Miguel Soares
@elmiguelche.bsky.social
📤 94
📥 203
📝 53
Antifascist&Scientist
Honoring immigrants in research: The Vilcek Prizes in Biomedical Science | Science | AAAS
www.science.org/content/arti...
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Honoring immigrants in research: The Vilcek Prizes in Biomedical Science
Diverse voices overcome scientific challenges
https://www.science.org/content/article/honoring-immigrants-research-vilcek-prizes-biomedical-science
about 9 hours ago
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The biggest science breakthroughs in 2025 | Science | AAAS
www.science.org/content/arti...
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The biggest science breakthroughs in 2025
From supercharged cancer cells to the first personalized gene-editing therapy, last year was full of scientific advances
https://www.science.org/content/article/biggest-science-breakthroughs-2025
5 days ago
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reposted by
Miguel Soares
GIMM Institute
17 days ago
@elmiguelche.bsky.social
from GIMM and Daniel Costa Gomes from ULSSM and FMUL are leading a project aimed at developing a multi-omics atlas for sepsis patients to identify cellular mechanisms that lead to organ failure.
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Miguel Soares
GIMM Institute
13 days ago
Two days of scientific discussion and networking will be followed by a day open to the public — reinforcing our commitment to sharing research with society. Secure your ticket! 🔗 Get your ticket:
fest.gimm.pt
🎟️ Early bird special rates
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Miguel Soares
GIMM Institute
13 days ago
GIMM Fest returns September 17–19 with three days dedicated to the future of science and health, this year focusing on microbes. 🦠 Join researchers and innovators for a programme designed to promote scientific exchange and collaboration.
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The great Ruslan Medzhitov strikes again!
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On the balance of knowledge
Nature Reviews Immunology - Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern...
https://www.nature.com/articles/s41577-026-01276-4.epdf?sharing_token=BrsXOJkT-JEfGTDeNp-nhNRgN0jAjWel9jnR3ZoTv0O_MqcPCL7-l2KZSAlmtWfGz3fRgx8obVor5LB0pRPS2iAQ3K2yytg-ZfOZPaJ-nOeLP_jIKLVTBwRn2XaMdB9hNltDNhM8FarT7zaB1sepJqMT9eLZ98bIUT6ikANHfZM%3D
12 days ago
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Miguel Soares
Iannacone Lab
15 days ago
Join us for the 2026 GRC Immunochemistry and Immunobiology "Immune Circuitry and Molecular Pathways in Tissue Homeostasis, Infection, and Disease" in beautiful Barcelona. June 28 - July 3, 2026. Great lineup of speakers!
www.grc.org/immunochemis...
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2026 Immunochemistry and Immunobiology Conference GRC
The 2026 Gordon Research Conference on Immunochemistry and Immunobiology will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
https://www.grc.org/immunochemistry-and-immunobiology-conference/2026/
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Incredible science at the CAML-GIMM PhD Meeting 2026! So proud of the outstanding presentations from our GIMM students across both campuses. 🧬 The meeting showcased "home made" cutting-edge research! Congratulations to Sonia Trikha, Madalena Pereira and Miguel Mesquita!
@gimmfoundation.bsky.social
21 days ago
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Miguel Soares
Ivan Zanoni
21 days ago
#DirtyIsBetter
!
@rmedzhitov.bsky.social
, Erickson &co show
@nature.com
that pet shop mice are protected from
#allergy
thanks to cross reactive type I (or tolerogenic) immune memory that prevents type II allergen-driven responses!
doi.org/10.1038/s415...
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Environmentally driven immune imprinting protects against allergy - Nature
In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship be...
https://doi.org/10.1038/s41586-025-10001-5
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Ageing rewires the body’s tolerance to infection
www.nature.com/articles/d41...
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Ageing rewires the body’s tolerance to infection
In life-threatening sepsis, the same signalling pathway that protects young mice from succumbing to organ dysfunction exacerbates damage and lethality in older animals.
https://www.nature.com/articles/d41586-025-04091-4
about 1 month ago
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Miguel Soares
Ivan Zanoni
about 1 month ago
#WeekendRead
!
#SameSameButDifferent
!
#FirstLove
! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out
@jimmunol.bsky.social
👇👇👇
academic.oup.com/jimmunol/art...
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TLR4al senses heme as a key damage/danger-associated molecular pattern to activate immune responses in lower vertebrates
Abstract. Toll-like receptor 4 (TLR4), a critical pattern recognition receptor, detects microbe- and damage/danger-associated molecular patterns to trigger
https://academic.oup.com/jimmunol/article-abstract/214/11/3083/8238229?redirectedFrom=fulltext
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This is not an anomaly. It is a method. Correction becomes harassment Public discourse becomes “stalking” Expertise becomes abuse Evidence is replaced by narrative Sex and victimhood are instrumentalised Reputation damage is the objective
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Disinformation: When falsehoods become a political identity
How storytelling is used as "investigation".
https://marcveldhoen.substack.com/p/disinformation-when-falsehoods-become
about 1 month ago
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reposted by
Miguel Soares
Healthcare in Europe
about 2 months ago
New research led by
@karinaxavierlab.bsky.social
at 🇵🇹
@gimmfoundation.bsky.social
demonstrates that a harmless strain of 🦠
#Klebsiella
– discovered by chance in 🧫 laboratory experiments – can eliminate
#infections
and reduce gut inflammation in mouse models of inflammatory bowel disease.
#IBD
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Klebsiella strain to protect against IBD gut infections
A team of researchers led by Karina Xavier has uncovered a promising new live biotherapeutic agent that may redefine how the medical field approaches microbiota-based therapies.
https://healthcare-in-europe.com/en/news/klebsiella-bacteria-protect-ibd-gut-infections.html
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1/10 🧵NEW PREPRINT: How does jaundice protect against malaria? We show it's ALL about biliverdin reductase (BVRA) catalytic activity and found the bilirubin threshold needed for protection.
www.biorxiv.org/content/10.6...
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Biliverdin Reductase Catalytic Activity Is Essential for Malaria Resistance
Jaundice, a condition characterized by elevated levels of circulating bilirubin, is an adaptive response to malaria sustained through bilirubin production by biliverdin reductase A (BVRA). Beyond its ...
https://www.biorxiv.org/content/10.64898/2025.12.19.694840v1
about 2 months ago
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Miguel Soares
Marc Veldhoen
3 months ago
@EMBO
Practical Course Pipetting scRNA-seq data into computational cells 18 – 23 May 2026 | Oeiras/Lisbon, Portugal
@gimmfoundation.bsky.social
Registration open!
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Pipetting scRNA-seq data into computational cells
Single-cell transcriptomics is transforming biology, uncovering hidden cell states, dynamic transitions, and intricate interactions across systems from immunity to cancer. Yet as these technologies s…
https://meetings.embo.org/event/26-scrna
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Miguel Soares
The EMBO Journal
3 months ago
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social
and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
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🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism.
www.embopress.org/doi/full/10....
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Homeostatic control of energy metabolism by monocyte-derived macrophages | The EMBO Journal
imageimageMacrophages play critical roles in the homeostatic control systems that maintain vital parameters within physiological ranges. This study characterizes how mouse monocyte-derived macrophages...
https://www.embopress.org/doi/full/10.1038/s44318-025-00622-x
3 months ago
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Miguel Soares
Marc Veldhoen
5 months ago
of the influenza vaccine is low (against infection). What is forgotten is the protection from non-communicable diseases. What if you could reduce your risk to heart disease by 40%? What is you could reduce you risk to dementia by at least 10%? That is what vaccines do! 3/10
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Food for thought from: @lferreiramoita.bsky.social in JCI - Biological and clinical implications of a model of surveillance immunity
www.jci.org/articles/vie...
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JCI - Biological and clinical implications of a model of surveillance immunity
https://www.jci.org/articles/view/191645
7 months ago
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At Folha de São Paulo:
folha.com/38iy72bz
@gimmfoundation.bsky.social
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Bilirrubina, pigmento amarelado natural do corpo, pode combater a malária
Substância controla doença de várias maneiras; pesquisador espera que, no futuro, seja possível usar descoberta em terapias
https://folha.com/38iy72bz
8 months ago
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Miguel Soares
Payal Yokota
8 months ago
Beautiful new work from Maz Divangahi lab about the enhanced anti-tumoral activity of β-glucan + BCG trained neutrophils leading to tumor eradication.
#freshoffthepress
@cp-immunity.bsky.social
add a skeleton here at some point
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Miguel Soares
Albert and Mary Lasker Foundation
8 months ago
A recent study based on observations in humans and experiments in mice proposes that induction of bilirubin production in response to Plasmodium spp. infection is an evolutionary conserved mechanism against malaria. 🧪
www.science.org/doi/10.1126/...
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Miguel Soares
Miguel Mesquita
8 months ago
Rewring lipid metabolism to sustain thermoregulation during sepsis. Don’t let it get cold! A very interesting piece from Miguel Soares lab
@elmiguelche.bsky.social
@gimmfoundation.bsky.social
add a skeleton here at some point
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Miguel Soares
Fil Swirski
8 months ago
The future of heart health: AI, immunity, and personalized prevention | Science | AAAS
www.science.org/content/webi...
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The future of heart health: AI, immunity, and personalized prevention
https://www.science.org/content/webinar/future-heart-health-ai-immunity-and-personalized-prevention
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reposted by
Miguel Soares
Karina Xavier Lab
8 months ago
Call for our new PhD program is open. Come join one of our labs at Gulbenkian Institute for Molecular Medicine - Lisbon-Oeiras, Portugal. Help us spread the word
add a skeleton here at some point
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Miguel Soares
bioRxivpreprint
8 months ago
A bioenergetic basis for multiorgan dysfunction in sepsis
https://www.biorxiv.org/content/10.1101/2025.06.12.659280v1
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Miguel Soares
Elo Lab
8 months ago
Check out the paper from our latest collaboration with Miguel Soares's lab: 🦠A metabolite-based resistance mechanism against malaria Now out in Science:
www.science.org/doi/10.1126/...
@gimmfoundation.bsky.social
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
@utu.fi
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Rethinking jaundice | Science
@gimmfoundation.bsky.social
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Rethinking jaundice
A buildup of unconjugated bilirubin may be a protective response to malaria
https://www.science.org/doi/10.1126/science.ady7161?fbclid=IwQ0xDSwK3955leHRuA2FlbQIxMQABHmhKcr-67U8oMHpGk90ON7o01KaIYEOHx6xvQYHekbj3DcJw54H8WHTZF5-v_aem_wp3vt-dxmYzU23PUMB7oLQ
8 months ago
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A metabolite-based resistance mechanism against malaria | Science
www.science.org/doi/10.1126/...
@gimmfoundation.bsky.social
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A metabolite-based resistance mechanism against malaria
Jaundice is a common presentation of Plasmodium falciparum malaria, which arises from the accumulation of circulating bilirubin. It is not understood whether it represents an adaptive or maladaptive r...
https://www.science.org/doi/10.1126/science.adq6741
8 months ago
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There is a price tag for everything…..
www.sciencedirect.com/science/arti...
Evolutionary medicine in action: Sickle hemoglobin fuels tumor progression - ScienceDirect
8 months ago
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Miguel Soares
Nature
9 months ago
Latest from the Nature Podcast 🔊 Male mice can grow female organs — if their mothers lack iron
https://go.nature.com/3SY8I2V
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Male mice can grow female organs — if their mothers lack iron
Nature - Hear the biggest stories from the world of science | 04 June 2025
https://go.nature.com/4mVzYgb
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reposted by
Miguel Soares
Marc Veldhoen
9 months ago
🚨Great new MSc and PhD positions available @gimmfoundation! Check out the links or use the QR code. MSc:
www.medicina.ulisboa...
PhD:
gimm.pt/course/phd-p...
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reposted by
Miguel Soares
GIMM Institute
9 months ago
Curious about aging & longevity research? Join us at GIMM Fest (Lisbon, Portugal) Discover groundbreaking insights & engage with top researchers. It's a celebration of curiosity & a catalyst for change. 🗓️ Sept 4-5: Scientific Sessions + Sept 6: Public Event 👉
gimm.pt/gimm-festival/
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expresso.pt/opiniao/2025...
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25 de Abril sempre! Malária nunca mais!
<p>Tal como na malária, também não existe uma vacina contra o fascismo. Apenas a educação, a liberdade, a justiça e a empatia nos podem proteger</p>
https://expresso.pt/opiniao/2025-04-24-25-de-abril-sempre-malaria-nunca-mais-08da21f1
10 months ago
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Miguel Soares
Nature Reviews Immunology
10 months ago
@cleeterichter.bsky.social
& Kelsey Voss discuss a study from
@elmiguelche.bsky.social
that highlights a role for monocyte-derived macrophages in iron homeostasis and its control of systemic energy metabolism
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Monocytes rule energy metabolism with an iron fist - Nature Reviews Immunology
A preprint by Martins, Blankehaus et al. highlights an important role for monocyte-derived macrophages in iron homeostasis and its control of systemic energy metabolism.
https://www.nature.com/articles/s41577-025-01177-y?utm_source=bluesky&utm_medium=social&utm_campaign=nr
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Red blood cells undergo lytic programmed cell death involving NLRP3: Cell
www.cell.com/cell/fulltex...
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Red blood cells undergo lytic programmed cell death involving NLRP3
Complement exposure induces programmed cell death of red blood cells due to the intracellular activation of miniNLRP3 and caspase-8. Inhibiting NLRP3 signaling reduces cytoskeletal damage and prevents...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900389-7
10 months ago
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Miguel Soares
Marc Veldhoen
10 months ago
Is it still not clear? Abusing the state to force your ideology on others. Fascism, Fascism, Fascism. There is no other term for this. Jay Bhattacharya? 🤡🤡🤡 a useful idiot.
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10 months ago
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Important definitions and concepts to understand that what is happening in many countries is not new.
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Fascism: Why Understanding the Past is Critical for the Present - Department of French, Hispanic and Italian Studies
Dr. Carlo Testa explains why understanding historical Fascism is critical to resisting the many forms of Fascism that are arising today.
https://fhis.ubc.ca/news/fascism-why-understanding-the-past-is-critical-for-the-present/
11 months ago
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Miguel Soares
Marc Veldhoen
11 months ago
"Fascism is rising again". It's been back for several years, out in the open. But these four words may need an explanation and a warning. 1/3
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Miguel Soares
Preprint Club - Immunology
11 months ago
Today in
#preprinthub2
Kelsey Voss +
@cleeterichter.bsky.social
will present a
#preprint
from
@elmiguelche.bsky.social
@gimmfoundation.bsky.social
on how monocytes control organismal energy homeostasis 🕹️🧍♀️🌊
www.biorxiv.org/content/10.1...
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Monocyte control of organismal energy homeostasis
Multicellular organisms rely on inter-organ communication networks to maintain vital parameters within a dynamic physiological range. Macrophages are central to this homeostatic control system, sensin...
https://www.biorxiv.org/content/10.1101/2025.02.20.639373v1
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Miguel Soares
Science Magazine
11 months ago
The U.S. National Institutes of Health’s recent decision to impose a 15% cap on facilities and administrative cost reimbursements is misguided and damaging, argue the authors of a new
#SciencePolicyForum
.
scim.ag/423AbVX
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Miguel Soares
Maria Leptin
11 months ago
More good news: MEP Christian Ehler's ITRE report adopted by the European Parliament: strong support for an expanded and independent ERC. Happy with the proposal of €220 billion for the EU's next research framework programme! Thank you! Press briefing
multimedia.europarl.europa.eu/en/webstream...
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Press conference by Christian EHLER (EPP, DE) rapporteur, on the implementation of the Horizon Europe programme - Multimedia Centre
The multimedia platform of the European Parliament is the official public available repository of the media production of the Secretariat of the European Parliament, managed by the Directorate-General...
https://multimedia.europarl.europa.eu/en/webstreaming/press-conference-by-christian-ehler-epp-de-rapporteur-on-implementation-of-horizon-europe-programme_20250311-1630-SPECIAL-PRESSER
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Miguel Soares
Carl Zimmer
12 months ago
Kennedy Links Measles Outbreak to Poor Diet and Health, Citing Fringe Theories. Story by
@teddyrosenbluth.bsky.social
Gift link:
nyti.ms/3FvFUej
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Kennedy Links Measles Outbreak to Poor Diet and Health, Citing Fringe Theories (Gift Article)
In a recent interview, the health secretary also suggested that the measles vaccine had harmed children in West Texas, center of an outbreak.
https://nyti.ms/3FvFUej
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www.nature.com/articles/d41...
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What sparked the COVID pandemic? Mounting evidence points to raccoon dogs
More than five years on, studies suggest the animal is the most likely culprit, but other candidates haven't been ruled out.
https://www.nature.com/articles/d41586-025-00426-3
12 months ago
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www.nature.com/articles/d41...
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Exclusive: These universities have the most retracted scientific articles
A first-of-its-kind analysis by Nature reveals which institutions are retraction hotspots.
https://www.nature.com/articles/d41586-025-00455-y
12 months ago
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Miguel Soares
Jonathan Kagan
about 1 year ago
If our "academic leaders" are wondering what a real leader looks like, look no further. Who will follow Dr. Varmus?
www.nytimes.com/2025/02/14/o...
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Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
https://www.nytimes.com/2025/02/14/opinion/trump-public-health-funding-nih.html?unlocked_article_code=1.xE4.Wtyy.6cRJD4FPyZip
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Miguel Soares
Thiago Carvalho
about 1 year ago
François Jacob, who fought and was wounded in North Africa, meets his former commander in chief, General DeGaulle. (From Jacob's memoir, La Statue Interieure).
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