Does mitochondrial respiration in DCs just “fuel” activation? In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s www.science.org/doi/10.1126/... At: CNIC_CARDIO @inmunosky

Mitochondrial complex I dysfunction in dendritic cells disrupts NAD+/NADH redox balance and impairs antigen cross-presentation @sciimmunology.bsky.social @sancholab.bsky.social www.science.org/doi/10.1126/...

Wonderful work, David! The concept that ETC flux—not ATP—licenses cDC1 immunogenicity through /metabolite control of DNA methylation is conceptually beautiful. Congrats to Ignacio, Stefanie and the whole team! Thanks for giving us the chance to learn throught this collaboration!

🤔Do you think that OXPHOS in DCs = tolerance? In our new @cp-cellmetabolism.bsky.social #cnic_cardio & @irbbarcelona.org, we show that active #mitochondrial ETC primes cDC1s for immunogenicity, not tolerance. Life (& #immunometabolism) is not simple ⚡️ OPEN: www.cell.com/cell-metabol... #immunoSky

Always a mind-blowing talk from @sancholab.bsky.social who showed, alongside cool data on macs, that cIII inhibition in cDC1 has functional consequence on anti-tumor immunity > mitochondrial ETC disruption impact on histone demethylase and alter PU.1 pioneer activity. Everything linked !

#WeekendRead! #InterferonPower! Dunphy @sancholab.bsky.social &co show @cp-immunity.bsky.social that in #macrophages, STING leads to type I #IFNs & ISG15-dependent ISGlatyion of mitochondrial proteins, increasing efferocytosis & driving epigenetic remodeling thus supporting inflammation resolution!

#PhD in #immunometabolism on fatty acid oxidation in #macrophage function. MSCA-DN: unimedizin-mainz.de/unlimited-ms... For our DC8 position apply in parallel in 2 sites: 1. unimedizin-mainz.de/unlimited-ms... 2. cnic.es/en/convocato... (DC8: NOT resident in Spain >12m in last 3 years) #immunosky

Great opportunity for a #PhD on how lipid #metabolism regulates immune cell function in diseases such as cancer and autoimmunity. Train in immunology, bioIT, & metabolism. Apply in parallel in: 1. UNLIMITED: www.unimedizin-mainz.de/unlimited-ms... 2. Local partner site that you choose. #immunosky

Excessive #inflammation? We uncover @cp-immunity.bsky.social that #IFN-I via #ISG15 in macrophages lowers #mitochondrial membrane potential, boosts #efferocytosis, and self limits #ISG amplification: a built in brake that promotes resolution. Open-access: www.cell.com/immunity/ful... #immunosky

A type I IFN-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages @cp-immunity.bsky.social @sancholab.bsky.social www.cell.com/immunity/ful...

Don't miss the 2nd Conference of the European ImmunoMetabolism Network - EIMN2026 📅10-12th June 2026 📌Luxembourg immunometnet.eu @immunometeurope.bsky.social linkedin.comevents/2ndconferenc...

7/ 🔬 What researcher @sancholab.bsky.social (CNIC) sees as an advance to improve cardiovascular health, artist and #laCaixaFoundFellows @guillermomora.bsky.social#laCaixaFoundFellowssees as a moving map. 🎨 They explain it to us in this #SnapshotsOfTheMonth. 👇 https://bit.ly/3XMZfOc

I had the pleasure of acting as an external PhD examiner for @aitorjarit.bsky.social in the lab of @sancholab.bsky.social 🇪🇸 during the summer. Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile. Thank you very much!

🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism. www.embopress.org/doi/full/10.... (1/9)

🌞 Day 2 begins at La Cristalera! Today we welcome 2 Invited Plenary Speakers: 🔶 Prof. David Sancho, @sancholab.bsky.social (CNIC) 🔶 Prof. Susana Guerrero Salazar (University of Málaga) ✨Another full day of science, ideas, and inspiring talks ahead! #RetreatIIBM_2025 #IIBmCSICUAM @csic.es @uam.es

Gracias @caixaresearch.bsky.social por el sólido apoyo a nuestra investigación. Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo www.ahajournals.org/doi/10.1161/... También apoyo fundamental en: www.nature.com/articles/s41...

This work identifies 'imidazole propionate' as a causal microbial metabolite that promotes atherosclerosis and shows that modulating its levels can potentially prevent cardiovascular disease risk, a promising therapeutic strategy.👇

A gut microbiota metabolite linked to atherosclerosis could revolutionise diagnosis and treatment|ERC erc.europa.eu/news-events/...

Fantástico resumen por @manuelansede.bsky.social 🙏 @caixaresearch.bsky.social por financiar proyecto con 1 millón € 🙏 @ageinves.bsky.social por Severo Ochoa que inició el proyecto + 100K€ a nuestro lab 🙏 @erc.europa.eu ERC-CoG ERC-POC #CNIC_CARDIO Open acess: www.nature.com/articles/s41...

Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del @sancholab.bsky.social, se acaba de publicar en la revista @nature.com 👇 elpais.com/salud-y-bien...

Esta investigación del CNIC revela que un metabolito de la microbiota intestinal favorece la aterosclerosis. Descubre más de la mano de uno de los investigadores del equipo 👇🧬

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s41... #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky

Thank you to my co-author @iroblesv.bsky.social and @sancholab.bsky.social for believing in this project and to all the researchers who contributed to this work!!

Congrats @iannaconelab.bsky.social & team on a wonderful work @natimmunol.nature.com on the immune regulation in the liver: CD4+ T cells license Kupffer cells to rescue CD8+ T cells through IL12 & mainly IL27. Highly relevant for liver immunotherapy!!! 👏🏻👏🏻👏🏻👏🏻👏🏻 #immunosky 👇🏻👇🏻👇🏻

🧬 New immunotherapy for atherosclerosis @ahajournals.bsky.social #CircRes Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles. 🔗 doi.org/10.1161/CIRC... #Immunotherapy #Atherosclerosis #Nanomedicine #CNIC_CARDIO #immunosky #cardiosky

Congrats Irene Adán-Barrientos: great thesis presentation & defense at CNIC & @uam.es Thx thesis commitee: Julián Aragonés, Arantxa Cruz-Adalia & Bart Everts on wonderful discussion and visit! Thx Gillian Dunphy @gilliandunphy.bsky.social on fantastic co-supervision!!!

A type of immune system cell boosts #immunotherapy and prevents #cancer relapse in animal models. ✍️ @ignaciohm.bsky.social @swculek.bsky.social @sancholab.bsky.social et al. 📰 @naturecomms.bsky.social  ➡️ https://shorturl.at/DaPr3 📌DOI: 10.1038/s41467-025-58289-1. PMID: 40204706 🧪

This week the world gained another Doctor of Immunology, and we are all the richer for it! Congratulations Dr. Irene on a great thesis and defense. Thank you to the examiners for the interesting discusion and to @sancholab.bsky.social for cosupervising with me these years - it has been a pleasure!

Heras-Murillo et al. treated mice with tumor cell lysate-loaded syngeneic splenic selected cDC populations. bit.ly/4cKkXJp  @sancholab.bsky.social

Great talk by @sancholab.bsky.social shedding light on the role of #dendriticcells in #atherosclerosis: players in shaping immune responses within plaques. #ImmunoAthero

Put a dendritic cell (DC) in your tumor #immunotherapy! cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse! #CNIC @ageinves.bsky.social @contracancerinv.bsky.social www.nature.com/articles/s41... #immunosky #cancersky (1/7)

Immunotherapy with cDC1 induces immune memory and limits tumor relapse @naturecomms.bsky.social @sancholab.bsky.social @swculek.bsky.social www.nature.com/articles/s41...

Kudos to @sancholab.bsky.social and @swculek.bsky.social for this work in @naturecomms.bsky.social showing that "that cDC1-based vaccination excels at immune memory induction and prevention of cancer recurrence" www.nature.com/articles/s41...

And it gives me the chance the highlight the best CD4+ T cell/ice cream crossover review: doi.org/10.1038/s415...

Stanley Huang told us about metabolic regulation of macrophages and Roser Vento gave us a great talk on spatial analysis of macrophages in reproductive tissues! What an amazing end of session. #EPW2025 #immunosky

I had a wonderful time! Great conference and speakers! Thanks @casanova-acebes.bsky.social @sancholab.bsky.social and Carlos Silvestre for the great work organizing such an amazing meeting!

Kati Mauel from our lab talking about splenic #macrophages and their response to #malaria infection at #EPW2025 🤩

#ElodieSegura investigating cellular and molecular changes of in monocytes upon AhR signaling at #EPW2025

#teamOrganizers at #EPW2025

🧪🔬And Joaquin Canton Sandoval brings home a Best Poster Award from the #EPW2025 YAY🤗🥳 #proudmentor 🤧 #zebrafish

We start the 3rd session of the #EPW2025 on Phagocytes in Motion! With the one and only Sussan Nourshargh! #immunosky

Time matters in Lung Cancer! And neutrophils (of course) are the main suspects! Great talk by Alba de Juan @casanova-acebes.bsky.social lab. #EPW2025 #immunosky

Last flash talk by Lucia de Prado Rivas on mTorc1 in macrophages and atherosclerosis. #EPW2025 #immunosky

We start the 3rd and final day! #EPW2025 with Venizelos Papayannopoulos and neutrophil heterogeneous anti-microbial activities! #immunosky

Mind blowing talk by Alejo Fraticelli! New techniques to understand HSC phylogeny! @alejofraticelli.bsky.social #EPW2025 #immunesky

María Luisa Gil on Trained neutrophils in infection! #EPW2025 #immunosky

@adrover.bsky.social rocking on a fantastic new and vascular-damaging Ly6Clo neutrophils, he will now investigate deeper in his #brandnewlab #EPW2025

Thanks to the organisers @silvestreroiglab.bsky.social @casanova-acebes.bsky.social and #DavidSancho for this amazing conference #EPW2025 and for selecting our abstract from @biogipuzkoa.bsky.social. I am learning a lot about myeloid immunology!

Beautiful work on Kupffer cells and LAMs during liver damage by Federico de Pinto! #EPW2025 #immunosky @charlottelscott.bsky.social

Third Juan Manuel Lozano-Gil on ninjurins and HSPCs function. #EPW2025 #immunosky