🧬 Big news: our team at @gimminstitute.bsky.social and I have been awarded a €2.5M ERC Advanced Grant (#ERCAdG) for a project we couldn't resist naming KILLBILL. Yes, like the Tarantino film. Bear with me — the analogy runs deeper than the title. 🧵 ⚔️

An American leader who believes in science.

🧬 New findings from our lab @gimminstitute.bsky.social, out in iScience, led by PhD student Miguel Mesquita who defends his thesis very soon! We define a bilirubin threshold for malaria protection using catalytically deficient BVRA mouse mutants. 🔗 doi.org/10.1016/j.isci.2026.115958

🎟️Do you want to be part of a dynamic platform for dialogue and discovery? Register your Early Bird acess for GIMM Festival 2026, taking place 17–19 September in Lisbon, and hear from Charles Rice, Yasmine Belkaid and many others speakers. 🔗Register now: linktr.ee/gimm_institute

Red blood cells don't always make their own heme - under stress, they scavange it from neighbors. Our new paper in @ScienceMagazine reveals a cell-nonautonomous heme acquisition pathway essential for erythroid hemoglobinization. #heme #erythropoiesis #anemia www.science.org/doi/10.1126/...

Applications are open for the Master in Biomedical Research (MIB)! Hands-on training at GIMM & FMUL. Cancer Biology, Neurosciences, Cardiovascular, Infection & Immunity. English-taught. Deadline: May 31. (@gimminstitute.bsky.social) Please share! medicina.ulisboa.pt/en/biomedical-research

This is the front cover of the new edition of @thelancet.com (thanks to @profstevegriffin.bsky.social for sharing) #HealthPolicy #Science 🧪🧵

Honoring immigrants in research: The Vilcek Prizes in Biomedical Science | Science | AAAS www.science.org/content/arti...

The biggest science breakthroughs in 2025 | Science | AAAS www.science.org/content/arti...

@elmiguelche.bsky.social from GIMM and Daniel Costa Gomes from ULSSM and FMUL are leading a project aimed at developing a multi-omics atlas for sepsis patients to identify cellular mechanisms that lead to organ failure.

Two days of scientific discussion and networking will be followed by a day open to the public — reinforcing our commitment to sharing research with society. Secure your ticket! 🔗 Get your ticket: fest.gimm.pt 🎟️ Early bird special rates

GIMM Fest returns September 17–19 with three days dedicated to the future of science and health, this year focusing on microbes. 🦠 Join researchers and innovators for a programme designed to promote scientific exchange and collaboration.

The great Ruslan Medzhitov strikes again!

Join us for the 2026 GRC Immunochemistry and Immunobiology "Immune Circuitry and Molecular Pathways in Tissue Homeostasis, Infection, and Disease" in beautiful Barcelona. June 28 - July 3, 2026. Great lineup of speakers! www.grc.org/immunochemis...

Incredible science at the CAML-GIMM PhD Meeting 2026! So proud of the outstanding presentations from our GIMM students across both campuses. 🧬 The meeting showcased "home made" cutting-edge research! Congratulations to Sonia Trikha, Madalena Pereira and Miguel Mesquita! @gimmfoundation.bsky.social

#DirtyIsBetter! @rmedzhitov.bsky.social, Erickson &co show @nature.com that pet shop mice are protected from #allergy thanks to cross reactive type I (or tolerogenic) immune memory that prevents type II allergen-driven responses! doi.org/10.1038/s415...

Ageing rewires the body’s tolerance to infection www.nature.com/articles/d41...

#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...

This is not an anomaly. It is a method. Correction becomes harassment Public discourse becomes “stalking” Expertise becomes abuse Evidence is replaced by narrative Sex and victimhood are instrumentalised Reputation damage is the objective

New research led by @karinaxavierlab.bsky.social at 🇵🇹 @gimmfoundation.bsky.social demonstrates that a harmless strain of 🦠 #Klebsiella – discovered by chance in 🧫 laboratory experiments – can eliminate #infections and reduce gut inflammation in mouse models of inflammatory bowel disease. #IBD

1/10 🧵NEW PREPRINT: How does jaundice protect against malaria? We show it's ALL about biliverdin reductase (BVRA) catalytic activity and found the bilirubin threshold needed for protection. www.biorxiv.org/content/10.6...

@EMBO Practical Course Pipetting scRNA-seq data into computational cells 18 – 23 May 2026 | Oeiras/Lisbon, Portugal @gimmfoundation.bsky.social Registration open!

Homeostatic control of energy metabolism by monocyte-derived macrophages @elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells www.embopress.org/doi/full/10....

🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism. www.embopress.org/doi/full/10.... (1/9)

of the influenza vaccine is low (against infection). What is forgotten is the protection from non-communicable diseases. What if you could reduce your risk to heart disease by 40%? What is you could reduce you risk to dementia by at least 10%? That is what vaccines do! 3/10

Food for thought from: ‪@lferreiramoita.bsky.social‬ in JCI - Biological and clinical implications of a model of surveillance immunity www.jci.org/articles/vie...

At Folha de São Paulo: folha.com/38iy72bz @gimmfoundation.bsky.social

Beautiful new work from Maz Divangahi lab about the enhanced anti-tumoral activity of β-glucan + BCG trained neutrophils leading to tumor eradication. #freshoffthepress @cp-immunity.bsky.social

A recent study based on observations in humans and experiments in mice proposes that induction of bilirubin production in response to Plasmodium spp. infection is an evolutionary conserved mechanism against malaria. 🧪 www.science.org/doi/10.1126/...

Rewring lipid metabolism to sustain thermoregulation during sepsis. Don’t let it get cold! A very interesting piece from Miguel Soares lab @elmiguelche.bsky.social @gimmfoundation.bsky.social

The future of heart health: AI, immunity, and personalized prevention | Science | AAAS www.science.org/content/webi...

Call for our new PhD program is open. Come join one of our labs at Gulbenkian Institute for Molecular Medicine - Lisbon-Oeiras, Portugal. Help us spread the word

A bioenergetic basis for multiorgan dysfunction in sepsis https://www.biorxiv.org/content/10.1101/2025.06.12.659280v1

Check out the paper from our latest collaboration with Miguel Soares's lab: 🦠A metabolite-based resistance mechanism against malaria Now out in Science: www.science.org/doi/10.1126/... @gimmfoundation.bsky.social @turkubioscience.bsky.social @inflames-flagship.bsky.social @utu.fi

Rethinking jaundice | Science @gimmfoundation.bsky.social

A metabolite-based resistance mechanism against malaria | Science www.science.org/doi/10.1126/... @gimmfoundation.bsky.social

There is a price tag for everything….. www.sciencedirect.com/science/arti... Evolutionary medicine in action: Sickle hemoglobin fuels tumor progression - ScienceDirect

Latest from the Nature Podcast 🔊 Male mice can grow female organs — if their mothers lack iron https://go.nature.com/3SY8I2V

🚨Great new MSc and PhD positions available @gimmfoundation! Check out the links or use the QR code. MSc: www.medicina.ulisboa... PhD: gimm.pt/course/phd-p...

Curious about aging & longevity research? Join us at GIMM Fest (Lisbon, Portugal) Discover groundbreaking insights & engage with top researchers. It's a celebration of curiosity & a catalyst for change. 🗓️ Sept 4-5: Scientific Sessions + Sept 6: Public Event 👉 gimm.pt/gimm-festival/

@cleeterichter.bsky.social & Kelsey Voss discuss a study from @elmiguelche.bsky.social that highlights a role for monocyte-derived macrophages in iron homeostasis and its control of systemic energy metabolism

Red blood cells undergo lytic programmed cell death involving NLRP3: Cell www.cell.com/cell/fulltex...

Is it still not clear? Abusing the state to force your ideology on others. Fascism, Fascism, Fascism. There is no other term for this. Jay Bhattacharya? 🤡🤡🤡 a useful idiot.

Important definitions and concepts to understand that what is happening in many countries is not new.

"Fascism is rising again". It's been back for several years, out in the open. But these four words may need an explanation and a warning. 1/3

Today in #preprinthub2 Kelsey Voss + @cleeterichter.bsky.social will present a #preprint from @elmiguelche.bsky.social @gimmfoundation.bsky.social on how monocytes control organismal energy homeostasis 🕹️🧍‍♀️🌊 www.biorxiv.org/content/10.1...

The U.S. National Institutes of Health’s recent decision to impose a 15% cap on facilities and administrative cost reimbursements is misguided and damaging, argue the authors of a new #SciencePolicyForum. scim.ag/423AbVX