Ferroptosis is a Physiologic Vulnerability of Iron-Recycling Macrophages https://www.biorxiv.org/content/10.64898/2026.06.22.732688v1

🧬 Big news: our team at @gimminstitute.bsky.social and I have been awarded a €2.5M ERC Advanced Grant (#ERCAdG) for a project we couldn't resist naming KILLBILL. Yes, like the Tarantino film. Bear with me — the analogy runs deeper than the title. 🧵 ⚔️

Fantastic to see this part of my PhD out! We define the minimal amount of bilirubin in circulation that provides malaria protection! Thanks to the amazing support from @elmiguelche.bsky.social and its lab @gimminstitute.bsky.social in particular to Ana Figueiredo! Check it out 👇👇👇

Incredible science at the CAML-GIMM PhD Meeting 2026! So proud of the outstanding presentations from our GIMM students across both campuses. 🧬 The meeting showcased "home made" cutting-edge research! Congratulations to Sonia Trikha, Madalena Pereira and Miguel Mesquita! @gimmfoundation.bsky.social

1/10 🧵NEW PREPRINT: How does jaundice protect against malaria? We show it's ALL about biliverdin reductase (BVRA) catalytic activity and found the bilirubin threshold needed for protection. www.biorxiv.org/content/10.6...

Biliverdin Reductase Catalytic Activity Is Essential for Malaria Resistance https://www.biorxiv.org/content/10.64898/2025.12.19.694840v1

Homeostatic control of energy metabolism by monocyte-derived macrophages @elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells www.embopress.org/doi/full/10....

🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism. www.embopress.org/doi/full/10.... (1/9)

Better late than never, but I am thrilled to share our newest research from the Treeck lab!!! www.nature.com/articles/s41...

Rewring lipid metabolism to sustain thermoregulation during sepsis. Don’t let it get cold! A very interesting piece from Miguel Soares lab @elmiguelche.bsky.social @gimmfoundation.bsky.social

Rethinking jaundice | Science www.science.org/doi/10.1126/... Excellent work to start the week in full force! Miguel Soares lab uncovers a protective role for bilirubin, a product of heme catabolism, during malaria infection. A must read!

A metabolite-based resistance mechanism against malaria | Science www.science.org/doi/10.1126/... @gimmfoundation.bsky.social

📼 A coluna de Salgueiro Maia dirige-se para o Quartel da GNR no Largo do Carmo. https://j.mp/QuartelGNR #25a74

For portuguese readers. Tomorrow is Portugal’s liberty day and it was never so fragile. A necessary awakening call for what’s happening indoors and outdoors, comparing malaria infection with other parasites. expresso.pt/opiniao/2025...

Bilirubin metabolism in the liver orchestrates antiviral innate immunity in the body @cp-cellreports.bsky.social www.cell.com/cell-reports...

Time to give an update on the fantastic work by @taniafpaulo.bsky.social during her PhD, now published in @royalsocietypublishing.org on the evolution of resistance and disease tolerance mechanisms to oral infection in #Drosophila royalsocietypublishing.org/doi/10.1098/... #infection #immunity 🤓🎊

What childhood was like before vaccines www.vox.com/health/40268...