and #DavidSancho for this amazing conference #EPW2025 and for selecting our abstract from @biogipuzkoa.bsky.social. I am learning a lot about myeloid immunology!

Beautiful work on Kupffer cells and LAMs during liver damage by Federico de Pinto! #EPW2025 #immunosky @charlottelscott.bsky.social

Third Juan Manuel Lozano-Gil on ninjurins and HSPCs function. #EPW2025 #immunosky

Mathis Richter shows us the importance of preNEUs in myocardial infarction! #EPW2025 #immunosky @mathisrichter.bsky.social

Second Maria Caffarel with Oncostatin M in tumor immunity. #EPW2025 #immunosky

🧪🔬 I'm so proud of Cassia presenting her project on neutrophil prioritization of injuries in complex organs using a zebrafish model of polytraumatic injury at #EPW2025 #CNIC 👏🏽 well done 🤗😍 #neutrophils #zebrafish

My favourite part of being a PI… watching your team members grow and shine! Great talk by @federicodeponti.bsky.social at #EPW2025 super talented PhD student about to defend and looking for a postdoc…. One to watch for the future!

@udalovalab.bsky.social on stage! VSIG4+ aquaporin1 macs take care of your moves...macs in other difficult niches to look or isolate like joints...impressive imaging!

Neutrophil stalling in #stroke by #MohamadElAmki. Amazing imaging and a scary phenotype in neutrophils for small capillaries body-wide!

Second day! And we start with @sancholab.bsky.social also co-organizer of #EPW2025. We will know more about trained immunity and metabolic reprogramming of myeloid cells!

Starting day 2 with great talks from @sancholab.bsky.social immunometabolism hardcore on the role of calcineurin / NFAT regulation of inflammation in macs upon #trained immunity, followed by #GillianDunphy showing us how ISG15 is required for mitochondrial metabolism.

Thanks to the organizers @sancholab.bsky.social @casanova-acebes.bsky.social & Carlos Silvestre for giving me the opportunity to kick-off this fantastic meeting #EPW2025 What a day for #macrophage lovers!

#immunosky #epw2025 Fantastic & extensive technical & scientific Keynote talk by @charlottelscott.bsky.social!!! Top discoveries on Kupffer cell function & so much to come!👏🏻👏🏻👏🏻👏🏻

Final short talk from today! #immunosky #EPW2025. Clarissa Döring #TRR359. We keep having fun!