2 new efforts: from Megan Teh on metabolism of CD8 Tcells in iron deficiency and why they love aspartate (+ @sarahdimeloe.bsky.social @lindavsinclair.bsky.social); & reviewing the strong influence of iron on immunity @joefrost.bsky.social www.nature.com/articles/s41... www.nature.com/articles/s41...

Special issue Immunometabolism and Beyond: from Liver to Brain! European Journal of Immunology Article types: reviews and research articles Submission deadline 1 November 2025 Thanks to Nadja, Matteo and Bin for this wonderful opportunity! #immunometabolism #EJI #CRC1292 #CRC355 #CRC156 #FZI

🚨Last week's #immunometabolism findings @biomednews.bsky.social 🔽🔽🔽 biomed.news/bims-imicid/... Interesting paper: Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells

Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells #immunometabolism www.nature.com/articles/s41...

So cool to start the afternoon session with @plantophagy.bsky.social !! Here in the @autophagyuk and @UK_proteostasis meeting

What if Tregs are not a separate lineage, but part of spontaneously activated T cells? In this work, we integrate this idea with our recent findings: Adult T cell leukemia (ATL) is not 'Treg cancer', challenging the current concept of Treg as a distinct entity.🧵(1/4) academic.oup.com/discovimmuno...

Review @annualreviews.bsky.social @lindavsinclair.bsky.social @cantrell-lab.bsky.social Protein Synthesis and Metabolism in T Cells www.annualreviews.org/content/jour...

Our review on Protein Synthesis and Metabolism in T cells is out @annualreviews.bsky.social @cantrell-lab.bsky.social Protein Synthesis and Metabolism in T Cells #proteomics #immunometabolism #Tcells www.annualreviews.org/content/jour...

Very excited to be just a weekend away from this UK conference on neutrophil biology that we are hosting at Newcastle. It includes international keynotes but most important the majority of speakers are early career researchers. #immunology #inflammation #neutrophils #humandisease

ICYMI by First release - now in print @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection. buff.ly/3DjNQ1e By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

A lovely News and Views on Samantha Pretto/Max Mazzone’s “ #Elov1 and #CD8s and #tumour paper “ - check it out! www.nature.com/articles/s42...

📢 A new episode of the podcast is out! We chat with Dr. Luke O’Neill (@lukeanthonyoneill.bsky.social) at Trinity College Dublin (@tcddublin.bsky.social) about the metabolic regulation of immune cell function and the innate #ImmuneSystem. 🎧 Listen now: bit.ly/3QybMBq

Two weeks left to apply for a postdoc position with the Slack group! Please spread the word!

I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.

Very happy to share our new preprint on hallmarks of human #lung #macrophage activation by type 2 cytokines, and metabolic control of this process 🙂. #immunometabolism #ImmunoSky 🧪 @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social www.biorxiv.org/content/10.1...

Okey dokey here goes! First real post - please reshare if appropriate 🙏 🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔 We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.

I am overjoyed to present our latest paper on Autophagy in CD8 Tcells! www.nature.com/articles/s41... It was, as all ‘sciencing’ is, a huge team effort. I will try to do it some justice in the following thread 😊 1/n @cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social

📢 Still time to be part of SIGNET 2025! We're accepting late-breaking abstracts until Monday. Share your latest discoveries with the immunology community in Scotland on Thursday 27 March 🔬 Don't miss this final chance! Submit here: bit.ly/4euIWLO

Fine-tuning tumor immunogenicity with mitochondrial complex I Our views on a very cool paper from @ppuigserverb.bsky.social we hope you like it! www.nature.com/articles/s43...

Delighted to have had the opportunity to write this spotlight with @juanquintana.bsky.social and the lab, on the recent @lydialynch.bsky.social paper, showing rhythmicity of IL-17 expression in adipose! Fascinating paper, which raises loads of cool questions #immunosky www.cell.com/immunity/ful...

Our Communication and Engagement Grant is open to all BSI members who want to take part in #PublicEngagement 🌟 Share your passion, build skills, and make a difference to the world of #immunology 💪 Application deadline: 1 Feb 2025 🗓️ Apply now 👉 bit.ly/3Y9j8gm

Elegant work by Jason Cyster's group "Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky

Thank you Drs. Dan Klionsky and Dimitra Dialynaki for your commentary on our work: www.tandfonline.com/doi/epdf/10....

Michael J Fox has had tremendous influence on people with Parkinson's Disease (PD), their carers, families and those working on PD. He is a shining example of what a single person is capable of. Well deserved recognition.

Organelles meets dinos! 🦖🔬 Featuring Mitosaur, ERsaur, Golgisaur, Lysosaur, and others, it's such a creative take on the cellular world we know and love. 💚 Which dino-organelle is your favorite? Let us know below! 👇

LPS stimulates dynamic changes in B cell metabolism to promote proliferation https://www.biorxiv.org/content/10.1101/2024.12.16.628649v1

A proteomic map of B cell activation and its shaping by mTORC1, MYC and iron https://www.biorxiv.org/content/10.1101/2024.12.19.629506v1

Here is link to Shixin's new paper: www.science.org/doi/epdf/10....

T cells get hungry! Check out Shixin Ma's new paper showing nutrient switching controls T cell exhaustion. Nutrients metabolized in the nucleus by ACSS2 and ACLY direct histone acetylation at key loci via binding to specific HATs, indicating a metabolic code guides our histone code. @science.org

Just recently I wrote an opinion piece with Shingo Kajimura, based around the idea that adipocytes, besides having energy storage/endocrine function, also act as immune hubs #Immunosky 🧪 1/🧵 febs.onlinelibrary.wiley.com/doi/10.1111/...

Can you explain your doctoral research through interpretive dance? The 17th annual #DanceYourPhD competition is open! Submit by 28 March for a chance to win $2000: scim.ag/3BcKi0e

Our annual Dance Your Ph.D. contest is open for submissions until March 28 💃 The entry form is here (plus more details in the article linked below): www.science.org/content/page...

Hello BlueSky! Looking forward to sharing all things #Immunology, #Host-pathogen and #hematology! As we are heading towards the end of 2024, I'll post highlights published @science.org so far this year - and hot-of-the press research from our December issues!

🎉 I'm a #newPI , and I'm so excited to share our new paper out in Nature Comms today! 🧵 rdcu.be/d2gBV Quick intro for the new followers: I'm from Monash Uni in Melbourne, and we study T and B cell responses to viruses, bacteria & parasites with the goal of improving vaccines. #ImmunoSky #MicroSky

A starter pack for PhD students and Postdocs in Immunology to connect 🔽 Drop a 🧬 and I'll add you to the list. Let's build the upcoming immuno community! #ImmunoSky 🧪 go.bsky.app/RABVXY4

Fascinating new paper about how commensal #fungi can promote #type2 responses in mice, a process involving fungal induction of #IL-33 🍄 🧪 #ImmunoSky www.nature.com/articles/s41...

Our latest paper reveals an intriguing and essential role for the class III #PI3K VPS34 in Treg homeostasis and function. Selective deletion of VPS34 in Treg led to a scurfy-like phenotype, suggesting an essential role for VPS34 in Treg-suppression. doi.org/10.3389/fimm... #immunosky

#Immunosky #neuroskyence our team is expanding and we’re recruiting a colleague with a strong background in neuroscience (PhD level) to conduct curiosity-driven research into the role of adaptive immunity in controlling sleep. Details & how to apply here: www.jobs.manchester.ac.uk/Job/JobDetai...

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

PhD opportunity in my lab together plus collaborative placement with Jenny Mjosberg's group at Karolinska. Looking for someone with a passion to learn and develop spatial 'omics pipelines in the gut. Deadline end of the week! Spread the word: www.findaphd.com/phds/project...

New PhD opportunity in the lab with @profjudiallen.bsky.social and @douglaspdyer.bsky.social looking at interactions between ILCs and the extracellular matrix. Application deadline Jan 10th 2025 - spread the word Bluesky immunologists! www.findaphd.com/phds/project...

ICYMI: earlier this year in #Science #Immunology, Josh Gray, Donna Farber & al. analyzed the phenotype, transcriptome, function, & repertoire of #gdTcells in mucosal & lymphoid tissues & blood from 176 #human donors across the life span! Subjects ranged in age from just a few days to over 80 years!

Mice and humans develop intestinal inflammation when PI3Kdelta is inhibited. Lyn Lim, Shimon Sakaguchi and colleagues provide evidence this is secondary to defects in the differentiation and maturation of pTreg:

🎓 Exciting #PhD opportunity in our lab at @mcbleicester.bsky.social and @leicstructbio.bsky.social. Join the BBSRC-funded MIBTP programme for a 4-year fully funded studentship with comprehensive training in year 1 + research project years 2-4. #PhDSky #AcademicSky Details: tinyurl.com/4fhavzxh

Very proud of this one. Sarah Hamoudi, PhD student in the lab, developed autologous cocultures between mucosal T cells and epithelial organoids from control or from patients with Crohn's disease. www.biorxiv.org/content/10.1...

Another lactate dependent immunosuppressant mechanism, here in Glioblastoma #GBM #Lactate #CD47 #HistoneLactylation JCI - Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation www.jci.org/articles/vie...

The bad news: Many people don’t get enough iron in their diet. The good news: One ounce of dark chocolate has 3.37 mg of iron Ladies, that’s 5.5 ounces a day that you clearly need. Sorry guys, you’ll get your daily allotment with 2.5.

Obesity imprints adipose tissue even after weight loss - promoting regain and progression. Same is observed with GLP-1 therapies were we see regain in the majority of individuals who stop TX www.nature.com/articles/s41...

Metabolism starter pack now full with 150 contacts! go.bsky.app/VavECSX