@gilliandunphy.bsky.social
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Glutathione is critical for NK cell-mediated immunity: Cell Reports
www.cell.com/cell-reports...
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Glutathione is critical for NK cell-mediated immunity
Guerra et al. show that glutathione (GSH) sustains IL-15-driven NK cell metabolism and effector functions. Loss of GSH unleashes T cell immunity and improves viral clearance. In contrast, NK cell-medi...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2826%2900064-1
about 1 month ago
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reposted by
Science Magazine
about 1 month ago
It’s the first time a frog—or any amphibian—has been observed pollinating a plant, researchers reported in 2023. Learn more on
#WorldWildlifeDay
:
https://scim.ag/4riUU1G
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Super Salva with the immunology facts! And just in time for the start of hay-fever season. 🌿
add a skeleton here at some point
about 1 month ago
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Some beautiful xenotopic synthetic biology to shed light on the importance of pyrimidine biosynthesis in cells with a defective ETC!
www.nature.com/articles/s42...
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Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport - Nature Metabolism
Cytosolic ScURA uncouples de novo pyrimidine synthesis from mitochondrial electron transport, and rescues pyrimidine production and cell proliferation under pharmacological or genetic mETC disruption.
https://www.nature.com/articles/s42255-026-01454-7
about 2 months ago
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reposted by
David Sancho
about 2 months ago
Excessive
#inflammation
? We uncover
@cp-immunity.bsky.social
that
#IFN-I
via
#ISG15
in macrophages lowers
#mitochondrial
membrane potential, boosts
#efferocytosis
, and self limits
#ISG
amplification: a built in brake that promotes resolution. Open-access:
www.cell.com/immunity/ful...
#immunosky
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reposted by
David Finlay
2 months ago
****2-NBDG does not measure glucose uptake**** Just your regular reminder of this fact 😁. See the rigorous proof of this fact in
@lindavsinclair.bsky.social
2020 paper. This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄
pmc.ncbi.nlm.nih.gov/articles/PMC...
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Single Cell Glucose Uptake Assays: A Cautionary Tale
Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...
https://pmc.ncbi.nlm.nih.gov/articles/PMC7116014/
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Very interesting pre-print comparing cell culture media with physiologically available metabolic substrate levels
www.biorxiv.org/content/10.1...
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https://www.biorxiv.org/content/10.1101/2025.09.22.677838v1
3 months ago
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www.nature.com/immersive/d4...
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The best science images of 2025 — Nature’s picks
The Sun’s fiery surface, a tattooed tardigrade, rare red lightning and more.
https://www.nature.com/immersive/d41586-025-03935-3/index.html?utm_source=Live+Audience&utm_campaign=cc38c2083d-nature-briefing-weekly-20251225&utm_medium=email&utm_term=0_-33f35e09ea-50647816
3 months ago
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reposted by
William Shakespeare
3 months ago
[Dance. Exeunt.]
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reposted by
Molecular Cell
3 months ago
Online Now: IFI16 senses and protects stalled replication forks Online now:
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IFI16 senses and protects stalled replication forks
Gamble et al. demonstrate that detection of stalled replication forks by the innate immune sensor IFI16 induces an early STING-dependent pro-inflammatory cytokine response independently of cGAS and DNA damage. Furthermore, IFI16 exhibits dual functionality during replication stress by protecting stalled, remodeled replication forks from nucleolytic degradation.
http://dlvr.it/TQF0Kn
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reposted by
Nature
4 months ago
Nature research paper: Architecture of the neutrophil compartment
go.nature.com/4oD2Nh5
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Architecture of the neutrophil compartment - Nature
Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.
https://go.nature.com/4oD2Nh5
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www.nature.com/articles/s42...
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Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism
Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pathway analysis in metabolomics often yields misleading or nonsensical results.
https://www.nature.com/articles/s42255-025-01283-0#citeas
6 months ago
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What a shame.
www.theguardian.com/us-news/2025...
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RFK Jr’s health department to halt $500m in mRNA vaccine research
Agency to end 22 federal contracts, questioning safety of technology credited with helping end Covid pandemic
https://www.theguardian.com/us-news/2025/aug/05/rfk-jr-hhs-mrna-vaccine-research?CMP=Share_AndroidApp_Other
8 months ago
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This month Mr.
@aitorjarit.bsky.social
became (very deservedly) Dr. Aitor with a great thesis! Super interesting discussion during the defense with the input of the wise committee - lots of cool experiments to do 🧪🔬❤️
9 months ago
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reposted by
Annalaura Mastrangelo
9 months ago
🌟Proud to share our latest research: "Imidazole propionate (ImP) is a driver therapeutic target in atherosclerosis" in
@nature.com
A step toward early diagnosis & targeted therapy in cardiovascular care!
#metabolites
#impact
#PersonalizedMedicine
👇🧵https://www.nature.com/articles/s41586-025-09263-w
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Woah, very cool study, relevant for mRNA vaccine success.
add a skeleton here at some point
9 months ago
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Our preview of the cool work from the Rabinovich lab in this issue of Immunity:
www.sciencedirect.com/science/arti...
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A sweet spot in myeloid cell pro-tumoral functions
The regulation of myeloid cell responses can determine tumor outcomes. In this issue of Immunity, Blidner et al. report that galectin-1 triggers both …
https://www.sciencedirect.com/science/article/abs/pii/S1074761325002365
10 months ago
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This week the world gained another Doctor of Immunology, and we are all the richer for it! Congratulations Dr. Irene on a great thesis and defense. Thank you to the examiners for the interesting discusion and to
@sancholab.bsky.social
for cosupervising with me these years - it has been a pleasure!
10 months ago
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reposted by
Science Magazine
11 months ago
Lab-kept bumble bees roll small wooden balls around for no apparent purpose other than fun, a 2022 study reveals. Learn more on
#WorldBeeDay
:
scim.ag/4dAwCuD
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I do not see a lack of scientific talent in the EU. I see a lack of job opportunity and stability, with great scientists being forced to leave their home country to do what they love. France and EU to incentivise US-based scientists to come to Europe
www.theguardian.com/world/2025/m...
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France and EU to incentivise US-based scientists to come to Europe
Macron and von der Leyen expected to announce protections for researchers seeking to relocate amid Trump’s crackdown
https://www.theguardian.com/world/2025/may/04/france-eu-us-based-scientists-come-to-europe-emmanuel-macron-ursula-von-der-leyen?CMP=Share_AndroidApp_Other
11 months ago
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reposted by
David Sancho
12 months ago
Put a dendritic cell (DC) in your tumor
#immunotherapy
! cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse!
#CNIC
@ageinves.bsky.social
@contracancerinv.bsky.social
www.nature.com/articles/s41...
#immunosky
#cancersky
(1/7)
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Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse - Nature Communications
Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...
https://www.nature.com/articles/s41467-025-58289-1
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reposted by
Nature
12 months ago
Researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases
https://go.nature.com/3RcyzDa
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Cells are swapping their mitochondria. What does this mean for our health?
Nature - Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
https://go.nature.com/3RcyzDa
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So cool! A very functional relevance of the Nrf2-Keap1 axis 🐎
add a skeleton here at some point
about 1 year ago
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I really enjoyed writing this research highlight with
@sancholab.bsky.social
The original paper from the Rathmell lab answers many questions and opens the way for many more!
journals.lww.com/immunometabo...
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Mitochondrial response to fever boosts TH1-driven... : Immunometabolism
n. In a recent study, Heintzman, et al investigated the effect of febrile temperature (39 °C) on T cell function. They describe increased TH1 function and fitness accompanied by a decrease in regulato...
https://journals.lww.com/immunometabolism/fulltext/2025/04000/mitochondrial_response_to_fever_boosts_th1_driven.1.aspx
about 1 year ago
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Congratulations Iñaki et al.! 🦴🦠💕
add a skeleton here at some point
about 1 year ago
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you reached the end!!
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